Full Text Journal Articles by
Author Simon P G Padley

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Suveer Singh, Diana A Gorog, Ciara F Mahon, Bhavin Rawal, Thomas R Semple, Edward D Nicol, Deepa R J Arachchillage, Susanna Price, Sujal Desai, Carole A Ridge, Simon P G Padley, Saeed Mirsadraee,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1190-e1191]

Cited: 0 times

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Prevalence of Thrombotic Complications in ICU-Treated Patients With Coronavirus Disease 2019 Detected With Systematic CT Scanning.

Saeed Mirsadraee, Diana A Gorog, Ciara F Mahon, Bhavin Rawal, Thomas R Semple, Edward D Nicol, Deepa R J Arachchillage, Anand Devaraj, Susanna Price, Sujal R Desai, Carole A Ridge, Suveer Singh, Simon P G Padley,

<h4>Objectives</h4>Severe coronavirus disease 2019 is associated with an extensive pneumonitis and frequent coagulopathy. We sought the true prevalence of thrombotic complications in critically ill patients with severe coronavirus disease 2019 on the ICU, with or without extracorporeal membrane oxygenation.<h4>Design</h4>We undertook a single-center, retrospective analysis of 72 critically ill patients with ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(5):804-815]

Cited: 4 times

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Reply to Sanfilippo et al. and to Caviedes et al.

Deepa J Arachchillage, Sujal R Desai, Anand Devaraj, Carole A Ridge, Simon P G Padley, Brijesh V Patel,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 203(2):261-263]

Cited: 0 times

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Pulmonary Angiopathy in Severe COVID-19: Physiologic, Imaging, and Hematologic Observations.

Brijesh V Patel, Deepa J Arachchillage, Carole A Ridge, Paolo Bianchi, James F Doyle, Benjamin Garfield, Stephane Ledot, Cliff Morgan, Maurizio Passariello, Susanna Price, Suveer Singh, Louit Thakuria, Sarah Trenfield, Richard Trimlett, Christine Weaver, S John Wort, Tina Xu, Simon P G Padley, Anand Devaraj, Sujal R Desai,

<b>Rationale:</b> Clinical and epidemiologic data in coronavirus disease (COVID-19) have accrued rapidly since the outbreak, but few address the underlying pathophysiology.<b>Objectives:</b> To ascertain the physiologic, hematologic, and imaging basis of lung injury in severe COVID-19 pneumonia.<b>Methods:</b> Clinical, physiologic, and laboratory data were collated. Radiologic (computed tomography (CT) pulmonary angiography [<i>n</i> = 39] ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 202(5):690-699]

Cited: 73 times

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Baseline Results of the West London lung cancer screening pilot study - Impact of mobile scanners and dual risk model utilisation.

Emily C Bartlett, Samuel V Kemp, Carole A Ridge, Sujal R Desai, Saeed Mirsadraee, Jaymin B Morjaria, Pallav L Shah, Sanjay Popat, Andrew G Nicholson, Alexandra J Rice, Simon Jordan, Sofina Begum, Aleksander Mani, Jane Derbyshire, Katie Morris, Michelle Chen, Christine Peacock, James Addis, Maria Martins, Stan B Kaye, Simon P G Padley, Anand Devaraj, ,

<h4>Objectives</h4>The West London lung screening pilot aimed to identify early-stage lung cancer by targeting low-dose CT (LDCT) to high risk participants. Successful implementation of screening requires maximising participant uptake and identifying those at highest risk. As well as reporting pre-specified baseline screening metrics, additional objectives were to 1) compare participant ... Read more >>

Lung Cancer (Lung cancer (Amsterdam, Netherlands))
[2020, 148:12-19]

Cited: 3 times

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A Golden Conundrum.

Justin L Garner, Jackie Donovan, Ines Meireles, Simon P G Padley, David Cunningham, Pallav L Shah,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2019, 200(5):631-632]

Cited: 0 times

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Evaluation of High-Pitch Ungated Pediatric Cardiovascular Computed Tomography for the Assessment of Cardiac Structures in Neonates.

Mona Sriharan, Olga Lazoura, Christopher W Pavitt, Isabel Castellano, Catherine M Owens, Michael B Rubens, Simon P G Padley, Edward D Nicol,

<h4>Purpose</h4>We evaluated a high-pitch, non-electrocardiogram-gated cardiac computed tomographic protocol, designed to image both cardiac and extracardiac structures, including coronary arteries, in a neonatal population (less than 1 year old) that was referred for congenital heart disease assessment and compared it with an optimized standard-pitch protocol in an equivalent cohort.<h4>Materials and ... Read more >>

J Thorac Imaging (Journal of thoracic imaging)
[2016, 31(3):177-182]

Cited: 7 times

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Clinical and economic consequences of non-cardiac incidental findings detected on cardiovascular computed tomography performed prior to transcatheter aortic valve implantation (TAVI).

Alistair C Lindsay, Mona Sriharan, Olga Lazoura, Arunashis Sau, Michael Roughton, Richard J Jabbour, Carlo Di Mario, Simon W Davies, Neil E Moat, Simon P G Padley, Michael B Rubens, Edward D Nicol,

Transcatheter aortic valve implantation (TAVI) is an effective treatment option for patients with severe degenerative aortic valve stenosis who are high risk for conventional surgery. Computed tomography (CT) performed prior to TAVI can detect pathologies that could influence outcomes following the procedure, however the incidence, cost, and clinical impact of ... Read more >>

Int J Cardiovasc Imaging (The international journal of cardiovascular imaging)
[2015, 31(7):1435-1446]

Cited: 14 times

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Multidetector computed tomography of congenital aortic abnormalities.

Alistair C Lindsay, Mona Sriharan, Olga Lazoura, Simon P G Padley, Edward D Nicol, Michael B Rubens,

For many years invasive angiographic techniques have been considered as the gold standard for the assessment of large arterial abnormalities. However, the complexities and complications inherent to invasive imaging have meant that more recently non-invasive techniques such as echocardiography, Magnetic Resonance Imaging (MRI) and multidetector CT (MDCT) have been increasingly ... Read more >>

Int J Cardiol (International journal of cardiology)
[2014, 172(3):537-547]

Cited: 9 times

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Great vessel and coronary artery anatomy in transposition and other coronary anomalies: a universal descriptive and alphanumerical sequential classification.

Sasi Sithamparanathan, Simon P G Padley, Michael B Rubens, Michael A Gatzoulis, Siew Yen Ho, Edward D Nicol,

In patients with transposition of the great arteries, the identification of coronary anatomy is fundamental to optimal surgical outcome. A number of classifications describing the coronary vessels' origin and course in transposition of the great arteries have been published. However, all are limited to operative or pathological case series. They ... Read more >>

JACC Cardiovasc Imaging (JACC. Cardiovascular imaging)
[2013, 6(5):624-630]

Cited: 7 times

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Prevalence of scoliosis in cystic fibrosis.

Valentina Fainardi, Sergio D Koo, Simon P G Padley, Sonia H Y Lam, A Bush,

<h4>Background</h4>The prevalence of idiopathic scoliosis in the general pediatric population is reported to be between 0.5% and 3.2%. Previous studies have reported an increased prevalence of scoliosis in children with cystic fibrosis (CF).<h4>Hypothesis</h4>The prevalence of scoliosis in CF children is greater than in the normal population.<h4>Methods</h4>Chest X-rays of 319 patients ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2013, 48(6):553-555]

Cited: 8 times

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Secondary vascular changes in pulmonary sequestrations.

Saral Desai, Michael Dusmet, George Ladas, Sabine Pomplun, Simon P G Padley, Nyree Griffin, Jamal Badreddine, Peter Goldstraw, Andrew G Nicholson,

<h4>Aims</h4>Whilst parenchymal changes in pulmonary sequestrations are well described, there are comparatively little data on associated vascular changes and their extent. The aim of this study was to retrospectively review morphological changes within sequestrations, concentrating on vascular changes and associations with clinical parameters.<h4>Methods and results</h4>Twenty-seven resected cases of sequestrations (intralobar ... Read more >>

Histopathology (Histopathology)
[2010, 57(1):121-127]

Cited: 6 times

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X-ray computed tomography of the heart.

Nevin T Wijesekera, Mark K Duncan, Simon P G Padley,

<h4>Introduction</h4>Cardiac imaging is an emerging application of multidetector computed tomography (MDCT). This review summarizes the current capabilities, possible applications, limitations and developments of cardiac CT.<h4>Sources of data</h4>Relevant publications in peer reviewed literature and national and international guidelines are used to discuss important issues in cardiac CT imaging.<h4>Areas of agreement and ... Read more >>

Br Med Bull (British medical bulletin)
[2010, 93:49-67]

Cited: 2 times

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Implications for single phase prospective CT coronary angiography for the diagnosis of significant coronary stenoses in clinical practice.

Maria Isabel Sá, Edward D Nicol, James Stirrup, Andrew Crean, Michael Roughton, Simon P G Padley, Michael B Rubens,

<h4>Background</h4>CT coronary angiography (CTA) with 64 slice multi-detector CT (64-MDCT) has assumed an increasing role in clinical practice; however the high radiation dose associated with retrospective ECG-gated CTA has led to suggestions that a low dose prospectively gated strategy may be more appropriate. This study aims to assess the feasibility ... Read more >>

Int J Cardiol (International journal of cardiology)
[2011, 147(3):393-397]

Cited: 3 times

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Defining the appropriate CTA stenosis threshold for gatekeeping to invasive angiography: 50% or 70%?

Edward D Nicol, Carl Schultz, James Stirrup, Michael Roughton, Simon P G Padley, Michael B Rubens, Simon W Davies, Carlo Di Mario,

There is currently much debate around the limited positive predictive value (PPV) of CT coronary angiography (CTA). There remain no published studies comparing different thresholds to define significant visual stenoses on CTA compared to the gold standard quantitative coronary angiography (QCA). The spatial resolution for ICA is (0.1 mm)(3) compared ... Read more >>

Int J Cardiol (International journal of cardiology)
[2010, 144(2):297-298]

Cited: 0 times

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Diagnostic accuracy of 64-slice computed tomography coronary angiography: a flawed comparison.

Edward D Nicol, James Stirrup, Simon P G Padley, Michael B Rubens,

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2009, 53(19):1824-5; author reply 1825-6]

Cited: 1 time

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64-Channel cardiac computed tomography: intraobserver and interobserver variability, part 2: global and regional ventricular function, mass, and first pass perfusion.

Edward D Nicol, James Stirrup, Michael Roughton, Simon P G Padley, Michael B Rubens,

<h4>Objectives</h4>To assess intraobserver and interobserver variability in cardiac computed tomographic measurements of global biventricular function, left ventricular (LV) regional wall motion, systolic wall thickening, and first pass perfusion in 3 patient cohorts at very low, low to intermediate, and intermediate to high cardiac risk.<h4>Methods</h4>One hundred thirty-three patients underwent 64-channel cardiac ... Read more >>

J Comput Assist Tomogr (Journal of computer assisted tomography)
[2009, 33(2):169-174]

Cited: 0 times

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Clinical management and short-term cost - 64-slice MDCT vs. myocardial perfusion scintigraphy.

Edward D Nicol, James Stirrup, Edward Leatham, Michael Roughton, S Richard Underwood, Simon P G Padley, Michael B Rubens,

There are currently no published studies of the impact of CT coronary angiography (CTA) on patient management or cost when compared with other established imaging techniques. We assessed the short term investigation and treatment costs of CTA compared with myocardial perfusion scintigraphy (MPS) using real clinical scenarios. Clinical information with ... Read more >>

Int J Cardiol (International journal of cardiology)
[2010, 144(2):248-250]

Cited: 4 times

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64-Channel cardiac computed tomography: intraobserver and interobserver variability (part 1): coronary angiography.

Edward D Nicol, James Stirrup, Michael Roughton, Simon P G Padley, Michael B Rubens,

<h4>Objectives</h4>To assess intraobserver and interobserver variation in computed tomography coronary angiography (CTA) in 3 patient cohorts at very low, low-to-intermediate, and intermediate-to-high likelihood of coronary artery disease (CAD).<h4>Methods</h4>One hundred thirty-three patients underwent 64-channel CTA. Coronary arteries were analyzed by 2 experienced blinded observers and reported as having 0%, 1% to ... Read more >>

J Comput Assist Tomogr (Journal of computer assisted tomography)
[2009, 33(2):161-168]

Cited: 5 times

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A single, comprehensive non-invasive cardiovascular assessment in pulmonary arterial hypertension: combined computed tomography pulmonary and coronary angiography.

Edward D Nicol, Henryk Kafka, James Stirrup, Simon P G Padley, Michael B Rubens, Philip J Kilner, Michael A Gatzoulis,

<h4>Background</h4>Comprehensive assessment of pulmonary arterial hypertension (PAH) should identify structural causes and subsequent cardiopulmonary consequences of PAH. This currently requires the use of several imaging modalities. Computed tomography (CT) is routinely used for pulmonary angiography (CTPA). Our aim was to assess whether combined pulmonary and coronary angiography (CTPCA) using ECG-gated, ... Read more >>

Int J Cardiol (International journal of cardiology)
[2009, 136(3):278-288]

Cited: 13 times

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Comparison of 64-slice cardiac computed tomography with myocardial perfusion scintigraphy for assessment of global and regional myocardial function and infarction in patients with low to intermediate likelihood of coronary artery disease.

Edward D Nicol, James Stirrup, Eliana Reyes, Michael Roughton, Simon P G Padley, Michael B Rubens, S Richard Underwood,

<h4>Background</h4>Cardiac computed tomography (CCT) has the potential to assess both coronary anatomy and ventricular function in a single study. We examined the agreement between CCT and myocardial perfusion scintigraphy (MPS) for the assessment of global and regional ventricular function.<h4>Methods and results</h4>Research CCT was performed in 52 patients with a low ... Read more >>

J Nucl Cardiol (Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology)
[2008, 15(4):497-502]

Cited: 10 times

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Sixty-four-slice computed tomography coronary angiography compared with myocardial perfusion scintigraphy for the diagnosis of functionally significant coronary stenoses in patients with a low to intermediate likelihood of coronary artery disease.

Edward D Nicol, James Stirrup, Eliana Reyes, Michael Roughton, Simon P G Padley, Michael B Rubens, S Richard Underwood,

<h4>Background</h4>Multislice computed tomography coronary angiography (CTA) was proposed as a method for investigating possible coronary artery disease (CAD) in patients who present with chest pain but with a low to intermediate likelihood of CAD. Sixty-four-channel CTA was compared prospectively with (99m)Tc-tetrofosmin myocardial perfusion scintigraphy (MPS) (as the gold standard in ... Read more >>

J Nucl Cardiol (Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology)
[2008, 15(3):311-318]

Cited: 19 times

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Left main coronary atresia: a more commonly identified condition after the advent of 64-slice CT coronary angiography?

Edward D Nicol, Jonathan Lyne, Michael B Rubens, Simon P G Padley, Siew Yen Ho,

J Nucl Cardiol (Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology)
[2007, 14(5):715-718]

Cited: 4 times

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The use of a D-dimer assay in patients undergoing CT pulmonary angiography for suspected pulmonary embolus.

Guy J C Burkill, James R G Bell, Roger J S Chinn, Jeremiah C Healy, Christine Costello, Lyn Acton, Simon P G Padley,

<h4>Purpose</h4>To assess the ability of a semi-quantitative latex agglutination D-dimer test Accuclot with bedside measurements of arterial oxygen saturation, respiratory and cardiac rates to exclude pulmonary embolism (PE) on computed tomographic pulmonary angiography (CTPA).<h4>Materials and methods</h4>All patients referred to our CT unit for investigation of suspected acute pulmonary embolism were ... Read more >>

Clin Radiol (Clinical radiology)
[2002, 57(1):41-46]

Cited: 16 times

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Asymmetric ARDS following pulmonary resection: CT findings initial observations.

Simon P G Padley, Simon J Jordan, Peter Goldstraw, Athol U Wells, David M Hansell,

<h4>Purpose</h4>To investigate whether asymmetric distribution of acute respiratory distress syndrome (ARDS) following lobectomy is due to compensatory hyperexpansion of the residual lung within the hemithorax operated on and to discern if this distribution reflects true asymmetry of the disease process.<h4>Materials and methods</h4>Retrospective review of the intensive care unit database was ... Read more >>

Radiology (Radiology)
[2002, 223(2):468-473]

Cited: 24 times

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