Full Text Journal Articles by
Author Simon J Lees

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Cystathionine gamma-lyase/H2 S signaling facilitates myogenesis under aging and injury condition.

Yanjie Zhang, Laura Masters, Yuehong Wang, Lingyun Wu, Yanxi Pei, Baoqing Guo, Amadeo Parissenti, Simon J Lees, Rui Wang, Guangdong Yang,

Hydrogen sulfide (H<sub>2</sub> S) can be endogenously produced and belongs to the class of signaling molecules known as gasotransmitters. Cystathionine gamma-lyase (CSE)-derived H<sub>2</sub> S is implicated in the regulation of cell differentiation and the aging process, but the involvements of the CSE/H<sub>2</sub> S system in myogenesis upon aging and injury ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21511]

Cited: 0 times

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Oxidative Stress Mediates the Fetal Programming of Hypertension by Glucocorticoids.

Jeremy Lamothe, Sandhya Khurana, Sujeenthar Tharmalingam, Chad Williamson, Collin J Byrne, Simon J Lees, Neelam Khaper, Aseem Kumar, T C Tai,

The field of cardiovascular fetal programming has emphasized the importance of the uterine environment on postnatal cardiovascular health. Studies have linked increased fetal glucocorticoid exposure, either from exogenous sources (such as dexamethasone (Dex) injections), or from maternal stress, to the development of adult cardiovascular pathologies. Although the mechanisms are not ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2021, 10(4):]

Cited: 0 times

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Mirabegron: The most promising adipose tissue beiging agent.

Jocelyn S Bel, T C Tai, Neelam Khaper, Simon J Lees,

Accumulation of white adipose tissue (WAT) underlies the obesity epidemic, leading to current therapeutic techniques that are being investigated for their ability to activate/"beige" this tissue. Adipose tissue (AT) beiging has been reported through intermittent cold exposure (CE), exercise, and β3-Adrenergic Receptor (β3AR) agonists. But how AT beiging can help ... Read more >>

Physiol Rep (Physiological reports)
[2021, 9(5):e14779]

Cited: 0 times

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A novel specialized tissue culture incubator designed and engineered for radiobiology experiments in a sub-natural background radiation research environment.

Jake Pirkkanen, Taylor Laframboise, Peter Liimatainen, Tom Sonley, Stephen Stankiewicz, Mike Hood, Mehwish Obaid, Andrew Zarnke, T C Tai, Simon J Lees, Douglas R Boreham, Christopher Thome,

Extensive research has been conducted investigating the effects of ionizing radiation on biological systems, including specific focus at low doses. However, at the surface of the planet, there is the ubiquitous presence of ionizing natural background radiation (NBR) from sources both terrestrial and cosmic. We are currently conducting radiobiological experiments ... Read more >>

J Environ Radioact (Journal of environmental radioactivity)
[2021, 228:106512]

Cited: 0 times

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Leucine Potentiates Glucose-mediated 18F-FDG Uptake in Brown Adipose Tissue via β-Adrenergic Activation.

Brenda Huska, Sarah Niccoli, Christopher P Phenix, Simon J Lees,

Significant depots of brown adipose tissue (BAT) have been identified in many adult humans through positron emission tomography (PET), with the amount of BAT being inversely correlated with obesity. As dietary activation of BAT has implications for whole body glucose metabolism, leucine was used in the present study to determine ... Read more >>

Biomedicines (Biomedicines)
[2020, 8(6):]

Cited: 1 time

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Dose threshold for radiation induced fetal programming in a mouse model at 4 months of age: Hepatic expression of genes and proteins involved in glucose metabolism and glucose uptake in brown adipose tissue.

Caitlund Q Davidson, Sujeenthar Tharmalingam, Sarah Niccoli, Ashley Nemec-Bakk, Sandhya Khurana, Alyssa Murray, T C Tai, Douglas R Boreham, Neelam Khaper, Simon J Lees,

Exposure to ionizing radiation contributing to negative health outcomes is a widespread concern. However, the impact of low dose and sub-lethal dose radiation (SLDR) exposures remain contentious, particularly in pregnant women who represent a vulnerable group. The fetal programming hypothesis states that an adverse in utero environment or stress during ... Read more >>

PLoS One (PloS one)
[2020, 15(4):e0231650]

Cited: 0 times

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Ascorbic acid diminishes bone morphogenetic protein 2-induced osteogenic differentiation of muscle precursor cells.

Paige C Ferrazzo, Sarah Niccoli, Neelam Khaper, Christopher R Rathbone, Simon J Lees,

<h4>Introduction</h4>Muscle precursor cells (MPC) are integral to the maintenance of skeletal muscle and have recently been implicated in playing a role in bone repair. The primary objective of this study was to understand better the role of oxidative stress during the osteogenic differentiation of MPCs.<h4>Methods</h4>Muscle precursor cells were treated with ... Read more >>

Muscle Nerve (Muscle & nerve)
[2019, 59(4):501-508]

Cited: 2 times

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Searching for novel PET radiotracers: imaging cardiac perfusion, metabolism and inflammation.

Caitlund Q Davidson, Christopher P Phenix, T C Tai, Neelam Khaper, Simon J Lees,

Advances in medical imaging technology have led to an increased demand for radiopharmaceuticals for early and accurate diagnosis of cardiac function and diseased states. Myocardial perfusion, metabolism, and hypoxia positron emission tomography (PET) imaging radiotracers for detection of cardiac disease lack specificity for targeting inflammation that can be an early ... Read more >>

Am J Nucl Med Mol Imaging (American journal of nuclear medicine and molecular imaging)
[2018, 8(3):200-227]

Cited: 3 times

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Non-radioactive 2-deoxy-2-fluoro-D-glucose inhibits glucose uptake in xenograft tumours and sensitizes HeLa cells to doxorubicin in vitro.

Sarah Niccoli, Douglas R Boreham, Christopher P Phenix, Simon J Lees,

A glucose analog called 2-deoxy-D-glucose (2DG) has been successfully used to sensitize cancer cells to ROS-inducing cancer treatments such as ionizing radiation, through the inhibition of glycolysis. However, the use of 2DG can be limited by several factors such as availability, non-specific cytotoxicity, and chemoresistance under hypoxic conditions. The purpose ... Read more >>

PLoS One (PloS one)
[2017, 12(11):e0187584]

Cited: 4 times

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Whey Protein Supplementation Improves Rehabilitation Outcomes in Hospitalized Geriatric Patients: A Double Blinded, Randomized Controlled Trial.

Sarah Niccoli, Anton Kolobov, Trevor Bon, Seda Rafilovich, Heather Munro, Kim Tanner, Trina Pearson, Simon J Lees,

Whey protein supplementation (WPS) has been shown to improve functional outcomes in populations that are able to participate in high-intensity resistance training. The purpose of the study was to evaluate the efficacy of WPS on rehabilitation outcomes in a frail, hospitalized elderly population. Men and women (n = 47) were randomly assigned ... Read more >>

J Nutr Gerontol Geriatr (Journal of nutrition in gerontology and geriatrics)
[2017, 36(4):149-165]

Cited: 11 times

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Two common variants of human papillomavirus type 16 E6 differentially deregulate sugar metabolism and hypoxia signalling in permissive human keratinocytes.

Sean Cuninghame, Robert Jackson, Simon J Lees, Ingeborg Zehbe,

Human papillomavirus type 16 (HPV16) is responsible for most cancers attributable to HPV infection and naturally occurring variants of the HPV16 E6 oncoprotein predispose individuals to varying risk for developing cancer. Population studies by us and others have demonstrated that the common Asian-American E6 (AAE6) variant is a higher risk ... Read more >>

J Gen Virol (The Journal of general virology)
[2017, 98(9):2310-2319]

Cited: 3 times

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Impact of Ionizing Radiation on the Cardiovascular System: A Review.

Stephanie Puukila, Jennifer A Lemon, Simon J Lees, T C Tai, Douglas R Boreham, Neelam Khaper,

Radiation therapy has become one of the main forms of treatment for various types of cancers. Cancer patients previously treated with high doses of radiation are at a greater risk to develop cardiovascular complications later in life. The heart can receive varying doses of radiation depending on the type of ... Read more >>

Radiat Res (Radiation research)
[2017, 188(4.2):539-546]

Cited: 5 times

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Ionizing Radiation Exposure During Pregnancy: Effects on Postnatal Development and Life.

Shayenthiran Sreetharan, Christopher Thome, Sujeenthar Tharmalingam, Devon E Jones, Adomas V Kulesza, Neelam Khaper, Simon J Lees, Joanna Y Wilson, Douglas R Boreham, T C Tai,

Reliable human data on the effects of prenatal exposure to ionizing radiation are largely based on high-dose exposures. Exposure to low doses may produce effects that are not easily observable at birth, and may persist over the course of the offspring's postnatal life. This is important when considering fetal programing, ... Read more >>

Radiat Res (Radiation research)
[2017, 187(6):647-658]

Cited: 5 times

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Voluntary physical activity prevents insulin resistance in a tissue specific manner.

Jessica L Sarvas, Jeffrey S Otis, Neelam Khaper, Simon J Lees,

Physical inactivity and a sedentary lifestyle are risk factors for the development of type 2 diabetes. Here, we identified the effects 8 weeks of voluntary physical activity had on the prevention of insulin resistance in mouse skeletal muscles and liver (a hallmark of T2D). To do this, 8 week old ... Read more >>

Physiol Rep (Physiological reports)
[2015, 3(2):]

Cited: 3 times

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Metformin induces apoptosis and cell cycle arrest mediated by oxidative stress, AMPK and FOXO3a in MCF-7 breast cancer cells.

Eveline A I F Queiroz, Stephanie Puukila, Rosangela Eichler, Sandra C Sampaio, Heidi L Forsyth, Simon J Lees, Aneli M Barbosa, Robert F H Dekker, Zuleica B Fortes, Neelam Khaper,

Recent studies have demonstrated that the anti-diabetic drug, metformin, can exhibit direct antitumoral effects, or can indirectly decrease tumor proliferation by improving insulin sensitivity. Despite these recent advances, the underlying molecular mechanisms involved in decreasing tumor formation are not well understood. In this study, we examined the antiproliferative role and ... Read more >>

PLoS One (PloS one)
[2014, 9(5):e98207]

Cited: 110 times

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Interleukin-6 deficiency causes tissue-specific changes in signaling pathways in response to high-fat diet and physical activity.

Jessica L Sarvas, Sarah Niccoli, Eric Walser, Neelam Khaper, Simon J Lees,

This study was designed to investigate the role of interleukin-6 (IL-6) on high-fat diet (HFD)-induced glucose intolerance, and the response to voluntary physical activity in the prevention of insulin resistance. Six-week-old wild-type (WT) and IL-6 knockout (KO) mice with (RUN) or without (SED) access to running wheels were fed a ... Read more >>

Physiol Rep (Physiological reports)
[2014, 2(7):]

Cited: 4 times

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Pro-inflammatory mediation of myoblast proliferation.

Jeffrey S Otis, Sarah Niccoli, Nicole Hawdon, Jessica L Sarvas, Melinda A Frye, Adam J Chicco, Simon J Lees,

Skeletal muscle satellite cell function is largely dictated by the surrounding environment following injury. Immune cell infiltration dominates the extracellular space in the injured area, resulting in increased cytokine concentrations. While increased pro-inflammatory cytokine expression has been previously established in the first 3 days following injury, less is known about ... Read more >>

PLoS One (PloS one)
[2014, 9(3):e92363]

Cited: 30 times

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The IL-6 Paradox: Context Dependent Interplay of SOCS3 and AMPK.

Jessica L Sarvas, Neelam Khaper, Simon J Lees,

Insulin resistance is the principle step towards the progression of type 2 diabetes, and has been linked to increased circulating levels of cytokines, leading to chronic low-grade inflammation. Specifically, in chronic disease states increased IL-6 is thought to play a critical role in the regulation of insulin resistance in the ... Read more >>

J Diabetes Metab (Journal of diabetes & metabolism)
[2013, Suppl 13:]

Cited: 15 times

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The antioxidant resveratrol down-regulates inflammation in an in-vitro model of Pseudomonas aeruginosa infection of lung epithelial cells.

Ashley M Cerqueira, Neelam Khaper, Simon J Lees, Marina Ulanova,

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that can cause severe pulmonary infection in immunocompromized individuals. During the infectious process, P. aeruginosa provokes a potent inflammatory response and induces the release of reactive oxygen species (ROS). Cells undergo oxidative stress when cellular antioxidants are unable to effectively scavenge and detoxify ... Read more >>

Can J Physiol Pharmacol (Canadian journal of physiology and pharmacology)
[2013, 91(3):248-255]

Cited: 8 times

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Age-related impairment of T cell-induced skeletal muscle precursor cell function.

Breanna R Dumke, Simon J Lees,

Sarcopenia is the age-associated loss of skeletal muscle mass and strength. Recent evidence suggests that an age-associated loss of muscle precursor cell (MPC) functionality contributes to sarcopenia. The objectives of the present study were to examine the influence of activated T cells on MPCs and determine whether an age-related defect ... Read more >>

Am J Physiol Cell Physiol (American journal of physiology. Cell physiology)
[2011, 300(6):C1226-33]

Cited: 9 times

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IGF-I activates the mouse type IIb myosin heavy chain gene.

R Andrew Shanely, Kevin A Zwetsloot, Thomas E Childs, Simon J Lees, Richard W Tsika, Frank W Booth,

IGF-I increases skeletal muscle mass, but whether IGF-I increases type IIb myosin heavy chain (MyHC) transcriptional activity is not known. C2C12 myotubes were cultured with or without IGF-I to determine whether IGF-I increases type IIb MyHC promoter activity, and if so, what region of the promoter might IGF-I signaling regulate. ... Read more >>

Am J Physiol Cell Physiol (American journal of physiology. Cell physiology)
[2009, 297(4):C1019-27]

Cited: 16 times

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Fibroblast growth factor 2-stimulated proliferation is lower in muscle precursor cells from old rats.

Seth S Jump, Tom E Childs, Kevin A Zwetsloot, Frank W Booth, Simon J Lees,

In aged skeletal muscle, impairments in regrowth and regeneration may be explained by a decreased responsiveness of muscle precursor cells (MPCs) to environmental cues such as growth factors. We hypothesized that impaired responsiveness to fibroblast growth factor 2 (FGF2) in MPCs from old animals would be explained by impaired FGF2 ... Read more >>

Exp Physiol (Experimental physiology)
[2009, 94(6):739-748]

Cited: 11 times

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Muscle precursor cells isolated from aged rats exhibit an increased tumor necrosis factor- alpha response.

Simon J Lees, Kevin A Zwetsloot, Frank W Booth,

Improving muscle precursor cell (MPC, muscle-specific stem cells) function during aging has been implicated as a key therapeutic target for improving age-related skeletal muscle loss. MPC dysfunction during aging can be attributed to both the aging MPC population and the changing environment in skeletal muscle. Previous reports have identified elevated ... Read more >>

Aging Cell (Aging cell)
[2009, 8(1):26-35]

Cited: 18 times

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Age-dependent FOXO regulation of p27Kip1 expression via a conserved binding motif in rat muscle precursor cells.

Simon J Lees, Tom E Childs, Frank W Booth,

Previously, we have demonstrated that forkhead box O3a (FOXO3a) overexpression increased p27(Kip1) promoter activity and protein expression, whereas it decreased proliferation in muscle precursor cells (MPCs). The objectives of the present study were to 1) locate and identify FOXO regulatory elements in the rat p27(Kip1) promoter using deletion analysis of ... Read more >>

Am J Physiol Cell Physiol (American journal of physiology. Cell physiology)
[2008, 295(5):C1238-46]

Cited: 24 times

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FoxO3a preferentially induces p27Kip1 expression while impairing muscle precursor cell-cycle progression.

Christopher R Rathbone, Frank W Booth, Simon J Lees,

Previous work has demonstrated that forkhead transcription factors, which include the FoxO subfamily, play a critical role in muscle atrophy by inducing expression of the atrophy-related ubiquitin ligases. The proliferation of muscle precursor cells (MPC) is also essential for skeletal muscle mass. The hypothesis was tested that the FoxO forkhead ... Read more >>

Muscle Nerve (Muscle & nerve)
[2008, 37(1):84-89]

Cited: 30 times

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