Full Text Journal Articles by
Author Simon Dobson

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Exact formula for bond percolation on cliques.

Peter Mann, V Anne Smith, John B O Mitchell, Christopher Jefferson, Simon Dobson,

We present exact solutions for the size of the giant connected component of complex networks composed of cliques following bond percolation. We use our theoretical result to find the location of the percolation threshold of the model, providing analytical solutions where possible. We expect the results derived here to be ... Read more >>

Phys Rev E (Physical review. E)
[2021, 104(2-1):024304]

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Symbiotic and antagonistic disease dynamics on networks using bond percolation.

Peter Mann, V Anne Smith, John B O Mitchell, Simon Dobson,

In this paper we introduce a description of the equilibrium state of a bond percolation process on random graphs using the exact method of generating functions. This allows us to find the expected size of the giant connected component (GCC) of two sequential bond percolation processes in which the bond ... Read more >>

Phys Rev E (Physical review. E)
[2021, 104(2-1):024303]

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Non-inferior antibody levels for HPV16/18 after extended two-dose schedules compared with a six-month interval: findings of a systematic review and meta-analysis.

Aneisha Collins-Fairclough, Robine Donken, Bohdan Nosyk, Simon Dobson, Gina Ogilivie, Manish Sadarangani,

Protection after human papillomavirus (HPV) vaccination can be maximized by optimizing vaccination schedules. We systematically reviewed immunogenicity and effectiveness of HPV vaccines administered 6 months apart compared with longer intervals. Seroconversion to vaccine-type HPV was non-inferior for 12- compared with 6-month intervals, but inconclusive for comparison of 36-96 months with 6 months. A ... Read more >>

Hum Vaccin Immunother (Human vaccines & immunotherapeutics)
[2021, 17(10):3554-3561]

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Two-pathogen model with competition on clustered networks.

Peter Mann, V Anne Smith, John B O Mitchell, Simon Dobson,

Networks provide a mathematically rich framework to represent social contacts sufficient for the transmission of disease. Social networks are often highly clustered and fail to be locally treelike. In this paper, we study the effects of clustering on the spread of sequential strains of a pathogen using the generating function ... Read more >>

Phys Rev E (Physical review. E)
[2021, 103(6-1):062308]

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Declining rates of cervical intraepithelial neoplasia in British Columbia, Canada: An ecological analysis on the effects of the school-based human papillomavirus vaccination program.

Robine Donken, Dirk van Niekerk, Jeremy Hamm, John J Spinelli, Laurie Smith, Manish Sadarangani, Arianne Albert, Deborah Money, Simon Dobson, Dianne Miller, Marette Lee, Sheona Mitchell-Foster, Mel Krajden, Monika Naus, Gina Ogilvie,

Since 2008, girls in British Columbia (BC), Canada, have been offered HPV vaccination through a school-based, publicly funded immunization program. The oldest birth cohort eligible for the vaccination program was born in 1994 and uptake is on average 63%. To evaluate the impact of the HPV vaccine in BC, ecological ... Read more >>

Int J Cancer (International journal of cancer)
[2021, 149(1):191-199]

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Cooperative coinfection dynamics on clustered networks.

Peter Mann, V Anne Smith, John B O Mitchell, Simon Dobson,

Coinfection is the process by which a host that is infected with a pathogen becomes infected by a second pathogen at a later point in time. An immunosuppressant host response to a primary disease can facilitate spreading of a subsequent emergent pathogen among the population. Social contact patterns within the ... Read more >>

Phys Rev E (Physical review. E)
[2021, 103(4-1):042307]

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Nasopharyngeal Expression of Angiotensin-Converting Enzyme 2 (ACE2) and Transmembrane Serine Protease 2 (TMPRSS2) in Children Compared to Adults Within Family Clusters Exposed to COVID-19

Mohammad Hasan, Muneera Ahmad, Soha Dargham, Hatem Ibrahim, Alaa Al Hashemi, Nonhlanhla Ngwabi, Andres Lopez, Simon Dobson, Laith Abu-Raddad, Patrick Tang,

There is accumulating evidence that the lower levels of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) in the nasal epithelium of children may be related to a lower incidence of COVID-19 compared to adults. However, no direct evidence is available to support this hypothesis. In this study, ... Read more >>

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Percolation in random graphs with higher-order clustering.

Peter Mann, V Anne Smith, John B O Mitchell, Simon Dobson,

Percolation theory can be used to describe the structural properties of complex networks using the generating function formulation. This mapping assumes that the network is locally treelike and does not contain short-range loops between neighbors. In this paper we use the generating function formulation to examine clustered networks that contain ... Read more >>

Phys Rev E (Physical review. E)
[2021, 103(1-1):012313]

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Three-Year Follow-up of 2-Dose Versus 3-Dose HPV Vaccine.

Jacob Bornstein, Surita Roux, Lone Kjeld Petersen, Li-Min Huang, Simon R Dobson, Punnee Pitisuttithum, Javier Diez-Domingo, Andrea Schilling, Hany Ariffin, Richard Tytus, Richard Rupp, Shelly Senders, Eli Engel, Daron Ferris, Yae-Jean Kim, Young Tae Kim, Zafer Kurugol, Oliver Bautista, Katrina M Nolan, Sandhya Sankaranarayanan, Alfred Saah, Alain Luxembourg,

<h4>Background and objectives</h4>Human papillomavirus (HPV) antibody responses to the 9-valent human papillomavirus (9vHPV) vaccine among girls and boys (aged 9-14 years) receiving 2-dose regimens (months 0, 6 or 0, 12) were noninferior to a 3-dose regimen (months 0, 2, 6) in young women (aged 16-26 years) 4 weeks after last ... Read more >>

Pediatrics (Pediatrics)
[2021, 147(1):]

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Random graphs with arbitrary clustering and their applications.

Peter Mann, V Anne Smith, John B O Mitchell, Simon Dobson,

The structure of many real networks is not locally treelike and, hence, network analysis fails to characterize their bond percolation properties. In a recent paper [P. Mann, V. A. Smith, J. B. O. Mitchell, and S. Dobson, arXiv:2006.06744], we developed analytical solutions to the percolation properties of random networks with ... Read more >>

Phys Rev E (Physical review. E)
[2021, 103(1-1):012309]

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Peritoneal Dialysis-Associated Peritonitis Caused by Mycobacterium abscessus in Children-A Case Report.

Omar Imam, Khaled Al-Zubaidi, Mohammad Janahi, Abubakr Imam, Bassil Leghrouz, Simon Dobson, Sathyavathi Sundararaju, Kin Ming Tsui, Mohammad Rubayet Hasan, Andres Perez-Lopez,

Peritoneal dialysis (PD)-associated peritonitis constitutes a major complication associated with the procedure. PD-associated peritonitis caused by nontuberculous mycobacteria, usually as a result of an infection related to the PD catheter, has been reported in adults and is associated with significant complications and poor outcome. The management of PD-associated peritonitis caused ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(1):ofaa579]

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Modelling the effects of environmental heterogeneity within the lung on the tuberculosis life-cycle.

Michael J Pitcher, Ruth Bowness, Simon Dobson, Raluca Eftimie, Stephen H Gillespie,

Progress in shortening the duration of tuberculosis (TB) treatment is hampered by the lack of a predictive model that accurately reflects the diverse environment within the lung. This is important as TB has been shown to produce distinct localisations to different areas of the lung during different disease stages, with ... Read more >>

J Theor Biol (Journal of theoretical biology)
[2020, 506:110381]

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Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report.

Mohammad Rubayet Hasan, Manu Somasundaram Sundaram, Sathyavathi Sundararaju, Kin-Ming Tsui, Mohammed Yousuf Karim, Diane Roscoe, Omar Imam, Mohammad A Janahi, Eva Thomas, Simon Dobson, Rusung Tan, Patrick Tang, Andres Perez Lopez,

BACKGROUND:Infections with multidrug-resistant organisms (MDRO) pose a serious threat to patients with dysregulated immunity such as in hemophagocytic lymphohistiocytosis (HLH), but such infections have rarely been comprehensively characterized. Here, we present a fatal case of HLH secondary to cytomegalovirus (CMV) infection complicated by both anti-viral drug resistance and sepsis from ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2020, 20(1):237]

Cited: 2 times

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Modelling the effects of environmental heterogeneity within the lung on the tuberculosis life-cycle

Michael Pitcher, Ruth Bowness, Simon Dobson, Raluca Eftimie, Stephen Gillespie,

Progress in shortening the duration of tuberculosis (TB) treatment is hampered by the lack of a predictive model that accurately reflects the diverse environment within the lung. This is important as TB has been shown to produce distinct localisations to different areas of the lung during different disease stages, with ... Read more >>

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The immune response to a two-dose schedule of quadrivalent HPV vaccine in 9-13 year-old girls: Is it influenced by age, menarche status or body mass index?

Chantal Sauvageau, Vladimir Gilca, Robine Donken, Shu Yu Fan, Gina Ogilvie, Simon Dobson,

HPV vaccines are highly immunogenic. A two-dose schedule for 9-14 year-old is recommended. However, no data exist regarding the impact of age, menarche status and body mass index (BMI) on the immune response to a two-dose schedule. In this post-hoc analysis, we present antibody titers to HPV6/11/16/18 in 9-13 year-old girls participating ... Read more >>

Vaccine (Vaccine)
[2019, 37(49):7203-7206]

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Baylisascariasis: A young boy with neural larva migrans due to the emerging raccoon round worm.

Mary Dunbar, Sandy Lu, Benetta Chin, Linda Huh, Simon Dobson, Ghada N Al-Rawahi, Muhammad G Morshed, Koen Vanden Driessche,

A 17-month-old boy from Vancouver, Canada, presented with a 5-day history of progressive somnolence, ataxia, and torticollis. Additional investigations revealed eosinophilic encephalitis with deep white matter changes on MR imaging. On day 13, serology came back positive for <i>Baylisascaris procyonis</i> antibodies. While prophylaxis after ingestion of soil or materials potentially ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2019, 6(2):397-400]

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Pediatric oncology and stem cell transplant patients with healthcare-associated Clostridium difficile infection were already colonized on admission.

Ghada N Al-Rawahi, Abeer Al-Najjar, Rachel McDonald, Rebecca J Deyell, George R Golding, Rollin Brant, Peter Tilley, Eva Thomas, Shahrad R Rassekh, Aisling O'Gorman, Peggy Wong, Lucy Turnham, Simon Dobson,

Clostridium difficile is the leading cause of healthcare-associated infections worldwide. The diagnosis of C. difficile infection (CDI) in pediatric oncology patients is complex as diarrhea is common, and there is a high rate of colonization in infants and young children. This study was conducted to assess the accuracy of the ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2019, 66(5):e27604]

Cited: 2 times

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Population-level sexual behaviours in adolescent girls before and after introduction of the human papillomavirus vaccine (2003-2013).

Gina S Ogilvie, Felicia Phan, Heather N Pedersen, Simon R Dobson, Monika Naus, Elizabeth M Saewyc,

<h4>Background</h4>The human papillomavirus (HPV) vaccine is delivered widely through school-based immunization programs. Some groups have expressed concern that HPV vaccination programs will result in an increase in sexual risk-taking behaviours among adolescents. We aimed to evaluate population-level changes in sexual behaviours before and after implementation of the school-based HPV vaccination ... Read more >>

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2018, 190(41):E1221-E1226]

Cited: 3 times

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A Randomized Controlled Trial of the Safety and Immunogenicity of Tetanus, Diphtheria, and Acellular Pertussis Vaccine Immunization During Pregnancy and Subsequent Infant Immune Response.

Scott A Halperin, Joanne M Langley, Lingyun Ye, Donna MacKinnon-Cameron, May Elsherif, Victoria M Allen, Bruce Smith, Beth A Halperin, Shelly A McNeil, Otto G Vanderkooi, Shannon Dwinnell, R Douglas Wilson, Bruce Tapiero, Marc Boucher, Nicole Le Saux, Andrée Gruslin, Wendy Vaudry, Sue Chandra, Simon Dobson, Deborah Money,

<h4>Background</h4>Immunization of pregnant women with tetanus-diphtheria-acellular pertussis vaccine (Tdap) provides protection against pertussis to the newborn infant.<h4>Methods</h4>In a randomized, controlled, observer-blind, multicenter clinical trial, we measured the safety and immunogenicity of Tdap during pregnancy and the effect on the infant's immune response to primary vaccination at 2, 4, and 6 ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2018, 67(7):1063-1071]

Cited: 16 times

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Improving vaccination uptake in pediatric Cochlear implant recipients.

Lisa Jin, Paula Téllez, Ruth Chia, Daphne Lu, Neil K Chadha, Julie Pauwels, Simon Dobson, Hazim Al Eid, Frederick K Kozak,

<h4>Background</h4>An Infectious Disease vaccine specialist joined our institution's Cochlear Implant Team in 2010 in order to address the high percentage of non-compliance to immunization prior to surgery identified previously from an internal review. The purpose of this study was to (1) review the immunization status of cochlear implant recipients in ... Read more >>

J Otolaryngol Head Neck Surg (Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale)
[2018, 47(1):56]

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Immunogenicity and Safety of the Quadrivalent Human Papillomavirus Vaccine in Girls Living With HIV.

Jason Brophy, Ari Bitnun, Ariane Alimenti, Normand Lapointe, Lindy Samson, Stanley Read, Christos Karatzios, Simon Dobson, Erin Moses, Sandra Blitz, Nancy-Grace Lipsky, Gina Ogilvie, Sharon Walmsley, Janet Raboud, Deborah Money, ,

We evaluated quadrivalent human papillomavirus vaccine seroresponses among 35 girls living with HIV (9-13 years of ages) and compared with data on girls without HIV, as part of a subgroup analysis. The quadrivalent human papillomavirus vaccine was safe and well tolerated. However, antibody response was significantly lower in girls living ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2018, 37(6):595-597]

Cited: 1 time

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The long shadow of lemierre's syndrome.

Joshua Osowicki, Sarah Kapur, Linny Kimly Phuong, Simon Dobson,

Lemierre's syndrome is a rare and feared complication of pharyngitis, occurring most commonly in adolescents and young adults. It is typically defined by the constellation of septic internal jugular vein thrombophlebitis, pulmonary and other septic emboli, and sterilesite infection by Fusobacterium necrophorum. The rarity and severity of Lemierre's syndrome has ... Read more >>

J Infect (The Journal of infection)
[2017, 74 Suppl 1:S47-S53]

Cited: 9 times

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Fecal microbiota transplantation for recurrent clostridium difficile infection in children.

Becky Chen, Vishal Avinashi, Simon Dobson,

Fecal microbiota transplantation (FMT) is a relatively simple, promising treatment for recurrent Clostridium difficile infection. While there are a wide variety of approaches including mode of delivery, the results are nonetheless encouraging, even amongst younger children. Experience with FMT in the pediatric population is increasing, showing similar success compared to ... Read more >>

J Infect (The Journal of infection)
[2017, 74 Suppl 1:S120-S127]

Cited: 5 times

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Preface.

Nigel Curtis, Andrew J Pollard, Adam Finn, Octavio Ramilo, Simon Dobson, Adilia Warris, Annemarie van Rossum,

J Infect (The Journal of infection)
[2017, 74 Suppl 1:S1]

Cited: 0 times

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Immunogenicity of 2 vs 3 Doses of the Quadrivalent Human Papillomavirus Vaccine in Girls Aged 9 to 13 Years After 60 Months.

Gina Ogilvie, Chantal Sauvageau, Marc Dionne, Shelly McNeil, Mel Krajden, Deborah Money, Simon Dobson,

JAMA (JAMA)
[2017, 317(16):1687-1688]

Cited: 4 times

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