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Author Silvia Tenembaum

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Pediatric NMOSD: A Review and Position Statement on Approach to Work-Up and Diagnosis.

Silvia Tenembaum, E Ann Yeh, ,

Neuromyelitis Optica Spectrum Disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system (CNS) primarily affecting the optic nerves and spinal cord, but also involving other regions of the CNS including the area postrema, periaqueductal gray matter, and hypothalamus. Knowledge related to pediatric manifestations of NMOSD has grown ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:339]

Cited: 0 times

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Rituximab in patients with pediatric multiple sclerosis and other demyelinating disorders of the CNS: Practical considerations.

Angelo Ghezzi, Brenda Banwell, Amit Bar-Or, Tanuja Chitnis, Russell C Dale, Mark Gorman, Barbara Kornek, Lauren Krupp, Kristen M Krysko, Margherita Nosadini, Kevin Rostasy, Jonatan Salzer, Teri Schreiner, Silvia Tenembaum, Emmanuelle Waubant,

Anti-CD20 therapies have established efficacy in the treatment of immune-mediated neurological and non-neurological diseases. Rituximab, one of the first B-cell-directed therapies, is relatively inexpensive compared to newer anti-CD20 molecules, is available in many countries, and has been used off-label in pediatric patients with neuroimmune conditions. The objective of this paper ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2020, :1352458520932798]

Cited: 0 times

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Treatment of MOG-IgG-associated disorder with rituximab: An international study of 121 patients.

Daniel H Whittam, Alvaro Cobo-Calvo, A Sebastian Lopez-Chiriboga, Santiago Pardo, Matthew Gornall, Silvia Cicconi, Alexander Brandt, Klaus Berek, Thomas Berger, Ilijas Jelcic, Grace Gombolay, Luana Micheli Oliveira, Dagoberto Callegaro, Kimihiko Kaneko, Tatsuro Misu, Marco Capobianco, Emily Gibbons, Venkatraman Karthikeayan, Bruno Brochet, Bertrand Audoin, Guillaume Mathey, David Laplaud, Eric Thouvenot, Mikaël Cohen, Ayman Tourbah, Elisabeth Maillart, Jonathan Ciron, Romain Deschamps, Damien Biotti, Kevin Rostasy, Rinze Neuteboom, Cheryl Hemingway, Rob Forsyth, Marcelo Matiello, Stewart Webb, David Hunt, Katy Murray, Yael Hacohen, Ming Lim, M Isabel Leite, Jacqueline Palace, Tom Solomon, Andreas Lutterotti, Kazuo Fujihara, Ichiro Nakashima, Jeffrey L Bennett, Lekha Pandit, Tanuja Chitnis, Brian G Weinshenker, Brigitte Wildemann, Douglas Kazutoshi Sato, Su-Hyun Kim, Saif Huda, Ho Jin Kim, Markus Reindl, Michael Levy, Sven Jarius, Silvia Tenembaum, Friedemann Paul, Sean Pittock, Romain Marignier, Anu Jacob,

OBJECTIVE:To assess the effect of anti-CD20 B-cell depletion with rituximab (RTX) on relapse rates in myelin oligodendrocyte glycoprotein antibody-associated disorder (MOGAD). METHODS:Retrospective review of RTX-treated MOGAD patients from 29 centres in 13 countries. The primary outcome measure was change in relapse rate after starting rituximab (Poisson regression model). RESULTS:Data on ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2020, 44:102251]

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Prognostic indicators of improvement with therapeutic plasma exchange in pediatric demyelination.

Andrea Savransky, Adrian Rubstein, Marina Huaman Rios, Silvana L Vergel, Mabel Castro Velasquez, Sara Perez Sierra, Gabriela Marcarian, Romina Alba, Ana M Pugliese, Silvia Tenembaum,

OBJECTIVES:To determine the safety and clinical benefit of therapeutic plasma exchange (TPE) as rescue therapy in children with acute inflammatory demyelinating CNS syndromes and to identify baseline prognostic indicators of treatment improvement. METHODS:This single-center retrospective pediatric cohort included all consecutive patients admitted to our hospital over the period from 2003 ... Read more >>

Neurology (Neurology)
[2019, 93(22):e2065-e2073]

Cited: 1 time

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Clinical trials of disease-modifying agents in pediatric MS: Opportunities, challenges, and recommendations from the IPMSSG.

Emmanuelle Waubant, Brenda Banwell, Evangeline Wassmer, Maria-Pia Sormani, Maria-Pia Amato, Rogier Hintzen, Lauren Krupp, Kevin Rostásy, Silvia Tenembaum, Tanuja Chitnis, ,

OBJECTIVE:The impetus for this consensus discussion was to recommend clinical trial designs that can deliver high-quality data for effective therapies for pediatric patients, in a reasonable timeframe, with a key focus on short- and long-term safety. METHODS:The International Pediatric Multiple Sclerosis Study Group convened a meeting of experts to review ... Read more >>

Neurology (Neurology)
[2019, 92(22):e2538-e2549]

Cited: 2 times

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Oligoclonal bands increase the specificity of MRI criteria to predict multiple sclerosis in children with radiologically isolated syndrome.

Naila Makhani, Christine Lebrun, Aksel Siva, Sona Narula, Evangeline Wassmer, David Brassat, J Nicholas Brenton, Philippe Cabre, Clarisse Carra Dallière, Jérôme de Seze, Francoise Durand Dubief, Matilde Inglese, Megan Langille, Guillaume Mathey, Rinze F Neuteboom, Jean Pelletier, Daniela Pohl, Daniel S Reich, Juan Ignacio Rojas, Veronika Shabanova, Eugene D Shapiro, Robert T Stone, Silvia Tenembaum, Mar Tintoré, Ugur Uygunoglu, Wendy Vargas, Sunita Venkateswaren, Patrick Vermersch, Orhun Kantarci, Darin T Okuda, Daniel Pelletier, ,

Background:Steps towards the development of diagnostic criteria are needed for children with the radiologically isolated syndrome to identify children at risk of clinical demyelination. Objectives:To evaluate the 2005 and 2016 MAGNIMS magnetic resonance imaging criteria for dissemination in space for multiple sclerosis, both alone and with oligoclonal bands in cerebrospinal ... Read more >>

Mult Scler J Exp Transl Clin (Multiple sclerosis journal - experimental, translational and clinical)
[2019, 5(1):2055217319836664]

Cited: 1 time

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Pediatric Multiple Sclerosis: Distinguishing Clinical and MR Imaging Features.

Silvia N Tenembaum,

This article presents an overview of evolving diagnostic criteria of pediatric multiple sclerosis and related disorders, emphasizing distinguishing clinical and neuroimaging features that should be considered for differential diagnosis in childhood and adolescence. New data on the integrity of brain tissue in children with MS provided by advanced MR imaging ... Read more >>

Neuroimaging Clin. N. Am. (Neuroimaging clinics of North America)
[2017, 27(2):229-250]

Cited: 0 times

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Pediatric multiple sclerosis: Conventional first-line treatment and general management.

Angelo Ghezzi, Maria Pia Amato, Naila Makhani, Teri Shreiner, Jutta Gärtner, Silvia Tenembaum,

Many disease-modifying therapies are currently available for adults with relapsing-remitting multiple sclerosis (MS) but none of them has been tested in pediatric MS in randomized placebo-controlled trials. At present, as suggested by observational studies and experts' guidelines, interferon-β and glatiramer acetate continue to be the standard first-line treatments for pediatric ... Read more >>

Neurology (Neurology)
[2016, 87(9 Suppl 2):S97-S102]

Cited: 20 times

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Acute disseminated encephalomyelitis: Updates on an inflammatory CNS syndrome.

Daniela Pohl, Gulay Alper, Keith Van Haren, Andrew J Kornberg, Claudia F Lucchinetti, Silvia Tenembaum, Anita L Belman,

Acute disseminated encephalomyelitis (ADEM) is an immune-mediated demyelinating CNS disorder with predilection to early childhood. ADEM is generally considered a monophasic disease. However, recurrent ADEM has been described and defined as multiphasic disseminated encephalomyelitis. ADEM often occurs postinfectiously, although a causal relationship has never been established. ADEM and multiple sclerosis ... Read more >>

Neurology (Neurology)
[2016, 87(9 Suppl 2):S38-45]

Cited: 29 times

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International Pediatric MS Study Group Global Members Symposium report.

Evangeline Wassmer, Tanuja Chitnis, Daniela Pohl, Maria Pia Amato, Brenda Banwell, Angelo Ghezzi, Rogier Q Hintzen, Lauren B Krupp, Naila Makhani, Kevin Rostásy, Marc Tardieu, Silvia Tenembaum, Amy Waldman, Emmanuelle Waubant, Andrew J Kornberg,

The International Pediatric Multiple Sclerosis Study Group held its inaugural educational program, "The World of Pediatric MS: A Global Update," in September 2014 to discuss advances and challenges in the diagnosis and management of pediatric multiple sclerosis (MS) and other neuroinflammatory CNS disorders. Highlights included a discussion on the revised ... Read more >>

Neurology (Neurology)
[2016, 87(9 Suppl 2):S110-6]

Cited: 4 times

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Neuromyelitis optica spectrum disorders in children and adolescents.

Silvia Tenembaum, Tanuja Chitnis, Ichiro Nakashima, Nicolas Collongues, Andrew McKeon, Michael Levy, Kevin Rostasy,

Neuromyelitis optica (NMO) is a severe autoimmune disease of the CNS characterized by recurrent inflammatory events primarily involving the optic nerves and spinal cord. NMO is infrequent in children, but early recognition is important to start adequate treatment. In this article, we review the evolving diagnostic criteria of NMO and ... Read more >>

Neurology (Neurology)
[2016, 87(9 Suppl 2):S59-66]

Cited: 18 times

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Dystonia in a Patient with Autosomal-Dominant Progressive External Ophthalmoplegia Type 1 Caused by Mutation in the POLG Gene.

Malco Rossi, Alex Medina Escobar, Martin Radrizzani, Silvia Tenembaum, Claudia Perandones, Marcelo Merello,

Mov Disord Clin Pract (Movement Disorders Clinical Practice)
[2017, 4(2):266-269]

Cited: 1 time

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Subcutaneous interferon β-1a in pediatric patients with multiple sclerosis: Regional differences in clinical features, disease management, and treatment outcomes in an international retrospective study.

Lauren B Krupp, Daniela Pohl, Angelo Ghezzi, Alexey Boyko, Silvia Tenembaum, Liang Chen, Ernesto Aycardi, Brenda Banwell, ,

To further understand management of pediatric patients with multiple sclerosis (MS), we examined disease features, clinical practice patterns, and response to treatment in the United States (US) and seven other countries ('rest of World'; ROW).Anonymized data, recorded as part of routine clinical practice, were obtained from medical records (1997-2009) of ... Read more >>

J. Neurol. Sci. (Journal of the Neurological Sciences)
[2016, 363:33-38]

Cited: 4 times

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Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder.

Stephane Kremer, Felix Renard, Sophie Achard, Marco A Lana-Peixoto, Jacqueline Palace, Nasrin Asgari, Eric C Klawiter, Silvia N Tenembaum, Brenda Banwell, Benjamin M Greenberg, Jeffrey L Bennett, Michael Levy, Pablo Villoslada, Albert Saiz, Kazuo Fujihara, Koon Ho Chan, Sven Schippling, Friedemann Paul, Ho Jin Kim, Jerome de Seze, Jens T Wuerfel, , Philippe Cabre, Romain Marignier, Thomas Tedder, Danielle van Pelt, Simon Broadley, Tanuja Chitnis, Dean Wingerchuk, Lekha Pandit, Maria Isabel Leite, Metha Apiwattanakul, Ingo Kleiter, Naraporn Prayoonwiwat, May Han, Kerstin Hellwig, Katja van Herle, Gareth John, D Craig Hooper, Ichiro Nakashima, Douglas Sato, Michael R Yeaman, Emmanuelle Waubant, Scott Zamvil, Olaf Stüve, Orhan Aktas, Terry J Smith, Anu Jacob, Kevin O'Connor,

Brain parenchymal lesions are frequently observed on conventional magnetic resonance imaging (MRI) scans of patients with neuromyelitis optica (NMO) spectrum disorder, but the specific morphological and temporal patterns distinguishing them unequivocally from lesions caused by other disorders have not been identified. This literature review summarizes the literature on advanced quantitative ... Read more >>

JAMA Neurol (JAMA neurology)
[2015, 72(7):815-822]

Cited: 25 times

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Update on biomarkers in neuromyelitis optica.

Esther Melamed, Michael Levy, Patrick J Waters, Douglas Kazutoshi Sato, Jeffrey L Bennett, Gareth R John, Douglas C Hooper, Albert Saiz, Amit Bar-Or, Ho Jin Kim, Lakha Pandit, Maria Isabel Leite, Nasrin Asgari, Najib Kissani, Rogier Hintzen, Romain Marignier, Sven Jarius, John Marcelletti, Terry J Smith, Michael R Yeaman, May H Han, Orhan Aktas, Metha Apiwattanakul, Brenda Banwell, Denis Bichuetti, Simon Broadley, Philippe Cabre, Tanuja Chitnis, Jerome De Seze, Kazuo Fujihara, Benjamin Greenberg, Kerstin Hellwig, Raffaele Iorio, Sven Jarius, Eric Klawiter, Ingo Kleiter, Marco Lana-Peixoto, Nakashima, Kevin O'Connor, Jacqueline Palace, Friedman Paul, Naraporn Prayoonwiwat, Klemens Ruprecht, Olaf Stuve, Thomas Tedder, Silvia Tenembaum, Juan P Garrahan, Buenos Aires, Katja van Herle, Danielle van Pelt, Pablo Villoslada, Emmanuelle Waubant, Brian Weinshenker, Dean Wingerchuk, Jens Würfel, Scott Zamvil,

Neuromyelitis optica (NMO) (and NMO spectrum disorder) is an autoimmune inflammatory disease of the CNS primarily affecting spinal cord and optic nerves. Reliable and sensitive biomarkers for onset, relapse, and progression in NMO are urgently needed because of the heterogeneous clinical presentation, severity of neurologic disability following relapses, and variability ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2015, 2(4):e134]

Cited: 29 times

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Comment on multiphasic disseminated encephalomyelitis followed by optic neuritis in a child with gluten sensitivity.

Silvia Tenembaum,

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2015, 21(9):1212-1214]

Cited: 1 time

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International consensus diagnostic criteria for neuromyelitis optica spectrum disorders.

Dean M Wingerchuk, Brenda Banwell, Jeffrey L Bennett, Philippe Cabre, William Carroll, Tanuja Chitnis, Jérôme de Seze, Kazuo Fujihara, Benjamin Greenberg, Anu Jacob, Sven Jarius, Marco Lana-Peixoto, Michael Levy, Jack H Simon, Silvia Tenembaum, Anthony L Traboulsee, Patrick Waters, Kay E Wellik, Brian G Weinshenker, ,

Neuromyelitis optica (NMO) is an inflammatory CNS syndrome distinct from multiple sclerosis (MS) that is associated with serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). Prior NMO diagnostic criteria required optic nerve and spinal cord involvement but more restricted or more extensive CNS involvement may occur. The International Panel for NMO Diagnosis ... Read more >>

Neurology (Neurology)
[2015, 85(2):177-189]

Cited: 679 times

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MRI characteristics of neuromyelitis optica spectrum disorder: an international update.

Ho Jin Kim, Friedemann Paul, Marco A Lana-Peixoto, Silvia Tenembaum, Nasrin Asgari, Jacqueline Palace, Eric C Klawiter, Douglas K Sato, Jérôme de Seze, Jens Wuerfel, Brenda L Banwell, Pablo Villoslada, Albert Saiz, Kazuo Fujihara, Su-Hyun Kim, ,

Since its initial reports in the 19th century, neuromyelitis optica (NMO) had been thought to involve only the optic nerves and spinal cord. However, the discovery of highly specific anti-aquaporin-4 antibody diagnostic biomarker for NMO enabled recognition of more diverse clinical spectrum of manifestations. Brain MRI abnormalities in patients seropositive ... Read more >>

Neurology (Neurology)
[2015, 84(11):1165-1173]

Cited: 136 times

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Treatment of multiple sclerosis and neuromyelitis optica in children and adolescents.

Silvia N Tenembaum,

Paediatric multiple sclerosis (MS) accounts for up to 5% of all MS cases. No therapies have been formally approved for paediatric patients with MS. However, there is published experience on the use of disease modifying therapies in children and adolescents with MS. Neuromyelitis optica (NMO) is an autoimmune inflammatory disease ... Read more >>

Clin Neurol Neurosurg (Clinical neurology and neurosurgery)
[2013, 115 Suppl 1:S21-9]

Cited: 6 times

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Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing-remitting multiple sclerosis.

Keith Van Haren, Beren H Tomooka, Brian A Kidd, Brenda Banwell, Amit Bar-Or, Tanuja Chitnis, Silvia N Tenembaum, Daniela Pohl, Kevin Rostasy, Russell C Dale, Kevin C O'Connor, David A Hafler, Lawrence Steinman, William H Robinson,

Acute disseminated encephalomyelitis (ADEM) and relapsing-remitting multiple sclerosis (RRMS) share overlapping clinical, radiologic and laboratory features at onset. Because autoantibodies may contribute to the pathogenesis of both diseases, we sought to identify autoantibody biomarkers that are capable of distinguishing them.We used custom antigen arrays to profile anti-myelin-peptide autoantibodies in sera ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2013, 19(13):1726-1733]

Cited: 14 times

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Subcutaneous interferon Beta-1a in pediatric multiple sclerosis: a retrospective study.

Silvia N Tenembaum, Brenda Banwell, Daniela Pohl, Lauren B Krupp, Alexey Boyko, Michael Meinel, Lorenz Lehr, Sanda Rocak, Elisabetta Verdun di Cantogno, Margaretha Stam Moraga, Angelo Ghezzi, ,

To expand current knowledge, we examined the safety and tolerability of subcutaneous interferon β-1a in patients with pediatric-onset multiple sclerosis. Records from 307 patients who had received at least 1 injection of subcutaneous interferon β-1a for demyelinating events when aged younger than 18 years were reviewed. Overall, 168 (54.7%) patients ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2013, 28(7):849-856]

Cited: 18 times

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International Pediatric MS Study Group Clinical Trials Summit: meeting report.

Tanuja Chitnis, Marc Tardieu, Maria Pia Amato, Brenda Banwell, Amit Bar-Or, Angelo Ghezzi, Andrew Kornberg, Lauren B Krupp, Daniela Pohl, Kevin Rostasy, Silvia Tenembaum, Emmanuelle Waubant, Evangeline Wassmer,

OBJECTIVE: Pediatric studies for new biological agents are mandated by recent legislation, necessitating careful thought to evaluation of emerging multiple sclerosis (MS) therapies in children with MS. Challenges include a small patient population, the lack of prior randomized clinical trials, and ethical concerns. The goal of this meeting was to ... Read more >>

Neurology (Neurology)
[2013, 80(12):1161-1168]

Cited: 23 times

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International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions.

Lauren B Krupp, Marc Tardieu, Maria Pia Amato, Brenda Banwell, Tanuja Chitnis, Russell C Dale, Angelo Ghezzi, Rogier Hintzen, Andrew Kornberg, Daniela Pohl, Kevin Rostasy, Silvia Tenembaum, Evangeline Wassmer, ,

BACKGROUND: There has been tremendous growth in research in pediatric multiple sclerosis (MS) and immune mediated central nervous system demyelinating disorders since operational definitions for these conditions were first proposed in 2007. Further, the International Pediatric Multiple Sclerosis Study Group (IPMSSG), which proposed the criteria, has expanded substantially in membership ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2013, 19(10):1261-1267]

Cited: 233 times

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Acute disseminated encephalomyelitis.

Silvia N Tenembaum,

The advent of magnetic resonance imaging (MRI) has contributed to increase the interest and awareness in childhood white matter disorders. Pediatric inflammatory demyelinating diseases of the central nervous system (CNS) are clinically heterogeneous with respect to their mode of presentation, clinical severity, rate of progression, and prognosis. Acute disseminated encephalomyelitis ... Read more >>

Handb Clin Neurol (Handbook of clinical neurology)
[2013, 112:1253-1262]

Cited: 14 times

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Treatment of Neuromyelitis Optica: Review and Recommendations.

Dorlan J Kimbrough, Kazuo Fujihara, Anu Jacob, Marco A Lana-Peixoto, Maria Isabel Leite, Michael Levy, Romain Marignier, Ichiro Nakashima, Jacqueline Palace, Jérôme de Seze, Olaf Stuve, Silvia N Tenembaum, Anthony Traboulsee, Emmanuelle Waubant, Brian G Weinshenker, Dean M Wingerchuk, ,

Neuromyelitis optica (NMO) is an autoimmune demyelinating disease preferentially targeting the optic nerves and spinal cord. Once regarded as a variant of multiple sclerosis (MS), NMO is now recognized to be a different disease with unique pathology and immunopathogenesis that does not respond to traditional MS immunomodulators such as interferons. ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2012, 1(4):180-187]

Cited: 72 times

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