Full Text Journal Articles by
Author Sigrid Conings


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Integration of Placental Transfer in a Fetal-Maternal Physiologically Based Pharmacokinetic Model to Characterize Acetaminophen Exposure and Metabolic Clearance in the Fetus.

Paola Mian, Karel Allegaert, Sigrid Conings, Pieter Annaert, Dick Tibboel, Marc Pfister, Kristel van Calsteren, John N van den Anker, André Dallmann,

BACKGROUND AND OBJECTIVE:Although acetaminophen is frequently used during pregnancy, little is known about fetal acetaminophen pharmacokinetics. Acetaminophen safety evaluation has typically focused on hepatotoxicity, while other events (fetal ductal closure/constriction) are also relevant. We aimed to develop a fetal-maternal physiologically based pharmacokinetic (PBPK) model (f-m PBPK) to quantitatively predict placental ... Read more >>

Clin Pharmacokinet (Clinical pharmacokinetics)
[2020, 59(7):911-925]

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Transplacental transport of paracetamol and its phase II metabolites using the ex vivo placenta perfusion model.

Sigrid Conings, Fotini Tseke, Annick Van den Broeck, Bing Qi, Jasmin Paulus, Frédéric Amant, Pieter Annaert, Kristel Van Calsteren,

In Europe, 50-60% of pregnant women uses paracetamol (PCM), also known as acetaminophen. While it was considered to be safe, recent studies have shown an association between prenatal exposure to PCM and increased incidences of autism, cryptorchidism, asthma and ADHD. In this study the transplacental transfer of PCM and its ... Read more >>

Toxicol. Appl. Pharmacol. (Toxicology and applied pharmacology)
[2019, 370:14-23]

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Sildenafil crosses the placenta at therapeutic levels in a dually perfused human cotyledon model.

Francesca M Russo, Sigrid Conings, Karel Allegaert, Tim Van Mieghem, Jaan Toelen, Kristel Van Calsteren, Pieter Annaert, Jan Deprest,

BACKGROUND:Sildenafil already is administered during gestation in patients with pulmonary hypertension and is under evaluation as a treatment for several pregnancy complications, such as preeclampsia and intrauterine growth restriction. Animal studies have shown a potential therapeutic effect of the drug in fetuses with congenital diaphragmatic hernia, rescuing peripheral pulmonary vasculature, ... Read more >>

Am. J. Obstet. Gynecol. (American journal of obstetrics and gynecology)
[2018, 219(6):619.e1-619.e10]

Cited: 1 time

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Integration and validation of the ex vivo human placenta perfusion model.

Sigrid Conings, Frédéric Amant, Pieter Annaert, Kristel Van Calsteren,

The ex vivo human placenta perfusion model is an effective and non-invasive method to study transplacental passage of drugs and environmental compounds in humans. Due to many challenges and its high complexity it remains difficult to incorporate it routinely into laboratories.This article describes a step-by-step protocol for the implementation and ... Read more >>

J Pharmacol Toxicol Methods (Journal of pharmacological and toxicological methods)
[2017, 88(Pt 1):25-31]

Cited: 2 times

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