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Worldwide post-marketing safety surveillance experience with tofacitinib in ulcerative colitis.

David T Rubin, Irene Modesto, Séverine Vermeire, Silvio Danese, Siew C Ng, Kenneth K Kwok, Nana Koram, Thomas V Jones,

<h4>Background</h4>Tofacitinib is an oral Janus kinase inhibitor for the treatment of ulcerative colitis (UC). Post-marketing surveillance (PMS) is an important part of monitoring adverse events (AEs).<h4>Aims</h4>To report an analysis of PMS case safety reports for tofacitinib in patients with UC METHODS: Worldwide tofacitinib PMS reports received in the Pfizer safety ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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The role of gut mycobiome in health and diseases.

Lin Zhang, Hui Zhan, Wenye Xu, Shuai Yan, Siew C Ng,

The gut microbiome comprised of microbes from multiple kingdoms, including bacteria, fungi, and viruses. Emerging evidence suggests that the intestinal fungi (the gut "mycobiome") play an important role in host immunity and inflammation. Advances in next generation sequencing methods to study the fungi in fecal samples and mucosa tissues have ... Read more >>

Therap Adv Gastroenterol (Therapeutic advances in gastroenterology)
[2021, 14:17562848211047130]

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Targeting the gut microbiota in COVID-19: hype or hope?

Harry Cheuk-Hay Lau, Siew C Ng, Jun Yu,

Gastroenterology (Gastroenterology)
[2021, :]

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Impact of Medications on COVID-19 Outcomes in Inflammatory Bowel Disease: Analysis of Over 6,000 Patients from an International Registry.

Ryan C Ungaro, Erica J Brenner, Manasi Agrawal, Xian Zhang, Michael D Kappelman, Jean-Frederic Colombel, ,

Gastroenterology (Gastroenterology)
[2021, :]

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International consensus on the prevention of venous and arterial thrombotic events in patients with inflammatory bowel disease.

Pablo A Olivera, Stephane Zuily, Paulo G Kotze, Veronique Regnault, Sameer Al Awadhi, Peter Bossuyt, Richard B Gearry, Subrata Ghosh, Taku Kobayashi, Patrick Lacolley, Edouard Louis, Fernando Magro, Siew C Ng, Alfredo Papa, Tim Raine, Fabio V Teixeira, David T Rubin, Silvio Danese, Laurent Peyrin-Biroulet,

Patients with inflammatory bowel disease (IBD) are at increased risk of thrombotic events. Therapies for IBD have the potential to modulate this risk. The aims of this Evidence-Based Guideline were to summarize available evidence and to provide practical recommendations regarding epidemiological aspects, prevention and drug-related risks of venous and arterial ... Read more >>

Nat Rev Gastroenterol Hepatol (Nature reviews. Gastroenterology & hepatology)
[2021, :]

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Underdevelopment of the gut microbiota and bacteria species as non-invasive markers of prediction in children with autism spectrum disorder.

Yating Wan, Tao Zuo, Zhilu Xu, Fen Zhang, Hui Zhan, Dorothy Chan, Ting-Fan Leung, Yun Kit Yeoh, Francis K L Chan, Ruth Chan, Siew C Ng,

<h4>Objective</h4>The gut microbiota has been suggested to play a role in autism spectrum disorder (ASD). We postulate that children with ASD harbour an altered developmental profile of the gut microbiota distinct from that of typically developing (TD) children. Here, we aimed to characterise compositional and functional alterations in gut microbiome ... Read more >>

Gut (Gut)
[2021, :]

Cited: 1 time

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The role of precision nutrition in the modulation of microbial composition and function in people with inflammatory bowel disease.

Alexa N Sasson, Richard J M Ingram, Zhengxiao Zhang, Lorian M Taylor, Ashwin N Ananthakrishnan, Gilaad G Kaplan, Siew C Ng, Subrata Ghosh, Maitreyi Raman,

Inflammatory bowel diseases, principally Crohn's disease and ulcerative colitis, are multifactorial chronic conditions. Alterations in gut microbial patterns partly affect disease onset and severity. Moreover, the evolution of dietary patterns, and their effect on gut microbial behaviour, have been shown to play a crucial role in disease processes. This Viewpoint ... Read more >>

Lancet Gastroenterol Hepatol (The lancet. Gastroenterology & hepatology)
[2021, 6(9):754-769]

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Alterations in the Gut Virome in Obesity and Type 2 Diabetes Mellitus.

Keli Yang, Junkun Niu, Tao Zuo, Yang Sun, Zhilu Xu, Whitney Tang, Qin Liu, Jingwan Zhang, Enders K W Ng, Simon K H Wong, Yun Kit Yeoh, Paul K S Chan, Francis K L Chan, Yinglei Miao, Siew C Ng,

<h4>Background & aims</h4>Obesity and type 2 diabetes mellitus (T2DM) are associated with changes in the gut bacterial composition, but little is known about the role of the viral community (virome) in disease development. This study aims to characterize the gut virome alterations in obese subjects with or without T2DM.<h4>Methods</h4>There were ... Read more >>

Gastroenterology (Gastroenterology)
[2021, 161(4):1257-1269.e13]

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Microscopic colitis.

Kristin E Burke, Mauro D'Amato, Siew C Ng, Darrell S Pardi, Jonas F Ludvigsson, Hamed Khalili,

Microscopic colitis (MC) is an inflammatory disease of the large intestine associated with urgent watery diarrhoea. MC may occur in people of all ages, although the disease primarily affects older women. Once believed to be rare, MC is now known to be a common cause of chronic watery diarrhoea in ... Read more >>

Nat Rev Dis Primers (Nature reviews. Disease primers)
[2021, 7(1):39]

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COVID-19 Outcomes Among Racial and Ethnic Minority Individuals With Inflammatory Bowel Disease in the United States.

Manasi Agrawal, Erica J Brenner, Joyce Wing Yan Mak, Xian Zhang, Gilaad G Kaplan, Siew C Ng, Walter Reinisch, Flavio Steinwurz, James D Lewis, Michele Kissous-Hunt, Irene Modesto, Ryan C Ungaro, Jean-Frederic Colombel, Michael D Kappelman,

The coronavirus disease 2019 (COVID-19) has affected more than 29 million people and led to more than 542,000 deaths in the United States.<sup>1</sup> Older age, comorbidities, and racial and ethnic minority status are associated with severe COVID-19.<sup>2</sup> Among patients with inflammatory bowel disease (IBD), racial and ethnic minorities have worse ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, 19(10):2210-2213.e3]

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Biobetters in patients with immune-mediated inflammatory disorders: An international Delphi consensus.

Ferdinando D'Amico, Virginia Solitano, Daniel Aletaha, Ailsa Hart, Fernando Magro, Carlo Selmi, Siew C Ng, Sameer Al Awadhi, Ernest Choy, Hendrik Schulze-Koops, Peter Bossuyt, Pablo A Olivera, Paulo Gustavo Kotze, Subrata Ghosh, Laurent Peyrin-Biroulet, Silvio Danese,

Several efforts have been made to improve the available therapeutic armamentarium of patients with immune-mediated inflammatory disorders (IMIDs) leading to the development of biobetters. To date, there is no commonly accepted definition of biobetters. Sixteen physicians with expertise in the field of IMIDs from eleven countries attended a virtual international ... Read more >>

Autoimmun Rev (Autoimmunity reviews)
[2021, 20(7):102849]

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Modulation of gut microbiota protects against viral respiratory tract infections: a systematic review of animal and clinical studies.

Hai Yun Shi, Xi Zhu, Wei Lin Li, Joyce W Y Mak, Sunny H Wong, Sheng Tao Zhu, Shui Long Guo, Francis K L Chan, Shu Tian Zhang, Siew C Ng,

<h4>Background</h4>Earlier studies suggest that probiotics have protective effects in the prevention of respiratory tract infections (RTIs). Whether such benefits apply to RTIs of viral origin and mechanisms supporting the effect remain unclear.<h4>Aim</h4>To determine the role of gut microbiota modulation on clinical and laboratory outcomes of viral RTIs.<h4>Methods</h4>We conducted a systematic ... Read more >>

Eur J Nutr (European journal of nutrition)
[2021, :]

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Physician Practice Patterns in Holding Inflammatory Bowel Disease Medications due to COVID-19, in the SECURE-IBD Registry.

Manasi Agrawal, Erica J Brenner, Xian Zhang, Jean-Frederic Colombel, Michael D Kappelman, Ryan C Ungaro, , Richard B Gearry, Gilaad G Kalpan, Michele Kissous-Hunt, James D Lewis, Siew C Ng, Jean-Francois Rahier, Walter Reinisch, Frank M Ruemmele, Flavio Steinwurz, Fox E Underwood,

<h4>Background</h4>We aimed to describe physician practice patterns in holding or continuing IBD therapy in the setting of COVID-19 infection, using the Surveillance Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease [SECURE-IBD] registry.<h4>Methods</h4>IBD medications that were stopped due to COVID-19 were recorded in the SECURE-IBD registry in addition to ... Read more >>

J Crohns Colitis (Journal of Crohn's & colitis)
[2021, 15(5):860-863]

Cited: 3 times

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Worldwide Management of Inflammatory Bowel Disease During the COVID-19 Pandemic: An International Survey.

Charles N Bernstein, Siew C Ng, Rupa Banerjee, Flavio Steinwurz, Bo Shen, Franck Carbonnel, Saeed Hamid, Ajit Sood, Jesus K Yamamoto-Furusho, Anne Griffiths, Eric I Benchimol, Simon Travis, Susana Lopes, David T Rubin, Gilaad G Kaplan, David Armstrong, Richard Gearry, ,

<h4>Background and aims</h4>Persons with inflammatory bowel disease (IBD) may be particularly vulnerable to COVID-19 either because of their underlying disease or its management. Guidance has been presented on the management of persons with IBD in the time of this pandemic by different groups. We aimed to determine how gastroenterologists around ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2021, 27(6):836-847]

Cited: 5 times

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Temporal landscape of human gut RNA and DNA virome in SARS-CoV-2 infection and severity.

Tao Zuo, Qin Liu, Fen Zhang, Yun Kit Yeoh, Yating Wan, Hui Zhan, Grace C Y Lui, Zigui Chen, Amy Y L Li, Chun Pan Cheung, Nan Chen, Wenqi Lv, Rita W Y Ng, Eugene Y K Tso, Kitty S C Fung, Veronica Chan, Lowell Ling, Gavin Joynt, David S C Hui, Francis K L Chan, Paul K S Chan, Siew C Ng,

<h4>Background</h4>Coronavirus disease 2019 (COVID-19) caused by the enveloped RNA virus SARS-CoV-2 primarily affects the respiratory and gastrointestinal tracts. SARS-CoV-2 was isolated from fecal samples, and active viral replication was reported in human intestinal cells. The human gut also harbors an enormous amount of resident viruses (collectively known as the virome) ... Read more >>

Microbiome (Microbiome)
[2021, 9(1):91]

Cited: 3 times

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Microbiota engraftment after faecal microbiota transplantation in obese subjects with type 2 diabetes: a 24-week, double-blind, randomised controlled trial.

Siew C Ng, Zhilu Xu, Joyce Wing Yan Mak, Keli Yang, Qin Liu, Tao Zuo, Whitney Tang, Louis Lau, Rashid N Lui, Sunny H Wong, Yee Kit Tse, Amy Y L Li, Kitty Cheung, Jessica Y L Ching, Vincent W S Wong, Alice P S Kong, Ronald C W Ma, Elaine Y K Chow, Simon K H Wong, Ivan Chak Hang Ho, Paul K S Chan, Francis K L Chan,

<h4>Objective</h4>The impact of faecal microbiota transplantation (FMT) on microbiota engraftment in patients with metabolic syndrome is uncertain. We aimed to study whether combining FMT with lifestyle modification could enhance the engraftment of favourable microbiota in obese patients with type 2 diabetes mellitus (T2DM).<h4>Design</h4>In this double-blind, randomised, placebo-controlled trial, 61 obese ... Read more >>

Gut (Gut)
[2021, :]

Cited: 2 times

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Transethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals not only shared but also ethnicity-specific disease associations.

Frauke Degenhardt, Gabriele Mayr, Mareike Wendorff, Gabrielle Boucher, Eva Ellinghaus, David Ellinghaus, Hesham ElAbd, Elisa Rosati, Matthias Hübenthal, Simonas Juzenas, Shifteh Abedian, Homayon Vahedi, B K Thelma, Suk-Kyun Yang, Byong Duk Ye, Jae Hee Cheon, Lisa Wu Datta, Naser Ebrahim Daryani, Pierre Ellul, Motohiro Esaki, Yuta Fuyuno, Dermot P B McGovern, Talin Haritunians, Myhunghee Hong, Garima Juyal, Eun Suk Jung, Michiaki Kubo, Subra Kugathasan, Tobias L Lenz, Stephen Leslie, Reza Malekzadeh, Vandana Midha, Allan Motyer, Siew C Ng, David T Okou, Soumya Raychaudhuri, John Schembri, Stefan Schreiber, Kyuyoung Song, Ajit Sood, Atsushi Takahashi, Esther A Torres, Junji Umeno, Behrooz Z Alizadeh, Rinse K Weersma, Sunny H Wong, Keiko Yamazaki, Tom H Karlsen, John D Rioux, Steven R Brant, , Andre Franke, ,

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gut. Genetic association studies have identified the highly variable human leukocyte antigen (HLA) region as the strongest susceptibility locus for IBD and specifically DRB1*01:03 as a determining factor for ulcerative colitis (UC). However, for most of the association signal ... Read more >>

Hum Mol Genet (Human molecular genetics)
[2021, 30(5):356-369]

Cited: 1 time

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Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice.

Lin Wang, Dominik Aschenbrenner, Zhiyang Zeng, Xiya Cao, Daniel Mayr, Meera Mehta, Melania Capitani, Neil Warner, Jie Pan, Liren Wang, Qi Li, Tao Zuo, Sarit Cohen-Kedar, Jiawei Lu, Rico Chandra Ardy, Daniel J Mulder, Dilan Dissanayake, Kaiyue Peng, Zhiheng Huang, Xiaoqin Li, Yuesheng Wang, Xiaobing Wang, Shuchao Li, Samuel Bullers, Anís N Gammage, Klaus Warnatz, Ana-Iris Schiefer, Gergely Krivan, Vera Goda, Walter H A Kahr, Mathieu Lemaire, , Chien-Yi Lu, Iram Siddiqui, Michael G Surette, Daniel Kotlarz, Karin R Engelhardt, Helen R Griffin, Robert Rottapel, Hélène Decaluwe, Ronald M Laxer, Michele Proietti, Sophie Hambleton, Suzanne Elcombe, Cong-Hui Guo, Bodo Grimbacher, Iris Dotan, Siew C Ng, Spencer A Freeman, Scott B Snapper, Christoph Klein, Kaan Boztug, Ying Huang, Dali Li, Holm H Uhlig, Aleixo M Muise,

Spleen tyrosine kinase (SYK) is a critical immune signaling molecule and therapeutic target. We identified damaging monoallelic SYK variants in six patients with immune deficiency, multi-organ inflammatory disease such as colitis, arthritis and dermatitis, and diffuse large B cell lymphomas. The SYK variants increased phosphorylation and enhanced downstream signaling, indicating ... Read more >>

Nat Genet (Nature genetics)
[2021, 53(4):500-510]

Cited: 1 time

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Risks of post-colonoscopic polypectomy bleeding and thromboembolism with warfarin and direct oral anticoagulants: a population-based analysis.

Louis Hs Lau, Cosmos Lt Guo, Terry Cf Yip, Joyce Wy Mak, Sunny H Wong, Kelvin Ly Lam, Grace Lh Wong, Siew C Ng, Francis Kl Chan,

<h4>Background</h4>There were limited data on the risk of post-polypectomy bleeding (PPB) in patients on direct oral anticoagulants (DOAC). We aimed to evaluate the PPB and thromboembolic risks among DOAC and warfarin users in a population-based cohort.<h4>Methods</h4>We performed a territory-wide retrospective cohort study involving patients in Hong Kong from 2012 to ... Read more >>

Gut (Gut)
[2021, :]

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SARS-CoV-2 vaccination for patients with inflammatory bowel diseases: recommendations from an international consensus meeting.

Corey A Siegel, Gil Y Melmed, Dermot Pb McGovern, Victoria Rai, Florian Krammer, David T Rubin, Maria T Abreu, Marla C Dubinsky, , ,

Gut (Gut)
[2021, 70(4):635-640]

Cited: 25 times

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Implications of COVID-19 for patients with pre-existing digestive diseases: an update.

Ren Mao, Florian Rieder, Shomron Ben-Horin, Gilaad G Kaplan, Siew C Ng, Grace Lh Wong, Subrata Ghosh, Min-Hu Chen,

Lancet Gastroenterol Hepatol (The lancet. Gastroenterology & hepatology)
[2021, 6(4):258-260]

Cited: 3 times

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What Are the Most Challenging Aspects of Inflammatory Bowel Disease? An International Survey of Gastroenterologists Comparing Developed and Developing Countries.

Richard B Gearry, Andrew M McCombie, Morten Vatn, David T Rubin, Flavio Steinwurz, Edward V Loftus, Wolfgang Kruis, Curt Tysk, Jean-Frederic Colombel, Siew C Ng, Gert Van Assche, Charles N Bernstein,

<h4>Background and aims</h4>As inflammatory bowel disease (IBD) becomes more prevalent, the challenges that gastroenterologists face in managing these patients evolve. We aimed to describe the most important challenges facing gastroenterologists from around the world and compare these between those working in developed and developing countries.<h4>Methods</h4>An online questionnaire was developed, and ... Read more >>

Inflamm Intest Dis (Inflammatory intestinal diseases)
[2021, 6(2):78-86]

Cited: 0 times

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Review article: Probiotics, prebiotics and dietary approaches during COVID-19 pandemic

Jielun Hu, Lin Zhang, Winnie Lin, Whitney Tang, Francis K L Chan, Siew C Ng,

Patients with COVID-19 caused by SARS-CoV-2 exhibit diverse clinical manifestations and severity including enteric involvement. Commensal gut bacteria can contribute to defense against potential pathogens by promoting beneficial immune interactions. Interventions targeting the gut microbiome may have systemic anti-viral effects in SARS-CoV-2 infection.To summarise alterations of gut microbiota in patients ... Read more >>

(Trends in food science & technology.)
[2021, 108:187-196]

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SARS-CoV-2 vaccines and donor recruitment for FMT.

Gianluca Ianiro, Benjamin H Mullish, Christian Lodberg Hvas, Jonathan P Segal, Ed J Kuijper, Samuel P Costello, Colleen R Kelly, Jessica R Allegretti, Monika Fischer, Tariq H Iqbal, Reetta Satokari, Dina Kao, Joffrey van Prehn, Siew C Ng, Stefano Bibbò, Simon Mark Dahl Baunwall, Mohammed N Quraishi, Harry Sokol, Faming Zhang, Josbert Keller, Luca Masucci, Gianluca Quaranta, Zain Kassam, Maurizio Sanguinetti, Herbert Tilg, Antonio Gasbarrini, Giovanni Cammarota,

Lancet Gastroenterol Hepatol (The lancet. Gastroenterology & hepatology)
[2021, 6(4):264-266]

Cited: 0 times

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Reply.

Zhilu Xu, Francis K L Chan, Siew C Ng,

Gastroenterology (Gastroenterology)
[2021, 160(6):2195-2196]

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