Full Text Journal Articles by
Author Siennah R Miller

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Multiple Computational Approaches for Predicting Drug Interactions with Human Equilibrative Nucleoside Transporter 1.

Siennah R Miller, Thomas R Lane, Kimberley M Zorn, Sean Ekins, Stephen H Wright, Nathan J Cherrington,

Equilibrativenucleoside transporters (ENTs) participate in the pharmacokinetics and disposition of nucleoside analog drugs. Understanding drug interactions with the ENTs may inform and facilitate the development of new drugs, including chemotherapeutics and antivirals that require access to sanctuary sites such as the male genital tract. This study created three-dimensional pharmacophores for ... Read more >>

Drug Metab Dispos (Drug metabolism and disposition: the biological fate of chemicals)
[2021, 49(7):479-489]

Cited: 1 time

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Implications of Species Differences in Function and Localization of Transporters at the Blood-Testis Barrier.

Raymond K Hau, Siennah R Miller, Nathan J Cherrington,

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2021, 181(1):1-2]

Cited: 0 times

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Predicting Drug Interactions with Human Equilibrative Nucleoside Transporters 1 and 2 Using Functional Knockout Cell Lines and Bayesian Modeling.

Siennah R Miller, Xiaohong Zhang, Raymond K Hau, Joseph L Jilek, Erin Q Jennings, James J Galligan, Daniel H Foil, Kimberley M Zorn, Sean Ekins, Stephen H Wright, Nathan J Cherrington,

Equilibrative nucleoside transporters (ENTs) 1 and 2 facilitate nucleoside transport across the blood-testis barrier (BTB). Improving drug entry into the testes with drugs that use endogenous transport pathways may lead to more effective treatments for diseases within the reproductive tract. In this study, CRISPR/CRISPR-associated protein 9 was used to generate ... Read more >>

Mol Pharmacol (Molecular pharmacology)
[2021, 99(2):147-162]

Cited: 2 times

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Generation of a hTERT-Immortalized Human Sertoli Cell Model to Study Transporter Dynamics at the Blood-Testis Barrier.

Raymond K Hau, Siennah R Miller, Stephen H Wright, Nathan J Cherrington,

The blood-testis barrier (BTB) formed by adjacent Sertoli cells (SCs) limits the entry of many chemicals into seminiferous tubules. Differences in rodent and human substrate-transporter selectivity or kinetics can misrepresent conclusions drawn using rodent in vitro models. Therefore, human in vitro models are preferable when studying transporter dynamics at the ... Read more >>

Pharmaceutics (Pharmaceutics)
[2020, 12(11):]

Cited: 1 time

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Proximal Tubule β 2-Adrenergic Receptor Mediates Formoterol-Induced Recovery of Mitochondrial and Renal Function after Ischemia-Reperfusion Injury.

Robert B Cameron, Whitney S Gibbs, Siennah R Miller, Tess V Dupre, Judit Megyesi, Craig C Beeson, Rick G Schnellmann,

Acute kidney injury (AKI) is the rapid loss of renal function after an insult, and renal proximal tubule cells (RPTCs) are central to the pathogenesis of AKI. The β 2-adrenergic receptor (β 2AR) agonist formoterol accelerates the recovery of renal function in mice after ischemia-reperfusion injury (IRI) with associated rescue ... Read more >>

J Pharmacol Exp Ther (The Journal of pharmacology and experimental therapeutics)
[2019, 369(1):173-180]

Cited: 8 times

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