Full Text Journal Articles by
Author Siegmund Lang

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The Incidence of Fractures Among the Adult Population of Germany – and Analysis From 2009 through 2019.

Markus Rupp, Nike Walter, Christian Pfeifer, Siegmund Lang, Maximilian Kerschbaum, Werner Krutsch, Florian Baumann, Volker Alt,

<h4>Background</h4>Detailed analyses of epidemiological data on fractures are an important resource for persons and institutions providing health care services, as they yield information on the effects of current treatment strategies and on the need for preventive measures. The epidemiology of fractures in Germany, however, is unknown. The goal of this ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, (Forthcoming):]

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The Tibial Plateau Map: Fracture Line Morphology of Intra-Articular Proximal Tibial Fractures.

Maximilian Kerschbaum, Morgane Tyczka, Lisa Klute, Marie Theres Heller, Matthias Koch, Daniel Popp, Siegmund Lang, Volker Alt, Michael Worlicek,

The purpose of this study was to characterize the patterns of a large series of tibial plateau fractures with the use of fracture mapping, with regard to different fracture types using the OTA/AO and Schatzker classification. Patients with intra-articular fractures of the tibial plateau were evaluated, using the OTA/AO and ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:9920189]

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Football-related injuries are the major reason for the career end of professional male football players.

Matthias Koch, Martin Klügl, Borys Frankewycz, Siegmund Lang, Michael Worlicek, Daniel Popp, Volker Alt, Werner Krutsch,

<h4>Purpose</h4>Little is known about the consequences of injuries on professional male football players' career and retirement period. The aim of this study is to investigate the impact of injuries that male professional football players endure during their career, reasons for the end of their career and the post-career phase of ... Read more >>

Knee Surg Sports Traumatol Arthrosc (Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA)
[2021, :]

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Decision-making to stop or continue playing after football injuries - a systematic video analysis of 711 injury situations in amateur football.

Krutsch Volker, Oberhauser Julia, Krutsch Werner, Loose Oliver, Weber Johannes, Kerschbaum Maximilian, Lang Siegmund, Koch Matthias, Alt Volker, Worlicek Michael,

Scientific injury registration via video analysis is lacking in amateur football. The purpose of this study was to analyse match injury situations with a focus on the decisions made by players and referees after sustaining a football trauma. In a retrospective cohort study, traumatic injuries sustained in any of the ... Read more >>

Eur J Sport Sci (European journal of sport science)
[2021, :1-7]

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[Infections of the spine : Pyogenic spondylodiscitis and implant-associated vertebral osteomyelitis].

Siegmund Lang, Markus Rupp, Frank Hanses, Carsten Neumann, Markus Loibl, Volker Alt,

Pyogenic (unspecific) spondylodiscitis and implant-associated vertebral osteomyelitis (IAVO) are important diseases with the risk of neurological and septic complications. An early diagnosis is essential in which magnetic resonance imaging (MRI), histopathology and microbiological identification of the pathogen play key roles. The goals of conservative treatment in uncomplicated spondylodiscitis are antibiotic ... Read more >>

Unfallchirurg (Der Unfallchirurg)
[2021, 124(6):489-504]

Cited: 1 time

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[Use of video-assisted thoracoscopy in dorsoventral stabilization of osteodestructive pyogenic spondylodiscitis of the thoracic spine].

Siegmund Lang, Markus Loibl, Carsten Neumann, Volker Alt,

Unfallchirurg (Der Unfallchirurg)
[2021, 124(6):505-511]

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The epidemiology of fracture-related infections in Germany.

Nike Walter, Markus Rupp, Siegmund Lang, Volker Alt,

The epidemiology of fracture-related infection (FRI) is unknown, which makes it difficult to estimate future demands and evaluate progress in infection prevention. Therefore, we aimed to determine the nationwide burden's development over the last decade as a function of age group and gender. FRI prevalence as a function of age ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):10443]

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Influence of Oral Anticoagulation and Antiplatelet Drugs on Outcome of Elderly Severely Injured Patients.

Maximilian Kerschbaum, Siegmund Lang, Leopold Henssler, Antonio Ernstberger, Volker Alt, Christian Pfeifer, Michael Worlicek, Daniel Popp,

<h4>Introduction</h4>Severely injured elderly patients have a poorer prognosis and higher mortality rates after severe trauma compared with younger patients. The aim of this study was to correlate the influence of pre-existing oral anticoagulation (OAC) and antiplatelet drugs (PAI) on the outcome of severely injured elderly patients.<h4>Methods</h4>Using a prospective cohort study ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(8):]

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Iliac Bone Corridors to Host the Transiliac Internal Fixator-An Experimental CT Based Analysis.

Paul Schmitz, Maximilian Kerschbaum, Philipp Lamby, Siegmund Lang, Volker Alt, Michael Worlicek,

<h4>Background</h4>The transiliac internal fixator (TIFI) is a novel minimally invasive surgical procedure to stabilize posterior pelvic ring fractures. Two bone corridors with different lengths, widths, and angulations are suitable to host screws in the posterior iliac wing. While the length and the width have been described previously, the angulation has ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(7):]

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Does Dynamic Anterior Plate Fixation Provide Adequate Stability for Traumatic Subaxial Cervical Spine Fractures at Mid-Term Follow-Up?

Siegmund Lang, Carsten Neumann, Lasse Fiedler, Volker Alt, Markus Loibl, Maximilian Kerschbaum,

<h4>Background</h4>It remains questionable if the treatment of cervical fractures with dynamic plates in trauma surgery provides adequate stability for unstable fractures with disco-ligamentous injuries. The primary goal of this study was to assess the radiological and mid-term patient-reported outcome of traumatic subaxial cervical fractures treated with different plate systems.<h4>Patients and ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(6):]

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Management and Mid-Term Outcome After "Real SCIWORA" in Children and Adolescents.

Viola Freigang, Katja Butz, Caroline Theresa Seebauer, Julia Karnosky, Siegmund Lang, Volker Alt, Florian Baumann,

<h4>Study design</h4>Retrospective analysis.<h4>Objective</h4>The SCIWORA Syndrome (Spinal Cord Injury Without Radiographic Abnormalities) is a rare but potentially severe injury with a peak in childhood and adolescence. With a better understanding of injury patterns and advances in MRI, there is ongoing discussion regarding the "Real SCIWORA" syndrome, a clinical picture of neurologic ... Read more >>

Global Spine J (Global spine journal)
[2021, :2192568220979131]

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Two-Dimensional Visualization of the Three-Dimensional Planned Sacroiliac Screw Corridor with the Slice Fusion Method.

Maximilian Kerschbaum, Siegmund Lang, Florian Baumann, Volker Alt, Michael Worlicek,

Insertion of sacro-iliac (SI) screws for stabilization of the posterior pelvic ring without intraoperative navigation or three-dimensional imaging can be challenging. The aim of this study was to develop a simple method to visualize the ideal SI screw corridor, on lateral two-dimensional images, corresponding to the lateral fluoroscopic view, used ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(2):]

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Does Dynamic Ventral Plate Fixation Provide Adequate Stability for Traumatic Subaxial Cervical Spine Fractures in Mid-term Follow-up?

Siegmund Lang, Carsten Neumann, Lasse Fiedler, Volker Alt, Markus Loibl, Maximilian Kerschbaum,

<h4>Background: </h4> It remains questionable if the treatment of cervical fractures with dynamic plates in trauma surgery provides adequate stability for fractures with disco-ligamentous injuries. The primary goal of this study was to assess the radiological and mid-term patient-reported outcome of traumatic subaxial cervical fractures treated with a dynamic plate ... Read more >>

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Radiological and Long-Term Patient-Reported Outcome after Stabilization of Traumatic Thoraco-Lumbar Spinal Fractures using an Expandable Vertebral Body Replacement Implant.

Siegmund Lang, Carsten Neumann, Christina Schwaiger, Andreas Voss, Volker Alt, Markus Loibl, Maximilian Kerschbaum,

<h4>Background: </h4> A combined posterior and anterior stabilization was found to offer a better restoration of the sagittal profile of thoracolumbar fractures in comparison to posterior-only stabilization. Data on restoring the bisegmental kyphotic endplate angle (BKA) and on patient-reported outcome measures (PROM) is sparse.Patients and Methods136 patients with traumatic thoraco-lumbar ... Read more >>

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Physioxia Expanded Bone Marrow Derived Mesenchymal Stem Cells Have Improved Cartilage Repair in an Early Osteoarthritic Focal Defect Model.

Girish Pattappa, Jonas Krueckel, Ruth Schewior, Dustin Franke, Alexander Mench, Matthias Koch, Johannes Weber, Siegmund Lang, Christian G Pfeifer, Brian Johnstone, Denitsa Docheva, Volker Alt, Peter Angele, Johannes Zellner,

Focal early osteoarthritis (OA) or degenerative lesions account for 60% of treated cartilage defects each year. The current cell-based regenerative treatments have an increased failure rate for treating degenerative lesions compared to traumatic defects. Mesenchymal stem cells (MSCs) are an alternative cell source for treating early OA defects, due to ... Read more >>

Biology (Basel) (Biology)
[2020, 9(8):]

Cited: 4 times

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Health Related Quality of Life after Multiple Trauma in Adolescents

Viola Freigang, Antonio Ernstberger, Florian Zeman, Johannes Weber, Moritz Riedl, Siegmund Lang, Volker Alt, Florian Baumann,

<h4>Purpose: </h4> Trauma is still a major burden in global public health. In the past, multiple pieces of trauma research focused on mortality as an outcome parameter. The purpose of this study is to evaluate the global health-related quality of life (HRQoL) of adolescents after multiple trauma. Methods We conducted ... Read more >>

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Phenotypic Characterization of Bone Marrow Mononuclear Cells and Derived Stromal Cell Populations from Human Iliac Crest, Vertebral Body and Femoral Head.

Marietta Herrmann, Maria Hildebrand, Ursula Menzel, Niamh Fahy, Mauro Alini, Siegmund Lang, Lorin Benneker, Sophie Verrier, Martin J Stoddart, Jennifer J Bara,

(1) In vitro, bone marrow-derived stromal cells (BMSCs) demonstrate inter-donor phenotypic variability, which presents challenges for the development of regenerative therapies. Here, we investigated whether the frequency of putative BMSC sub-populations within the freshly isolated mononuclear cell fraction of bone marrow is phenotypically predictive for the in vitro derived stromal ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(14):]

Cited: 12 times

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Controversies in regenerative medicine: Should intervertebral disc degeneration be treated with mesenchymal stem cells?

Markus Loibl, Karin Wuertz-Kozak, Gianluca Vadala, Siegmund Lang, Jeremy Fairbank, Jill P Urban,

Low back pain (LBP) can significantly reduce the quality of life of patients, and has a considerable economic and social impact worldwide. It is commonly associated with disc degeneration, even though many people with degenerate discs are asymptomatic. Degenerate disc disease (DDD), is thus a common term for intervertebral disc ... Read more >>

JOR Spine (JOR spine)
[2019, 2(1):e1043]

Cited: 15 times

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Bone Marrow Aspirate Concentrate for the Treatment of Avascular Meniscus Tears in a One-Step Procedure-Evaluation of an In Vivo Model.

Matthias Koch, Selma Hammer, Julian Fuellerer, Siegmund Lang, Christian G Pfeifer, Girish Pattappa, Johannes Weber, Markus Loibl, Michael Nerlich, Peter Angele, Johannes Zellner,

Avascular meniscus tears show poor intrinsic regenerative potential. Thus, lesions within this area predispose the patient to developing knee osteoarthritis. Current research focuses on regenerative approaches using growth factors or mesenchymal stem cells (MSCs) to enhance healing capacity within the avascular meniscus zone. The use of MSCs especially as progenitor ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(5):]

Cited: 3 times

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TGF-β Signalling is Suppressed under Pro-Hypertrophic Conditions in MSC Chondrogenesis Due to TGF-β Receptor Downregulation.

Christian G Pfeifer, Alexandra Karl, Maximilian Kerschbaum, Arne Berner, Siegmund Lang, Rupert Schupfner, Matthias Koch, Peter Angele, Michael Nerlich, Michael B Mueller,

Background and Objectives:Mesenchymal stem cells (MSCs) become hypertrophic in long term despite chondrogenic differentiation following the pathway of growth plate chondrocytes. This terminal differentiation leads to phenotypically unstable cartilage and was mirrored in vitro by addition of hypertrophy inducing medium. We investigated how intrinsic TGF-β signaling is altered in pro-hypertrophic ... Read more >>

Int J Stem Cells (International journal of stem cells)
[2019, 12(1):139-150]

Cited: 4 times

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Platelet-Rich Plasma in Tissue Engineering: Hype and Hope.

Siegmund Lang, Markus Loibl, Marietta Herrmann,

<h4>Background</h4>Platelet-rich plasma (PRP) refers to an enriched platelet suspension in plasma. In addition to the clinical application of PRP in the context of various orthopedic diseases and beyond, PRP and platelet lysate (PL) have been in focus in the field of tissue engineering. In this review, we discuss the application ... Read more >>

Eur Surg Res (European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes)
[2018, 59(3-4):265-275]

Cited: 16 times

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Partial Anterior Cruciate Ligament Ruptures: Advantages by Intraligament Autologous Conditioned Plasma Injection and Healing Response Technique-Midterm Outcome Evaluation.

Matthias Koch, Felix Mayr, Leonard Achenbach, Werner Krutsch, Siegmund Lang, Franz Hilber, Johannes Weber, Christian G Pfeifer, Rebecca Woehl, Jürgen Eichhorn, Johannes Zellner, Michael Nerlich, Peter Angele,

The historical treatment options for partial anterior cruciate ligament (ACL) ruptures were conservative therapy or ACL reconstruction by injured bundle or entire ACL replacement. In awareness of the regenerative potential of biologic agents such as mesenchymal stem cells or platelet rich plasma (PRP), the healing response technique was developed to ... Read more >>

Biomed Res Int (BioMed research international)
[2018, 2018:3204869]

Cited: 3 times

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Autologous mesenchymal stem cells or meniscal cells: what is the best cell source for regenerative meniscus treatment in an early osteoarthritis situation?

Johannes Zellner, Girish Pattappa, Matthias Koch, Siegmund Lang, Johannes Weber, Christian G Pfeifer, Michael B Mueller, Richard Kujat, Michael Nerlich, Peter Angele,

<h4>Background</h4>Treatment of meniscus tears within the avascular region represents a significant challenge, particularly in a situation of early osteoarthritis. Cell-based tissue engineering approaches have shown promising results. However, studies have not found a consensus on the appropriate autologous cell source in a clinical situation, specifically in a challenging degenerative environment. ... Read more >>

Stem Cell Res Ther (Stem cell research & therapy)
[2017, 8(1):225]

Cited: 17 times

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Long-term radiographic appearance of calcium-phosphate synthetic bone grafts after surgical treatment of tibial plateau fractures.

Alexander Hanke, Martin Bäumlein, Siegmund Lang, Boyko Gueorguiev, Michael Nerlich, Thomas Perren, Paavo Rillmann, Christian Ryf, Theodore Miclau, Markus Loibl,

<h4>Objectives</h4>Synthetic bone grafts (SBGs) are widely used to fill bone defects after fracture reduction. This study assessed the long-term resorption of two different calcium phosphate products (A=ChronOS™ inject and B=Norian<sup>®</sup> SRS<sup>®</sup>; both DePuy Synthes, Oberdorf, Switzerland) used in the surgical treatment of tibial plateau fractures.<h4>Design</h4>Long-term clinical and radiologic follow-up of ... Read more >>

Injury (Injury)
[2017, 48(12):2807-2813]

Cited: 1 time

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Leukocyte-reduced platelet-rich plasma increases proliferation of tenocytes treated with prednisolone: a cell cycle analysis.

Franz Hilber, Markus Loibl, Siegmund Lang, Maximilian Kerschbaum, Gero Brockhoff, Peter Angele, Johannes Zellner, Paul Schmitz, Michael Nerlich, Michael Worlicek,

<h4>Introduction</h4>The purpose of this study was to evaluate the effect of allogenic leukocyte-reduced platelet-rich plasma on human tenocytes after treatment with prednisolone and to develop a standardization of its application for clinical practice.<h4>Methods</h4>A leukocyte-reduced PRP was produced using the Arthrex Double Syringe (Arthrex, Inc., Naples, FL, USA), in a modified ... Read more >>

Arch Orthop Trauma Surg (Archives of orthopaedic and trauma surgery)
[2017, 137(10):1417-1422]

Cited: 3 times

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