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A rare complication of pauci-immune crescentic glomerulonephritis in a child: Answers.

Sidharth Kumar Sethi, Abhyuday Rana, Shyam Bihari Bansal, Alka Rana, Dinesh Kumar Yadav, Kritika Soni, Marie-Agnès Dragon-Durey, Rupesh Raina, Vijay Kher,

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, :]

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AGREEing on the Management of Idiopathic Steroid-sensitive Nephrotic Syndrome in Children: A Systematic Review of Clinical Practice Guidelines

Khalid Abdulaziz Alhasan, Reem Al Khalifah, Majed Aloufi, Weiam Almaiman, Muddathir Hamad, Naif Fahad Abdulmajeed, Abdullah Al Salloum, Jameela Kari, Muneera AlJelaify, Rolan Bassrawi, Turki Al Hussain, Adi Alherbish, Abdulhadi Al Talhi, Mohamad-Hani Temsah, Sidharth Kumar Sethi, Rupesh Raina, Reny Joseph, Yasser Sami Amer,

<h4>Background: </h4> Nephrotic syndrome is the most common kidney disease in children worldwide. Our aim was to critically appraise the quality of recent Clinical Practice Guidelines (CPGs) for idiopathic steroid-sensitive nephrotic syndrome (SSNS) in children in addition to summarize and compare their recommendations. <h4>Methods: </h4> Systematic review of CPGs. We ... Read more >>

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Challenges of long-term vascular access in pediatric hemodialysis: Recommendations for practitioners.

Rupesh Raina, Hirva Joshi, Ronith Chakraborty, Sidharth Kumar Sethi,

Kidney transplantation is the preferred treatment of end-stage renal disease in children. However, time to transplant varies, making a well-functioning long-term vascular access essential for performing hemodialysis efficiently and without disruption until a kidney becomes available. However, establishing long-term vascular access in pediatric patients can present distinct challenges due to ... Read more >>

Hemodial Int (Hemodialysis international. International Symposium on Home Hemodialysis)
[2021, 25(1):3-11]

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A rare complication of pauci-immune crescentic glomerulonephritis in a child: Questions.

Sidharth Kumar Sethi, Abhyuday Rana, Shyam Bihari Bansal, Alka Rana, Dinesh Kumar Yadav, Kritika Soni, Marie-Agnès Dragon-Durey, Rupesh Raina, Vijay Kher,

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, :]

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Cerebral venous sinus thrombosis in pediatric nephrotic syndrome.

Sidharth Kumar Sethi, Vivek Sharma, Ronith Chakraborty, Vijay Kher, Rupesh Raina,

Kidney Int (Kidney international)
[2020, 98(4):1056]

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Uncommon cause of fever in a child with steroid-dependent nephrotic syndrome.

Sidharth Kumar Sethi, Shyam Bansal, Ronith Chakraborty, Rahul Jain, Nikita Wadhwani, Rupesh Raina,

<h4>Background</h4>Children with nephrotic syndrome are vulnerable to developing infections due to a state of relative immunodeficiency, malnourishment, and use of immunosuppression. Case characteristics: We herein report the case of a 3-year-old child with steroid-dependent nephrotic syndrome who presented to us with fever of unknown origin.<h4>Observation</h4>The child was found to have ... Read more >>

Clin Nephrol Case Stud (Clinical nephrology. Case studies)
[2020, 8:49-52]

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Kidney Replacement Therapy in COVID-19 Induced Kidney Failure and Septic Shock: A Pediatric Continuous Renal Replacement Therapy [PCRRT] Position on Emergency Preparedness With Resource Allocation.

Rupesh Raina, Ronith Chakraborty, Sidharth Kumar Sethi, Timothy Bunchman,

The recent worldwide pandemic of COVID-19 has had a detrimental worldwide impact on people of all ages. Although data from China and the United States indicate that pediatric cases often have a mild course and are less severe in comparison to adults, there have been several cases of kidney failure ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:413]

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Mystery of black urine: alkaptonuria.

Sidharth Kumar Sethi, Rupesh Raina, Ronith Chakraborty, Vijay Kher,

Kidney Int (Kidney international)
[2020, 97(6):1303]

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Challenges of Vascular Access in the Pediatric Population.

Rupesh Raina, Aliza Mittal, Sidharth Kumar Sethi, Ronith Chakraborty,

The incidence and prevalence of renal replacement therapy has continued to increase in the pediatric population. Recent data have shown that hemodialysis was the most frequently used dialysis modality, especially in pediatric ESRD patients (age 0-21 years). A well-functioning vascular access is required for effective hemodialysis and choosing the best vascular ... Read more >>

Adv Chronic Kidney Dis (Advances in chronic kidney disease)
[2020, 27(3):268-275]

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Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy.

Rupesh Raina, Jirair K Bedoyan, Uta Lichter-Konecki, Philippe Jouvet, Stefano Picca, Nicholas Ah Mew, Marcel C Machado, Ronith Chakraborty, Meghana Vemuganti, Manpreet K Grewal, Timothy Bunchman, Sidharth Kumar Sethi, Vinod Krishnappa, Mignon McCulloch, Khalid Alhasan, Arvind Bagga, Rajit K Basu, Franz Schaefer, Guido Filler, Bradley A Warady,

Hyperammonaemia in children can lead to grave consequences in the form of cerebral oedema, severe neurological impairment and even death. In infants and children, common causes of hyperammonaemia include urea cycle disorders or organic acidaemias. Few studies have assessed the role of extracorporeal therapies in the management of hyperammonaemia in ... Read more >>

Nat Rev Nephrol (Nature reviews. Nephrology)
[2020, 16(8):471-482]

Cited: 2 times

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Pediatric Continuous Renal Replacement Therapy (PCRRT) expert committee recommendation on prescribing prolonged intermittent renal replacement therapy (PIRRT) in critically ill children.

Sidharth Kumar Sethi, Aliza Mittal, Nikhil Nair, Arvind Bagga, Arpana Iyenger, Uma Ali, Rajiv Sinha, Indira Agarwal, Marcelo de Sousa Tavares, Asiri Abeyagunawardena, Mohammed Hanif, Devender Shreshtha, Khemchand Moorani, Sadaf Asim, Vijay Kher, Khalid Alhasan, Chebl Mourani, Mohammed Al Riyami, Timothy E Bunchman, Mignon McCulloch, Rupesh Raina,

INTRODUCTION:Recently, prolonged intermittent renal replacement therapies (PIRRT) have emerged as cost-effective alternatives to conventional CRRT and their use in the pediatric population has started to become more prominent. However, there is a lack of consensus guidelines on the use of PIRRT in pediatric patients in an intensive care setting. METHODS:A ... Read more >>

Hemodial Int (Hemodialysis international. International Symposium on Home Hemodialysis)
[2020, 24(2):237-251]

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Renal Replacement Therapy in Pediatric Acute Kidney Injury.

Sidharth Kumar Sethi, Ronith Chakraborty, Hirva Joshi, Rupesh Raina,

Acute kidney injury (AKI) is common in critically ill children and affects nearly 30-40% of patients admitted to the pediatric intensive care unit (ICU). Even with technological advances in critical care and dialysis, there is a high mortality rate of 66.8% to 90% in ICU patients. Renal replacement therapy (RRT) ... Read more >>

Indian J Pediatr (Indian journal of pediatrics)
[2020, 87(8):608-617]

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Management of Intoxication via Extracorporeal Therapy in Pediatrics.

Rupesh Raina, Sidharth Kumar Sethi, Timothy Bunchman,

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, 35(5):913-914]

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A boy with IgA vasculitis and anuria: Answers.

Vivek Sharma, Sidharth Kumar Sethi, Rupesh Raina, Shyam Bansal, S S Baijal, Vijay Kher,

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, 35(3):401-402]

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A boy with IgA vasculitis and anuria: Questions.

Vivek Sharma, Sidharth Kumar Sethi, Rupesh Raina, Shyam Bansal, S S Baijal, Vijay Kher,

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, 35(3):399-400]

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Congenital Nephrotic Syndrome in India in the Current Era: A Multicenter Case Series.

Rajiv Sinha, Anil Vasudevan, Indira Agarwal, Sidharth Kumar Sethi, Abhijeet Saha, Subal Pradhan, Sudha Ekambaram, Nilam Thaker, Manoj Matnani, Sushmita Banerjee, Jyoti Sharma, Jyoti Singhal, Shazia Ashraf, Kausik Mandal,

BACKGROUND:There is a paucity of information on epidemiology, diagnosis, and treatment outcomes of congenital nephrotic syndrome (CNS) in developing countries. METHODS:Retrospective (2012-2017) review of case records undertaken across 12 Indian pediatric nephrology centers. RESULTS:Sixty-five children (58% male, median birth weight 2.4 kg [interquartile range (IQR) 2.1-2.86]) were identified with CNS. ... Read more >>

Nephron (Nephron)
[2020, 144(1):21-29]

Cited: 1 time

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Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup.

Rupesh Raina, Manpreet K Grewal, Martha Blackford, Jordan M Symons, Michael J G Somers, Christoph Licht, Rajit K Basu, Sidharth Kumar Sethi, Deepa Chand, Gaurav Kapur, Mignon McCulloch, Arvind Bagga, Vinod Krishnappa, Hui-Kim Yap, Marcelo de Sousa Tavares, Timothy E Bunchman, Michelle Bestic, Bradley A Warady, Maria Díaz-González de Ferris,

<h4>Background</h4>Intentional or unintentional ingestions among children and adolescents are common. There are a number of ingestions amenable to renal replacement therapy (RRT).<h4>Methods</h4>We systematically searched PubMed/Medline, Embase, and Cochrane databases for literature regarding drugs/intoxicants and treatment with RRT in pediatric populations. Two experts from the PCRRT (Pediatric Continuous Renal Replacement Therapy) ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2019, 34(11):2427-2448]

Cited: 1 time

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Risk Stratification for Acute Kidney Injury in Critically-ill Children.

Sidharth Kumar Sethi, Rupesh Raina,

Indian Pediatr (Indian pediatrics)
[2019, 56(8):641-642]

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Neonatal Acute Kidney Injury: A Survey of Perceptions and Management Strategies Amongst Pediatricians and Neonatologists.

Sidharth Kumar Sethi, Gopal Agrawal, Sanjay Wazir, Smriti Rohatgi, Arpana Iyengar, Ronith Chakraborty, Rahul Jain, Nikhil Nair, Rajiv Sinha, Raktima Chakrabarti, Deepak Kumar, Rupesh Raina,

Background: Neonatal Acute Kidney Injury (AKI) occurs in 40-70% of critically ill newborn infants and is independently associated with increased morbidity and mortality. Understanding the practice patterns of physicians (neonatologists and pediatricians), caring for neonates in India is important to optimize care and outcomes in neonatal AKI. Aim: The aim ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:553]

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Pediatric intradialytic hypotension: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) Workgroup.

Rupesh Raina, Stephanie Lam, Hershita Raheja, Vinod Krishnappa, Daljit Hothi, Andrew Davenport, Deepa Chand, Gaurav Kapur, Franz Schaefer, Sidharth Kumar Sethi, Mignon McCulloch, Arvind Bagga, Timothy Bunchman, Bradley A Warady,

Intradialytic hypotension (IDH) is a common adverse event resulting in premature interruption of hemodialysis, and consequently, inadequate fluid and solute removal. IDH occurs in response to the reduction in blood volume during ultrafiltration and subsequent poor compensatory mechanisms due to abnormal cardiac function or autonomic or baroreceptor failure. Pediatric patients ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2019, 34(5):925-941]

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Fluid Overload in Critically Ill Children.

Rupesh Raina, Sidharth Kumar Sethi, Nikita Wadhwani, Meghana Vemuganti, Vinod Krishnappa, Shyam B Bansal,

<b>Background:</b> A common practice in the management of critically ill patients is fluid resuscitation. An excessive administration of fluids can lead to an imbalance in fluid homeostasis and cause fluid overload (FO). In pediatric critical care patients, FO can lead to a multitude of adverse effects and increased risk of ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2018, 6:306]

Cited: 1 time

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Antibiotic Dosing in Sustained Low-Efficiency Dialysis in Critically Ill Patients.

Sidharth Kumar Sethi, Vinod Krishnappa, Nisha Nangethu, Paul Nemer, Lawrence A Frazee, Rupesh Raina,

Purpose of review:Sustained low-efficiency dialysis (SLED) is increasingly used as a renal replacement modality in critically ill patients with acute kidney injury (AKI) and hemodynamic instability. There is, therefore, a greater need for the understanding of the antibiotic dosage and pharmacokinetics in these patients, to provide them with optimal therapy. ... Read more >>

Can J Kidney Health Dis (Canadian journal of kidney health and disease)
[2018, 5:2054358118792229]

Cited: 1 time

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Myelofibrosis-Induced Erythropoietin-Resistant Anemia Due to Severe Refractory Hyperparathyroidism.

Sidharth Kumar Sethi, Shyam Bihari Bansal, Nikita Wadhwani, Mayur Makasana, Ashish Nandwani, Vijay Kher, Rupesh Raina,

Kidney Int Rep (Kidney international reports)
[2018, 3(4):1010-1014]

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Heparin free dialysis in critically sick children using sustained low efficiency dialysis (SLEDD-f): A new hybrid therapy for dialysis in developing world.

Sidharth Kumar Sethi, Shyam B Bansal, Anshika Khare, Maninder Dhaliwal, Veena Raghunathan, Nikita Wadhwani, Ashish Nandwani, Dinesh Kumar Yadav, Amit Kumar Mahapatra, Rupesh Raina,

<h4>Background</h4>In critically sick adults, sustained low efficiency dialysis [SLED] appears to be better tolerated hemodynamically and outcomes seem to be comparable to CRRT. However, there is paucity of data in critically sick children. In children, two recent studies from Taiwan (n = 11) and India (n = 68) showed benefits ... Read more >>

PLoS One (PloS one)
[2018, 13(4):e0195536]

Cited: 1 time

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A young child with fever and unexplained acute kidney injury: Answers.

Sidharth Kumar Sethi, Arushi Nautiyal, Alka Rana, Rajan Duggal, Ashish Nandwani, Dinesh Yadav, Amit Mahapatra, Maninder Dhaliwal, Veena Raghunathan, Shyam Bihari Bansal,

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2018, 33(10):1691-1693]

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