Full Text Journal Articles by
Author Sidharth K Sethi

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Hypertensive Crisis in Pediatric Patients: An Overview.

Rupesh Raina, Zubin Mahajan, Aditya Sharma, Ronith Chakraborty, Sarisha Mahajan, Sidharth K Sethi, Gaurav Kapur, David Kaelber,

Hypertensive crisis can be a source of morbidity and mortality in the pediatric population. While the epidemiology has been difficult to pinpoint, it is well-known that secondary causes of pediatric hypertension contribute to a greater incidence of hypertensive crisis in pediatrics. Hypertensive crisis may manifest with non-specific symptoms as well ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:588911]

Cited: 0 times

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Renal Manifestations of Tuberous Sclerosis Complex.

Nikhil Nair, Ronith Chakraborty, Zubin Mahajan, Aditya Sharma, Sidharth K Sethi, Rupesh Raina,

Tuberous sclerosis complex (TSC) is a genetic condition caused by a mutation in either the TSC1 or TSC2 gene. Disruption of either of these genes leads to impaired production of hamartin or tuberin proteins, leading to the manifestation of skin lesions, tumors, and seizures. TSC can manifest in multiple organ ... Read more >>

(Journal of kidney cancer and VHL)
[2020, 7(3):5-19]

Cited: 0 times

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Development of acute kidney injury following pediatric cardiac surgery.

Aditya Sharma, Ronith Chakraborty, Katyayini Sharma, Sidharth K Sethi, Rupesh Raina,

Acute kidney injury (AKI) in the pediatric population is a relatively common phenomenon. Specifically, AKI has been found in increasing numbers within the pediatric population following cardiac surgery, with up to 43% of pediatric patients developing AKI post-cardiac surgery. However, recent advances have allowed for the identification of risk factors. ... Read more >>

Kidney Res Clin Pract (Kidney research and clinical practice)
[2020, 39(3):259-268]

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Low hemoglobin levels are independently associated with neonatal acute kidney injury: a report from the AWAKEN Study Group.

Arwa Nada, David Askenazi, Louis J Boohaker, Linzi Li, John D Mahan, Jennifer Charlton, Russell L Griffin, ,

BACKGROUND:Studies in adults showed a relationship between low hemoglobin (Hb) and acute kidney injury (AKI). We performed this study to evaluate this association in newborns. METHODS:We evaluated 1891 newborns from the Assessment of Worldwide AKI Epidemiology in Neonates (AWAKEN) database. We evaluated the associations for the entire cohort and 3 ... Read more >>

Pediatr Res (Pediatric research)
[2020, :]

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Immunoadsorption in ABO-incompatible kidney transplantation in adult and pediatric patients with follow-up on graft and patient survival: First series from India.

Aseem Kumar Tiwari, Geet Aggarwal, Dinesh Arora, Gunjan Bhardwaj, Manish Jain, Shyam Bihari Bansal, Sidharth K Sethi,

BACKGROUND:There are no published reports on desensitization protocol for ABO-incompatible kidney transplants using Immuno-Adsorption (IA) plasmapheresis from India. IA offers certain advantages including processing of larger plasma volumes, quicker reduction of isoagglutinin titers and no requirement of replacement fluids. AIMS AND OBJECTIVES:Authors' center evaluated success of desensitization protocol, and graft/patient ... Read more >>

Asian J Transfus Sci (Asian journal of transfusion science)
[2020, 14(1):13-18]

Cited: 0 times

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Acute Kidney Injury and Bronchopulmonary Dysplasia in Premature Neonates Born Less than 32 Weeks' Gestation.

Michelle C Starr, Louis Boohaker, Laurie C Eldredge, Shina Menon, Russell Griffin, Dennis E Mayock, Linzi Li, David Askenazi, Sangeeta Hingorani, ,

OBJECTIVE:This study aimed to evaluate the association between acute kidney injury (AKI) and bronchopulmonary dysplasia (BPD) in infants born <32 weeks of gestational age (GA). STUDY DESIGN:Present study is a secondary analysis of premature infants born at <32 weeks of GA in the Assessment of Worldwide Acute Kidney Injury Epidemiology ... Read more >>

Am J Perinatol (American journal of perinatology)
[2020, 37(3):341-348]

Cited: 4 times

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Acute Kidney Injury is Associated with Poor Lung Outcomes in Infants Born ≥32 Weeks of Gestational Age.

Michelle C Starr, Louis Boohaker, Laurie C Eldredge, Shina Menon, Russell Griffin, Dennis Mayock, David Askenazi, Sangeeta Hingorani, ,

OBJECTIVE:This study aimed to evaluate the association between acute kidney injury (AKI) and lung outcomes in infants born ≥32 weeks of gestational age (GA). STUDY DESIGN:Secondary analysis of infants ≥32 weeks of GA in the assessment of worldwide acute kidney injury epidemiology in neonates (AWAKEN) retrospective cohort (n = 1,348). We used ... Read more >>

Am J Perinatol (American journal of perinatology)
[2020, 37(2):231-240]

Cited: 1 time

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The impact of fluid balance on outcomes in premature neonates: a report from the AWAKEN study group.

David T Selewski, Katja M Gist, Amy T Nathan, Stuart L Goldstein, Louis J Boohaker, Ayse Akcan-Arikan, Elizabeth M Bonachea, Mina Hanna, Catherine Joseph, John D Mahan, Cherry Mammen, Arwa Nada, Kimberly Reidy, Amy Staples, Pia Wintermark, Russell Griffin, David J Askenazi, Ronnie Guillet, ,

BACKGROUND:We evaluated the epidemiology of fluid balance (FB) over the first postnatal week and its impact on outcomes in a multi-center cohort of premature neonates from the AWAKEN study. METHODS:Retrospective analysis of infants <36 weeks' gestational age from the AWAKEN study (N = 1007). FB was defined by percentage of change from ... Read more >>

Pediatr Res (Pediatric research)
[2020, 87(3):550-557]

Cited: 2 times

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Correction to: Acute kidney injury in neonatal encephalopathy: an evaluation of the AWAKEN database.

Megan J Kirkley, Louis Boohaker, Russell Griffin, Danielle E Soranno, Jason Gien, David Askenazi, Katja M Gist, ,

The original version of this article unfortunately contained a mistake. The collaborators of the Neonatal Kidney Collaborative (NKC) were not named individually. The list of all collaborators is given below. ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2019, 34(2):363]

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Mutations of ADAMTS9 Cause Nephronophthisis-Related Ciliopathy.

Yo Jun Choi, Jan Halbritter, Daniela A Braun, Markus Schueler, David Schapiro, John Hoon Rim, Sumeda Nandadasa, Won-Il Choi, Eugen Widmeier, Shirlee Shril, Friederike Körber, Sidharth K Sethi, Richard P Lifton, Bodo B Beck, Suneel S Apte, Heon Yung Gee, Friedhelm Hildebrandt,

Nephronophthisis-related ciliopathies (NPHP-RCs) are a group of inherited diseases that are associated with defects in primary cilium structure and function. To identify genes mutated in NPHP-RC, we performed homozygosity mapping and whole-exome sequencing for >100 individuals, some of whom were single affected individuals born to consanguineous parents and some of ... Read more >>

Am J Hum Genet (American journal of human genetics)
[2019, 104(1):45-54]

Cited: 3 times

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Incidence and Risk Factors of Early Onset Neonatal AKI.

Jennifer R Charlton, Louis Boohaker, David Askenazi, Patrick D Brophy, Carl D'Angio, Mamta Fuloria, Jason Gien, Russell Griffin, Sangeeta Hingorani, Susan Ingraham, Ayesa Mian, Robin K Ohls, Shantanu Rastogi, Christopher J Rhee, Mary Revenis, Subrata Sarkar, Alexandra Smith, Michelle Starr, Alison L Kent, ,

BACKGROUND AND OBJECTIVES:Neonatal AKI is associated with poor short- and long-term outcomes. The objective of this study was to describe the risk factors and outcomes of neonatal AKI in the first postnatal week. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS:The international retrospective observational cohort study, Assessment of Worldwide AKI Epidemiology in Neonates ... Read more >>

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2019, 14(2):184-195]

Cited: 2 times

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Optimizing the AKI definition during first postnatal week using Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) cohort.

David Askenazi, Carolyn Abitbol, Louis Boohaker, Russell Griffin, Rupesh Raina, Joshua Dower, T Keefe Davis, Patricio E Ray, Sofia Perazzo, Marissa DeFreitas, Lawrence Milner, Namasivayam Ambalavanan, F Sessions Cole, Erin Rademacher, Michael Zappitelli, Maroun Mhanna, ,

BACKGROUND:Neonates with serum creatinine (SCr) rise ≥0.3 mg/dL and/or ≥50% SCr rise are more likely to die, even when controlling for confounders. These thresholds have not been tested in newborns. We hypothesized that different gestational age (GA) groups require different SCr thresholds. METHODS:Neonates in Assessment of Worldwide Acute Kidney Epidemiology in ... Read more >>

Pediatr Res (Pediatric research)
[2019, 85(3):329-338]

Cited: 3 times

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Late onset neonatal acute kidney injury: results from the AWAKEN Study.

Jennifer R Charlton, Louis Boohaker, David Askenazi, Patrick D Brophy, Mamta Fuloria, Jason Gien, Russell Griffin, Sangeeta Hingorani, Susan Ingraham, Ayesa Mian, Robin K Ohls, Shantanu Rastogi, Christopher J Rhee, Mary Revenis, Subrata Sarkar, Michelle Starr, Alison L Kent, ,

BACKGROUND:Most studies of neonatal acute kidney injury (AKI) have focused on the first week following birth. Here, we determined the outcomes and risk factors for late AKI (>7d). METHODS:The international AWAKEN study examined AKI in neonates admitted to an intensive care unit. Late AKI was defined as occurring >7 days ... Read more >>

Pediatr Res (Pediatric research)
[2019, 85(3):339-348]

Cited: 3 times

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The impact of fluid balance on outcomes in critically ill near-term/term neonates: a report from the AWAKEN study group.

David T Selewski, Ayse Akcan-Arikan, Elizabeth M Bonachea, Katja M Gist, Stuart L Goldstein, Mina Hanna, Catherine Joseph, John D Mahan, Arwa Nada, Amy T Nathan, Kimberly Reidy, Amy Staples, Pia Wintermark, Louis J Boohaker, Russell Griffin, David J Askenazi, Ronnie Guillet, ,

BACKGROUND:In sick neonates admitted to the NICU, improper fluid balance can lead to fluid overload. We report the impact of fluid balance in the first postnatal week on outcomes in critically ill near-term/term neonates. METHODS:This analysis includes infants ≥36 weeks gestational age from the Assessment of Worldwide Acute Kidney injury ... Read more >>

Pediatr Res (Pediatric research)
[2019, 85(1):79-85]

Cited: 1 time

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Fluid Overload and Renal Angina Index at Admission Are Associated With Worse Outcomes in Critically Ill Children.

Sidharth K Sethi, Veena Raghunathan, Shilpi Shah, Maninder Dhaliwal, Pranaw Jha, Maneesh Kumar, Sravanthi Paluri, Shyam Bansal, Maroun J Mhanna, Rupesh Raina,

Objectives: We investigated the association of fluid overload and oxygenation in critically sick children, and their correlation with various outcomes (duration of ventilation, ICU stay, and mortality). We also assessed whether renal angina index (RAI) at admission can predict mortality or acute kidney injury (AKI) on day 3 after admission. ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2018, 6:118]

Cited: 2 times

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Incidence and outcomes of neonatal acute kidney injury (AWAKEN): a multicentre, multinational, observational cohort study.

Jennifer G Jetton, Louis J Boohaker, Sidharth K Sethi, Sanjay Wazir, Smriti Rohatgi, Danielle E Soranno, Aftab S Chishti, Robert Woroniecki, Cherry Mammen, Jonathan R Swanson, Shanty Sridhar, Craig S Wong, Juan C Kupferman, Russell L Griffin, David J Askenazi, ,

Background:Single-center studies suggest that neonatal acute kidney injury (AKI) is associated with poor outcomes. However, inferences regarding the association between AKI, mortality, and hospital length of stay are limited due to the small sample size of those studies. In order to determine whether neonatal AKI is independently associated with increased ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2017, 1(3):184-194]

Cited: 33 times

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Feasibility of sustained low efficiency dialysis in critically sick pediatric patients: A multicentric retrospective study.

Sidharth K Sethi, Rajiv Sinha, Pranaw Jha, Nikita Wadhwani, Veena Raghunathan, Maninder Dhaliwal, Shyam B Bansal, Vijay Kher, Valentine Lobo, Jyoti Sharma, Rupesh Raina,

INTRODUCTION:Sustained low-efficiency dialysis (SLED) has emerged as a cost effective alternative to Continuous Renal Replacement Therapy in the management of hemodynamically unstable adult patients with acute kidney injury. The objective of the study was to document the SLED practices in these centers, and to look at the feasibility, and tolerability ... Read more >>

Hemodial Int (Hemodialysis international. International Symposium on Home Hemodialysis)
[2018, 22(2):228-234]

Cited: 1 time

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A novel CFHR1-CFHR5 hybrid leads to a familial dominant C3 glomerulopathy.

Shambhuprasad K Togarsimalemath, Sidharth K Sethi, Rajan Duggal, Moglie Le Quintrec, Pranaw Jha, Régis Daniel, Florence Gonnet, Shyam Bansal, Lubka T Roumenina, Veronique Fremeaux-Bacchi, Vijay Kher, Marie-Agnes Dragon-Durey,

The intrinsic similarity shared between the members of the complement factor H family, which comprises complement factor H and five complement factor H-related (CFHR) genes, leads to various recombination events. In turn these events lead to deletions of some genes or abnormal proteins, which are found in patients with atypical ... Read more >>

Kidney Int. (Kidney international)
[2017, 92(4):876-887]

Cited: 11 times

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A Familial Infantile Renal Failure.

Sidharth K Sethi, Nikita Wadhwani, Pranaw Jha, Rajan Duggal, Virginia Vega-Warner, Rupesh Raina, Shyam B Bansal, Vijay Kher, Matthew G Sampson, Edgar A Otto,

Kidney Int Rep (Kidney international reports)
[2017, 2(2):130-133]

Cited: 0 times

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Cascade plasmapheresis as preconditioning regimen for ABO-incompatible renal transplantation: a single-center experience.

Pranaw K Jha, Aseem K Tiwari, Shyam B Bansal, Sidharth K Sethi, Rajesh Ahlawat, Vijay Kher,

Removal of anti-ABO is an important component of the preconditioning regimen for ABO-incompatible (ABOi) renal transplant. Cascade plasmapheresis (CP) is one of the extracorporeal methods of antibody removal, others being conventional plasma exchange (PE) and immunoadsorption. There is no previous published experience with CP in this context. The purpose of ... Read more >>

Transfusion (Transfusion)
[2016, 56(4):956-961]

Cited: 5 times

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Whole Exome Sequencing Reveals Novel PHEX Splice Site Mutations in Patients with Hypophosphatemic Rickets.

Sara L Ma, Virginia Vega-Warner, Christopher Gillies, Matthew G Sampson, Vijay Kher, Sidharth K Sethi, Edgar A Otto,

Hypophosphatemic rickets (HR) is a heterogeneous genetic phosphate wasting disorder. The disease is most commonly caused by mutations in the PHEX gene located on the X-chromosome or by mutations in CLCN5, DMP1, ENPP1, FGF23, and SLC34A3. The aims of this study were to perform molecular diagnostics for four patients with ... Read more >>

PLoS One (PloS one)
[2015, 10(6):e0130729]

Cited: 6 times

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Characterization of 28 novel patients expands the mutational and phenotypic spectrum of Lowe syndrome.

Florian Recker, Marcin Zaniew, Detlef Böckenhauer, Nunzia Miglietti, Arend Bökenkamp, Anna Moczulska, Anna Rogowska-Kalisz, Guido Laube, Valerie Said-Conti, Belde Kasap-Demir, Anna Niemirska, Mieczysław Litwin, Grzegorz Siteń, Krystyna H Chrzanowska, Małgorzata Krajewska-Walasek, Sidharth K Sethi, Velibor Tasic, Franca Anglani, Maria Addis, Anna Wasilewska, Maria Szczepańska, Krzysztof Pawlaczyk, Przemysław Sikora, Michael Ludwig,

The oculocerebrorenal syndrome of Lowe (OCRL) is a rare X-linked multi-systemic disorder, almost always characterized by the triad of congenital cataract, cognitive and behavioral impairment and a proximal tubulopathy.Twenty-eight novel patients with suspected Lowe syndrome were studied.All patients carried OCRL gene defects with mutational hot spots at CpG dinucleotides. Mutations ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2015, 30(6):931-943]

Cited: 15 times

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Novel techniques and newer markers for the evaluation of "proximal tubular dysfunction".

Michael Ludwig, Sidharth K Sethi,

Renal Fanconi syndromes are both clinically challenging and physiologically fascinating. The diagnosis requires a certain index of suspicion to correctly identify the clinical symptomatology and pursue the appropriate laboratory evaluations. The renal Fanconi syndrome (FS) is a defect of proximal tubular function attributable to different rare inherited diseases or acquired ... Read more >>

Int Urol Nephrol (International urology and nephrology)
[2011, 43(4):1107-1115]

Cited: 2 times

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Coffin-Siris syndrome with Mayer-Rokitansky-Küster-Hauser syndrome: a case report.

Deepak Goyal, Dinesh K Yadav, Umesh Shukla, Sidharth K Sethi,

INTRODUCTION: We report the case of an unusual association of Coffin-Siris syndrome with Mayer-Rokitansky-Küster-Hauser syndrome. This association has never previously been reported in the medical literature. CASE PRESENTATION: A nine-year-old Indian girl was referred to our hospital for growth retardation, mental retardation, lax joints, generalized hypertrichosis, and hypoplastic fifth fingernails ... Read more >>

J Med Case Rep (Journal of medical case reports)
[2010, 4:354]

Cited: 1 time

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Elevated FGF-23 and parathormone in linear nevus sebaceous syndrome with resistant rickets.

Sidharth K Sethi, Pankaj Hari, Arvind Bagga,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2010, 25(8):1577-1578]

Cited: 11 times

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