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Author Shyam Bansal

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Uncommon cause of fever in a child with steroid-dependent nephrotic syndrome.

Sidharth Kumar Sethi, Shyam Bansal, Ronith Chakraborty, Rahul Jain, Nikita Wadhwani, Rupesh Raina,

BACKGROUND:Children with nephrotic syndrome are vulnerable to developing infections due to a state of relative immunodeficiency, malnourishment, and use of immunosuppression. Case characteristics: We herein report the case of a 3-year-old child with steroid-dependent nephrotic syndrome who presented to us with fever of unknown origin. OBSERVATION:The child was found to ... Read more >>

Clin Nephrol Case Stud (Clinical nephrology. Case studies)
[2020, 8:49-52]

Cited: 0 times

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The Apolipoprotein A-I Mimetic L-4F Attenuates Monocyte Activation and Adverse Cardiac Remodeling after Myocardial Infarction.

Tariq Hamid, Mohamed Ameen Ismahil, Shyam S Bansal, Bindiya Patel, Mehak Goel, C Roger White, G M Anantharamaiah, Sumanth D Prabhu,

Excessive inflammation after myocardial infarction (MI) can promote infarct expansion and adverse left ventricular (LV) remodeling. L-4F, a mimetic peptide of apolipoprotein A-I (apoA-I), exhibits anti-inflammatory and anti-atherogenic properties; however, whether L-4F imparts beneficial effects after myocardial infarction (MI) is unknown. Here we demonstrate that L-4F suppresses the expansion of ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(10):]

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Fibroblast growth factor-inducible 14 mediates macrophage infiltration in heart to promote pressure overload-induced cardiac dysfunction.

Sathya D Unudurthi, Drew M Nassal, Nehal J Patel, Evelyn Thomas, Jane Yu, Curtis G Pierson, Shyam S Bansal, Peter J Mohler, Thomas J Hund,

AIMS:Heart failure (HF) is characterized by compromised cardiac structure and function. Previous work has identified a link between upregulation of pro-inflammatory cytokines and HF. Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a pro-inflammatory cytokine, which binds to fibroblast growth factor inducible 14 (Fn14), a ubiquitously expressed cell-surface ... Read more >>

Life Sci. (Life sciences)
[2020, 247:117440]

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A boy with IgA vasculitis and anuria: Answers.

Vivek Sharma, Sidharth Kumar Sethi, Rupesh Raina, Shyam Bansal, S S Baijal, Vijay Kher,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(3):401-402]

Cited: 0 times

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A boy with IgA vasculitis and anuria: Questions.

Vivek Sharma, Sidharth Kumar Sethi, Rupesh Raina, Shyam Bansal, S S Baijal, Vijay Kher,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(3):399-400]

Cited: 0 times

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Response by Bansal et al to Letter Regarding Article, "Dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy".

Shyam S Bansal, M Ameen Ismahil, Mehak Goel, Guihua Zhou, Gregg Rokosh, Tariq Hamid, Sumanth D Prabhu,

Circulation (Circulation)
[2019, 139(24):e1035-e1036]

Cited: 0 times

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Dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy.

Shyam S Bansal, Mohamed Ameen Ismahil, Mehak Goel, Guihua Zhou, Gregg Rokosh, Tariq Hamid, Sumanth D Prabhu,

BACKGROUND:Heart failure (HF) is a state of inappropriately sustained inflammation, suggesting the loss of normal immunosuppressive mechanisms. Regulatory T-lymphocytes (Tregs) are considered key suppressors of immune responses; however, their role in HF is unknown. We hypothesized that Tregs are dysfunctional in ischemic cardiomyopathy and HF, and they promote immune activation ... Read more >>

Circulation (Circulation)
[2019, 139(2):206-221]

Cited: 15 times

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Fluid Overload in Critically Ill Children.

Rupesh Raina, Sidharth Kumar Sethi, Nikita Wadhwani, Meghana Vemuganti, Vinod Krishnappa, Shyam B Bansal,

Background: A common practice in the management of critically ill patients is fluid resuscitation. An excessive administration of fluids can lead to an imbalance in fluid homeostasis and cause fluid overload (FO). In pediatric critical care patients, FO can lead to a multitude of adverse effects and increased risk of ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2018, 6:306]

Cited: 1 time

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Fluid Overload and Renal Angina Index at Admission Are Associated With Worse Outcomes in Critically Ill Children.

Sidharth K Sethi, Veena Raghunathan, Shilpi Shah, Maninder Dhaliwal, Pranaw Jha, Maneesh Kumar, Sravanthi Paluri, Shyam Bansal, Maroun J Mhanna, Rupesh Raina,

Objectives: We investigated the association of fluid overload and oxygenation in critically sick children, and their correlation with various outcomes (duration of ventilation, ICU stay, and mortality). We also assessed whether renal angina index (RAI) at admission can predict mortality or acute kidney injury (AKI) on day 3 after admission. ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2018, 6:118]

Cited: 0 times

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Myelofibrosis-Induced Erythropoietin-Resistant Anemia Due to Severe Refractory Hyperparathyroidism.

Sidharth Kumar Sethi, Shyam Bihari Bansal, Nikita Wadhwani, Mayur Makasana, Ashish Nandwani, Vijay Kher, Rupesh Raina,

Kidney Int Rep (Kidney International Reports)
[2018, 3(4):1010-1014]

Cited: 0 times

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CCR2+ Monocyte-Derived Infiltrating Macrophages Are Required for Adverse Cardiac Remodeling During Pressure Overload.

Bindiya Patel, Shyam S Bansal, Mohamed Ameen Ismahil, Tariq Hamid, Gregg Rokosh, Matthias Mack, Sumanth D Prabhu,

Although chronic inflammation is a central feature of heart failure (HF), the immune cell profiles differ with different underlying causes. This suggests that for immunomodulatory therapy in HF to be successful, it needs to be tailored to the specific etiology. Here, the authors demonstrate that monocyte-derived C-C chemokine receptor 2 ... Read more >>

JACC Basic Transl Sci (JACC. Basic to translational science)
[2018, 3(2):230-244]

Cited: 24 times

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A young child with fever and unexplained acute kidney injury: Answers.

Sidharth Kumar Sethi, Arushi Nautiyal, Alka Rana, Rajan Duggal, Ashish Nandwani, Dinesh Yadav, Amit Mahapatra, Maninder Dhaliwal, Veena Raghunathan, Shyam Bihari Bansal,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2018, 33(10):1691-1693]

Cited: 0 times

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Heparin free dialysis in critically sick children using sustained low efficiency dialysis (SLEDD-f): A new hybrid therapy for dialysis in developing world.

Sidharth Kumar Sethi, Shyam B Bansal, Anshika Khare, Maninder Dhaliwal, Veena Raghunathan, Nikita Wadhwani, Ashish Nandwani, Dinesh Kumar Yadav, Amit Kumar Mahapatra, Rupesh Raina,

In critically sick adults, sustained low efficiency dialysis [SLED] appears to be better tolerated hemodynamically and outcomes seem to be comparable to CRRT. However, there is paucity of data in critically sick children. In children, two recent studies from Taiwan (n = 11) and India (n = 68) showed benefits ... Read more >>

PLoS ONE (PloS one)
[2018, 13(4):e0195536]

Cited: 1 time

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Pediatric ABO-incompatible kidney transplantation: Evolving with the advancing apheresis technology: A single-center experience.

Sidharth Kumar Sethi, Shyam Bihari Bansal, Nikita Wadhwani, Aseem Tiwari, Dinesh Arora, Reetesh Sharma, Ashish Nandwani, Dinesh Kumar Yadav, Amit Kumar Mahapatra, Manish Jain, Pranaw Jha, Prasun Ghosh, Anil Bhan, Maninder Dhaliwal, Veena Raghunathan, Vijay Kher,

Recent literature has endorsed favorable outcomes following ABOi kidney transplantation in pediatric population. Nevertheless, reluctance to pursue an ABOi still remains pervasive. This could be ascribed to various legitimate reasons, namely less extensive pediatric ABOi data, technical difficulties encountered during PP, cost restraints, and concerns regarding higher rates of antibody-mediated ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2018, 22(3):e13138]

Cited: 0 times

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A young child with fever and unexplained acute kidney injury: Questions.

Sidharth Kumar Sethi, Arushi Nautiyal, Alka Rana, Rajan Duggal, Ashish Nandwani, Dinesh Yadav, Amit Mahapatra, Maninder Dhaliwal, Veena Raghunathan, Shyam Bihari Bansal,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2018, 33(10):1689-1690]

Cited: 0 times

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Secondary Pseudohypoaldosteronism Masquerading Congenital Adrenal Hyperplasia in a Neonate.

Sidharth Kumar Sethi, Sanjay Wazir, Shyam Bansal, Surender Khokhar, Nikita Wadhwani, Rupesh Raina,

Kidney Int Rep (Kidney International Reports)
[2018, 3(3):752-754]

Cited: 0 times

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Feasibility of sustained low efficiency dialysis in critically sick pediatric patients: A multicentric retrospective study.

Sidharth K Sethi, Rajiv Sinha, Pranaw Jha, Nikita Wadhwani, Veena Raghunathan, Maninder Dhaliwal, Shyam B Bansal, Vijay Kher, Valentine Lobo, Jyoti Sharma, Rupesh Raina,

INTRODUCTION:Sustained low-efficiency dialysis (SLED) has emerged as a cost effective alternative to Continuous Renal Replacement Therapy in the management of hemodynamically unstable adult patients with acute kidney injury. The objective of the study was to document the SLED practices in these centers, and to look at the feasibility, and tolerability ... Read more >>

Hemodial Int (Hemodialysis international. International Symposium on Home Hemodialysis)
[2018, 22(2):228-234]

Cited: 1 time

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A novel CFHR1-CFHR5 hybrid leads to a familial dominant C3 glomerulopathy.

Shambhuprasad K Togarsimalemath, Sidharth K Sethi, Rajan Duggal, Moglie Le Quintrec, Pranaw Jha, Régis Daniel, Florence Gonnet, Shyam Bansal, Lubka T Roumenina, Veronique Fremeaux-Bacchi, Vijay Kher, Marie-Agnes Dragon-Durey,

The intrinsic similarity shared between the members of the complement factor H family, which comprises complement factor H and five complement factor H-related (CFHR) genes, leads to various recombination events. In turn these events lead to deletions of some genes or abnormal proteins, which are found in patients with atypical ... Read more >>

Kidney Int. (Kidney international)
[2017, 92(4):876-887]

Cited: 11 times

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Activated T Lymphocytes are Essential Drivers of Pathological Remodeling in Ischemic Heart Failure.

Shyam S Bansal, Mohamed Ameen Ismahil, Mehak Goel, Bindiya Patel, Tariq Hamid, Gregg Rokosh, Sumanth D Prabhu,

BACKGROUND:Inappropriately sustained inflammation is a hallmark of chronic ischemic heart failure (HF); however, the pathophysiological role of T lymphocytes is unclear. METHODS AND RESULTS:Permanent coronary ligation was performed in adult C57BL/6 mice. When compared with sham-operated mice, mice with HF (8 weeks after ligation) exhibited the following features: (1) significant ... Read more >>

Circ Heart Fail (Circulation. Heart failure)
[2017, 10(3):e003688]

Cited: 48 times

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Efficacy and safety of sofosbuvir-based regimens in chronic hepatitis C patients on dialysis.

Narendra S Choudhary, Amit Kumar, Vijay Bodh, Shyam Bihari Bansal, Reetesh Sharma, Manish Jain, Sanjiv Saigal, Neeraj Saraf,

INTRODUCTION:Patients with end-stage renal disease (ESRD) have poor treatment tolerance and outcome to interferon-based regimens. Sofosbuvir-based regimens have improved treatment success in chronic hepatitis C. There is limited data in ESRD patients as sofosbuvir is excreted by the kidney. Several small studies have shown good results. METHODS:Sixteen consecutive patients of ... Read more >>

Indian J Gastroenterol (Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology)
[2017, 36(2):113-116]

Cited: 7 times

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Leukocyte iNOS is required for inflammation and pathological remodeling in ischemic heart failure.

Justin R Kingery, Tariq Hamid, Robert K Lewis, Mohamed Ameen Ismahil, Shyam S Bansal, Gregg Rokosh, Tim M Townes, Suzanne T Ildstad, Steven P Jones, Sumanth D Prabhu,

In the failing heart, iNOS is expressed by both macrophages and cardiomyocytes. We hypothesized that inflammatory cell-localized iNOS exacerbates left ventricular (LV) remodeling. Wild-type (WT) C57BL/6 mice underwent total body irradiation and reconstitution with bone marrow from iNOS-/- mice (iNOS-/-c) or WT mice (WTc). Chimeric mice underwent coronary ligation to ... Read more >>

Basic Res. Cardiol. (Basic research in cardiology)
[2017, 112(2):19]

Cited: 23 times

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Mononuclear Phagocytes Are Dispensable for Cardiac Remodeling in Established Pressure-Overload Heart Failure.

Bindiya Patel, Mohamed Ameen Ismahil, Tariq Hamid, Shyam S Bansal, Sumanth D Prabhu,

Although cardiac and splenic mononuclear phagocytes (MPs), i.e., monocytes, macrophages and dendritic cells (DCs), are key contributors to cardiac remodeling after myocardial infarction, their role in pressure-overload remodeling is unclear. We tested the hypothesis that these immune cells are required for the progression of remodeling in pressure-overload heart failure (HF), ... Read more >>

PLoS ONE (PloS one)
[2017, 12(1):e0170781]

Cited: 16 times

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Median channel shift less than the cutoff in flow cytometric crossmatch: Not to be ignored!

Pranav Dorwal, Shyam Bihari Bansal, Rajni Chauhan, Dharmendra Jain, Vimarsh Raina, Vijay Kher,

Asian J Transfus Sci (Asian journal of transfusion science)
[2017, 11(1):73-75]

Cited: 0 times

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Uncommon cause of fever in a pediatric kidney transplant recipient: Questions.

Sidharth Kumar Sethi, Nikita Wadhwani, Pranaw Jha, Rajan Duggal, Reetesh Sharma, Shyam Bansal, Vijay Kher,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2017, 32(9):1525-1526]

Cited: 0 times

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Uncommon cause of fever in a pediatric kidney transplant recipient: Answers.

Sidharth Kumar Sethi, Nikita Wadhwani, Pranaw Jha, Rajan Duggal, Reetesh Sharma, Shyam Bansal, Vijay Kher,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2017, 32(9):1527-1529]

Cited: 0 times

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