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Mechanism Based Quality Control (MBQC) of Herbal Products: A Case Study YIV-906 (PHY906).

Wing Lam, Yongshen Ren, Fulan Guan, Zaoli Jiang, William Cheng, Chang-Hua Xu, Shwu-Huey Liu, Yung-Chi Cheng,

YIV-906 (PHY906), a four-herb Chinese medicine formulation, is inspired by an 1800 year-old Chinese formulation called Huang Qin Tang which is traditionally used to treat gastrointestinal (GI) symptoms. In animal studies, it could enhance anti-tumor activity of different classes of anticancer agents and promote faster recovery of the damaged intestines ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2018, 9:1324]

Cited: 1 time

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PHY906(KD018), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Sorafenib by changing the tumor microenvironment.

Wing Lam, Zaoli Jiang, Fulan Guan, Xiu Huang, Rong Hu, Jing Wang, Scott Bussom, Shwu-Huey Liu, Hongyu Zhao, Yun Yen, Yung-Chi Cheng,

PHY906 (KD018) is a four-herb Chinese Medicine Formula. It has been shown to potentially enhance the therapeutic indices of different class anticancer agents in vivo. Here, PHY906 is reported to enhance the anti-tumor activity of Sorafenib in nude mice bearing HepG2 xenografts. Among the four herbal ingredients of PHY906, Scutellaria ... Read more >>

Sci Rep (Scientific Reports)
[2015, 5:9384]

Cited: 34 times

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The number of intestinal bacteria is not critical for the enhancement of antitumor activity and reduction of intestinal toxicity of irinotecan by the Chinese herbal medicine PHY906 (KD018).

Wing Lam, Zaoli Jiang, Fulan Guan, Rong Hu, Shwu-Huey Liu, Edward Chu, Yung-Chi Cheng,

The four-herb Chinese medicine PHY906(KD018) has been shown to both enhance the in vivo antitumor activity of irinotecan (CPT-11) against colon cancer tumor allografts and alleviate intestinal toxicity caused by CPT-11.Since intestinal bacteria can metabolize CPT-11 and PHY906, we investigated whether intestinal bacteria play a critical role in the in ... Read more >>

BMC Complement Altern Med (BMC complementary and alternative medicine)
[2014, 14:490]

Cited: 12 times

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First-in-human phase II trial of the botanical formulation PHY906 with capecitabine as second-line therapy in patients with advanced pancreatic cancer.

Muhammad Wasif Saif, Jia Li, Lynne Lamb, Kristin Kaley, Kyle Elligers, Zaoli Jiang, Scott Bussom, Shwu-Huey Liu, Yung-Chi Cheng,

Preclinical studies showed a Chinese botanical formula, PHY906, has synergistic anti-tumor activity with capecitabine. Our phase I study determined maximal tolerated dose of capecitabine 1,500 mg/m(2) BID day 1-7 and PHY906 800 mg BID day 1-4 every 2 weeks. We conducted this phase II study to explore the efficacy of capecitabine and PHY906 ... Read more >>

Cancer Chemother. Pharmacol. (Cancer chemotherapy and pharmacology)
[2014, 73(2):373-380]

Cited: 27 times

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Ganoderma tsugae Induces S Phase Arrest and Apoptosis in Doxorubicin-Resistant Lung Adenocarcinoma H23/0.3 Cells via Modulation of the PI3K/Akt Signaling Pathway.

Yang-Hao Yu, Han-Peng Kuo, Hui-Hsia Hsieh, Jhy-Wei Li, Wu-Huei Hsu, Shih-Jung Chen, Muh-Hwan Su, Shwu-Huey Liu, Yung-Chi Cheng, Chih-Yi Chen, Ming-Ching Kao,

Ganoderma tsugae (GT) is a traditional Chinese medicine that exhibits significant antitumor activities against many types of cancer. This study investigated the molecular mechanism by which GT suppresses the growth of doxorubicin-resistant lung adenocarcinoma H23/0.3 cells. Our results reveal that GT inhibits the viability of H23/0.3 cells in vitro and ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2012, 2012:371286]

Cited: 10 times

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Old formula, new Rx: the journey of PHY906 as cancer adjuvant therapy.

Shwu-Huey Liu, Yung-Chi Cheng,

ETHNOPHARMACOLOGICAL RELEVANCE: PHY906, is a decoction of a mixture of the four herbs Scutellaria baicalensis Geori, Glycyrrhiza uralensis Fisch, Paeonia lactiflora Pall, and Ziziphus jujuba Mill. A combination of these four herbs has been in continuous use in traditional Chinese medicine for over 1800 years for treating a variety of ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2012, 140(3):614-623]

Cited: 54 times

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A phase I study of the chinese herbal medicine PHY906 as a modulator of irinotecan-based chemotherapy in patients with advanced colorectal cancer.

Shivaani Kummar, M Sitki Copur, Michal Rose, Scott Wadler, Joe Stephenson, Mark O'Rourke, Wayne Brenckman, Robert Tilton, Shwu-Huey Liu, Zaoli Jiang, Tahmun Su, Yung-Chi Cheng, Edward Chu,

PHY906 is a novel Chinese herbal preparation that has been used in the Orient for over 1800 years to treat a wide range of gastrointestinal side effects including diarrhea, abdominal cramps, vomiting, fever, and headache. Preclinical and clinical studies were conducted to further investigate the biologic and clinical activities of ... Read more >>

Clin Colorectal Cancer (Clinical colorectal cancer)
[2011, 10(2):85-96]

Cited: 47 times

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The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity.

Wing Lam, Scott Bussom, Fulan Guan, Zaoli Jiang, Wei Zhang, Elizabeth A Gullen, Shwu-Huey Liu, Yung-Chi Cheng,

PHY906, a four-herb Chinese medicine formula first described 1800 years ago, decreases gastrointestinal toxicity induced by the chemotherapeutic drug CPT-11 (irinotecan), as shown in a phase I/II clinical study. Similarly, in a murine colon 38 allograft model, PHY906 increased the antitumor activity of CPT-11 while decreasing animal weight loss caused ... Read more >>

Sci Transl Med (Science translational medicine)
[2010, 2(45):45ra59]

Cited: 122 times

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A comprehensive platform for quality control of botanical drugs (PhytomicsQC): a case study of Huangqin Tang (HQT) and PHY906.

Robert Tilton, Anthony A Paiva, Jing-Qu Guan, Rajendra Marathe, Zaoli Jiang, Winfried van Eyndhoven, Jeffrey Bjoraker, Zachary Prusoff, Hailong Wang, Shwu-Huey Liu, Yung-Chi Cheng,

BACKGROUND: Establishing botanical extracts as globally-accepted polychemical medicines and a new paradigm for disease treatment, requires the development of high-level quality control metrics. Based on comprehensive chemical and biological fingerprints correlated with pharmacology, we propose a general approach called PhytomicsQC to botanical quality control. METHODS: Incorporating the state-of-the-art analytical methodologies, ... Read more >>

Chin Med (Chinese medicine)
[2010, 5:30]

Cited: 37 times

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Phase I/II study of PHY906/capecitabine in advanced hepatocellular carcinoma.

Yun Yen, Samuel So, Michal Rose, M Wasif Saif, Edward Chu, Shwu-Huey Liu, Angeline Foo, Zaoli Jiang, Tahmun Su, Yung-Chi Cheng,

PHY906 is a Chinese medicine formula with claims for the treatment of severe gastrointestinal distress. PHY906 enhanced the therapeutic index of various chemotherapeutic agents in human hepatocellular carcinoma xenografts. Accordingly, here a phase I/II clinical study was conducted with the combination of capecitabine in patients with advanced, unresectable hepatocellular carcinoma. ... Read more >>

Anticancer Res. (Anticancer research)
[2009, 29(10):4083-4092]

Cited: 29 times

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Liquid chromatography/mass spectrometry analysis of PHY906, a Chinese medicine formulation for cancer therapy.

Min Ye, Shwu-Huey Liu, Zaoli Jiang, Yashang Lee, Robert Tilton, Yung-Chi Cheng,

PHY906 is a Chinese medicine formulation prepared from four medicinal herbs for adjuvant cancer chemotherapy. In this paper, liquid chromatography/electrospray ionization time-of-flight mass spectrometry (LC/ESI-TOFMS) was used to clarify the chemical composition of PHY906. The aqueous extract of PHY906 was separated on a Waters Atlantis C(18) column, and was eluted ... Read more >>

Rapid Commun. Mass Spectrom. (Rapid communications in mass spectrometry : RCM)
[2007, 21(22):3593-3607]

Cited: 47 times

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Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring.

Yashang Lee, Hosup Yeo, Shwu-Huey Liu, Zaoli Jiang, Ruben M Savizky, David J Austin, Yung-chi Cheng,

The aqueous extract of Scutellariae baicalensis Georgi has inhibitory activity against P-gp 170, a multiple drug resistant gene product. Baicalein, one of the major flavones, was found to be responsible for this activity. The hydroxyl groups of the A ring of baicalein were systematically alkylated in order to assess the ... Read more >>

J. Med. Chem. (Journal of medicinal chemistry)
[2004, 47(22):5555-5566]

Cited: 17 times

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Herbal composition phy906 and its use in chemotheraphy

YUNG-CHI CHENG, SHWU-HUEY LIU,

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Cited: 0 times

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