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Author Shuxia Zhang

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Photo-driven self-powered biosensor for ultrasensitive microRNA detection via DNA conformation-controlled co-sensitization behavior.

Panpan Gai, Xinke Kong, Shuxia Zhang, Panpan Song, Feng Li,

We successfully developed a photoelectrochemical enzymatic fuel cell (PEFC)-based self-powered biosensing platform for microRNA detection via DNA conformation change-controlled co-sensitization behavior, which could offer ultrasensitive detection of microRNA down to 0.05 fM and realize microRNA determination in human serum. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(52):7116-7119]

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Molecular characteristics of the H9N2 avian influenza viruses in live poultry markets in Anhui Province, China, 2013 to 2018.

Shuxia Zhang, Jun-Ling Yu, Lan He, Lei Gong, Sai Hou, Meng Zhu, Jia-Bing Wu, Bin Su, Jia Liu, Guizhen Wu, Jun He,

<h4>Background and aims</h4>H9N2 subtype avian influenza virus (AIV) has low-pathogenicity but causes respiratory symptoms and drop in egg production in chicken with long-term virus shedding, resulting in great economic losses due to high mortality related to secondary infection with other pathogens. In recent years, H9N2 viruses have been posing a ... Read more >>

Health Sci Rep (Health science reports)
[2021, 4(1):e230]

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Late-onset Hearing Loss From Congenital Cytomegalovirus Infection After Newborn Period in a Highly Immune Population in China.

Chengbin Wang, Xiaolin Liu, Shiwen Wang, Wenqiang Zhang, Haiyan Wang, Wei Ma, Xiangxin Meng, Xingqu Xu, Zhan Li, Qiang Pan, Shuxia Zhang, Ping Wang, Qian Lin, Xiaofang Wang, Minal Amin, Sheila Dollard, Aiqiang Xu, Winnie Chung,

After following 141 children with likely asymptomatic congenital cytomegalovirus infection in a highly immune population in China, four children (2.8%) were found to have late-onset hearing loss. No maternal or childhood factors, except higher saliva cytomegalovirus viral load at birth (P = 0.03), were associated with increased risk of developing ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):70-73]

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Egr2 upregulation induced mitochondrial iron overload implicating in sevoflurane-induced cognitive deficits in developing mice

Piao Zhang, Yeru Chen, Shuxia Zhang, Man Fang, Xianyi Lin, Tieshuai Liu, Youfa Zhou, Xin Yu, Gang Chen,

<h4>Background: </h4> Sevoflurane inhalation initiated cognitive deficits implicated in mitochondrial dysfunction and synaptogenesis impairment. Bioinformatics analysis indicated that Egr2 may play a crucial role in maintaining cognitive function. Therefore, we attempted to clarify the potential mechanism regarding Egr2 expression and cognitive deficits induced by sevoflurane administration. <h4>Methods: </h4> Animals received ... Read more >>

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Egr2 Upregulation Induced Mitochondrial Iron Overload Implicating in Cognitive Deficits after Sevoflurane Administration

Piao Zhang, Yeru Chen, Shuxia Zhang, Man Fang, Xianyi Lin, Tieshuai Liu, Youfa Zhou, Xin Yu, Gang Chen,

<h4>Background: </h4> Sevoflurane inhalation initiated cognitive deficits implicated in mitochondrial dysfunction, synaptogenesis impairment and neuroinflammation. Egr2 plays a crucial role in maintaining cognitive function. Therefore, we attempted to clarify the potential correlation regarding Egr2 expression and cognitive deficits induced by sevoflurane administration. <h4>Methods: </h4> Animals received sevoflurane anesthesia, and the ... Read more >>

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The related mechanism of Complete Freund's Adjuvant-induced chronic inflammation pain based on metabolomics analysis.

Weibo Zhang, Jie Lyu, Juxiang Xu, Piao Zhang, Shuxia Zhang, Yeru Chen, Yongjie Wang, Gang Chen,

Chronic inflammation pain is a debilitating disease, and its mechanism still remains poorly understood. This study was attempt to illuminate the metabolic mechanism of chronic inflammation pain induced by Complete Freund's adjuvant (CFA) injection especially at spinal level. The chronic inflammation pain model was established by CFA administration. The behavioral ... Read more >>

Biomed Chromatogr (Biomedical chromatography : BMC)
[2020, :e5020]

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Pseudolaric acid B induces apoptosis in human rhabdomyosarcoma RD cells.

Chunyu Liu, Fei Wang, Bin Wang, Ting Wu, Yue Wang, Wenbo Huo, Shuxia Zhang, Ying Su, Jinming Liu, Yumeng Liu, Jinghua Yu,

Pseudolaric acid B (PAB) is a diterpene-type acid isolated from the root and trunk bark of <i>Pseudolarix kaempferi</i> Gordon of the <i>Pinaceae</i> family that has been demonstrated to induce apoptosis in various cell lines and autophagy in certain cell lines including murine fibrosarcoma L929, human thyroid squamous cell carcinoma SW579 ... Read more >>

Oncol Lett (Oncology letters)
[2020, 20(6):358]

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Protective effects of Clostridium butyricum against oxidative stress induced by food processing and lipid-derived aldehydes in Caco-2 cells.

Jiayi Li, Haokun Shen, Zengjue Zhao, Ding Cao, Min Zeng, Haiming Cai, Jiatian Wei, Qin Fan, Jinbo Deng, Feiping Ming, Miaopeng Ma, Qianyi Liang, Junhao Jia, Shuxia Zhang, Linghua Zhang,

The human body is almost always facing the oxidative stress caused by foodborne aldehydes such as glyoxal (GO) and methylglyoxal (MGO), 4-hydroxyhexenal (HHE), and 4-hydroxynonenal (HNE). When these aldehydes build up, they can cause a range of harm. However, a probiotic, Clostridium butyricum, can increase nuclear factor erythroid-2 related factor ... Read more >>

Appl Microbiol Biotechnol (Applied microbiology and biotechnology)
[2020, 104(21):9343-9361]

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Molecular cloning, characterization and expression profiles of Annexin family (ANXA1~A6) in yellow catfish (Pelteobagrus fulvidraco) and ANX regulation by CpG ODN responding to bacterial infection.

Haiming Cai, Jiatian Wei, Haokun Shen, Jiayi Li, Qin Fan, Zengjue Zhao, Jinbo Deng, Feiping Ming, Min Zeng, Miaopeng Ma, Peijing Zhao, Qianyi Liang, Junhao Jia, Shuxia Zhang, Linghua Zhang,

Up to now, many previous reports have emphasized that Annexins (ANX) family played an important role in immune responses. Aeromonas hydrophila (A. hydrophila), the most common zoonotic pathogenic bacteria of yellow catfish (Pelteobagrus fulvidraco), can cause serious economic loss, especially to yellow catfish with high economic value. In our previous ... Read more >>

Fish Shellfish Immunol (Fish & shellfish immunology)
[2020, 99:609-630]

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Identification of RBP4 from bighead carp (Hypophthalmichthys nobilis) / silver carp (Hypophthalmichthys molitrix) and effects of CpG ODN on RBP4 expression under A. hydrophila challenge.

Jiaoqing Li, Qin Fan, Haiming Cai, Jinbo Deng, Feiping Ming, Jiayi Li, Min Zeng, Miaopeng Ma, Peijing Zhao, Qianyi Liang, Junhao Jia, Shuxia Zhang, Linghua Zhang,

Retinol-binding protein 4 (RBP4) is known as a highly conserved adipokine for immune activation. Aeromonas hydrophila (A. hydrophila) is the most common zoonotic pathogen in aquaculture, which causes serious economic losses to aquaculture, especially to bighead carp (Hypophthalmichthys nobilis, H. nobilis) and silver carp (Hypophthalmichthys molitrix, H. molitrix). Recent studies ... Read more >>

Fish Shellfish Immunol (Fish & shellfish immunology)
[2020, 100:476-488]

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Co-expressing GroEL-GroES, Ssa1-Sis1 and Bip-PDI chaperones for enhanced intracellular production and partial-wall breaking improved stability of porcine growth hormone.

Jinbo Deng, Jiaoqing Li, Miaopeng Ma, Peijing Zhao, Feiping Ming, Zhipeng Lu, Juqing Shi, Qin Fan, Qianyi Liang, Junhao Jia, Jiayi Li, Shuxia Zhang, Linghua Zhang,

Porcine growth hormone (pGH) is a class of peptide hormones secreted from the pituitary gland, which can significantly improve growth and feed utilization of pigs. However, it is unstable and volatile in vitro. It needs to be encapsulated in liposomes when feeding livestock, whose high cost greatly limits its application ... Read more >>

Microb Cell Fact (Microbial cell factories)
[2020, 19(1):35]

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Host CARD11 Inhibits Newcastle Disease Virus Replication by Suppressing Viral Polymerase Activity in Neurons.

Wenbin Wang, Xudong Chang, Wei Yao, Ning Wei, Na Huo, Yanhong Wang, Qiaolin Wei, Haijin Liu, Xinglong Wang, Shuxia Zhang, Zengqi Yang, Sa Xiao,

Host factors play multiple essential roles in the replication and pathogenesis of mammalian neurotropic viruses. However, the cellular proteins of the central nervous system (CNS) involved in avian neurotropic virus infection have not been completely elucidated. Here, we employed a gene microarray to identify caspase recruitment domain-containing protein 11 (CARD11), ... Read more >>

J Virol (Journal of virology)
[2019, 93(24):]

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Antibacterial and Antibiofilm Activity of Temporin-GHc and Temporin-GHd Against Cariogenic Bacteria, Streptococcus mutans.

Hengren Zhong, Zhipeng Xie, Hanqi Wei, Shuxia Zhang, Yanting Song, Manchuriga Wang, Yingxia Zhang,

Temporin-GHc (GHc) and temporin-GHd (GHd) produced by the frog Hylarana guentheri had shown broad-spectrum antibacterial activities against bacteria and fungi. In this study, we investigated whether they exert antibacterial and antibiofilm activities against cariogenic bacteria, Streptococcus mutans. GHc and GHd adopt the random coil conformation in aqueous solution and convert ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2019, 10:2854]

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Assessing impact of risk perception and environmental regulation on household carcass waste recycling behaviour in China.

Ruishi Si, Meizhi Wang, Qian Lu, Shuxia Zhang,

Carcass waste recycling exerts an important influence on preventing epidemic diseases, improving the ecological environment, and promoting sustainable development of the livestock industry although it has rarely aroused widespread attention throughout the world. Based on the data of 470 households engaged in breeding pigs in Hebei, Henan, and Hubei, China, ... Read more >>

Waste Manag Res (Waste management & research : the journal of the International Solid Wastes and Public Cleansing Association, ISWA)
[2020, 38(5):528-536]

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Effects of porcine IL-17B and IL-17E against intestinal pathogenic microorganism.

Shuxia Zhang, Li Wu, Jiawei Chen, Jiatian Wei, Haiming Cai, Miaopeng Ma, Peijing Zhao, Feiping Ming, Junhao Jia, Jiayi Li, Qin Fan, Qianyi Liang, Jinbo Deng, Min Zeng, Linghua Zhang,

The interleukin-17 (IL-17) family plays a critical role in host defense, allergic reactions, and even tumorigenesis on different mucous membranes. IL-17 family has been cloned in human and mouse, as well IL-17A, IL-17 F in swine. So far, current knowledge on the cloning and biological functions of porcine IL-17B (poIL-17B) and ... Read more >>

Mol Immunol (Molecular immunology)
[2019, 116:151-159]

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Catalytic epoxidation of olefins in liquid phase over manganese based magnetic nanoparticles.

Wenjuan Yan, Jinyao Wang, Jie Ding, Puhua Sun, Shuxia Zhang, Jian Shen, Xin Jin,

Epoxidation of olefins stands out as a crucial class of reactions and is of great interest in academic research and industry due to the production of various important fine chemicals and intermediates. Manganese complexes have the potential to catalyze the epoxidation of olefins with high efficiency. Magnetic nanocatalysts have attracted ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2019, 48(45):16827-16843]

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Brevinin-GR23 from frog Hylarana guentheri with antimicrobial and antibiofilm activities against Staphylococcus aureus.

Hengren Zhong, Zhipeng Xie, Shuxia Zhang, Hanqi Wei, Yanting Song, Yingxia Zhang, Manchuriga Wang,

Brevinin-GR23 (B-GR23) was a brevinin-2 like antimicrobial peptide, which had antimicrobial activity against Staphylococcus aureus with minimum inhibitory concentration (MIC) of 16 μM. B-GR23 increased the bacterial membrane permeation, leading to the damage of membrane integrity and the leakage of genomic DNA, then causing the cell death. The peptide nearly ... Read more >>

Biosci Biotechnol Biochem (Bioscience, biotechnology, and biochemistry)
[2020, 84(1):143-153]

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Recent Advances in Facile Liquid Phase Epoxidation of Light Olefins over Heterogeneous Molybdenum Catalysts.

Wenjuan Yan, Mengyuan Liu, Jinyao Wang, Jian Shen, Shuxia Zhang, Xiaoqiang Xu, Shuaishuai Wang, Jie Ding, Xin Jin,

Molybdenum complexes are versatile and efficient for liquid phase olefin epoxidation reactions. Rational design of catalysts is critical to achieve high atom efficiency during epoxidation processes. Although liquid phase epoxidation has been a popular topic for decades, three key issues, (a) rational control of morphology of molybdenum nanoparticles, (b) manipulating ... Read more >>

Chem Rec (Chemical record (New York, N.Y.))
[2020, 20(3):230-251]

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Melatonin inhibits lung metastasis of gastric cancer in vivo.

Xiaoting Wang, Bin Wang, Weiwu Zhan, Lixia Kang, Shuxia Zhang, Canwei Chen, Diyu Hou, Ruolan You, Huifang Huang,

<h4>Aim</h4>Melatonin shows therapeutic benefits in gastric cancer, but the mechanism underlying its anticancer effects remains elusive. The aim of this study was to determine whether melatonin inhibits lung metastasis in gastric cancer.<h4>Main methods</h4>A lung metastasis model of gastric cancer was established in nude mice injected with human gastric adenocarcinoma MGC80-3 ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2019, 117:109018]

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NKX2-8 deletion-induced reprogramming of fatty acid metabolism confers chemoresistance in epithelial ovarian cancer.

Jinrong Zhu, Geyan Wu, Libing Song, Lixue Cao, Zhanyao Tan, Miaoling Tang, Ziwen Li, Dongni Shi, Shuxia Zhang, Jun Li,

<h4>Background</h4>Aberrant fatty acid (FA) metabolism is a unique vulnerability of cancer cells and may present a promising target for cancer therapy. Our study aims to elucidate the molecular mechanisms by which NKX2-8 deletion reprogrammed FA metabolism-induced chemoresistance in epithelial ovarian cancer (EOC).<h4>Methods</h4>The deletion frequency and expression of NKX2-8 in 144 ... Read more >>

EBioMedicine (EBioMedicine)
[2019, 43:238-252]

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Recombinant plasmids containing CpG with porcine host defense peptides (PR-39/pBD-1) modulates the innate and adaptive intestinal immune responses (including maternal-derived) in piglets.

Shuxia Zhang, Haiming Cai, Ding Cao, Jinbo Deng, Junhao Jia, Jiaoqing Li, Feiping Ming, Peijing Zhao, Miaopeng Ma, Qianyi Liang, Min Zeng, Linghua Zhang,

CpG oligodeoxynucleotides (CpG-ODN) is an immunoenhancer, which is composed of unmethylated cytosine and guanine. Host Defense Peptides (HDPs) are small molecule polypeptides with various immunological activities that have been shown to induce a stronger innate immune response in piglets with synthetic CpG-ODN. Therefore, combination of CpG-ODN and HDPs was expected ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2019, 70:467-476]

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Light-driven ultrasensitive self-powered cytosensing of circulating tumor cells via integration of biofuel cells and a photoelectrochemical strategy.

Chengcheng Gu, Ting Hou, Shuxia Zhang, Panpan Gai, Feng Li,

Herein, a light-driven, membrane-less and mediator-less self-powered cytosensing platform via integration of biofuel cells (BFCs) and a photoelectrochemical strategy was developed for ultrasensitive detection of circulating tumor cells (CTCs). To construct cytosensors, an elaborately designed SH-Sgc8c aptamer/AuNP/g-C3N4 photoelectrode was used as an alternative anode for glucose oxidation, avoiding the introduction ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2019, 7(14):2277-2283]

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Truncated chicken MDA5 enhances the immune response to inactivated NDV vaccine.

Qingsong Han, Xiaolong Gao, Zhili Chu, Xiangwei Wang, Fathalrhman Eisa Addoma Adam, Shuxia Zhang, Yanqing Jia, Xinxin Qiu, Xinglong Wang, Zengqi Yang,

Melanoma Differentiation-Associated protein 5 (MDA5) is a cytoplasmic sensor for viral invasion and plays an important role in regulation of the immune response against Newcastle disease virus (NDV) in chickens. MDA5 was used as an adjuvant to enhance the humoral immune response against influenza virus. In the current study, truncated ... Read more >>

Vet Immunol Immunopathol (Veterinary immunology and immunopathology)
[2019, 208:44-52]

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Effect of ingredients from Chinese herbs on enterovirus D68 production.

Xiangling Meng, Xiaoyan Yu, Chunyu Liu, Ying Wang, Fengmei Song, Chen Huan, Wenbo Huo, Shuxia Zhang, Zhaolong Li, Jun Zhang, Wenyan Zhang, Jinghua Yu,

Human enterovirus 68 (EVD68) is a primary causative agent for respiratory illness worldwide. Until now, there has been no available medication for treating EVD68-related diseases. Rheum emodin, artemisinin, astragaloside, pseudolaric acid B, oridonin, and erianin are natural extracts from Chinese herbs that have traditionally been used for the treatment and ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2019, 33(1):174-186]

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High level expression of ISG12(1) promotes cell apoptosis via mitochondrial-dependent pathway and so as to hinder Newcastle disease virus replication.

Xiaoqin Li, Yanqing Jia, Haijin Liu, Xiangwei Wang, Zhili Chu, Ruochen Hu, Juan Ren, Sa Xiao, Shuxia Zhang, Xinglong Wang, Zengqi Yang,

Newcastle disease (ND), caused by virulent Newcastle disease virus (NDV), poses a considerable risk for the poultry industry. A comprehensive understanding of the interaction between NDV and its host is therefore critical for control of this disease. Previously, we found that chicken ISG12(1) was among the significantly upregulated interferon-stimulated genes ... Read more >>

Vet Microbiol (Veterinary microbiology)
[2019, 228:147-156]

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