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Author Shuqing Liu

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miR-429-CRKL axis regulates clear cell renal cell carcinoma malignant progression through SOS1/MEK/ERK/MMP2/MMP9 pathway.

Jinxia Wang, Chengyi Wang, Qian Li, Chunmei Guo, Weibin Sun, Dongting Zhao, Sixiong Jiang, Lihong Hao, Yuxiang Tian, Shuqing Liu, Ming-Zhong Sun,

The pathogenesis and tumorigenesis of clear cell renal cell carcinoma (ccRCC) remain unclear. The deregulations of miR-429, a member of miR-200 family, and v-crk sarcoma virus CT10 oncogene homologue (avian)-like (CRKL), an adaptor protein of CRK family, are involved in the development, metastasis and prognosis of various cancers. Current study ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 127:110215]

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Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis.

Zhaohai Zheng, Fang Peng, Buyun Xu, Jingjing Zhao, Huahua Liu, Jiahao Peng, Qingsong Li, Chongfu Jiang, Yan Zhou, Shuqing Liu, Chunji Ye, Peng Zhang, Yangbo Xing, Hangyuan Guo, Weiliang Tang,

BACKGROUND:An epidemic of Coronavirus Disease 2019 (COVID-19) began in December 2019 and triggered a Public Health Emergency of International Concern (PHEIC). We aimed to find risk factors for the progression of COVID-19 to help reducing the risk of critical illness and death for clinical help. METHODS:The data of COVID-19 patients ... Read more >>

J. Infect. (The Journal of infection)
[2020, :]

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Erratum to: Smad4 mediates malignant behaviors of human ovarian carcinoma cell through the effect on expressions of E-cadherin, plasminogen activator inhibitor-1 and VEGF.

Chen Chen, Ming-Zhong Sun, Shuqing Liu, Dongmei Yeh, Lijun Yu, Yang Song, Linlin Gong, Lihong Hao, Jun Hu, Shujuan Shao,

[Erratum to: BMB Reports 2010; 43(8): 554-560, PMID: 20797318] The authors apologize that due to our neglect when doing the picture layout of Fig. 1A, the wrong Western blot analysis image were pasted for the "β-actin"group in the middle plot of Fig. 1A. The middle plot of Fig. 1A and ... Read more >>

BMB Rep (BMB reports)
[2020, 53(4):240]

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GRIM-19 deficiency promotes clear cell renal cell carcinoma progression and is associated with high TNM stage and Fuhrman grade.

Naimeng Yan, Xue Feng, Sixiong Jiang, Weibin Sun, Ming-Zhong Sun, Shuqing Liu,

Clear cell renal cell carcinoma (ccRCC) exhibits the highest mortality among all urological malignancies. The investigation of the potential disease progression markers can improve ccRCC diagnosis and treatment. Gene associated with retinoid-interferon-induced mortality-19 (GRIM-19) is involved in carcinogenesis and cancer progression in a variety of cancer types including RCC. While, ... Read more >>

Oncol Lett (Oncology letters)
[2020, 19(6):4115-4121]

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Bidirectional interaction of lncRNA AFAP1-AS1 and CRKL accelerates the proliferative and metastatic abilities of hepatocarcinoma cells.

Sattar Abdul, Abbasi Majid, Jinxia Wang, Qinlong Liu, Ming-Zhong Sun, Shuqing Liu,

Actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1), a long non-coding RNA transcribed from the antisense strand of protein coding gene AFAP1, has attracted attention in cancer research. Despite, its biological function and regulatory mechanism in hepatocellular carcinoma still unknown. The present study revealed AFAP1-AS1 mediated hepatocarcinoma progression through targeting ... Read more >>

J Adv Res (Journal of advanced research)
[2020, 24:121-130]

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Matrine alleviates astrogliosis through sphingosine 1-phosphate signaling in experimental autoimmune encephalomyelitis.

Wendi Ma, Mingliang Zhang, Shuqing Liu, Mengru Wang, Yamin Shi, Ting Yang, Xing Li, Lin Zhu,

Expression of sphingosine/sphingosine 1-phosphate (SPH/S1P) in resident cells of the central nervous system plays an important role in the pathogenesis of multiple sclerosis (MS). Accumulated evidence has shown the protective effects of S1P receptor modulators on MS and its animal model, experimental autoimmune encephalomyelitis (EAE). However, effective therapies to regulate ... Read more >>

Neurosci. Lett. (Neuroscience letters)
[2020, 715:134599]

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miR-4521-FAM129A axial regulation on ccRCC progression through TIMP-1/MMP2/MMP9 and MDM2/p53/Bcl2/Bax pathways.

Xue Feng, Naimeng Yan, Weibin Sun, Shanliang Zheng, Sixiong Jiang, Jinxia Wang, Chunmei Guo, Lihong Hao, Yuxiang Tian, Shuqing Liu, Ming-Zhong Sun,

Clear cell renal cell carcinoma (ccRCC) is the most aggressive RCC subtype with high metastasis, chemotherapy and radiotherapy resistance, and poor prognosis. This study attempted to establish the deregulations of miR-4521 and FAM129A together with their correlation to and mechanism of regulation of ccRCC development and progression. FAM129A acted as ... Read more >>

Cell Death Discov (Cell death discovery)
[2019, 5:89]

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CRKII overexpression promotes the in vitro proliferation, migration and invasion potential of murine hepatocarcinoma Hca-P cells.

Zanmei Zhou, Xiuyan Sun, Chunmei Guo, Ming-Zhong Sun, Shuqing Liu,

Lymphatic metastasis is a major mechanism of tumor metastasis. The present study aimed to investigate the association of CRKII, a member of the CRK family, with the in vitro malignant behaviors of a murine hepatocarcinoma Hca-P cell line, with a lymph node metastatic rate of ~25%. Total mRNA was extracted ... Read more >>

Oncol Lett (Oncology letters)
[2019, 17(6):5169-5174]

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Autologous tumor cell-derived microparticle-based targeted chemotherapy in lung cancer patients with malignant pleural effusion.

Mengfei Guo, Feng Wu, Guorong Hu, Lian Chen, Juanjuan Xu, Pingwei Xu, Xuan Wang, Yumei Li, Shuqing Liu, Shuai Zhang, Qi Huang, Jinshuo Fan, Zhilei Lv, Mei Zhou, Limin Duan, Tingting Liao, Guanghai Yang, Ke Tang, Bifeng Liu, Xiaofei Liao, Xiaonan Tao, Yang Jin,

Cell membrane-derived microparticles (MPs), the critical mediators of intercellular communication, have gained much interest for use as natural drug delivery systems. Here, we examined the therapeutic potential of tumor cell-derived MPs (TMPs) in the context of malignant pleural effusion (MPE). TMPs packaging the chemotherapeutic drug methotrexate (TMPs-MTX) markedly restricted MPE ... Read more >>

Sci Transl Med (Science translational medicine)
[2019, 11(474):]

Cited: 1 time

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A CpG oligodeoxynucleotide enhances the immune response to rabies vaccination in mice.

Pengcheng Yu, Jianghong Yan, Weicheng Wu, Xiaoyan Tao, Xuexin Lu, Shuqing Liu, Wuyang Zhu,

BACKGROUND:Rabies is a fatal disease that is preventable when post exposure prophylaxis (PEP) is administered in a timely fashion. CpG oligodeoxynucleotides (ODNs) can trigger cells that express Toll-like receptor 9, and their immunopotentiation activity in an inactivated aluminum-adjuvanted rabies vaccine for dogs has been identified using mouse and dog models. ... Read more >>

Virol. J. (Virology journal)
[2018, 15(1):174]

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Annexin A5 regulates hepatocarcinoma malignancy via CRKI/II-DOCK180-RAC1 integrin and MEK-ERK pathways.

Xujuan Sun, Shuqing Liu, Jinxia Wang, Bin Wei, Chunmei Guo, Chen Chen, Ming-Zhong Sun,

As a calcium-dependent phospholipid binding annexin protein, annexin A5 (Anxa5) links to the progression, metastasis, survival, and prognosis of a variety of cancers. Current work showed ANXA5 overexpression was positively correlated with the upregulations of CRKI/II and RAC1 in hepatocarcinoma (HCC) patients' tissues, which potentially enhanced the clinical progression and ... Read more >>

Cell Death Dis (Cell death & disease)
[2018, 9(6):637]

Cited: 2 times

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Retinoic Acid Receptor-Related Orphan Receptors: Critical Roles in Tumorigenesis.

Jinshuo Fan, Zhilei Lv, Guanghai Yang, Ting Ting Liao, Juanjuan Xu, Feng Wu, Qi Huang, Mengfei Guo, Guorong Hu, Mei Zhou, Limin Duan, Shuqing Liu, Yang Jin,

Retinoic acid receptor-related orphan receptors (RORs) include RORα (NR1F1), RORβ (NR1F2), and RORγ (NR1F3). These receptors are reported to activate transcription through ligand-dependent interactions with co-regulators and are involved in the development of secondary lymphoid tissues, autoimmune diseases, inflammatory diseases, the circadian rhythm, and metabolism homeostasis. Researches on RORs contributing ... Read more >>

Front Immunol (Frontiers in immunology)
[2018, 9:1187]

Cited: 4 times

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Recombinant Mtb9.8 of Mycobacterium bovis stimulates TNF-α and IL-1β secretion by RAW264.7 macrophages through activation of NF-κB pathway via TLR2.

Shuqing Liu, Hong Jia, Shaohua Hou, Ting Xin, Xiaoyu Guo, Gaimei Zhang, Xintao Gao, Ming Li, Wuyang Zhu, Hongfei Zhu,

The Mtb9.8 antigenic protein of Mycobacterium bovis/Mycobacterium tuberculosis has been identified as a target of the T-cell response. However, the interaction of Mtb9.8 with Toll-like receptors (TLRs) and the relevant signaling pathways have not been fully clarified. In this study, recombinant Mtb9.8 (rMtb9.8) derived from M. bovis-stimulated RAW264.7 cells initiated ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):1928]

Cited: 3 times

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miR-429 suppresses tumor migration and invasion by targeting CRKL in hepatocellular carcinoma via inhibiting Raf/MEK/ERK pathway and epithelial-mesenchymal transition.

Chunmei Guo, Dongting Zhao, Qiuling Zhang, Shuqing Liu, Ming-Zhong Sun,

Tumor metastasis is one of the main causes of hepatocellular carcinoma (HCC) high mortality. CRKL (v-crk sarcoma virus CT10 oncogene homologue (avian)-like) play important roles in tumor metastasis, however, the exact role and underlying mechanism of CRKL in HCC is still unknown. In our study, we demonstrated miR-429 negatively regulated ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):2375]

Cited: 5 times

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Value of 18F-FDG PET/CT for predicting EGFR mutations and positive ALK expression in patients with non-small cell lung cancer: a retrospective analysis of 849 Chinese patients.

Zhilei Lv, Jinshuo Fan, Juanjuan Xu, Feng Wu, Qi Huang, Mengfei Guo, Tingting Liao, Shuqing Liu, Xiaoli Lan, Shanshan Liao, Wei Geng, Yang Jin,

PURPOSE:Epidermal growth factor receptor (EGFR) mutations and the anaplastic lymphoma kinase (ALK) rearrangement are the two most common druggable targets in non-small cell lung cancer (NSCLC). However, genetic testing is sometimes unavailable. Previous studies regarding the predictive role of 18F-FDG PET/CT for EGFR mutations in NSCLC patients are conflicting. We ... Read more >>

Eur. J. Nucl. Med. Mol. Imaging (European journal of nuclear medicine and molecular imaging)
[2018, 45(5):735-750]

Cited: 7 times

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Role of annexin A6 in cancer.

Houbao Qi, Shuqing Liu, Chunmei Guo, Jiasheng Wang, Frederick T Greenaway, Ming-Zhong Sun,

Annexin A6 (AnxA6) is a member of a conserved superfamily of Ca(2+)-dependent membrane-binding annexin proteins. It participates in membrane and cytoskeleton organization, cholesterol homeostasis, membrane trafficking, cell adhesion and signal transduction. The expression levels of AnxA6 are closely associated with melanoma, cervical cancer, epithelial carcinoma, breast cancer, gastric cancer, prostate ... Read more >>

Oncol Lett (Oncology letters)
[2015, 10(4):1947-1952]

Cited: 12 times

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Role of systemic injection of rabies immunoglobulin in rabies vaccination.

Weichen Wu, Shuqing Liu, Pengcheng Yu, Xiaoyan Tao, Xuexin Lu, Jianghong Yan, Qian Wang, Zongshen Zhang, Wuyang Zhu,

To determine the role of systemic injection of rabies immunoglobulin (RIG) in rabies vaccination, we analyzed the level of antibody against rabies virus in the serum of mice that received various doses of RIG combined with rabies vaccine. Our results indicate that systemic injection of RIG does not contribute detectably ... Read more >>

Arch. Virol. (Archives of virology)
[2017, 162(6):1701-1703]

Cited: 1 time

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[Preparation and Preliminary Application of a Virus Library for the Neutralizing Activity of a Monoclonal Antibody Against the Rabies Virus].

Pengcheng Yu, Xiaoyan Tao, Lihua Wang, Qing Tang, Shuqing Liu, Wuyang Zhu,

To establish a method for measurement of the neutralizing activity of a monoclonal antibody against the rabies virus. Twenty-four rabies street virus-positive samples were isolated by the mouse inoculation test. Isolated rabies street viruses were cultured and the virus titer tested in N2A cells. We established a rabies street virus ... Read more >>

Bing Du Xue Bao (Bing du xue bao = Chinese journal of virology)
[2016, 32(6):790-795]

Cited: 0 times

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Anxa5 mediates the in vitro malignant behaviours of murine hepatocarcinoma Hca-F cells with high lymph node metastasis potential preferentially via ERK2/p-ERK2/c-Jun/p-c-Jun(Ser73) and E-cadherin.

Xujuan Sun, Bin Wei, Shuqing Liu, Chunmei Guo, Na Wu, Qinlong Liu, Ming-Zhong Sun,

Annexin A5 (Anxa5) is associated with the progression of some cancers, while its role and regulation mechanism in tumor lymphatic metastasis is rarely reported. This study aims to investigate the influence of Anxa5 knockdown on the malignant behaviours of murine hepatocarcinoma Hca-F cell line with high lymph node metastatic (LNM) ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2016, 84:645-654]

Cited: 5 times

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Formyl-Modified Polyaniline for the Catalytic Dehydration of Fructose to 5-Hydroxymethylfurfural.

Liangfang Zhu, Jinhang Dai, Mingyang Liu, Dianyong Tang, Shuqing Liu, Changwei Hu,

We report an unprecedented solid organic-base catalyst, formyl-modified polyaniline (FS-PAN), for the dehydration of fructose to 5-hydroxymethylfurfural (HMF) with a high yield of 90.4 mol %. We demonstrate that the nitrogen atoms incorporated between the phenyl rings in the backbone of the polyaniline chain contribute to the basicity of the catalyst. The ... Read more >>

ChemSusChem (ChemSusChem)
[2016, 9(16):2174-2181]

Cited: 1 time

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ANXA11 regulates the tumorigenesis, lymph node metastasis and 5-fluorouracil sensitivity of murine hepatocarcinoma Hca-P cells by targeting c-Jun.

Shuqing Liu, Chunmei Guo, Jiasheng Wang, Bo Wang, Houbao Qi, Ming-Zhong Sun,

Annexin A11 (Anxa11) is associated with various cancers. Using a pair of syngeneic murine hepatocarcinoma cells, Hca-P with ~25% and Hca-F with ~75% lymph node metastatic (LNM) potentials, we demonstrated Anxa11 involvement in hepatocarcinoma lymphatic metastasis. Here, ANXA11 acted as a suppressor for the tumorigenicity, LNM and 5-FU resistance of ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(13):16297-16310]

Cited: 5 times

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Pretransplant Recipient Circulating CD4+CD127lo/- Tumor Necrosis Factor Receptor 2+ Regulatory T Cells: A Surrogate of Regulatory T Cell-Suppressive Function and Predictor of Delayed and Slow Graft Function After Kidney Transplantation.

Minh-Tri J P Nguyen, Elise Fryml, Sossy K Sahakian, Shuqing Liu, Marcelo Cantarovich, Mark Lipman, Jean I Tchervenkov, Steven Paraskevas,

Delayed graft function (DGF) and slow graft function (SGF) are ischemia-reperfusion-associated acute kidney injuries (AKI) that decrease long-term graft survival after kidney transplantation. Regulatory T (Treg) cells are protective in murine AKI, and their suppressive function predictive of AKI in kidney transplantation. The conventional Treg cell function coculture assay is ... Read more >>

Transplantation (Transplantation)
[2016, 100(2):314-324]

Cited: 9 times

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Akbu-LAAO exhibits potent anti-tumor activity to HepG2 cells partially through produced H2O2 via TGF-β signal pathway.

Chunmei Guo, Shuqing Liu, Panpan Dong, Dongting Zhao, Chengyi Wang, Zhiwei Tao, Ming-Zhong Sun,

Previously, we characterized the biological properties of Akbu-LAAO, a novel L-amino acid oxidase from Agkistrodon blomhoffii ussurensis snake venom (SV). Current work investigated its in vitro anti-tumor activity and underlying mechanism on HepG2 cells. Akbu-LAAO inhibited HepG2 growth time and dose-dependently with an IC50 of ~38.82 μg/mL. It could induce the ... Read more >>

Sci Rep (Scientific reports)
[2015, 5:18215]

Cited: 7 times

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Effect of emodin on Aquaporin 5 expression in rats with sepsis-induced acute lung injury.

Yanni Sun, Lijing Sun, Shuqing Liu, Juan Song, Jiejing Cheng, Jun Liu,

OBJECTIVE:To investigate the effects of emodin on aquaporin 5 (AQP5) expression in rats with sepsis-induced acute lung injury. METHODS:We divided 60 adult male Sprague-Dawley rats, weighing 200-230 g, into four groups: control, sham surgery, model and emodin groups (n = 15 for each). We created a sepsis model with cecal ... Read more >>

J Tradit Chin Med (Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan)
[2015, 35(6):679-684]

Cited: 3 times

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ANXA5 level is linked to in vitro and in vivo tumor malignancy and lymphatic metastasis of murine hepatocarcinoma cell.

Boya Peng, Shuqing Liu, Chunmei Guo, Xujuan Sun, Ming-Zhong Sun,

To investigate ANXA5 overexpression on in vitro and in vivo malignancies of murine Hca-P cells.Hca-P with low lymph node metastasis (LNM) potential was used as cell model. TEM, CCK-8 and Boyden transwell assays were performed for in vitro Hca-P behaviors. Hca-P-transplanted mouse model was established for in vivo experiment.ANXA5-overexpressing monoclonal ... Read more >>

Future Oncol (Future oncology (London, England))
[2016, 12(1):31-42]

Cited: 2 times

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