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Author Shukuan Ling

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Vascular smooth muscle cell-specific miRNA-214 knockout inhibits angiotensin II-induced hypertension through upregulation of Smad7.

Youyou Li, Hongxing Li, Wenjuan Xing, Jianwei Li, Ruikai Du, Dengchao Cao, Yinbo Wang, Xueyi Yang, Guohui Zhong, Yinlong Zhao, Weijia Sun, Caizhi Liu, Xingcheng Gao, Yeheng Li, Zizhong Liu, Xiaoyan Jin, Dingsheng Zhao, Yingjun Tan, Yanqing Wang, Shujuan Liu, Min Yuan, Jinping Song, Yan-Zhong Chang, Feng Gao, Shukuan Ling, Yingxian Li,

Vascular remodeling is a prominent trait during the development of hypertension, attributable to the phenotypic transition of vascular smooth muscle cells (VSMCs). Increasing studies demonstrate that microRNA plays an important role in this process. Here, we surprisingly found that smooth muscle cell-specific miR-214 knockout (miR-214 cKO) significantly alleviates angiotensin II ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(11):e21947]

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3' untranslated region of Ckip-1 inhibits cardiac hypertrophy independently of its cognate protein.

Yinlong Zhao, Shukuan Ling, Jianwei Li, Guohui Zhong, Ruikai Du, Youyou Li, Yanqing Wang, Caizhi Liu, Xiaoyan Jin, Wei Liu, Tong Liu, Yuheng Li, Dingsheng Zhao, Weijia Sun, Zizhong Liu, Zifan Liu, Junjie Pan, Xinxin Yuan, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li,

<h4>Aims</h4>3' untranslated region (3' UTR) of mRNA is more conserved than other non-coding sequences in vertebrate genomes, and its sequence space has substantially expanded during the evolution of higher organisms, which substantiates their significance in biological regulation. However, the independent role of 3' UTR in cardiovascular disease was largely unknown.<h4>Methods ... Read more >>

Eur Heart J (European heart journal)
[2021, 42(36):3786-3799]

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Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.

Dingsheng Zhao, Guohui Zhong, Jianwei Li, Junjie Pan, Yinlong Zhao, Hailin Song, Weijia Sun, Xiaoyan Jin, Yuheng Li, Ruikai Du, Jielin Nie, Tong Liu, Junmeng Zheng, Yixin Jia, Zifan Liu, Wei Liu, Xinxin Yuan, Zizhong Liu, Jinping Song, Guanghan Kan, Youyou Li, Caizhi Liu, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li, Shukuan Ling,

<h4>Background</h4>Without adequate treatment, pathological cardiac hypertrophy induced by sustained pressure overload eventually leads to heart failure. WWP1 (WW domain-containing E3 ubiquitin protein ligase 1) is an important regulator of aging-related pathologies, including cancer and cardiovascular diseases. However, the role of WWP1 in pressure overload-induced cardiac remodeling and heart failure is ... Read more >>

Circulation (Circulation)
[2021, 144(9):694-711]

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Casein Kinase-2 Interacting Protein-1 Regulates Physiological Cardiac Hypertrophy via Inhibition of Histone Deacetylase 4 Phosphorylation.

Yinlong Zhao, Shukuan Ling, Guohui Zhong, Yuheng Li, Jianwei Li, Ruikai Du, Xiaoyan Jin, Dingsheng Zhao, Zizhong Liu, Guanghan Kan, Yan-Zhong Chang, Yingxian Li,

Different kinds of mechanical stimuli acting on the heart lead to different myocardial phenotypes. Physiological stress, such as exercise, leads to adaptive cardiac hypertrophy, which is characterized by a normal cardiac structure and improved cardiac function. Pathological stress, such as sustained cardiac pressure overload, causes maladaptive cardiac remodeling and, eventually, ... Read more >>

Front Physiol (Frontiers in physiology)
[2021, 12:678863]

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WWP1 deficiency protects from cardiac remodeling induced by simulated microgravity

Guohui Zhong, Dingsheng Zhao, Jianwei Li, Zifan Liu, Junjie Pan, Xinxin Yuan, Wenjuan Xing, Yinglong Zhao, Shukuan Ling, Yingxian Li,

Cardiac muscle is extremely sensitive to changes in loading conditions, the microgravity during space flight can cause cardiac remodeling and function decline. At present, the mechanism of microgravity-induced cardiac remodeling remains to be revealed. WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) is an important activator of pressure-overload induced cardiac ... Read more >>

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The coupling of reduced type H vessels with unloading-induced bone loss and the protection role of Panax quinquefolium saponin in the male mice.

Shuai Liang, Shukuan Ling, Ruikai Du, Yuheng Li, Caizhi Liu, Junhe Shi, Jie Gao, Weijia Sun, Jianwei Li, Guohui Zhong, Zizhong Liu, Dingsheng Zhao, Huiyuan Sun, Yang Li, Xinxin Yuan, Hua Qu, Xiaoyan Jin, Dong Li, Dazhuo Shi, Yingxian Li,

Unloading-induced bone loss is a critical complication characterized by the imbalance of bone formation and resorption induced by long-term confinement in bed or spaceflight. CD31<sup>hi</sup>Emcn<sup>hi</sup> (type H) vessel is a specific subtype of capillary, which was coupled with osteogenesis. However, the change of type H vessel and its contributions to ... Read more >>

Bone (Bone)
[2021, 143:115712]

Cited: 1 time

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Ginsenoside Re Treatment Attenuates Myocardial Hypoxia/Reoxygenation Injury by Inhibiting HIF-1α Ubiquitination.

Huiyuan Sun, Shukuan Ling, Dingsheng Zhao, Jianwei Li, Yang Li, Hua Qu, Ruikai Du, Ying Zhang, Feng Xu, Yuheng Li, Caizhi Liu, Guohui Zhong, Shuai Liang, Zizhong Liu, Xingcheng Gao, Xiaoyan Jin, Yingxian Li, Dazhuo Shi,

Previous studies have shown an attenuating effect of ginsenoside Re on myocardial injury induced by hypoxia/reoxygenation (H/R). However, the underlying mechanism remains unclear. This study was designed to determine the underlying mechanism by which ginsenoside Re protects from myocardial injury induced by H/R. HL-1 cells derived from AT-1 mouse atrial ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:532041]

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miR-214 stimulated by IL-17A regulates bone loss in patients with ankylosing spondylitis.

Zizhong Liu, Feng Huang, Gui Luo, Yiwen Wang, Ruikai Du, Weijia Sun, Jianwei Li, Xinxin Yuan, Dengchao Cao, Yuheng Li, Caizhi Liu, Shuai Liang, Xiaoyan Jin, Shukuan Ling, Deqing Wang, Yingxian Li,

<h4>Objective</h4>Bone loss is common in AS, and miR-214 plays an important role in regulating bone formation. The aim of this study was to investigate the effect of miR-214, the production of which is stimulated by IL-17A, on bone loss in AS.<h4>Methods</h4>Peripheral blood was obtained from 32 patients with AS and ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2020, 59(5):1159-1169]

Cited: 3 times

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Alteration of calcium signalling in cardiomyocyte induced by simulated microgravity and hypergravity.

Caizhi Liu, Guohui Zhong, Yuezhang Zhou, Yuchen Yang, Yingjun Tan, Yuheng Li, Xingcheng Gao, Weijia Sun, Jianwei Li, Xiaoyan Jin, Dengchao Cao, Xinxin Yuan, Zizhong Liu, Shuai Liang, Youyou Li, Ruikai Du, Yinlong Zhao, Jianqi Xue, Dingsheng Zhao, Jinping Song, Shukuan Ling, Yingxian Li,

<h4>Objectives</h4>Cardiac Ca<sup>2+</sup> signalling plays an essential role in regulating excitation-contraction coupling and cardiac remodelling. However, the response of cardiomyocytes to simulated microgravity and hypergravity and the effects on Ca<sup>2+</sup> signalling remain unknown. Here, we elucidate the mechanisms underlying the proliferation and remodelling of HL-1 cardiomyocytes subjected to rotation-simulated microgravity and ... Read more >>

Cell Prolif (Cell proliferation)
[2020, 53(3):e12783]

Cited: 3 times

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Effects of spaceflight on the composition and function of the human gut microbiota.

Zizhong Liu, Gui Luo, Ruikai Du, Weijia Sun, Jianwei Li, Haiyun Lan, Pu Chen, Xinxin Yuan, Dengchao Cao, Yuheng Li, Caizhi Liu, Shuai Liang, Xiaoyan Jin, Ruifu Yang, Yujing Bi, Yanping Han, Ping Cao, Wei Zhao, Shukuan Ling, Yingxian Li,

Interaction between humans and the gut microbiota is important for human physiology. Here, the gut microbiota was analyzed via metagenomic sequencing, and the fluctuations in the gut microbiota under the conditions of spaceflight were characterized. The composition and function of the gut microbiota were substantially affected by spaceflight; however, individual ... Read more >>

Gut Microbes (Gut microbes)
[2020, 11(4):807-819]

Cited: 5 times

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AAV-Anti-miR-214 Prevents Collapse of the Femoral Head in Osteonecrosis by Regulating Osteoblast and Osteoclast Activities.

Cheng Wang, Weijia Sun, Shukuan Ling, Yu Wang, Xin Wang, Haoye Meng, Yuheng Li, Xueling Yuan, Jianwei Li, Ruoxi Liu, Dingsheng Zhao, Qiang Lu, Aiyuan Wang, Quanyi Guo, Shibi Lu, Hua Tian, Yingxian Li, Jiang Peng,

Osteonecrosis of the femoral head, an intractable but common disease that eventually triggers collapse of the femoral head, is characterized by increased osteoclast activity and markedly decreased osteoblast activity in the necrotic region of the femoral head. MicroRNA (miRNA)-214 (miR-214) may play important roles in vertebrate skeletal development by inhibiting ... Read more >>

Mol Ther Nucleic Acids (Molecular therapy. Nucleic acids)
[2019, 18:841-850]

Cited: 3 times

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The mechanosensitive Piezo1 channel is required for bone formation.

Weijia Sun, Shaopeng Chi, Yuheng Li, Shukuan Ling, Yingjun Tan, Youjia Xu, Fan Jiang, Jianwei Li, Caizhi Liu, Guohui Zhong, Dengchao Cao, Xiaoyan Jin, Dingsheng Zhao, Xingcheng Gao, Zizhong Liu, Bailong Xiao, Yingxian Li,

Mechanical load of the skeleton system is essential for the development, growth, and maintenance of bone. However, the molecular mechanism by which mechanical stimuli are converted into osteogenesis and bone formation remains unclear. Here we report that Piezo1, a bona fide mechanotransducer that is critical for various biological processes, plays ... Read more >>

Elife (eLife)
[2019, 8:]

Cited: 36 times

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Personalized Epigenome Remodeling Under Biochemical and Psychological Changes During Long-Term Isolation Environment.

Fengji Liang, Ke Lv, Yue Wang, Yanhong Yuan, Liang Lu, Qiang Feng, Xiaolu Jing, Honghui Wang, Changning Liu, Simon Rayner, Shukuan Ling, Hailong Chen, Yumin Wan, Wanlong Zhou, Li He, Bin Wu, Lina Qu, Shanguang Chen, Jianghui Xiong, Yinghui Li,

It has been reported that several aspects of human health could be disturbed during a long-term isolated environment (for instance, the Mars-500 mission), including psychiatric disorders, circadian disruption, temporal dynamics of gut microbiota, immune responses, and physical-activity-related neuromuscular performance. Nevertheless, the mechanisms underlying these disturbances and the interactions among different ... Read more >>

Front Physiol (Frontiers in physiology)
[2019, 10:932]

Cited: 3 times

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NDUFAB1 confers cardio-protection by enhancing mitochondrial bioenergetics through coordination of respiratory complex and supercomplex assembly.

Tingting Hou, Rufeng Zhang, Chongshu Jian, Wanqiu Ding, Yanru Wang, Shukuan Ling, Qi Ma, Xinli Hu, Heping Cheng, Xianhua Wang,

The impairment of mitochondrial bioenergetics, often coupled with exaggerated reactive oxygen species (ROS) production, is a fundamental disease mechanism in organs with a high demand for energy, including the heart. Building a more robust and safer cellular powerhouse holds the promise for protecting these organs in stressful conditions. Here, we ... Read more >>

Cell Res (Cell research)
[2019, 29(9):754-766]

Cited: 12 times

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TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling.

Jianwei Li, Caizhi Liu, Yuheng Li, Qiaoxia Zheng, Youjia Xu, Beibei Liu, Weijia Sun, Yuan Li, Shuhui Ji, Mingwei Liu, Jing Zhang, Dingsheng Zhao, Ruikai Du, Zizhong Liu, Guohui Zhong, Cuiwei Sun, Yanqing Wang, Jinping Song, Shu Zhang, Jun Qin, Shukuan Ling, Xianhua Wang, Yingxian Li,

Transmembrane and coiled-coil domains 1 (TMCO1) is a recently identified Ca<sup>2+</sup> leak channel in the endoplasmic reticulum. TMCO1 dysfunction in humans is associated with dysmorphism, mental retardation, glaucoma and the occurrence of cancer. Here we show an essential role of TMCO1 in osteogenesis mediated by local Ca<sup>2+</sup>/CaMKII signaling in osteoblasts. ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):1589]

Cited: 7 times

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Hematopoietic stem cells and lineage cells undergo dynamic alterations under microgravity and recovery conditions.

Dengchao Cao, Jinping Song, Shukuan Ling, Shuaishuai Niu, Liang Lu, Zhengzhi Cui, Yuheng Li, Shanshan Hao, Guohui Zhong, Zhihong Qi, Weijia Sun, Xinxin Yuan, Hongxing Li, Dingsheng Zhao, Xiaoyan Jin, Caizhi Liu, Xiaorui Wu, Guanghan Kan, Hongqing Cao, Youmin Kang, Shuyang Yu, Yingxian Li,

Spaceflight leads to health risks including bone demineralization, skeletal muscle atrophy, cardiovascular dysfunction, and disorders of almost all physiologic systems. However, the impacts of microgravity on blood lineage cells and hematopoietic stem cells (HSCs) in vivo are largely unknown. In this study, we analyzed peripheral blood samples from 6 astronauts ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2019, 33(6):6904-6918]

Cited: 6 times

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Panax quinquefolium saponin attenuates cardiac remodeling induced by simulated microgravity.

Huiyuan Sun, Shukuan Ling, Dingsheng Zhao, Yang Li, Guohui Zhong, Ming Guo, Yuheng Li, Lin Yang, Jianpeng Du, Yuezhang Zhou, Jianwei Li, Shuai Liang, Yanqing Wang, Xingcheng Gao, Yating Zhang, Dengchao Cao, Caizhi Liu, Xiaoyan Jin, Zizhong Liu, Weijia Sun, Xiaorui Wu, Jinping Song, Yingxian Li, Dazhuo Shi,

<h4>Background</h4>Cardiac atrophy and reduced cardiac distensibility have been reported following space flight. Cardiac function is correspondingly regulated in response to changes in loading conditions. Panax quinquefolium saponin (PQS) improves ventricular remodeling after acute myocardial infarction by alleviating endoplasmic reticulum stress and Ca<sup>2+</sup>overload. However, whether PQS can ameliorate cardiac atrophy following ... Read more >>

Phytomedicine (Phytomedicine : international journal of phytotherapy and phytopharmacology)
[2019, 56:83-93]

Cited: 2 times

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Myocardial CKIP-1 Overexpression Protects from Simulated Microgravity-Induced Cardiac Remodeling.

Shukuan Ling, Yuheng Li, Guohui Zhong, Yongjun Zheng, Qing Xu, Dingsheng Zhao, Weijia Sun, Xiaoyan Jin, Hongxing Li, Jianwei Li, Huiyuan Sun, Dengchao Cao, Jinping Song, Caizhi Liu, Xinxin Yuan, Xiaorui Wu, Yinlong Zhao, Zizhong Liu, Qi Li, Yingxian Li,

Human cardiovascular system has adapted to Earth's gravity of 1G. The microgravity during space flight can induce cardiac remodeling and decline of cardiac function. At present, the mechanism of cardiac remodeling induced by microgravity remains to be disclosed. Casein kinase-2 interacting protein-1 (CKIP-1) is an important inhibitor of pressure-overload induced ... Read more >>

Front Physiol (Frontiers in physiology)
[2018, 9:40]

Cited: 5 times

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Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure.

Tong Liu, Deli Song, Jianzeng Dong, Pinghui Zhu, Jie Liu, Wei Liu, Xiaohai Ma, Lei Zhao, Shukuan Ling,

Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and death. Myocardial fibrosis results from increased myofibroblast activity and excessive extracellular matrix deposition. Various cells and molecules are involved in this process, providing targets for potential drug therapies. Currently, the main detection methods of myocardial ... Read more >>

Front Physiol (Frontiers in physiology)
[2017, 8:238]

Cited: 27 times

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Circulating microRNAs Correlated with Bone Loss Induced by 45 Days of Bed Rest.

Shukuan Ling, Guohui Zhong, Weijia Sun, Fengji Liang, Feng Wu, Hongxing Li, Yuheng Li, Dingsheng Zhao, Jinping Song, Xiaoyan Jin, Xiaorui Wu, Hailin Song, Qi Li, Yinghui Li, Shanguang Chen, Jianghui Xiong, Yingxian Li,

The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with bone loss induced by bed rest, and testify whether the selected miRNAs could reflect the bone mineral status of human after bed-rest. We analyzed plasma miRNA levels of 16 subjects after 45 days of -6° head-down ... Read more >>

Front Physiol (Frontiers in physiology)
[2017, 8:69]

Cited: 5 times

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Late Gadolinium Enhancement Amount As an Independent Risk Factor for the Incidence of Adverse Cardiovascular Events in Patients with Stage C or D Heart Failure.

Tong Liu, Xiaohai Ma, Wei Liu, Shukuan Ling, Lei Zhao, Lei Xu, Deli Song, Jie Liu, Zhonghua Sun, Zhanming Fan, Taiyang Luo, Junping Kang, Xiaohui Liu, Jianzeng Dong,

<b>Background:</b> Myocardial fibrosis (MF) is a risk factor for poor prognosis in dilated cardiomyopathy (DCM). Late gadolinium enhancement (LGE) of the myocardium on cardiac magnetic resonance (CMR) represents MF. We examined whether the LGE amount increases the incidence of adverse cardiovascular events in patients with stage C or D heart ... Read more >>

Front Physiol (Frontiers in physiology)
[2016, 7:484]

Cited: 5 times

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The regulation of iron metabolism by hepcidin contributes to unloading-induced bone loss.

Zi Xu, Weijia Sun, Yuheng Li, Shukuan Ling, Chenyang Zhao, Guohui Zhong, Dingsheng Zhao, Jinping Song, Hailin Song, Jinqiao Li, Linhao You, Guangjun Nie, Yanzhong Chang, Yingxian Li,

Iron overload inhibits osteoblast function and promotes osteoclastogenesis. Hepcidin plays an important role in this process. The changes in iron content and the regulation of hepcidin under unloading-induced bone loss remain unknown. A hindlimb suspension model was adopted to simulate unloading-induced bone loss in mice. The results showed that iron ... Read more >>

Bone (Bone)
[2017, 94:152-161]

Cited: 16 times

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Simulated Microgravity and Recovery-Induced Remodeling of the Left and Right Ventricle.

Guohui Zhong, Yuheng Li, Hongxing Li, Weijia Sun, Dengchao Cao, Jianwei Li, Dingsheng Zhao, Jinping Song, Xiaoyan Jin, Hailin Song, Xinxin Yuan, Xiaorui Wu, Qi Li, Qing Xu, Guanghan Kan, Hongqing Cao, Shukuan Ling, Yingxian Li,

Physiological adaptations to microgravity involve alterations in cardiovascular systems. These adaptations result in cardiac remodeling and orthostatic hypotension. However, the response of the left ventricle (LV) and right ventricle (RV) following hindlimb unloading (HU) and hindlimb reloading (HR) is not clear and the underlying mechanism remains to be understood. In ... Read more >>

Front Physiol (Frontiers in physiology)
[2016, 7:274]

Cited: 3 times

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Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients.

Wei Liu, Shukuan Ling, Weijia Sun, Tong Liu, Yuheng Li, Guohui Zhong, Dingsheng Zhao, Pengfei Zhang, Jinping Song, Xiaoyan Jin, Zi Xu, Hailin Song, Qi Li, Shujuan Liu, Meng Chai, Qinyi Dai, Yi He, Zhanming Fan, Yu Jie Zhou, Yingxian Li,

The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with the severity of coronary artery calcification (CAC), and testify whether the selected miRNAs could reflect the obstructive coronary artery disease in symptomatic patients. Patients with chest pain and moderated risk for coronary artery disease (CAD) were ... Read more >>

Sci Rep (Scientific reports)
[2015, 5:16099]

Cited: 29 times

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CD44 deficiency inhibits unloading-induced cortical bone loss through downregulation of osteoclast activity.

Yuheng Li, Guohui Zhong, Weijia Sun, Chengyang Zhao, Pengfei Zhang, Jinping Song, Dingsheng Zhao, Xiaoyan Jin, Qi Li, Shukuan Ling, Yingxian Li,

The CD44 is cellular surface adhesion molecule that is involved in physiological processes such as hematopoiesis, lymphocyte homing and limb development. It plays an important role in a variety of cellular functions including adhesion, migration, invasion and survival. In bone tissue, CD44 is widely expressed in osteoblasts, osteoclasts and osteocytes. ... Read more >>

Sci Rep (Scientific reports)
[2015, 5:16124]

Cited: 11 times

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