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Author Shona Falconer

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Neonatal white matter microstructure and emotional development during the pre-school years in children who were born very preterm.

Dana Kanel, Lucy Vanes, Diliana Pecheva, Laila Hadaya, Shona Falconer, Serena Counsell, David Edwards, Chiara Nosarti,

Children born very preterm (<33 weeks of gestation) are at a higher risk of developing socio-emotional difficulties compared to those born at term. In this longitudinal study, we tested the hypothesis that diffusion characteristics of white matter tracts implicated in socio-emotional processing assessed in the neonatal period are associated with ... Read more >>

eNeuro (eNeuro)
[2021, :]

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Preterm birth alters the development of cortical microstructure and morphology at term-equivalent age.

Ralica Dimitrova, Maximilian Pietsch, Judit Ciarrusta, Sean P Fitzgibbon, Logan Z J Williams, Daan Christiaens, Lucilio Cordero-Grande, Dafnis Batalle, Antonios Makropoulos, Andreas Schuh, Anthony N Price, Jana Hutter, Rui Pag Teixeira, Emer Hughes, Andrew Chew, Shona Falconer, Olivia Carney, Alexia Egloff, J-Donald Tournier, Grainne McAlonan, Mary A Rutherford, Serena J Counsell, Emma C Robinson, Joseph V Hajnal, Daniel Rueckert, A David Edwards, Jonathan O'Muircheartaigh,

<h4>Introduction</h4>The dynamic nature and complexity of the cellular events that take place during the last trimester of pregnancy make the developing cortex particularly vulnerable to perturbations. Abrupt interruption to normal gestation can lead to significant deviations to many of these processes, resulting in atypical trajectory of cortical maturation in preterm ... Read more >>

Neuroimage (NeuroImage)
[2021, 243:118488]

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Neurodevelopmental Outcomes following Intrauterine Growth Restriction and Very Preterm Birth.

Chiara Sacchi, Jonathan O'Muircheartaigh, Dafnis Batalle, Serena Jane Counsell, Alessandra Simonelli, Michela Cesano, Shona Falconer, Andrew Chew, Nigel Kennea, Phumza Nongena, Mary Ann Rutherford, Anthony David Edwards, Chiara Nosarti,

<h4>Objectives</h4>To evaluate whether intrauterine growth restriction (IUGR) adds further neurodevelopmental risk to that posed by very preterm birth alone in terms of alterations in brain growth and poorer toddlerhood outcomes.<h4>Study design</h4>Participants were 314 infants of very preterm birth enrolled in the Evaluation of Preterm Imaging Study (e-Prime) who were subsequently followed ... Read more >>

J Pediatr (The Journal of pediatrics)
[2021, :]

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Associations Between Neonatal Brain Structure, the Home Environment, and Childhood Outcomes Following Very Preterm Birth.

Lucy D Vanes, Laila Hadaya, Dana Kanel, Shona Falconer, Gareth Ball, Dafnis Batalle, Serena J Counsell, A David Edwards, Chiara Nosarti,

<h4>Background</h4>Very preterm birth is associated with an increased risk of childhood psychopathology and cognitive deficits. However, the extent to which these developmental problems associated with preterm birth are amenable to environmental factors or determined by neurobiology at birth remains unclear.<h4>Methods</h4>We derived neonatal brain structural covariance networks using non-negative matrix factorization ... Read more >>

Biol Psychiatry Glob Open Sci (Biological psychiatry global open science)
[2021, 1(2):146-155]

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Preterm birth alters the development of cortical microstructure and morphology at term-equivalent age

Ralica Dimitrova, Maximilian Pietsch, Judit Ciarrusta, Sean Fitzgibbon, Logan Williams, Daan Christiaens, Lucilio Cordero-Grande, Dafnis Batalle, Antonios Makropoulos, Andreas Schuh, Anthony Price, Jana Hutter, Rui PAG Teixeira, Emer Hughes, Andrew Chew, Shona Falconer, Olivia Carney, Alexia Egloff, J-Donald Tournier, Grainne McAlonan, Mary Rutherford, Serena Counsell, Emma Robinson, Joseph Hajnal, Daniel Rueckert, David Edwards, Jonathan O’Muircheartaigh,

<h4>Introduction</h4> The dynamic nature and complexity of the cellular events that take place during the last trimester of pregnancy make the developing cortex particularly vulnerable to perturbations. Abrupt interruption to normal gestation can lead to significant deviations to many of these processes, resulting in atypical trajectory of cortical maturation in ... Read more >>

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Incidental findings on brain MR imaging of asymptomatic term neonates in the Developing Human Connectome Project.

Olivia Carney, Emer Hughes, Nora Tusor, Ralica Dimitrova, Sophie Arulkumaran, Kelly Pegoretti Baruteau, Alexia Egloff Collado, Lucilio Cordero-Grande, Andrew Chew, Shona Falconer, Joanna M Allsop, Daniel Rueckert, Joseph Hajnal, A David Edwards, Mary Rutherford,

<h4>Background</h4>Interpretation of incidental findings on term neonatal MRI brain imaging can be challenging as there is a paucity of published normative data on asymptomatic term neonates. Reporting radiologists and clinicians need to be familiar with these incidental findings to avoid over-investigation and misinterpretation particularly in relation to neurodevelopmental outcome. This ... Read more >>

EClinicalMedicine (EClinicalMedicine)
[2021, 38:100984]

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Phenotyping the Preterm Brain: Characterizing Individual Deviations From Normative Volumetric Development in Two Large Infant Cohorts.

Ralica Dimitrova, Sophie Arulkumaran, Olivia Carney, Andrew Chew, Shona Falconer, Judit Ciarrusta, Thomas Wolfers, Dafnis Batalle, Lucilio Cordero-Grande, Anthony N Price, Rui P A G Teixeira, Emer Hughes, Alexia Egloff, Jana Hutter, Antonios Makropoulos, Emma C Robinson, Andreas Schuh, Katy Vecchiato, Johannes K Steinweg, Russell Macleod, Andre F Marquand, Grainne McAlonan, Mary A Rutherford, Serena J Counsell, Stephen M Smith, Daniel Rueckert, Joseph V Hajnal, Jonathan O'Muircheartaigh, A David Edwards,

The diverse cerebral consequences of preterm birth create significant challenges for understanding pathogenesis or predicting later outcome. Instead of focusing on describing effects common to the group, comparing individual infants against robust normative data offers a powerful alternative to study brain maturation. Here we used Gaussian process regression to create ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2021, 31(8):3665-3677]

Cited: 1 time

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Pro12Ala polymorphism of peroxisome proliferator activated receptor gamma 2 may be associated with adverse neurodevelopment in European preterm babies.

Suresh Victor, Andrew Chew, Shona Falconer,

<h4>Introduction</h4>Prematurity is the leading cause of death and disability in children under 5 years of age. Understanding the molecular mechanisms of the biological processes involved in preterm brain injury may help develop novel neuroprotective treatment strategies. A growing body of evidence suggest that peroxisome proliferator-activated receptor gamma (PPARγ) signaling is ... Read more >>

Brain Behav (Brain and behavior)
[2021, 11(8):e2256]

Cited: 1 time

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Effects of gestational age at birth on perinatal structural brain development in healthy term-born babies

Oliver Gale-Grant, Sunniva Fenn-Moltu, Lucas França, Ralica Dimitrova, Daan Christaens, Lucilio Cordero-Grande, Andrew Chew, Shona Falconer, Nicholas Harper, Anthony Price, Jana Hutter, Emer Hughes, Jonathan O’Muircheartaigh, Mary Rutherford, Serena Counsell, Daniel Rueckert, Chiara Nosarti, Joseph Hajnal, Grainne McAlonan, Tomoki Arichi, David Edwards, Dafnis Batalle,

Multiple studies have demonstrated less favourable childhood outcomes in infants born in early term (37-38 weeks gestation) compared to those born at full term (40-41 weeks gestation). While this could be due to higher perinatal morbidity, gestational age at birth may also have a direct effect on the brain and ... Read more >>

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Functional thalamocortical connectivity at term equivalent age and outcome at 2 years in infants born preterm.

Hilary Toulmin, Jonathan O'Muircheartaigh, Serena J Counsell, Shona Falconer, Andrew Chew, Christian F Beckmann, A David Edwards,

Infants born preterm are at high risk of long-term motor and neurocognitive deficits. In the majority of these infants structural MRI at the time of normal birth does not predict motor or cognitive outcomes accurately, and many infants without apparent brain lesions later develop motor and cognitive deficits. Thalamocortical connections ... Read more >>

Cortex (Cortex; a journal devoted to the study of the nervous system and behavior)
[2021, 135:17-29]

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Predicting age and clinical risk from the neonatal connectome

Yassine Taoudi-Benchekroun, Daan Christiaens, Irina Grigorescu, Andreas Schuh, Maximilian Pietsch, Andrew Chew, Nicholas Harper, Shona Falconer, Tanya Poppe, Emer Hughes, Jana Hutter, Anthony Price, J-Donald Tournier, Lucilio Cordero-Grande, Serena Counsell, Daniel Rueckert, Tomoki Arichi, Joseph Hajnal, David Edwards, Maria Deprez, Dafnis Batalle,

The development of perinatal brain connectivity underpins motor, cognitive and behavioural abilities in later life. With the rise of advanced imaging methods such as diffusion MRI, the study of brain connectivity has emerged as an important tool to understand subtle alterations associated with neurodevelopmental conditions. Brain connectivity derived from diffusion ... Read more >>

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Phenotyping the preterm brain: characterising individual deviations from normative volumetric development in two large infant cohorts

Ralica Dimitrova, Sophie Arulkumaran, Olivia Carney, Andrew Chew, Shona Falconer, Judit Ciarrusta, Thomas Wolfers, Dafnis Batalle, Lucilio Cordero-Grande, Anthony Price, Rui PAG Teixeira, Emer Hughes, Alexia Egloff, Jana Hutter, Antonios Makropoulos, Emma Robinson, Andreas Schuh, Katy Vecchiato, Johannes Steinweg, Russell Macleod, Andre Marquand, Grainne McAlonan, Mary Rutherford, Serena Counsell, Stephen Smith, Daniel Rueckert, Joseph Hajnal, Jonathan O’Muircheartaigh, David Edwards,

The diverse cerebral consequences of preterm birth create significant challenges for understanding pathogenesis or predicting later outcome. Instead of focusing on describing effects common to the group, comparing individual infants against robust normative data offers a powerful alternative to study brain maturation. Here we used Gaussian process regression to create ... Read more >>

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Heterogeneity in Brain Microstructural Development Following Preterm Birth.

Ralica Dimitrova, Maximilian Pietsch, Daan Christiaens, Judit Ciarrusta, Thomas Wolfers, Dafnis Batalle, Emer Hughes, Jana Hutter, Lucilio Cordero-Grande, Anthony N Price, Andrew Chew, Shona Falconer, Katy Vecchiato, Johannes K Steinweg, Olivia Carney, Mary A Rutherford, J-Donald Tournier, Serena J Counsell, Andre F Marquand, Daniel Rueckert, Joseph V Hajnal, Grainne McAlonan, A David Edwards, Jonathan O'Muircheartaigh,

Preterm-born children are at increased risk of lifelong neurodevelopmental difficulties. Group-wise analyses of magnetic resonance imaging show many differences between preterm- and term-born infants but do not reliably predict neurocognitive prognosis for individual infants. This might be due to the unrecognized heterogeneity of cerebral injury within the preterm group. This ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2020, 30(9):4800-4810]

Cited: 6 times

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Parental age effects on neonatal white matter development.

Oliver Gale-Grant, Daan Christiaens, Lucilio Cordero-Grande, Andrew Chew, Shona Falconer, Antonios Makropoulos, Nicholas Harper, Anthony N Price, Jana Hutter, Emer Hughes, Suresh Victor, Serena J Counsell, Daniel Rueckert, Joseph V Hajnal, A David Edwards, Jonathan O'Muircheartaigh, Dafnis Batalle,

<h4>Objective</h4>Advanced paternal age is associated with poor offspring developmental outcome. Though an increase in paternal age-related germline mutations may affect offspring white matter development, outcome differences could also be due to psychosocial factors. Here we investigate possible cerebral changes prior to strong environmental influences using brain MRI in a cohort ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2020, 27:102283]

Cited: 1 time

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The network properties of the brain at the time of normal birth support the acquisition of language processing

Piergiorgio Salvan, Tomoki Arichi, Diego Vidaurre, Donald Tournier, Shona Falconer, Andrew Chew, Serena Counsell, David Edwards,

Language acquisition appears to rely at least in part on recruiting pre-existing brain structures. We hypothesized that the neural substrate for language can be characterized by distinct, non-trivial network properties of the brain, that modulate language acquisition early in development. We tested whether these brain network properties present at the ... Read more >>

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Exploring the multiple-hit hypothesis of preterm white matter damage using diffusion MRI.

Madeleine L Barnett, Nora Tusor, Gareth Ball, Andrew Chew, Shona Falconer, Paul Aljabar, Jessica A Kimpton, Nigel Kennea, Mary Rutherford, A David Edwards, Serena J Counsell,

<h4>Background</h4>Preterm infants are at high risk of diffuse white matter injury and adverse neurodevelopmental outcome. The multiple hit hypothesis suggests that the risk of white matter injury increases with cumulative exposure to multiple perinatal risk factors. Our aim was to test this hypothesis in a large cohort of preterm infants ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2018, 17:596-606]

Cited: 27 times

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Punctate White Matter Lesions Associated With Altered Brain Development And Adverse Motor Outcome In Preterm Infants.

Nora Tusor, Manon J Benders, Serena J Counsell, Phumza Nongena, Moegamad A Ederies, Shona Falconer, Andrew Chew, Nuria Gonzalez-Cinca, Joseph V Hajnal, Sunay Gangadharan, Vasiliki Chatzi, Karina J Kersbergen, Nigel Kennea, Denis V Azzopardi, A David Edwards,

Preterm infants who develop neurodevelopmental impairment do not always have recognized abnormalities on cerebral ultrasound, a modality routinely used to assess prognosis. In a high proportion of infants, MRI detects punctate white matter lesions that are not seen on ultrasonography. To determine the relation of punctate lesions to brain development ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):13250]

Cited: 15 times

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Effect of MRI on preterm infants and their families: a randomised trial with nested diagnostic and economic evaluation.

A David Edwards, Maggie E Redshaw, Nigel Kennea, Oliver Rivero-Arias, Nuria Gonzales-Cinca, Phumza Nongena, Moegamad Ederies, Shona Falconer, Andrew Chew, Omar Omar, Pollyanna Hardy, Merryl Elizabeth Harvey, Oya Eddama, Naomi Hayward, Julia Wurie, Denis Azzopardi, Mary A Rutherford, Serena Counsell, ,

<h4>Background</h4>We tested the hypothesis that routine MRI would improve the care and well-being of preterm infants and their families.<h4>Design</h4>Parallel-group randomised trial (1.1 allocation; intention-to-treat) with nested diagnostic and cost evaluations (EudraCT 2009-011602-42).<h4>Setting</h4>Participants from 14 London hospitals, imaged at a single centre.<h4>Patients</h4>511 infants born before 33 weeks gestation underwent both MRI ... Read more >>

Arch Dis Child Fetal Neonatal Ed (Archives of disease in childhood. Fetal and neonatal edition)
[2018, 103(1):F15-F21]

Cited: 25 times

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Multimodal image analysis of clinical influences on preterm brain development.

Gareth Ball, Paul Aljabar, Phumza Nongena, Nigel Kennea, Nuria Gonzalez-Cinca, Shona Falconer, Andrew T M Chew, Nicholas Harper, Julia Wurie, Mary A Rutherford, Serena J Counsell, A David Edwards,

<h4>Objective</h4>Premature birth is associated with numerous complex abnormalities of white and gray matter and a high incidence of long-term neurocognitive impairment. An integrated understanding of these abnormalities and their association with clinical events is lacking. The aim of this study was to identify specific patterns of abnormal cerebral development and ... Read more >>

Ann Neurol (Annals of neurology)
[2017, 82(2):233-246]

Cited: 15 times

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Language ability in preterm children is associated with arcuate fasciculi microstructure at term.

Piergiorgio Salvan, J Donald Tournier, Dafnis Batalle, Shona Falconer, Andrew Chew, Nigel Kennea, Paul Aljabar, Ghislaine Dehaene-Lambertz, Tomoki Arichi, A David Edwards, Serena J Counsell,

In the mature human brain, the arcuate fasciculus mediates verbal working memory, word learning, and sublexical speech repetition. However, its contribution to early language acquisition remains unclear. In this work, we aimed to evaluate the role of the direct segments of the arcuate fasciculi in the early acquisition of linguistic ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2017, 38(8):3836-3847]

Cited: 15 times

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Methylphenidate delivery mechanisms for the treatment of children with attention deficit hyperactivity disorder: heterogeneity in parent preferences.

Andrew Lloyd, Paul Hodgkins, Sarah Dewilde, Rahul Sasané, Shona Falconer, Edmund Sonuga Barke,

<h4>Objectives</h4>Extended-release therapies avoid the need for children with attention-deficit/hyperactivity disorder (ADHD) to take medication at school. Recently a transdermal delivery system has been developed which can allow symptom control all day long but with greater dosing flexibility. This study explored the parents' preferences regarding oral and transdermal therapy.<h4>Methods</h4>A nonsystematic and ... Read more >>

Int J Technol Assess Health Care (International journal of technology assessment in health care)
[2011, 27(3):215-223]

Cited: 12 times

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Mild maternal thyroid dysfunction at delivery of infants born ≤34 weeks and neurodevelopmental outcome at 5.5 years.

Fiona Williams, Jennifer Watson, Simon Ogston, Robert Hume, Peter Willatts, Theo Visser, ,

<h4>Context</h4>Mild maternal thyroid dysfunction during early pregnancy is associated with poor neurodevelopment in affected offspring. Most studies are population based or are smaller populations of term/late preterm infants. No studies were found that focused on more preterm infants.<h4>Objective</h4>Our objective was to describe the relationship between mild maternal thyroid dysfunction at ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2012, 97(6):1977-1985]

Cited: 16 times

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Levels of neonatal thyroid hormone in preterm infants and neurodevelopmental outcome at 5 1/2 years: millennium cohort study.

Caroline Delahunty, Shona Falconer, Robert Hume, Lesley Jackson, Paula Midgley, Marie Mirfield, Simon Ogston, Oliver Perra, Judith Simpson, Jennifer Watson, Peter Willatts, Fiona Williams, ,

<h4>Context</h4>Transient hypothyroxinemia is the commonest thyroid dysfunction of premature infants, and recent studies have found adverse associations with neurodevelopment. The validity of these associations is unclear because the studies adjusted for a differing range of factors likely to influence neurodevelopment.<h4>Objective</h4>The aim was to describe the association of transient hypothyroxinemia with ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2010, 95(11):4898-4908]

Cited: 34 times

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Fundamental dimensions of subjective state in performance settings: task engagement, distress, and worry.

Gerald Matthews, Sian E Campbell, Shona Falconer, Lucy A Joyner, Jane Huggins, Kirby Gilliland, Rebecca Grier, Joel S Warm,

Subjective state constructs are defined within the traditional domains of affect, motivation, and cognition. Currently, there is no overarching state model that interrelates constructs within the different domains. This article reports 3 studies that provide converging evidence for 3 fundamental state dimensions labeled task engagement, distress, and worry that integrate ... Read more >>

Emotion (Emotion (Washington, D.C.))
[2002, 2(4):315-340]

Cited: 128 times

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