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Author Shivam Patel

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The Impact of Genistein Supplementation on Tendon Functional Properties and Gene Expression in Estrogen-Deficient Rats.

Chad C Carroll, Shivam H Patel, Jessica Simmons, Ben Dh Gordon, Jay F Olson, Kali Chemelewski, Shannon Saw, Taben M Hale, Reuben Howden, Arman Sabbaghi,

Tendinopathy risk increases with menopause. The phytoestrogen genistein prevents collagen loss during estrogen deficiency (ovariectomy [OVX]). The influence of genistein on tendon function and extracellular matrix (ECM) regulation is not well known. We determined the impact of genistein on tendon function and the expression of several genes important for the ... Read more >>

J Med Food (Journal of medicinal food)
[2020, :]

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Child Safety Matters: Randomized Control Trial of a School-Based, Child Victimization Prevention Curriculum.

Melissa A Bright, Mona Sayedul Huq, Shivam Patel, M David Miller, David Finkelhor,

Recognizing the potential of classrooms as a context for identifying and addressing child victimization, several U.S. states now mandate the inclusion of child abuse prevention in school curricula. There are, however, a limited number of evidence-based and developmentally appropriate curricula designed for elementary. This study utilized a randomized control trial ... Read more >>

J Interpers Violence (Journal of interpersonal violence)
[2020, :886260520909185]

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Clinical Considerations of Post Stroke Care in Taiwan.

Andrew Fung, Pengyi Zhu, Shivam Patel, Benjamin K P Woo,

J. Formos. Med. Assoc. (Journal of the Formosan Medical Association = Taiwan yi zhi)
[2020, :]

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Profile of acute poisoning cases and their outcome in a teaching hospital of north India.

Roshan Mathew, Nayer Jamshed, Praveen Aggarwal, Shivam Patel, R M Pandey,

Objectives:Aim of this study was to characterize acute poisoning and snakebite cases and their outcome in the Emergency Department (ED). Methods:This was a prospective study done in the ED of a tertiary healthcare center. Study included 184 patients of acute poisoning and 16 cases of snakebite. Data regarding demographics, type, ... Read more >>

J Family Med Prim Care (Journal of family medicine and primary care)
[2019, 8(12):3935-3939]

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The impact of genistein supplementation on tendon functional properties and gene expression in estrogen deficient rats

Chad Carroll, Shivam Patel, Jessica Simmons, Ben DH. Gordon, Jay Olson, Kali Chemelewski, Shannon Saw, Taben Hale, Reuben Howden, Arman Sabbaghi,

ABSTRACT Purpose Tendinopathy risk increases with menopause. The phytoestrogen genistein prevents collagen loss during estrogen deficiency [ovariectomy (OVX)]. The influence of genistein on tendon function and extracellular matrix (ECM) regulation are not well known. We determined the impact of genistein on tendon function and examined potential mechanisms by which genistein ... Read more >>

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Caution in diagnosing angioedema as anaphylaxis.

Shivam Patel, Roshan Mathew, Sanjeev Bhoi,

Angioedema is one of the commonest life-threatening conditions with good outcome timely definitive treatment. However, failure to recognise the common presentation of an uncommon bradykinin-mediated angioedema in time may lead to fatal outcome in the emergency department (ED). We report a case of a 79-year-old male patient who presented to ... Read more >>

BMJ Case Rep (BMJ case reports)
[2019, 12(9):]

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Advanced Glycation End-Products Suppress Mitochondrial Function and Proliferative Capacity of Achilles Tendon-Derived Fibroblasts.

Shivam H Patel, Feng Yue, Shannon K Saw, Rachel Foguth, Jason R Cannon, Jonathan H Shannahan, Shihuan Kuang, Arman Sabbaghi, Chad C Carroll,

Debilitating cases of tendon pain and degeneration affect the majority of diabetic individuals. The high rate of tendon degeneration persists even when glucose levels are well controlled, suggesting that other mechanisms may drive tendon degeneration in diabetic patients. The purpose of this study was to investigate the impact of advanced ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):12614]

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Advanced Glycation End-Products Suppress Mitochondrial Function and Proliferative Capacity of Achilles Tendon-Derived Fibroblasts

Shivam Patel, Feng Yue, Shannon Saw, Rachel Foguth, Jason Cannon, Jonathan Shannahan, Shihuan Kuang, Arman Sabbaghi, Chad Carroll,

Abstract Debilitating cases of tendon pain and degeneration affect the majority of diabetic individuals. The high rate of tendon degeneration persists even when glucose levels are well controlled, suggesting that other mechanisms may drive tendon degeneration in diabetic patients. The purpose of this study was to investigate the impact of ... Read more >>

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All-Cause 30-Day Mortality After Surgical Treatment for Head and Neck Squamous Cell Carcinoma in the United States.

Aleksandr R Bukatko, Parth B Patel, Vindhya Kakarla, Matthew C Simpson, Eric Adjei Boakye, Shivam H Patel, Katherine A Stamatakis, Mark A Varvares, Nosayaba Osazuwa-Peters,

OBJECTIVES:Thirty-day (30-day) mortality, a common posttreatment quality metric, is yet to be described following surgery for head and neck squamous cell carcinoma (HNSCC). This study aimed to measure 30-day postoperative mortality in HNSCC and describe clinical/nonclinical factors associated with 30-day mortality. METHODS:In this retrospective cohort study, the National Cancer Database ... Read more >>

Am. J. Clin. Oncol. (American journal of clinical oncology)
[2019, 42(7):596-601]

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Role of autobiographical memory in patient response to cognitive behavioural therapies for depression: protocol of an individual patient data meta-analysis.

Caitlin Hitchcock, Judita Rudokaite, Shivam Patel, Alicia Smith, Isla Kuhn, Edward Watkins, Tim Dalgleish,

INTRODUCTION:Cognitive behavioural therapies (CBTs) are one of the most effective treatments for major depression. However, ~50% of individuals do not adequately respond to intervention and of those who do remit from a depressive episode, over 50% will experience later relapse. Identification of patient-level factors which moderate treatment response may ultimately ... Read more >>

BMJ Open (BMJ open)
[2019, 9(6):e031110]

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Preclinical Evaluation of Safety and Biodistribution of Red Cell Microparticles: A Novel Hemostatic Agent.

Ashish K Rehni, Vibha Shukla, Hever Navarro Quero, Carlos Bidot, Conner R Haase, Ensign Anise A Crane, Shivam G Patel, Sebastian Koch, Yeon S Ahn, Wenche Jy, Kunjan R Dave,

BACKGROUND:Uncontrollable bleeding is a major cause of mortality and morbidity worldwide. Effective hemostatic agents are urgently needed. Red cell microparticles (RMPs) are a highly promising hemostatic agent. This study evaluated the safety profile of RMPs preliminary to clinical trial. METHODS AND RESULTS:RMPs were prepared from type O+ human red blood ... Read more >>

J. Cardiovasc. Pharmacol. Ther. (Journal of cardiovascular pharmacology and therapeutics)
[2019, 24(5):474-483]

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Identification of the Epstein Barr Virus portal.

Robert J Visalli, Adam M Schwartz, Shivam Patel, Melissa A Visalli,

Little is known about Epstein Barr Virus (EBV) proteins that participate in viral DNA cleavage and packaging. Genes encoding potential terminase subunit and portal protein homologs include BGRF1/BDRF1, BALF3, BFRF1A and BBRF1 respectively. EBV mutants with deletions in one or more of these genes were impaired for DNA packaging (Pavlova ... Read more >>

Virology (Virology)
[2019, 529:152-159]

Cited: 3 times

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Dietary material properties shape cranial suture morphology in the mouse calvarium.

Craig Byron, Meghan Segreti, Katelyn Hawkinson, Katelyn Herman, Shivam Patel,

Cranial sutures are fibrous connective tissue articulations found between intramembranous bones of the vertebrate cranium. Growth and remodeling of these tissues is partially regulated by biomechanical loading patterns that include stresses related to chewing. Advances in oral processing structure and function of the cranium that enabled mammalian-style chewing is commonly ... Read more >>

J. Anat. (Journal of anatomy)
[2018, 233(6):807-813]

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Changes of blood pressure following initiation of physical inactivity and after external addition of pulses to circulation.

Marvin A Sackner, Shivam Patel, Jose A Adams,

PURPOSE:To determine whether an innovative, motorized, wellness device that effortlessly produces physical activity (JD) can mitigate the hypertensive effects of prolonged sitting or lying down. METHODS:Twenty-two normotensive and hypertensive adults of both genders gave informed consent to participate in a randomized controlled crossover study of a passive simulated jogging device ... Read more >>

Eur. J. Appl. Physiol. (European journal of applied physiology)
[2019, 119(1):201-211]

Cited: 2 times

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Prevalence and sociodemographic factors associated with depression among hospitalized patients with head and neck cancer-Results from a national study.

Rebecca L Rohde, Eric Adjei Boakye, Sai Deepika Challapalli, Shivam H Patel, Christian J Geneus, Betelihem B Tobo, Matthew C Simpson, Kahee A Mohammed, Teresa Deshields, Mark A Varvares, Nosayaba Osazuwa-Peters,

OBJECTIVE:Depression is a significant problem for patients with head and neck cancer (HNC). This study explored the prevalence of and sociodemographic and clinical factors associated with depression, among patients with HNC. METHODS:We performed a retrospective analysis of 71 541 cases of HNC using a national dataset, the Nationwide Inpatient Sample, from ... Read more >>

Psychooncology (Psycho-oncology)
[2018, 27(12):2809-2814]

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The Effects of Passive Simulated Jogging on Short-Term Heart Rate Variability in a Heterogeneous Group of Human Subjects.

Jose A Adams, Shivam Patel, Jose R Lopez, Marvin A Sackner,

Background:Heart rate variability (HRV) reflects neural balance between sympathetic and parasympathetic autonomic nervous systems (ANS). Reduced HRV occurs in several chronic diseases and physical inactivity. External addition of pulses to the circulation restores HRV. A new method to add pulses to the circulation can be accomplished with a passive simulated ... Read more >>

J Sports Med (Hindawi Publ Corp) (Journal of sports medicine (Hindawi Publishing Corporation))
[2018, 2018:4340925]

Cited: 1 time

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Lower Fasted-State but Greater Increase in Muscle Protein Synthesis in Response to Elevated Plasma Amino Acids in Obesity.

Lee Tran, Katon A Kras, Nyssa Hoffman, Jayachandran Ravichandran, Jared M Dickinson, Andrew D'Lugos, Chad C Carroll, Shivam H Patel, Lawrence J Mandarino, Lori Roust, Christos S Katsanos,

OBJECTIVE:Obesity alters protein metabolism in skeletal muscle, but consistent evidence is lacking. This study compared muscle protein synthesis in adults with obesity and in lean controls in the fasted state and during an amino acid infusion. METHODS:Ten subjects with obesity (age: 36 ± 3 years; BMI: 34 ± 1 kg/m2 ) and ten controls ... Read more >>

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2018, 26(7):1179-1187]

Cited: 3 times

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Streptozotocin-induced diabetes alters transcription of multiple genes necessary for extracellular matrix remodeling in rat patellar tendon.

Shivam H Patel, Arman Sabbaghi, Chad C Carroll,

OVERVIEW:Tendon collagen fibril degradation is commonly seen in tendons of diabetics, but the mechanisms responsible for these changes remain to be elucidated. We have demonstrated that streptozotocin (STZ)-induced diabetes increases tendon cell proliferation and collagen content. In the present study, we evaluated that impact of STZ-induced diabetes on mRNA transcripts ... Read more >>

Connect. Tissue Res. (Connective tissue research)
[2018, 59(5):447-457]

Cited: 1 time

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Plasma Amino Acids Stimulate Uncoupled Respiration of Muscle Subsarcolemmal Mitochondria in Lean but Not Obese Humans.

Katon A Kras, Nyssa Hoffman, Lori R Roust, Shivam H Patel, Chad C Carroll, Christos S Katsanos,

Obesity is associated with mitochondrial dysfunction in skeletal muscle. Increasing the plasma amino acid (AA) concentrations stimulates mitochondrial adenosine triphosphate (ATP) production in lean individuals.To determine whether acute elevation in plasma AAs enhances muscle mitochondrial respiration and ATP production in subsarcolemmal (SS) and intermyofibrillar (IMF) mitochondria in obese adults.Assessment of ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2017, 102(12):4515-4525]

Cited: 1 time

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Do the folk need a meta-ethics?

Shivam Patel, Edouard Machery,

Stanford argues that cooperators achieve and maintain correlated interaction through the objectification of moral norms. We first challenge the moral/non-moral distinction that frames Stanford's discussion. We then argue that to the extent that norms are objectified (and we hold that they are at most objectified in a very thin sense), ... Read more >>

Behav Brain Sci (The Behavioral and brain sciences)
[2018, 41:e109]

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Prior acetaminophen consumption impacts the early adaptive cellular response of human skeletal muscle to resistance exercise.

Andrew C D'Lugos, Shivam H Patel, Jordan C Ormsby, Donald P Curtis, Christopher S Fry, Chad C Carroll, Jared M Dickinson,

Resistance exercise (RE) is a powerful stimulus for skeletal muscle adaptation. Previous data demonstrate that cyclooxygenase (COX)-inhibiting drugs alter the cellular mechanisms regulating the adaptive response of skeletal muscle. The purpose of this study was to determine whether prior consumption of the COX inhibitor acetaminophen (APAP) alters the immediate adaptive ... Read more >>

J. Appl. Physiol. (Journal of applied physiology (Bethesda, Md. : 1985))
[2018, 124(4):1012-1024]

Cited: 4 times

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Pediatric Development of Molecularly Targeted Oncology Drugs.

Shivam Kamlesh Patel, Ruby Leong, Hong Zhao, Amy Barone, Denise Casey, Qi Liu, Gilbert J Burckart, Gregory Reaman,

Oncology products developed for adult cancers often receive full waivers of pediatric studies. This analysis retrospectively identified products with potential pediatric development opportunities despite a full waiver. Initial pediatric study plans submitted to the US Food and Drug Administration from 2012 to 2016 for oncology products with plans to request ... Read more >>

Clin. Pharmacol. Ther. (Clinical pharmacology and therapeutics)
[2018, 104(2):384-389]

Cited: 1 time

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Exercise Protects Skeletal Muscle during Chronic Doxorubicin Administration.

Jared M Dickinson, Andrew C D'Lugos, Tara N Mahmood, Jordan C Ormsby, Lara Salvo, W Logan Dedmon, Shivam H Patel, Mark S Katsma, Farouk Mookadam, Rayna J Gonzales, Taben M Hale, Chad C Carroll, Siddhartha S Angadi,

This study aimed to assess the ability for exercise training performed before and during biweekly doxorubicin (DOX) administration to attenuate adverse effects of DOX on skeletal muscle. We hypothesized that DOX treatment would increase REDD1, impair mammalian target of rapamycin (mTOR) signaling, and reduce muscle fiber size, and that exercise ... Read more >>

Med Sci Sports Exerc (Medicine and science in sports and exercise)
[2017, 49(12):2394-2403]

Cited: 3 times

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Vancomycin vs. Vancomycin/Piperacillin-Tazobactam-Associated Acute Kidney Injury in Noncritically Ill Patients at a Tertiary Care Military Treatment Facility.

Caleb W Anderson, Kathy S Cazares, Michael B Lustik, Shivam M Patel, Troy M Denunzio,

<label>BACKGROUND</label>Broad-spectrum antibiotics are often used as initial empiric therapy in patients at risk for infections by multidrug-resistant organisms. Emerging literature and anecdotal reports within Tripler Army Medical Center indicate an increased incidence of vancomycin-associated acute kidney injury when used in combination with piperacillin-tazobactam. This is a retrospective, single-center study comparing ... Read more >>

Mil Med (Military medicine)
[2017, 182(9):e1773-e1778]

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Student-led widening access schemes.

Utkarsh Ojha, Shivam Patel,

Medicine is among the most competitive degrees in the UK. Successfully gaining admission into medical school requires students to demonstrate a variety of academic and nonacademic skills in addition to experience and insights into the profession. However, gaining relevant experience within medicine may not be equally available to all students. ... Read more >>

Adv Med Educ Pract (Advances in medical education and practice)
[2017, 8:581-585]

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