Full Text Journal Articles by
Author Shiqin Zhang


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Artificial Intelligence Distinguishes COVID-19 from Community Acquired Pneumonia on Chest CT.

Lin Li, Lixin Qin, Zeguo Xu, Youbing Yin, Xin Wang, Bin Kong, Junjie Bai, Yi Lu, Zhenghan Fang, Qi Song, Kunlin Cao, Daliang Liu, Guisheng Wang, Qizhong Xu, Xisheng Fang, Shiqin Zhang, Juan Xia, Jun Xia,

Background Coronavirus disease has widely spread all over the world since the beginning of 2020. It is desirable to develop automatic and accurate detection of COVID-19 using chest CT. Purpose To develop a fully automatic framework to detect COVID-19 using chest CT and evaluate its performances. Materials and Methods In ... Read more >>

Radiology (Radiology)
[2020, :200905]

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Dietary phosphate restriction attenuates polycystic kidney disease in mice.

Faith Omede, Shiqin Zhang, Cassandra Johnson, Emily Daniel, Yan Zhang, Timothy A Fields, Joseph Boulanger, Shiguang Liu, Ishfaq Ahmed, Shahid Umar, Darren Paul Wallace, Jason R Stubbs,

Studies in rodents with reduced nephron mass have suggested a strong positive correlation between dietary phosphate consumption and CKD progression. Prior work by our group demonstrated that dietary phosphate restriction can prevent tubular injury and microcyst formation in rodents with glomerulonephritis. Tubular injury and cystic dilation of tubules are key ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2020, 318(1):F35-F42]

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Surgical treatment is better than non-surgical treatment for primary patellar dislocation: a meta-analysis of randomized controlled trials.

Zhengdao Fu, Zhiqiang Zhu, Haitao Chen, Shiqin Zhang,

BACKGROUND:At present, the best treatment for primary patellar dislocation (PPD) has not been unified. Moreover, meta-analyses comparing the non-surgical and surgical treatments of PPD are lacking. Thus, we aimed to compare the clinical efficacy of surgical or non-surgical treatment of PPD. METHODS:Randomized controlled studies of surgical and non-surgical treatments of ... Read more >>

Arch Orthop Trauma Surg (Archives of orthopaedic and trauma surgery)
[2020, 140(2):219-229]

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Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden.

Jason R Stubbs, John A House, A Jacob Ocque, Shiqin Zhang, Cassandra Johnson, Cassandra Kimber, Kyle Schmidt, Aditi Gupta, James B Wetmore, Thomas D Nolin, John A Spertus, Alan S Yu,

Trimethlyamine-N-oxide (TMAO) was recently identified as a promoter of atherosclerosis. Patients with CKD exhibit accelerated development of atherosclerosis; however, no studies have explored the relationship between TMAO and atherosclerosis formation in this group. This study measured serum concentrations and urinary excretion of TMAO in a CKD cohort (n=104), identified the ... Read more >>

J. Am. Soc. Nephrol. (Journal of the American Society of Nephrology : JASN)
[2016, 27(1):305-313]

Cited: 78 times

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FGF23 directly impairs endothelium-dependent vasorelaxation by increasing superoxide levels and reducing nitric oxide bioavailability.

Neerupma Silswal, Chad D Touchberry, Dorothy R Daniel, Darla L McCarthy, Shiqin Zhang, Jon Andresen, Jason R Stubbs, Michael J Wacker,

Fibroblast growth factor 23 (FGF23) is secreted primarily by osteocytes and regulates phosphate and vitamin D metabolism. Elevated levels of FGF23 are clinically associated with endothelial dysfunction and arterial stiffness in chronic kidney disease (CKD) patients; however, the direct effects of FGF23 on endothelial function are unknown. We hypothesized that ... Read more >>

Am. J. Physiol. Endocrinol. Metab. (American journal of physiology. Endocrinology and metabolism)
[2014, 307(5):E426-36]

Cited: 55 times

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Dietary phosphate restriction suppresses phosphaturia but does not prevent FGF23 elevation in a mouse model of chronic kidney disease.

Shiqin Zhang, Ryan Gillihan, Nan He, Timothy Fields, Shiguang Liu, Troy Green, Jason R Stubbs,

Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone that in end-stage renal disease is markedly increased in serum; however, the mechanisms responsible for this increase are unclear. Here, we tested whether phosphate retention in chronic kidney disease (CKD) is responsible for the elevation of FGF23 in serum using Col4α3 ... Read more >>

Kidney Int. (Kidney international)
[2013, 84(4):713-721]

Cited: 12 times

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Dose-dependent effects of Runx2 on bone development.

Shiqin Zhang, Zhousheng Xiao, Junming Luo, Nan He, Josh Mahlios, L Darryl Quarles,

Runx2 controls the commitment of mesenchymal cells to the osteoblastic lineage. Distinct promoters, designated P1 and P2, give rise to functionally similar Runx2-II and Runx2-I isoforms. We postulate that this dual promoter gene structure permits temporal and spatial adjustments in the amount of Runx2 isoforms necessary for optimal bone development. ... Read more >>

J. Bone Miner. Res. (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research)
[2009, 24(11):1889-1904]

Cited: 36 times

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Conditional disruption of Pkd1 in osteoblasts results in osteopenia due to direct impairment of bone formation.

Zhousheng Xiao, Shiqin Zhang, Li Cao, Ni Qiu, Valentin David, L Darryl Quarles,

PKD1 (polycystin-1), the disease-causing gene for ADPKD, is widely expressed in various cell types, including osteoblasts, where its function is unknown. Although global inactivation of Pkd1 in mice results in abnormal skeletal development, the presence of polycystic kidneys and perinatal lethality confound ascertaining the direct osteoblastic functions of PKD1 in ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2010, 285(2):1177-1187]

Cited: 32 times

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B-ultrasound probe sterilizer


The utility model discloses an Ultrasonic B probe sterilizer, which belongs to the technical field of medical appliances. The technical scheme of the Ultrasonic B probe sterilizer comprises a probe cotton sock, which is characterized by arranging an elastic band on the probe cotton sock. The utility model has the ... Read more >>

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Blood sampling injection syringe


A blood sampling injector belongs to the medical appliance technical filed. The technical scheme of the utility model is that the blood sampling injector comprises a puncture needle, a needle tube, a piston and a pull rod, which is characterized in that the front end of the needle tube is ... Read more >>

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Polycystin-1 regulates skeletogenesis through stimulation of the osteoblast-specific transcription factor RUNX2-II.

Zhousheng Xiao, Shiqin Zhang, Brenda S Magenheimer, Junming Luo, L Darryl Quarles,

Polycystin-1 (PC1) may play an important role in skeletogenesis through regulation of the bone-specific transcription factor Runx2-II. In the current study we found that PC1 co-localizes with the calcium channel polycystin-2 (PC2) in primary cilia of MC3T3-E1 osteoblasts. To establish the role of Runx2-II in mediating PC1 effects on bone, ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2008, 283(18):12624-12634]

Cited: 38 times

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Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression.

Zhousheng Xiao, Shiqin Zhang, Josh Mahlios, Gan Zhou, Brenda S Magenheimer, Dayong Guo, Sarah L Dallas, Robin Maser, James P Calvet, Lynda Bonewald, Leigh Darryl Quarles,

We examined the osteoblast/osteocyte expression and function of polycystin-1 (PC1), a transmembrane protein that is a component of the polycystin-2 (PC2)-ciliary mechano-sensor complex in renal epithelial cells. We found that MC3T3-E1 osteoblasts and MLO-Y4 osteocytes express transcripts for PC1, PC2, and the ciliary proteins Tg737 and Kif3a. Immunohistochemical analysis detected ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2006, 281(41):30884-30895]

Cited: 106 times

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Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice.

Zhousheng Xiao, Hani A Awad, Shiguang Liu, Josh Mahlios, Shiqin Zhang, Farshid Guilak, Matthew S Mayo, Leigh Darryl Quarles,

Runx2 transcribes Runx2-II and Runx2-I isoforms with distinct N-termini. Deletion of both isoforms results in complete arrest of bone development, whereas selective loss of Runx2-II is sufficient to form a grossly intact skeleton with impaired endochondral bone development. To elucidate the role of Runx2-II in osteoblast function in adult mice, ... Read more >>

Dev. Biol. (Developmental biology)
[2005, 283(2):345-356]

Cited: 49 times

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[Development of sustained release tablet of tamoxifen citrate and its in vitro release profile].

Kuangshi Wu, Ganlin Zhao, Shiqin Zhang, Qiang Zhang,

To reduce the frequency of administration of tamoxifen citrate so as to improve its bioavailability and patients' compliance.HPMC(K4M) was employed as major retarded-release controller. The wetting granulation and directly compressing method was used to produce the sustained release tablet. Then the in vitro release profile was applied as main criteria ... Read more >>

Beijing Da Xue Xue Bao (Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences)
[2003, 35(6):625-628]

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