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Author Shinya Yokomizo

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Near-infrared II photobiomodulation augments nitric oxide bioavailability via phosphorylation of endothelial nitric oxide synthase.

Shinya Yokomizo, Malte Roessing, Atsuyo Morita, Timo Kopp, Emiyu Ogawa, Wataru Katagiri, Susanne Feil, Paul L Huang, Dmitriy N Atochin, Satoshi Kashiwagi,

There is solid evidence of the beneficial effect of photobiomodulation (PBM) with low-power near-infrared (NIR) light in the NIR-I window in increasing bioavailable nitric oxide (NO). However, it is not established whether this effect can be extended to NIR-II light, limiting broader applications of this therapeutic modality. Since we have ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2022, 36(9):e22490]

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Renal clearable bone-targeted contrast agents for theranostic imaging

Haoran Wang, Homan Kang, Jason Dinh, Shinya Yokomizo, Wesley Stiles, Molly Tully, Kevin Cardenas, Surbhi Srini, Jason Ingerick, Sung Ahn, Kai Bao, Hak Soo Choi,

<h4>Background: </h4> Due to the deep tissue penetration and reduced scattering, NIR-II fluorescence imaging is advantageous over conventional visible and NIR-I fluorescence imaging for the detection of bone growth, metabolism, metastasis, and other bone-related diseases. <h4>Methods: </h4>: Here, we designed bone-targeted heptamethine cyanine fluorophores by substituting the meso -carbon with ... Read more >>

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