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Differences in sex hormone recovery profile after cessation of 12-week gonadotropin-releasing hormone antagonist versus agonist therapy.

Hiroshi Sasaki, Kenta Miki, Kojiro Tashiro, Keiichiro Mori, Fumihiko Urabe, Wataru Fukuokaya, Takahiro Kimura, Shun Sato, Hiroyuki Takahashi, Manabu Aoki, Shin Egawa,

<h4>Background</h4>Pharmacobiological behavior differs between gonadotropin-releasing hormone (GnRH) antagonists and GnRH agonists. However, reliable evidence clarifying the difference between them is limited.<h4>Objectives</h4>We aimed to elucidate the difference in recovery profile between GnRH antagonist (degarelix) and GnRH agonist (leuprorelin acetate or goserelin acetate) as short-term (12 weeks) neoadjuvant androgen deprivation therapy (ADT) ... Read more >>

Andrology (Andrology)
[2021, :]

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The Value of Preoperative Plasma VEGF Levels in Urothelial Carcinoma of the Bladder Treated with Radical Cystectomy.

Keiichiro Mori, Victor M Schuettfort, Satoshi Katayama, Ekaterina Laukhtina, Benjamin Pradere, Fahad Quhal, Reza Sari Motlagh, Hadi Mostafaei, Nico C Grossmann, Pawel Rajwa, Frederik König, Abdulmajeed Aydh, Francesco Soria, Marco Moschini, Pierre I Karakiewicz, Yair Lotan, Douglas Scherr, Martin Haydter, Peter Nyirady, Jeremy Y C Teoh, Shin Egawa, Eva Compérat, Shahrokh F Shariat,

<h4>Background</h4>Elevated preoperative plasma levels of the angiogenesis-related marker VEGF have been associated with worse oncological outcomes in various malignancies.<h4>Objective</h4>To investigate the predictive/prognostic role of VEGF in patients with urothelial carcinoma of the bladder (UCB) treated with radical cystectomy (RC).<h4>Design, setting, and participants</h4>VEGF plasma levels were measured preoperatively in 1036 patients ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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The Impact of ABO Blood Type on Developing Venous Thromboembolism in Cancer Patients: Systematic Review and Meta-Analysis.

Fumihiko Urabe, Shoji Kimura, Kosuke Iwatani, Keiji Yasue, Yuhei Koike, Kojiro Tashiro, Shunsuke Tsuzuki, Hiroshi Sasaki, Takahiro Kimura, Shin Egawa,

The impact of ABO blood type in the development of venous thromboembolism in cancer patients remains controversial. To develop a sense of the current opinion in this area, we conducted a systematic review and meta-analysis. In March 2021, we performed a systematic search of PubMed, the Cochrane library, and Scopus ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(16):]

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Androgen receptor axis-targeted agents for non-metastatic castration-resistant prostate cancer impact on overall survival and safety profile: an updated systematic review and meta-analysis.

Keiichiro Mori, Fahad Quhal, Satoshi Katayama, Hadi Mostafaei, Ekaterina Laukhtina, Victor M Schuettfort, Reza Sari Motlagh, Nico C Grossmann, Pawel Rajwa, Guillaume Ploussard, Alberto Briganti, Takahiro Kimura, Shin Egawa, Rocco Papalia, Diego M Carrion, Cristian Fiori, Shahrokh F Shariat, Francesco Esperto, Benjamin Pradere,

<h4>Introduction</h4>The management of non-metastatic castration-resistant prostate cancer (nmCRPC) has undergone a paradigm shift with the development of androgen receptor axis-targeted (ARAT) agents. The updated results with final overall survival (OS) data of the phase III PROSPER, SPARTAN, and ARAMIS trials have recently been reported. Therefore, we performed an updated meta-analysis ... Read more >>

Minerva Urol Nephrol (Minerva urology and nephrology)
[2021, :]

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Prognostic model with alkaline phosphatase, lactate dehydrogenase and presence of Gleason pattern 5 for worse overall survival in low-risk metastatic hormone-sensitive prostate cancer.

Shunsuke Tsuzuki, Shota Kawano, Wataru Fukuokaya, Keiichiro Mori, Hideomi Nishikawa, Kojiro Tashiro, Daisuke Watanabe, Taizo Uchimoto, Kazuki Nishimura, Yusuke Yano, Masaya Murakami, Yusuke Koike, Kenichi Hata, Haruhisa Koide, Jun Miki, Hirokazu Abe, Hiroki Yamada, Takehito Naruoka, Shingo Sugaya, Takahiro Kimura, Masayuki Tomita, Hiroshi Nakajo, Shin Egawa,

<h4>Background</h4>Randomized trials showed the survival benefits of the combined use of androgen receptor axis-targeted agents with androgen deprivation therapy in metastatic hormone-sensitive prostate cancer (mHSPC), regardless of the risk. However, treating patients with low-risk mHSPC with such intensive treatment is still debatable.<h4>Methods</h4>This retrospective study included 155 low-risk patients among 467 ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2021, :]

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Risk Classification for Overall Survival by the Neutrophil-Lymphocyte Ratio and the Number of Metastatic Sites in Patients Treated with Pembrolizumab-A Multicenter Collaborative Study in Japan.

Taizo Uchimoto, Kazumasa Komura, Wataru Fukuokaya, Takahiro Kimura, Kazuhiro Takahashi, Yusuke Yano, Kazuki Nishimura, Keita Nakamori, Yuya Fujiwara, Tomohisa Matsunaga, Takeshi Tsutsumi, Takuya Tsujino, Ryoichi Maenosono, Yuki Yoshikawa, Kohei Taniguchi, Tomohito Tanaka, Hirofumi Uehara, Hajime Hirano, Hayahito Nomi, Kiyoshi Takahara, Teruo Inamoto, Shin Egawa, Haruhito Azuma,

Pembrolizumab has emerged as the new standard of care in patients with platinum-refractory metastatic urothelial carcinoma (mUC), whereas the optimal risk stratification to predict survival outcomes is still controversial. We examined a risk model for overall survival (OS) in mUC treated with pembrolizumab using our multi-institutional dataset (212 patients). The ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(14):]

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Prognostic value of the preoperative albumin-globulin ratio in patients with upper urinary tract urothelial carcinoma treated with radical nephroureterectomy: results from a large multicenter international collaboration.

Noriyoshi Miura, Keiichiro Mori, Ekaterina Laukhtina, Victor M Schuettfort, Mohammad Abufaraj, Jeremy Y C Teoh, Stefano Luzzago, Franziska Stolzenbach, Marina Deuker, Pierre I Karakiewicz, Alberto Briganti, Dmitry V Enikeev, Morgan Rouprêt, Vitaly Margulis, Piotr Chlosta, Peter Nyirady, Marek Babjuk, Shin Egawa, Takashi Saika, Shahrokh F Shariat,

<h4>Objective</h4>To assess the value of preoperative albumin to globulin ratio for predicting pathologic and oncological outcomes in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy in a large multi-institutional cohort.<h4>Materials and methods</h4>Preoperative albumin to globulin ratio was assessed in a multi-institutional cohort of 2492 patients. Logistic regression analyses ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2021, 51(7):1149-1157]

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Systemic therapies for metastatic hormone-sensitive prostate cancer: network meta-analysis.

Keiichiro Mori, Hadi Mostafaei, Reza Sari Motlagh, Benjamin Pradere, Fahad Quhal, Ekaterina Laukhtina, Victor M Schuettfort, Gero Kramer, Mohammad Abufaraj, Pierre I Karakiewicz, Takahiro Kimura, Shin Egawa, Shahrokh F Shariat,

<h4>Objectives</h4>To perform a systematic review and network meta-analysis to compare the efficacy and safety of currently available treatments for the management of metastatic hormone-sensitive prostate cancer (mHSPC), as there has been a paradigm shift with the use of next-generation androgen receptor inhibitors (ARIs) and docetaxel.<h4>Methods</h4>Multiple databases were searched for articles ... Read more >>

BJU Int (BJU international)
[2021, :]

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Differences in oncological and toxicity outcomes between programmed cell death-1 and programmed cell death ligand-1 inhibitors in metastatic renal cell carcinoma: A systematic review and meta-analysis.

Keiichiro Mori, Benjamin Pradere, Fahad Quhal, Satoshi Katayama, Hadi Mostafaei, Ekaterina Laukhtina, Victor M Schuettfort, David D'Andrea, Shin Egawa, Karim Bensalah, Manuela Schmidinger, Thomas Powles, Shahrokh F Shariat,

<h4>Background</h4>The programmed cell death ligand-1 (PD-L1)/programmed cell death-1 (PD-1) pathway is important in metastatic renal cell carcinoma (mRCC). However, some dissimilarities between anti-PD-1 and anti-PD-L1 inhibitors have emerged. We aimed to assess differences between anti-PD-1 and anti-PD-L1 combination immunotherapies as first-line treatments in mRCC patients.<h4>Methods</h4>Multiple databases (PubMed, Web of Science, ... Read more >>

Cancer Treat Rev (Cancer treatment reviews)
[2021, 99:102242]

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Impact of health-related quality of life on repeat protocol biopsy compliance on active surveillance for favorable prostate cancer: results from a prospective cohort in the PRIAS-JAPAN study.

Yoichiro Tohi, Takuma Kato, Akira Yokomizo, Koji Mitsuzuka, Ryotaro Tomida, Junichi Inokuchi, Ryuji Matsumoto, Toshihiro Saito, Hiroshi Sasaki, Koji Inoue, Hidefumi Kinoshita, Hiroshi Fukuhara, Satoru Maruyama, Shinichi Sakamoto, Toshiki Tanikawa, Shin Egawa, Haruhiko Ichikura, Takashige Abe, Masaki Nakamura, Yoshiyuki Kakehi, Mikio Sugimoto,

<h4>Objectives</h4>This study aimed to evaluate how health-related quality of life (HRQOL) is related to repeat protocol biopsy compliance.<h4>Materials and methods</h4>We conducted a retrospective analysis using data from a prospective cohort in the Prostate Cancer Research International: Active Surveillance (PRIAS)-JAPAN study between January 2010 and August 2019. We used the Short ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Prognostic value of the systemic immune-inflammation index in non-muscle invasive bladder cancer.

Satoshi Katayama, Keiichiro Mori, Benjamin Pradere, Ekaterina Laukhtina, Victor M Schuettfort, Fahad Quhal, Reza Sari Motlagh, Hadi Mostafaei, Nico C Grossmann, Pawel Rajwa, Marco Moschini, Romain Mathieu, Mohammad Abufaraj, David D'Andrea, Eva Compérat, Martin Haydter, Shin Egawa, Yasutomo Nasu, Shahrokh F Shariat, ,

<h4>Purpose</h4>We assessed the prognostic value of systemic immune-inflammation index (SII) to refine risk stratification of the heterogeneous spectrum of patients with non-muscle-invasive bladder cancer (NMIBC) METHODS: In this multi-institutional cohort, preoperative blood-based SII was retrospectively assessed in 1117 patients with NMIBC who underwent transurethral resection of bladder (TURB) between 1996 ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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ASO Author Reflections: Is There Any Difference Among Various Gleason Scores Classified as Grade Group 4 Prostate Cancer?

Keiichiro Mori, Vidit Sharma, Shin Egawa, Derya Tilki, Stephen A Boorjian, Shahrokh F Shariat,

Ann Surg Oncol (Annals of surgical oncology)
[2021, :]

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Performance of Indocyanine Green Fluorescence for Detecting Lymph Node Metastasis in Prostate Cancer: A Systematic Review and Meta-analysis.

Fumihiko Urabe, Shoji Kimura, Keiji Yasue, Takafumi Yanagisawa, Shunsuke Tsuzuki, Takahiro Kimura, Jun Miki, Shin Egawa,

<h4>Purpose</h4>The use of sentinel lymph node dissection in several cancers has been gaining attention with the emergence of indocyanine green fluorescence. We performed a meta-analysis to assess the diagnostic performance of indocyanine green fluorescence in detecting lymph node metastasis in prostate cancer patients.<h4>Methods</h4>A literature search was conducted using PubMed, Cochrane ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, 80(4):507-515]

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Prognostic Impact of Different Gleason Patterns on Biopsy Within Grade Group 4 Prostate Cancer.

Keiichiro Mori, Vidit Sharma, Eva M Comperat, Shun Sato, Ekaterina Laukhtina, Victor M Schuettfort, Benjamin Pradere, Reza Sari Motlagh, Hadi Mostafaei, Fahad Quhal, Mehdi Kardoust Parizi, Mohammad Abufaraj, Pierre I Karakiewicz, Shin Egawa, Derya Tilki, Stephen A Boorjian, Shahrokh F Shariat,

<h4>Background</h4>Grade group (GG) 4 prostate cancer (PC) is considered a single entity; however, there are questions regarding prognostic heterogeneity. This study assessed the prognostic differences among various Gleason scores (GSs) classified as GG 4 PC on biopsy before radical prostatectomy (RP).<h4>Methods</h4>We conducted a multicenter retrospective study, and a total of ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2021, :]

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Clinical benefit of continuing pembrolizumab treatment beyond progression in patients with metastatic urothelial carcinoma.

Wataru Fukuokaya, Takahiro Kimura, Takafumi Yanagisawa, Shoji Kimura, Shunsuke Tsuzuki, Yuhei Koike, Yuya Iwamoto, Yuki Enei, Masatoshi Tanaka, Fumihiko Urabe, Hajime Onuma, Mariko Honda, Jun Miki, Yu Oyama, Hirokazu Abe, Shin Egawa,

<h4>Background</h4>There has been no clinical evidence to justify continued pembrolizumab therapy beyond progression in patients with metastatic urothelial carcinoma (UC).<h4>Materials and methods</h4>We conducted a multicenter retrospective study evaluating the clinical efficacy of continued use of pembrolizumab beyond progression in patients with metastatic UC. Data from 51 patients with metastatic UC, ... Read more >>

Cancer Immunol Immunother (Cancer immunology, immunotherapy : CII)
[2021, :]

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What is next in second- and later-line treatment of metastatic renal cell carcinoma? review of the recent literature.

Keiichiro Mori, Manuela Schmidinger, Fahad Quhal, Shin Egawa, Shahrokh F Shariat, Viktor Grünwald,

<h4>Purpose of review</h4>The current treatment landscape of metastatic renal cell carcinoma has changed dramatically from the dominance of single-agent tyrosine kinase inhibitor (TKI) therapy to immune-checkpoint inhibitor (ICI)-based combinations in recent years. However, the optimal subsequent therapy remains ill-defined owing to the novelty of this approach.<h4>Recent findings</h4>Treatment with TKIs after ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(3):276-284]

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First-line immune-checkpoint inhibitor combination therapy for chemotherapy-eligible patients with metastatic urothelial carcinoma: A systematic review and meta-analysis.

Keiichiro Mori, Benjamin Pradere, Marco Moschini, Hadi Mostafaei, Ekaterina Laukhtina, Victor M Schuettfort, Reza Sari Motlagh, Francesco Soria, Jeremy Y C Teoh, Shin Egawa, Thomas Powles, Shahrokh F Shariat, ,

<h4>Introduction</h4>Platinum-based combination chemotherapy is the standard treatment for patients with chemotherapy-eligible metastatic urothelial carcinoma (mUC). Immune-checkpoint inhibitors (ICIs) are currently assessed in this setting. This review aimed to assess the role of ICIs alone or in combination as first-line treatment in chemotherapy-eligible patients with mUC.<h4>Methods</h4>Multiple databases were searched for articles ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 151:35-48]

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Intraspecific convergence of floral size correlates with pollinator size on different mountains: a case study of a bumblebee-pollinated Lamium (Lamiaceae) flowers in Japan.

Tsubasa Toji, Natsumi Ishimoto, Shin Egawa, Yuta Nakase, Mitsuru Hattori, Takao Itino,

<h4>Background</h4>Geographic differences in floral size sometimes reflect geographic differences in pollinator size. However, we know little about whether this floral size specialization to the regional pollinator size occurred independently at many places or occurred once and then spread across the distribution range of the plant species.<h4>Results</h4>We investigated the relationship between ... Read more >>

BMC Ecol Evol (BMC ecology and evolution)
[2021, 21(1):64]

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Prognostic value of PSA bounce in prostate cancer following definitive radiation therapy: a systematic review and meta-analysis.

Fumihiko Urabe, Shoji Kimura, Kojiro Tashiro, Masahito Kido, Hiroshi Sasaki, Manabu Aoki, Takahiro Kimura, Kenta Miki, Shin Egawa,

<h4>Background</h4>The prognostic significance of PSA bounce following definitive radiation therapy remains controversial. To develop a sense of current opinion in this area, we performed a systematic search of the literature based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.<h4>Methods</h4>In January 2021, we systematically searched PubMed, the Cochrane library, ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2021, :]

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Trimodal therapy with high-dose-rate brachytherapy and hypofractionated external beam radiation combined with long-term androgen deprivation for unfavorable-risk prostate cancer.

Keiichiro Mori, Hiroshi Sasaki, Yuki Tsutsumi, Shun Sato, Yuki Takiguchi, Shun Saito, Eriko Nishi, Gen Ishii, Toshihiro Yamamoto, Yusuke Koike, Jun Miki, Tatsuya Shimomura, Takahiro Kimura, Kenta Miki, Shahrokh F Shariat, Hiroyuki Takahashi, Manabu Aoki, Shin Egawa,

<h4>Purpose</h4>To assess the outcomes of high-dose-rate (HDR) brachytherapy and hypofractionated external beam radiation therapy (EBRT) combined with long-term androgen deprivation therapy (ADT) in very-high-risk (VHR) versus high-risk (HR) prostate cancer (PCa), as defined in the National Comprehensive Cancer Network (NCCN) criteria.<h4>Methods</h4>Data from 338 consecutive HR or VHR PCa patients who ... Read more >>

Strahlenther Onkol (Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al])
[2021, :]

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Feasibility and accuracy of pathological diagnosis in en-bloc transurethral resection specimens versus conventional transurethral resection specimens of bladder tumour: evaluation with pT1 substaging by 10 pathologists.

Takafumi Yanagisawa, Takashi Yorozu, Jun Miki, Kosuke Iwatani, Koki Obayashi, Shun Sato, Takahiro Kimura, Hiroyuki Takahashi, Shin Egawa,

<h4>Aims</h4>En-bloc transurethral resection (TUR) of bladder tumour (ERBT) is designed to provide more accurate pathological diagnosis of specimens than conventional TUR of bladder tumour (cTURBT). Some studies have reported that T1 bladder cancer substage could be a prognostic factor in assessing tumour progression, but such substaging has not been widely ... Read more >>

Histopathology (Histopathology)
[2021, 78(7):943-950]

Cited: 2 times

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First-line Immunotherapy-based Combinations for Metastatic Renal Cell Carcinoma: A Systematic Review and Network Meta-analysis.

Fahad Quhal, Keiichiro Mori, Andreas Bruchbacher, Irene Resch, Hadi Mostafaei, Benjamin Pradere, Victor M Schuettfort, Ekaterina Laukhtina, Shin Egawa, Harun Fajkovic, Mesut Remzi, Shahrokh F Shariat, Manuela Schmidinger,

<h4>Context</h4>There have been substantial changes in the management of patients with metastatic renal cell carcinoma (mRCC) over the past decade, with upfront immunotherapy-based combinations replacing targeted therapies. A broad range of combinations have been approved, and comparisons of their efficacy and safety are needed to guide the optimal choice of ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, :]

Cited: 1 time

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Clinical Significance of Horizontal and Vertical Margin of En Bloc Resection for Nonmuscle Invasive Bladder Cancer.

Takafumi Yanagisawa, Jun Miki, Keigo Sakanaka, Wataru Fukuokaya, Kosuke Iwatani, Shun Sato, Koki Obayashi, Shinichi Hirooka, Takahiro Kimura, Hiroyuki Takahashi, Shin Egawa,

<h4>Purpose</h4>The primary advantage of en bloc resection of bladder tumors is to provide better diagnostic accuracy. However, the clinical significance of horizontal and vertical margin has not been demonstrated. We evaluated the clinical importance of surgical margins in patients who underwent en bloc resection of bladder tumors.<h4>Materials and methods</h4>We retrospectively ... Read more >>

J Urol (The Journal of urology)
[2021, 206(2):252-259]

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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