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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

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Perinatal outcomes among births to women with infection during pregnancy.

Adama Baguiya, Mercedes Bonet, José Guilherme Cecatti, Vanessa Brizuela, Ala Curteanu, Meile Minkauskiene, Kapila Jayaratne, Carolina Carvalho Ribeiro-do-Valle, Mihaela-Alexandra Budianu, João Paulo Souza, Séni Kouanda, , ,

<h4>Objective</h4>This study is part of the Global Maternal Sepsis Study (GLOSS). It aimed to estimate neonatal near-miss (NNM) and perinatal death frequency and maternal risk factors among births to women with infection during pregnancy in low-income and middle-income countries (LMIC).<h4>Design</h4>We conducted a 1-week inception hospital-based cohort study.<h4>Setting</h4>The study was carried ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2021, 106(10):946-953]

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AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment: an update to the structured summary of a study protocol for a randomised platform trial letter.

Gareth O Griffiths, Richard FitzGerald, Thomas Jaki, Andrea Corkhill, Helen Reynolds, Sean Ewings, Susannah Condie, Emma Tilt, Lucy Johnson, Mike Radford, Catherine Simpson, Geoffrey Saunders, Sara Yeats, Pavel Mozgunov, Olana Tansley-Hancock, Karen Martin, Nichola Downs, Izabela Eberhart, Jonathan W B Martin, Cristiana Goncalves, Anna Song, Tom Fletcher, Kelly Byrne, David G Lalloo, Andrew Owen, Michael Jacobs, Lauren Walker, Rebecca Lyon, Christie Woods, Jennifer Gibney, Justin Chiong, Nomathemba Chandiwana, Shevin Jacob, Mohammed Lamorde, Catherine Orrell, Munir Pirmohamed, Saye Khoo, ,

<h4>Background</h4>There is an urgent unmet clinical need for the identification of novel therapeutics for the treatment of COVID-19. A number of COVID-19 late phase trial platforms have been developed to investigate (often repurposed) drugs both in the UK and globally (e.g. RECOVERY led by the University of Oxford and SOLIDARITY ... Read more >>

Trials (Trials)
[2021, 22(1):487]

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Availability of facility resources and services and infection-related maternal outcomes in the WHO Global Maternal Sepsis Study: a cross-sectional study.

Vanessa Brizuela, Cristina Cuesta, Gino Bartolelli, Abdulfetah Abdulkadir Abdosh, Sabina Abou Malham, Bouchra Assarag, Rigoberto Castro Banegas, Virginia Díaz, Faysal El-Kak, Mohamed El Sheikh, Aquilino M Pérez, João Paulo Souza, Mercedes Bonet, Edgardo Abalos, ,

<h4>Background</h4>Infections are among the leading causes of maternal mortality and morbidity. The Global Maternal Sepsis and Neonatal Initiative, launched in 2016 by WHO and partners, sought to reduce the burden of maternal infections and sepsis and was the basis upon which the Global Maternal Sepsis Study (GLOSS) was implemented in ... Read more >>

Lancet Glob Health (The Lancet. Global health)
[2021, 9(9):e1252-e1261]

Cited: 1 time

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"Kankasha" in Kassala: A prospective observational cohort study of the clinical characteristics, epidemiology, genetic origin, and chronic impact of the 2018 epidemic of Chikungunya virus infection in Kassala, Sudan.

Hilary Bower, Mubarak El Karsany, Abd Alhadi Adam Hussein Adam, Mubarak Ibrahim Idriss, Ma'aaza Abasher Alzain, Mohamed Elamin Ahmed Alfakiyousif, Rehab Mohamed, Iman Mahmoud, Omer Albadri, Suha Abdulaziz Alnour Mahmoud, Orwa Ibrahim Abdalla, Mawahib Eldigail, Nuha Elagib, Ulrike Arnold, Bernardo Gutierrez, Oliver G Pybus, Daniel P Carter, Steven T Pullan, Shevin T Jacob, Tajeldin Mohammedein Abdallah, Benedict Gannon, Tom E Fletcher,

<h4>Background</h4>The public health impact of Chikungunya virus (CHIKV) is often underestimated. Usually considered a mild condition of short duration, recent outbreaks have reported greater incidence of severe illness, fatality, and longer-term disability. In 2018/19, Eastern Sudan experienced the largest epidemic of CHIKV in Africa to date, affecting an estimated 487,600 ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2021, 15(4):e0009387]

Cited: 1 time

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AGILE: A Seamless Phase I/IIa Platform for the Rapid Evaluation of Candidates for COVID-19 treatment: An update to the structured summary of a study protocol for a randomised platform trial letter

Gareth Owen Griffiths, Richard FitzGerald, Thomas Jaki, Andrea Corkhill, Helen Reynolds, Sean Ewings, Susannah Condie, Emma Tilt, Lucy Johnson, Mike Radford, Catherine Simpson, Geoffrey Saunders, Sara Yeats, Pavel Mozgunov, Olana Tansley-Hancock, Karen Martin, Nichola Downs, Izabela Eberhart, Jonathan William Brian Martin, Cristiana Goncalves, Anna Song, Tom Fletcher, Kelly Byrne, David Griffith Lalloo, Andrew Owen, Michael Jacobs, Lauren Walker, Rebecca Lyon, Christie Woods, Jennifer Gibney, Justin Chiong, Nomathemba Chandiwana, Shevin Jacob, Mohammed Lamorde, Catherine Orrell, Munir Pirmohamed, Saye Khoo,

<h4>Background: </h4> There is an urgent unmet clinical need for the identification of novel therapeutics for the treatment of COVID-19. A number of COVID-19 late phase trial platforms have been developed to investigate (often repurposed) drugs both in the UK and globally (e.g. RECOVERY led by the University of Oxford ... Read more >>

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Knowledge of health workers relating to sepsis awareness and management in Lambaréné, Gabon.

Bayode R Adegbite, Jean Ronald Edoa, Jamie Rylance, Shevin T Jacob, Paul Kawale, Ayola A Adegnika, Martin P Grobusch,

Background In 2016, the third international consensus definitions for sepsis and septic shock (Sepsis-3) task force provided revised definitions for sepsis and septic shock. This study explores knowledge regarding sepsis among health workers in Lambaréné, Gabon. Methods We conducted a self-administered questionnaire-based survey about sepsis among health workers from the ... Read more >>

Acta Trop (Acta tropica)
[2021, 219:105914]

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“Kankasha” in Kassala: a prospective observational cohort study of the clinical characteristics, epidemiology, genetic origin, and chronic impact of the 2018 epidemic of Chikungunya virus infection in Kassala, Sudan

Hilary Bower, Mubarak el Karsany, Abd Alhadi Adam Hussein, Mubarak Ibrahim Idriss, Ma’aaza Abasher AlZain, Mohamed Elamin Ahmed Alfakiyousif, Rehab Mohamed, Iman Mahmoud, Omer Albadri, Suha Abdulaziz Alnour Mahmoud, Orwa Ibrahim Abdalla, Mawahib Eldigail, Nuha Elagib, Ulrike Arnold, Bernardo Gutierrez, Oliver Pybus, Daniel Carter, Steven Pullan, Shevin Jacob, Tajeldin Mohammedein Abdallah, Benedict Gannon, Tom Fletcher,

<h4>Background</h4> The public health impact of Chikungunya virus (CHIKV) is often underestimated. Usually considered a mild condition of short duration, recent outbreaks have reported greater incidence of severe illness, fatality, and longer-term disability. In 2018/19, Eastern Sudan experienced the largest epidemic of CHIKV in Africa to date, affecting an estimated ... Read more >>

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Multigroup, Adaptively Randomized Trials Are Advantageous for Comparing Coronavirus Disease 2019 (COVID-19) Interventions.

Amalia S Magaret, Shevin T Jacob, M Elizabeth Halloran, Katherine A Guthrie, Craig A Magaret, Christine Johnston, Noah R Simon, Anna Wald,

Ann Intern Med (Annals of internal medicine)
[2020, 173(7):576-577]

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Frequency and management of maternal infection in health facilities in 52 countries (GLOSS): a 1-week inception cohort study.

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BACKGROUND:Maternal infections are an important cause of maternal mortality and severe maternal morbidity. We report the main findings of the WHO Global Maternal Sepsis Study, which aimed to assess the frequency of maternal infections in health facilities, according to maternal characteristics and outcomes, and coverage of core practices for early ... Read more >>

Lancet Glob Health (The Lancet. Global health)
[2020, 8(5):e661-e671]

Cited: 12 times

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Recommendations for fluid management of adults with sepsis in sub-Saharan Africa: a systematic review of guidelines.

Benjamin Silberberg, Stephen Aston, Selda Boztepe, Shevin Jacob, Jamie Rylance,

<h4>Background</h4>Sepsis guidelines are widely used in high-income countries and intravenous fluids are an important supportive treatment modality. However, fluids have been harmful in intervention trials in low-income countries, most notably in sub-Saharan Africa. We assessed the relevance, quality and applicability of available guidelines for the fluid management of adult patients ... Read more >>

Crit Care (Critical care (London, England))
[2020, 24(1):286]

Cited: 1 time

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Mycobacterium tuberculosis bloodstream infection prevalence, diagnosis, and mortality risk in seriously ill adults with HIV: a systematic review and meta-analysis of individual patient data.

David A Barr, Joseph M Lewis, Nicholas Feasey, Charlotte Schutz, Andrew D Kerkhoff, Shevin T Jacob, Ben Andrews, Paul Kelly, Shabir Lakhi, Levy Muchemwa, Helio A Bacha, David J Hadad, Richard Bedell, Monique van Lettow, Rony Zachariah, John A Crump, David Alland, Elizabeth L Corbett, Krishnamoorthy Gopinath, Sarman Singh, Rulan Griesel, Gary Maartens, Marc Mendelson, Amy M Ward, Christopher M Parry, Elizabeth A Talbot, Patricia Munseri, Susan E Dorman, Neil Martinson, Maunank Shah, Kevin Cain, Charles M Heilig, Jay K Varma, Anne von Gottberg, Leonard Sacks, Douglas Wilson, S Bertel Squire, David G Lalloo, Gerry Davies, Graeme Meintjes,

<h4>Background</h4>The clinical and epidemiological significance of HIV-associated Mycobacterium tuberculosis bloodstream infection (BSI) is incompletely understood. We hypothesised that M tuberculosis BSI prevalence has been underestimated, that it independently predicts death, and that sputum Xpert MTB/RIF has suboptimal diagnostic yield for M tuberculosis BSI.<h4>Methods</h4>We did a systematic review and individual patient ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, 20(6):742-752]

Cited: 4 times

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Early evaluation of the 'STOP SEPSIS!' WHO Global Maternal Sepsis Awareness Campaign implemented for healthcare providers in 46 low, middle and high-income countries.

Vanessa Brizuela, Mercedes Bonet, Carla Lionela Trigo Romero, Edgardo Abalos, Adama Baguiya, Bukola Fawole, Marian Knight, Pisake Lumbiganon, Meilė Minkauskienė, Ashraf Nabhan, Nafissa Bique Osman, Zahida P Qureshi, João Paulo Souza, ,

<h4>Objective</h4>To evaluate changes in awareness of maternal sepsis among healthcare providers resulting from the WHO Global Maternal Sepsis Study (GLOSS) awareness campaign.<h4>Design</h4>Independent sample precampaign/postcampaign through online and paper-based surveys available for over 30 days before campaign roll-out (pre) and after study data collection (post). Descriptive statistics were used for campaign ... Read more >>

BMJ Open (BMJ open)
[2020, 10(5):e036338]

Cited: 1 time

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Current Challenges in the Management of Sepsis in ICUs in Resource-Poor Settings and Suggestions for the Future

Marcus J. Schultz, Martin W. Dünser, Arjen M. Dondorp, Neill K. J. Adhikari, Shivakumar Iyer, Arthur Kwizera, Yoel Lubell, Alfred Papali, Luigi Pisani, Elisabeth D. Riviello, Derek C. Angus, Luciano C. Azevedo, Timothy Baker, Janet V. Diaz, Emir Festic, Rashan Haniffa, Randeep Jawa, Shevin T. Jacob, Niranjan Kissoon, Rakesh Lodha, Ignacio Martin-Loeches, Ganbold Lundeg, David Misango, Mervyn Mer, Sanjib Mohanty, Srinivas Murthy, Ndidiamaka Musa, Jane Nakibuuka, Ary Serpa Neto, NT Hoang Mai, Binh Nguyen Thien, Rajyabardhan Pattnaik, Jason Phua, Jacobus Preller, Pedro Povoa, Suchitra Ranjit, Daniel Talmor, Jonarthan Thevanayagam, C. Louise Thwaites,

Sepsis is a major cause of critical illness worldwide, especially in resource-poor settings. Intensive care units (ICUs) in low- and middle-income countries (LMICs) face many challenges that could affect patient outcome. The aim of this review is to describe differences between resource-poor and resource-rich settings regarding the epidemiology, pathophysiology, economics, ... Read more >>

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Evaluating the Impact of Intravenous Fluid Resuscitation on Survival for the Management of Patients With Ebola Virus Disease.

Shevin T Jacob, Colin S Brown,

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 70(6):1048-1049]

Cited: 0 times

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Infrastructure and Organization of Adult Intensive Care Units in Resource-Limited Settings

Alfred Papali, Neill K. J. Adhikari, Janet V. Diaz, Arjen M. Dondorp, Martin W. Dünser, Shevin T. Jacob, Jason Phua, Marc Romain, Marcus J. Schultz,

In this chapter, we provide guidance on some basic structural requirements, focusing on organization, staffing, and infrastructure. We suggest a closed-format intensive care unit (ICU) with dedicated physicians and nurses, specifically trained in intensive care medicine whenever feasible. Regarding infrastructural components, a reliable electricity supply is essential, with adequate backup ... Read more >>

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Treating Ebola in eastern DRC.

Amanda M Rojek, Shevin T Jacob, Jake Dunning,

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, 20(3):284-285]

Cited: 1 time

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Exploring healthcare providers' perspectives of the paediatric discharge process in Uganda: a qualitative exploratory study.

Brooklyn Nemetchek, Asif Khowaja, Anthony Kavuma, Olive Kabajaasi, Alex Olirus Owilli, J Mark Ansermino, Susan Fowler-Kerry, Shevin T Jacob, Nathan Kenya-Mugisha, Jerome Kabakyenga, Matthew O Wiens,

INTRODUCTION:The burden of childhood mortality continues to be born largely by low-income and middle-income countries. The critical postdischarge period has been largely neglected despite evidence that mortality rates during this period can exceed inpatient mortality rates. However, there is a paucity of data on the paediatric discharge process from the ... Read more >>

BMJ Open (BMJ open)
[2019, 9(9):e029526]

Cited: 2 times

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Clinical emergency care research in low-income and middle-income countries: opportunities and challenges.

Adam R Aluisio, Shahan Waheed, Peter Cameron, Jermey Hess, Shevin T Jacob, Niranjan Kissoon, Adam C Levine, Asad Mian, Shammi Ramlakhan, Hendry R Sawe, Junaid Razzak,

Disease processes that frequently require emergency care constitute approximately 50% of the total disease burden in low-income and middle-income countries (LMICs). Many LMICs continue to deal with emergencies caused by communicable disease states such as pneumonia, diarrhoea, malaria and meningitis, while also experiencing a marked increase in non-communicable diseases, such ... Read more >>

BMJ Glob Health (BMJ global health)
[2019, 4(Suppl 6):e001289]

Cited: 3 times

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New filovirus disease classification and nomenclature.

Jens H Kuhn, Takuya Adachi, Neill K J Adhikari, Jose R Arribas, Ibrahima Elhadj Bah, Daniel G Bausch, Nahid Bhadelia, Matthias Borchert, Arne Broch Brantsæter, David M Brett-Major, Timothy H Burgess, Daniel S Chertow, Christopher G Chute, Theodore J Cieslak, Robert Colebunders, Ian Crozier, Richard T Davey, Hilde de Clerck, Rafael Delgado, Laura Evans, Mosoka Fallah, William A Fischer, Tom E Fletcher, Robert A Fowler, Thomas Grünewald, Andy Hall, Angela Hewlett, Andy I M Hoepelman, Catherine F Houlihan, Giuseppe Ippolito, Shevin T Jacob, Michael Jacobs, Robert Jakob, Frederique A Jacquerioz, Laurent Kaiser, Andre C Kalil, Rashidatu F Kamara, Jimmy Kapetshi, Hans-Dieter Klenk, Gary Kobinger, Mark G Kortepeter, Colleen S Kraft, Thomas Kratz, Henry S Kyobe Bosa, Marta Lado, François Lamontagne, H Cliff Lane, Leslie Lobel, Julius Lutwama, G Marshall Lyon, Moses B F Massaquoi, Thomas A Massaquoi, Aneesh K Mehta, Vital Mondonge Makuma, Srinivas Murthy, Tonny Seikikongo Musoke, Jean-Jacques Muyembe-Tamfum, Phiona Nakyeyune, Carolina Nanclares, Miriam Nanyunja, Justus Nsio-Mbeta, Tim O'Dempsey, Janusz T Pawęska, Clarence J Peters, Peter Piot, Christophe Rapp, Bertrand Renaud, Bruce Ribner, Pardis C Sabeti, John S Schieffelin, Werner Slenczka, Moses J Soka, Armand Sprecher, James Strong, Robert Swanepoel, Timothy M Uyeki, Michel van Herp, Pauline Vetter, David A Wohl, Timo Wolf, Anja Wolz, Alie H Wurie, Zabulon Yoti,

Nat Rev Microbiol (Nature reviews. Microbiology)
[2019, 17(5):261-263]

Cited: 18 times

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Shifting the Paradigm - Applying Universal Standards of Care to Ebola Virus Disease.

William A Fischer, Ian Crozier, Daniel G Bausch, Jean-Jacques Muyembe, Sabue Mulangu, Janet V Diaz, Richard Kojan, David A Wohl, Shevin T Jacob,

N Engl J Med (The New England journal of medicine)
[2019, 380(15):1389-1391]

Cited: 8 times

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Biomarkers of endothelial activation/dysfunction distinguish sub-groups of Ugandan patients with sepsis and differing mortality risks.

Danielle V Clark, Patrick Banura, Karen Bandeen-Roche, W Conrad Liles, Kevin C Kain, W Michael Scheld, William J Moss, Shevin T Jacob,

<h4>Background</h4>Sepsis is a complex clinical syndrome with substantial heterogeneity. We sought to identify patterns of serum biomarkers of endothelial activation and dysfunction in individuals with sepsis and evaluate subgroup-specific differences in mortality.<h4>Methods</h4>Adult patients with sepsis (n=426) were consecutively recruited from two hospitals in Uganda. Clinical information was collected and serum ... Read more >>

JCI Insight (JCI insight)
[2019, 5:]

Cited: 2 times

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Etiology of Sepsis in Uganda Using a Quantitative Polymerase Chain Reaction-based TaqMan Array Card.

Christopher C Moore, Shevin T Jacob, Patrick Banura, Jixian Zhang, Suzanne Stroup, David R Boulware, W Michael Scheld, Eric R Houpt, Jie Liu,

<h4>Background</h4>Knowledge of causes of sepsis in sub-Saharan Africa is limited. A better understanding of the microbiology of bloodstream infections could improve outcomes.<h4>Methods</h4>We used a quantitative polymerase chain reaction (qPCR)-based TaqMan Array Card (TAC) to directly test for 43 targets from whole blood. We analyzed 336 cryopreserved specimens from adult Ugandans ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, 68(2):266-272]

Cited: 11 times

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