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Dysbiosis of gut microbiota in inflammatory bowel disease: Current therapies and potential for microbiota-modulating therapeutic approaches.

Dikhnah Alshehri, Omar Saadah, Mahmoud Mosli, Sherif Edris, Rashad Alhindi, Ahmed Bahieldin,

There is a growing body of evidence reinforcing the unique connections between the host microbiome, health and diseases. Due to the extreme importance of the symbiotic relationship between the intestinal microbiome and the host, it is not surprising that any alteration in the gut microbiota would result in various diseases, ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

Cited: 0 times

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Identification of Genetic Variants Associated With Myocardial Infarction in Saudi Arabia.

Kamal W Ai-Ghalayini, Mohammed A Salama, Hadia Bassam Al Mahdi, Sameer Al-Harthi, Wesam A Alhejily, Mirvat A Alasnag, Noura O Tasbhji, Diana A H Al-Quwaie, Panos Deloukas, Sherif Edris,

The genetic variants associated with various genetic disorders have not been identified decisively in Saudi Arabia. Among these variants, six known for their association with coronary artery disease or myocardial infarction (MI) were studied on Saudi patients. Reference single nucleotide polymorphisms (SNPs) of these variants are rs5174, rs11591147, rs2259816, rs111245230, ... Read more >>

Heart Surg Forum (The heart surgery forum)
[2020, 23(4):E517-E523]

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Detection of Secondary Metabolites as Biomarkers for the Early Diagnosis and Prevention of Type 2 Diabetes.

Jumana Y Al-Aama, Hadiah B Al Mahdi, Mohammed A Salama, Khadija H Bakur, Amani Alhozali, Hala H Mosli, Suhad M Bahijri, Ahmed Bahieldin, Lothar Willmitzer, Sherif Edris,

Background:Type 2 diabetes, or T2D, is a metabolic disease that results in insulin resistance. In the present study, we hypothesize that metabolomic analysis in blood samples of T2D patients sharing the same ethnic background can recover new metabolic biomarkers and pathways that elucidate early diagnosis and predict the incidence of ... Read more >>

Diabetes Metab Syndr Obes (Diabetes, metabolic syndrome and obesity : targets and therapy)
[2019, 12:2675-2684]

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Molecular evolution of cytochrome C oxidase-I protein of insects living in Saudi Arabia.

Jamal S M Sabir, Samar Rabah, Haitham Yacoub, Nahid H Hajrah, Ahmed Atef, Mohammed Al-Matary, Sherif Edris, Mona G Alharbi, Magdah Ganash, Jazem Mahyoub, Rashad R Al-Hindi, Khalid M Al-Ghamdi, Neil Hall, Ahmed Bahieldin, Majid R Kamli, Irfan A Rather,

The study underpins barcode characterization of insect species collected from Saudi Arabia and explored functional constraints during evolution at the DNA and protein levels to expect the possible mechanisms of protein evolution in insects. Codon structure designated AT-biased insect barcode of the cytochrome C oxidase I (COI). In addition, the ... Read more >>

PLoS One (PloS one)
[2019, 14(11):e0224336]

Cited: 1 time

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Control of β-sitosterol biosynthesis under light and watering in desert plant Calotropis procera.

Ahmed M Ramadan, Ahmed Abdel Azeiz, Saeed Baabad, Sameh Hassanein, Nour O Gadalla, Sabah Hassan, Mardi Algandaby, Salwa Bakr, Thana Khan, Heba H Abouseadaa, Hani Mohammed Ali, Areej Al-Ghamdi, Gamal Osman, Sherif Edris, Hala Eissa, Ahmed Bahieldin,

Most scientific studies on Calotropis procera refer to the plant as an important source of pharmaceutical compounds and its valuable benefits in medicine. One of the most important substances in this plant is the potential immunostimulant β-sitosterol (BS) that acts in improving human health. This study focused on the effects ... Read more >>

Steroids (Steroids)
[2019, 141:1-8]

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Stepwise response of MeJA-induced genes and pathways in leaves of C. roseus.

Ahmed Bahieldin, Ahmed Atef, Sherif Edris, Nour O Gadalla, Mohammed Al-Matary, Magdy A Al-Kordy, Ahmed M Ramadan, Sameera Bafeel, Mona G Alharbi, Diana A H Al-Quwaie, Jamal S M Sabir, Hassan S Al-Zahrani, Mahmoud E Nasr, Fotouh M El-Domyati,

Catharanthus roseus is a perennial herb known for the production of important terpenoid indole alkaloids (TIAs) in addition to a variety of phenolic compounds. The goal of the present work was to detect the prolonged effects of MeJA (6 uM) treatment across time (up to 24 days) in order to ... Read more >>

C. R. Biol. (Comptes rendus biologies)
[2018, 341(9-10):411-420]

Cited: 0 times

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Depression and telomere length in colorectal cancer patients in Saudi Arabia.

Mahmoud Shaheen AlAhwal, Faten Al Zaben, Mohammad Gamal Sehlo, Doaa Ahmed Khalifa, Jumana Y Al-Aama, Sherif Edris, Jafar A Ashy, Harold G Koenig,

Asian J Psychiatr (Asian journal of psychiatry)
[2019, 40:130-131]

Cited: 0 times

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Transcriptomic and metabolic responses of Calotropis procera to salt and drought stress.

Mohammed Z Mutwakil, Nahid H Hajrah, Ahmed Atef, Sherif Edris, Mernan J Sabir, Areej K Al-Ghamdi, Meshaal J S M Sabir, Charlotte Nelson, Rania M Makki, Hani M Ali, Fotouh M El-Domyati, Abdulrahman S M Al-Hajar, Yoann Gloaguen, Hassan S Al-Zahrani, Jamal S M Sabir, Robert K Jansen, Ahmed Bahieldin, Neil Hall,

BACKGROUND:Calotropis procera is a wild plant species in the family Apocynaceae that is able to grow in harsh, arid and heat stressed conditions. Understanding how this highly adapted plant persists in harsh environments should inform future efforts to improve the hardiness of crop and forage plant species. To study the ... Read more >>

BMC Plant Biol. (BMC plant biology)
[2017, 17(1):231]

Cited: 5 times

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In Silico Approach to Investigate the Structural and Functional Attributes of Familial Hypercholesterolemia Variants Reported in the Saudi Population.

Fatima A Morad, Omran M Rashidi, Saida S Sadath, Faisal A Al-Allaf, Mohammad Athar, Mohamed N Alama, Sherif E Edris, Nabeel S Bondagji, Noor A Shaik, Babajan Banaganapalli, Zuhier Awan,

Familial hypercholesterolemia (FH) is a metabolic disorder that leads primarily to premature cardiovascular diseases, the main cause of mortality in Saudi Arabia (SA). FH is underreported and underdiagnosed in SA with statistical evidence of high expected prevalence in such a consanguineous community. Lacking knowledge of which and how these alterations ... Read more >>

J. Comput. Biol. (Journal of computational biology : a journal of computational molecular cell biology)
[2018, 25(2):170-181]

Cited: 0 times

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Molecular Screening for Malaria among Blood Donors in a WHO Claimed Region of Egypt, Fayoum Governorate.

Salwa Bakr, Sherif Edris, Nashwa S Abdel Fattah, Noha Mohamed Ibrahim, Manal F El-Khadragy,

Background:Transfusion-transmitted malaria is undoubtedly a potential health hazard for blood recipients. Egypt is still on the prevention of reintroduction phase of malaria control program. Fayoum Governorate is considered one of the high-risk foci in Egypt due to its geology. However, no studies have been reported to evaluate the current status ... Read more >>

(Mediterranean journal of hematology and infectious diseases)
[2017, 9(1):e2017065]

Cited: 2 times

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Replication of GWAS loci revealed the moderate effect of TNRC6B locus on susceptibility of Saudi women to develop uterine leiomyomas.

Nabeel Saleem Bondagji, Fatima Amanullah Morad, Afnan Abed Abdullah Al-Nefaei, Imran Ali Khan, Ramu Elango, Layla Saleh Abdullah, Nisma M Al-Mansouri, Jamal Sabir, Babajan Banaganapalli, Sherif Edris, Noor Ahmad Shaik,

Uterine leiomyomas (UL) are smooth muscular nodes, whose growth is dependant up on the complex interplay of hormones with genes and uterine physiology. Global statistics indicate the role of ethnic and racial background as contributory factors for UL development. Owing to the lack of data, this study aimed to examine ... Read more >>

J. Obstet. Gynaecol. Res. (The journal of obstetrics and gynaecology research)
[2017, 43(2):330-338]

Cited: 6 times

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Analysis of transcriptional response to heat stress in Rhazya stricta.

Abdullah Y Obaid, Jamal S M Sabir, Ahmed Atef, Xuan Liu, Sherif Edris, Fotouh M El-Domyati, Mohammed Z Mutwakil, Nour O Gadalla, Nahid H Hajrah, Magdy A Al-Kordy, Neil Hall, Ahmed Bahieldin, Robert K Jansen,

Climate change is predicted to be a serious threat to agriculture due to the need for crops to be able to tolerate increased heat stress. Desert plants have already adapted to high levels of heat stress so they make excellent systems for identifying genes involved in thermotolerance. Rhazya stricta is ... Read more >>

BMC Plant Biol. (BMC plant biology)
[2016, 16(1):252]

Cited: 8 times

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Structural identification of putative USPs in Catharanthus roseus.

Ahmed Bahieldin, Ahmed Atef, Ahmed M Shokry, Saleh Al-Karim, Sanaa G Al Attas, Nour O Gadallah, Sherif Edris, Magdy A Al-Kordy, Abdulkader M Shaikh Omer, Jamal S M Sabir, Ahmed M Ramadan, Abdulrahman S M Al-Hajar, Rania M Makki, Sabah M Hassan, Fotouh M El-Domyati,

Nucleotide sequences of the C. roseus SRA database were assembled and translated in order to detect putative universal stress proteins (USPs). Based on the known conserved USPA domain, 24 Pfam putative USPA proteins in C. roseus were detected and arranged in six architectures. The USPA-like domain was detected in all architectures, while the ... Read more >>

C. R. Biol. (Comptes rendus biologies)
[2015, 338(10):643-649]

Cited: 2 times

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RNA-Seq analysis of the wild barley (H. spontaneum) leaf transcriptome under salt stress.

Ahmed Bahieldin, Ahmed Atef, Jamal S M Sabir, Nour O Gadalla, Sherif Edris, Ahmed M Alzohairy, Nezar A Radhwan, Mohammed N Baeshen, Ahmed M Ramadan, Hala F Eissa, Sabah M Hassan, Nabih A Baeshen, Osama Abuzinadah, Magdy A Al-Kordy, Fotouh M El-Domyati, Robert K Jansen,

Wild salt-tolerant barley (Hordeum spontaneum) is the ancestor of cultivated barley (Hordeum vulgare or H. vulgare). Although the cultivated barley genome is well studied, little is known about genome structure and function of its wild ancestor. In the present study, RNA-Seq analysis was performed on young leaves of wild barley treated ... Read more >>

C. R. Biol. (Comptes rendus biologies)
[2015, 338(5):285-297]

Cited: 12 times

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Construction of naïve camelids VHH repertoire in phage display-based library.

Jamal S M Sabir, Ahmed Atef, Fotouh M El-Domyati, Sherif Edris, Nahid Hajrah, Ahmed M Alzohairy, Ahmed Bahieldin,

Camelids have unique antibodies, namely HCAbs (VHH) or commercially named Nanobodies(®) (Nb) that are composed only of a heavy-chain homodimer. As libraries based on immunized camelids are time-consuming, costly and likely redundant for certain antigens, we describe the construction of a naïve camelid VHHs library from blood serum of non-immunized ... Read more >>

C. R. Biol. (Comptes rendus biologies)
[2014, 337(4):244-249]

Cited: 5 times

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Retrotransposon-based molecular markers for assessment of genomic diversity.

Ahmed M Alzohairy, G Bor Gyulai, Mohamed F Ramadan, Sherif Edris, Jamal S M Sabir, Robert K Jansen, Hala F Eissa, Ahmed Bahieldin,

Retrotransposons (RTs) are major components of most eukaryotic genomes. They are ubiquitous, dispersed throughout the genome, and their abundance correlates with genome size. Their copy-and-paste lifestyle in the genome consists of three molecular steps involving transcription of an RNA copy from the genomic RT, followed by reverse transcription to generate ... Read more >>

Funct. Plant Biol. (Functional plant biology : FPB)
[2014, 41(8):781-789]

Cited: 0 times

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Whole mitochondrial and plastid genome SNP analysis of nine date palm cultivars reveals plastid heteroplasmy and close phylogenetic relationships among cultivars.

Jamal S M Sabir, Dhivya Arasappan, Ahmed Bahieldin, Salah Abo-Aba, Sameera Bafeel, Talal A Zari, Sherif Edris, Ahmed M Shokry, Nour O Gadalla, Ahmed M Ramadan, Ahmed Atef, Magdy A Al-Kordy, Fotoh M El-Domyati, Robert K Jansen,

Date palm is a very important crop in western Asia and northern Africa, and it is the oldest domesticated fruit tree with archaeological records dating back 5000 years. The huge economic value of this crop has generated considerable interest in breeding programs to enhance production of dates. One of the ... Read more >>

PLoS One (PloS one)
[2014, 9(4):e94158]

Cited: 15 times

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The possible antianginal effect of allopurinol in vasopressin-induced ischemic model in rats.

Yahya A Al-Zahrani, Sameer E Al-Harthi, Lateef M Khan, Hani M El-Bassossy, Sherif M Edris, Mai A Alim A Sattar,

The anti-anginal effects of allopurinol were assessed in experimental model rats of angina and their effects were evaluated with amlodipine. In the vasopressin-induced angina model, oral administration of allopurinol in dose of 10 mg/kg revealed remarkably analogous effects in comparison with amlodipine such as dose-dependent suppression of vasopressin-triggered time, duration and ... Read more >>

(Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society)
[2015, 23(5):487-498]

Cited: 1 time

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Control of glycerol biosynthesis under high salt stress in Arabidopsis

Ahmed Bahieldin, Jamal S M Sabir, Ahmed Ramadan, Ahmed M Alzohairy, Rania A Younis, Ahmed M Shokry, Nour O Gadalla, Sherif Edris, Sabah M Hassan, Magdy A Al-Kordy, Khalid B H Kamal, Samar Rabah, Osama A Abuzinadah, Fotouh M El-Domyati,

Loss-of-function and gain-of-function approaches were utilised to detect the physiological importance of glycerol biosynthesis during salt stress and the role of glycerol in conferring salt tolerance in Arabidopsis. The salt stress experiment involved wild type (WT) and transgenic Arabidopsis overexpressing the yeast GPD1 gene (analogue of Arabidopsis GLY1 gene). The ... Read more >>

Funct. Plant Biol. (Functional plant biology : FPB)
[2014, 41(1):87-95]

Cited: 4 times

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Retrotransposon-based molecular markers for assessment of genomic diversity

Ahmed M Alzohairy, Gábor Gyulai, Mohamed F Ramadan, Sherif Edris, Jamal S M Sabir, Robert K Jansen, Hala F Eissa, Ahmed Bahieldin,

Retrotransposons (RTs) are major components of most eukaryotic genomes. They are ubiquitous, dispersed throughout the genome, and their abundance correlates with genome size. Their copy-and-paste lifestyle in the genome consists of three molecular steps involving transcription of an RNA copy from the genomic RT, followed by reverse transcription to generate ... Read more >>

Funct. Plant Biol. (Functional plant biology : FPB)
[2014, 41(8):781-789]

Cited: 0 times

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An integrated catalog of reference genes in the human gut microbiome.

Junhua Li, Huijue Jia, Xianghang Cai, Huanzi Zhong, Qiang Feng, Shinichi Sunagawa, Manimozhiyan Arumugam, Jens Roat Kultima, Edi Prifti, Trine Nielsen, Agnieszka Sierakowska Juncker, Chaysavanh Manichanh, Bing Chen, Wenwei Zhang, Florence Levenez, Juan Wang, Xun Xu, Liang Xiao, Suisha Liang, Dongya Zhang, Zhaoxi Zhang, Weineng Chen, Hailong Zhao, Jumana Yousuf Al-Aama, Sherif Edris, Huanming Yang, Jian Wang, Torben Hansen, Henrik Bjørn Nielsen, Søren Brunak, Karsten Kristiansen, Francisco Guarner, Oluf Pedersen, Joel Doré, S Dusko Ehrlich, , Peer Bork, Jun Wang, ,

Many analyses of the human gut microbiome depend on a catalog of reference genes. Existing catalogs for the human gut microbiome are based on samples from single cohorts or on reference genomes or protein sequences, which limits coverage of global microbiome diversity. Here we combined 249 newly sequenced samples of ... Read more >>

Nat Biotechnol (Nature biotechnology)
[2014, 32(8):834-841]

Cited: 445 times

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Detection of phytochrome-like genes from Rhazya stricta (Apocynaceae) using de novo genome assembly.

Jamal S M Sabir, Nabih A Baeshen, Ahmed M Shokry, Nour O Gadalla, Sherif Edris, Mohammed H Mutwakil, Ahmed M Ramadan, Ahmed Atef, Magdy A Al-Kordy, Osama A Abuzinadah, Fotouh M El-Domyati, Robert K Jansen, Ahmed Bahieldin,

Phytochrome-like genes in the wild plant species Rhazya stricta Decne were characterized using a de novo genome assembly of next generation sequence data. Rhazya stricta contains more than 100 alkaloids with multiple pharmacological properties, and leaf extracts have been used to cure chronic rheumatism, to treat tumors, and in the ... Read more >>

C. R. Biol. (Comptes rendus biologies)
[2013, 336(11-12):521-529]

Cited: 0 times

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Control of glycerol biosynthesis under high salt stress in Arabidopsis.

Ahmed Bahieldin, Jamal S M Sabir, Ahmed Ramadan, Ahmed M Alzohairy, Rania A Younis, Ahmed M Shokry, Nour O Gadalla, Sherif Edris, Sabah M Hassan, Magdy A Al-Kordy, Khalid B H Kamal, Samar Rabah, Osama A Abuzinadah, Fotouh M El-Domyati,

Loss-of-function and gain-of-function approaches were utilised to detect the physiological importance of glycerol biosynthesis during salt stress and the role of glycerol in conferring salt tolerance in Arabidopsis. The salt stress experiment involved wild type (WT) and transgenic Arabidopsis overexpressing the yeast GPD1 gene (analogue of Arabidopsis GLY1 gene). The ... Read more >>

Funct. Plant Biol. (Functional plant biology : FPB)
[2013, 41(1):87-95]

Cited: 0 times

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Characterization of ten date palm (Phoenix dactylifera L.) cultivars from Saudi Arabia using AFLP and ISSR markers.

Jamal S M Sabir, Salah Abo-Aba, Sameera Bafeel, Talal A Zari, Sherif Edris, Ahmed M Shokry, Ahmed Atef, Nour O Gadalla, Ahmed M Ramadan, Magdy A Al-Kordy, Fotouh M El-Domyati, Robert K Jansen, Ahmed Bahieldin,

Date palm is the most economically important plant in the Middle East due to its nutritionally valuable fruit. The development of accurate DNA fingerprints to characterize cultivars and the detection of genetic diversity are of great value for breeding programs. The present study explores the usefulness of ISSR and AFLP ... Read more >>

C. R. Biol. (Comptes rendus biologies)
[2014, 337(1):6-18]

Cited: 3 times

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Autosomal recessive cortical myoclonic tremor and epilepsy: association with a mutation in the potassium channel associated gene CNTN2.

Elisabeth Stogmann, Eva Reinthaler, Salwa Eltawil, Mohammed A El Etribi, Mahmoud Hemeda, Nevine El Nahhas, Ahmed M Gaber, Amal Fouad, Sherif Edris, Anna Benet-Pages, Sebastian H Eck, Ekaterina Pataraia, Davide Mei, Alexis Brice, Suzanne Lesage, Renzo Guerrini, Friedrich Zimprich, Tim M Strom, Alexander Zimprich,

We characterize a consanguineous Egyptian family with an autosomal recessively inherited familial cortical myoclonic tremor and epilepsy. We used multipoint linkage analysis to map the causative mutation to a 12.7 megabase interval within 1q31.3-q32.2 with a log of odds score of 3.6. For further investigation of the linked region in ... Read more >>

Brain (Brain : a journal of neurology)
[2013, 136(Pt 4):1155-1160]

Cited: 23 times

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