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Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial.

Yaseen M Arabi, Anthony C Gordon, Lennie P G Derde, Alistair D Nichol, Srinivas Murthy, Farah Al Beidh, Djillali Annane, Lolowa Al Swaidan, Abi Beane, Richard Beasley, Lindsay R Berry, Zahra Bhimani, Marc J M Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Meredith Buxton, Adrian Buzgau, Allen Cheng, Menno De Jong, Michelle A Detry, Eamon J Duffy, Lise J Estcourt, Mark Fitzgerald, Rob Fowler, Timothy D Girard, Ewan C Goligher, Herman Goossens, Rashan Haniffa, Alisa M Higgins, Thomas E Hills, Christopher M Horvat, David T Huang, Andrew J King, Francois Lamontagne, Patrick R Lawler, Roger Lewis, Kelsey Linstrum, Edward Litton, Elizabeth Lorenzi, Salim Malakouti, Daniel F McAuley, Anna McGlothlin, Shay Mcguinness, Bryan J McVerry, Stephanie K Montgomery, Susan C Morpeth, Paul R Mouncey, Katrina Orr, Rachael Parke, Jane C Parker, Asad E Patanwala, Kathryn M Rowan, Marlene S Santos, Christina T Saunders, Christopher W Seymour, Manu Shankar-Hari, Steven Y C Tong, Alexis F Turgeon, Anne M Turner, Frank Leo Van de Veerdonk, Ryan Zarychanski, Cameron Green, Scott Berry, John C Marshall, Colin McArthur, Derek C Angus, Steven A Webb, ,

<h4>Purpose</h4>To study the efficacy of lopinavir-ritonavir and hydroxychloroquine in critically ill patients with coronavirus disease 2019 (COVID-19).<h4>Methods</h4>Critically ill adults with COVID-19 were randomized to receive lopinavir-ritonavir, hydroxychloroquine, combination therapy of lopinavir-ritonavir and hydroxychloroquine or no antiviral therapy (control). The primary endpoint was an ordinal scale of organ support-free days. Analyses ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(8):867-886]

Cited: 2 times

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The authors reply.

Rachael Parke, Shay McGuinness, ,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1192-e1193]

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Population pharmacokinetics of vancomycin in critically ill adult patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study).

Vesa Cheng, Mohd H Abdul-Aziz, Fay Burrows, Hergen Buscher, Young-Jae Cho, Amanda Corley, Arne Diehl, Eileen Gilder, Stephan M Jakob, Hyung-Sook Kim, Bianca J Levkovich, Sung Yoon Lim, Shay McGuinness, Rachael Parke, Vincent Pellegrino, Yok-Ai Que, Claire Reynolds, Sam Rudham, Steven C Wallis, Susan A Welch, David Zacharias, John F Fraser, Kiran Shekar, Jason A Roberts,

Our study aimed to describe the population pharmacokinetics (PK) of vancomycin in critically ill patients receiving extracorporeal membrane oxygenation (ECMO), including those receiving concomitant renal replacement therapy (RRT). Dosing simulations were used to recommend maximally effective and safe dosing regimens. Serial vancomycin plasma concentrations were measured and analysed using a ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2021, :AAC0137721]

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Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.

, Lise J Estcourt, Alexis F Turgeon, Zoe K McQuilten, Bryan J McVerry, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Donald M Arnold, Abigail Beane, Philippe Bégin, Wilma van Bentum-Puijk, Lindsay R Berry, Zahra Bhimani, Janet E Birchall, Marc J M Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Meredith Buxton, Jeannie L Callum, Michaël Chassé, Allen C Cheng, Matthew E Cove, James Daly, Lennie Derde, Michelle A Detry, Menno De Jong, Amy Evans, Dean A Fergusson, Matthew Fish, Mark Fitzgerald, Claire Foley, Herman Goossens, Anthony C Gordon, Iain B Gosbell, Cameron Green, Rashan Haniffa, Heli Harvala, Alisa M Higgins, Thomas E Hills, Veronica C Hoad, Christopher Horvat, David T Huang, Cara L Hudson, Nao Ichihara, Emma Laing, Abigail A Lamikanra, François Lamontagne, Patrick R Lawler, Kelsey Linstrum, Edward Litton, Elizabeth Lorenzi, Sheila MacLennan, John Marshall, Daniel F McAuley, John F McDyer, Anna McGlothlin, Shay McGuinness, Gail Miflin, Stephanie Montgomery, Paul R Mouncey, Srinivas Murthy, Alistair Nichol, Rachael Parke, Jane C Parker, Nicole Priddee, Damian F J Purcell, Luis F Reyes, Peter Richardson, Nancy Robitaille, Kathryn M Rowan, Jennifer Rynne, Hiroki Saito, Marlene Santos, Christina T Saunders, Ary Serpa Neto, Christopher W Seymour, Jon A Silversides, Alan A Tinmouth, Darrell J Triulzi, Anne M Turner, Frank van de Veerdonk, Timothy S Walsh, Erica M Wood, Scott Berry, Roger J Lewis, David K Menon, Colin McArthur, Ryan Zarychanski, Derek C Angus, Steve A Webb, David J Roberts, Manu Shankar-Hari,

<h4>Importance</h4>The evidence for benefit of convalescent plasma for critically ill patients with COVID-19 is inconclusive.<h4>Objective</h4>To determine whether convalescent plasma would improve outcomes for critically ill adults with COVID-19.<h4>Design, setting, and participants</h4>The ongoing Randomized, Embedded, Multifactorial, Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP) enrolled and randomized 4763 adults with suspected or ... Read more >>

JAMA (JAMA)
[2021, :]

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A pilot randomized clinical trial of cryopreserved versus liquid-stored platelet transfusion for bleeding in cardiac surgery: The cryopreserved versus liquid platelet-New Zealand pilot trial.

Shay McGuinness, Richard Charlewood, Eileen Gilder, Rachael Parke, Katia Hayes, Sarah Morley, Aous Al-Ibousi, Renae Deans, Belinda Howe, Lacey Johnson, Denese C Marks, Michael C Reade, , ,

<h4>Background and objectives</h4>Platelets for transfusion have a shelf-life of 7 days, limiting availability and leading to wastage. Cryopreservation at -80°C extends shelf-life to at least 1 year, but safety and effectiveness are uncertain.<h4>Materials and methods</h4>This single centre blinded pilot trial enrolled adult cardiac surgery patients who were at high risk of platelet ... Read more >>

Vox Sang (Vox sanguinis)
[2021, :]

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Impact of Nonpharmaceutical Interventions on ICU Admissions During Lockdown for Coronavirus Disease 2019 in New Zealand-A Retrospective Cohort Study.

Tobias P Gonzenbach, Shay P McGuinness, Rachael L Parke, Tobias M Merz,

<h4>Objectives</h4>Nonpharmaceutical interventions are implemented internationally to mitigate the spread of severe acute respiratory syndrome coronavirus 2 with the aim to reduce coronavirus disease 2019-related deaths and to protect the health system, particularly intensive care facilities from being overwhelmed. The aim of this study is to describe the impact of nonpharmaceutical ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(10):1749-1756]

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Population pharmacokinetics of piperacillin and tazobactam in critically ill patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study).

Vesa Cheng, Mohd H Abdul-Aziz, Fay Burrows, Hergen Buscher, Young-Jae Cho, Amanda Corley, Arne Diehl, Eileen Gilder, Stephan M Jakob, Hyung-Sook Kim, Bianca J Levkovich, Sung Yoon Lim, Shay McGuinness, Rachael Parke, Vincent Pellegrino, Yok-Ai Que, Claire Reynolds, Sam Rudham, Steven C Wallis, Susan A Welch, David Zacharias, John F Fraser, Kiran Shekar, Jason A Roberts,

Our study aimed to describe the population pharmacokinetics (PK) of piperacillin and tazobactam in patients on extracorporeal membrane oxygenation (ECMO), with and without renal replacement therapy (RRT). We also aimed to use dosing simulations to identify the optimal dosing strategy for these patient groups. Serial piperacillin and tazobactam plasma concentrations ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2021, :AAC0143821]

Cited: 0 times

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Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.

, , , Patrick R Lawler, Ewan C Goligher, Jeffrey S Berger, Matthew D Neal, Bryan J McVerry, Jose C Nicolau, Michelle N Gong, Marc Carrier, Robert S Rosenson, Harmony R Reynolds, Alexis F Turgeon, Jorge Escobedo, David T Huang, Charlotte A Bradbury, Brett L Houston, Lucy Z Kornblith, Anand Kumar, Susan R Kahn, Mary Cushman, Zoe McQuilten, Arthur S Slutsky, Keri S Kim, Anthony C Gordon, Bridget-Anne Kirwan, Maria M Brooks, Alisa M Higgins, Roger J Lewis, Elizabeth Lorenzi, Scott M Berry, Lindsay R Berry, Aaron W Aday, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C Cheng, Tamta Chkhikvadze, Benjamin Coiffard, Todd W Costantini, Sophie de Brouwer, Lennie P G Derde, Michelle A Detry, Abhijit Duggal, Vladimír Džavík, Mark B Effron, Lise J Estcourt, Brendan M Everett, Dean A Fergusson, Mark Fitzgerald, Robert A Fowler, Jean P Galanaud, Benjamin T Galen, Sheetal Gandotra, Sebastian García-Madrona, Timothy D Girard, Lucas C Godoy, Andrew L Goodman, Herman Goossens, Cameron Green, Yonatan Y Greenstein, Peter L Gross, Naomi M Hamburg, Rashan Haniffa, George Hanna, Nicholas Hanna, Sheila M Hegde, Carolyn M Hendrickson, R Duncan Hite, Alexander A Hindenburg, Aluko A Hope, James M Horowitz, Christopher M Horvat, Kristin Hudock, Beverley J Hunt, Mansoor Husain, Robert C Hyzy, Vivek N Iyer, Jeffrey R Jacobson, Devachandran Jayakumar, Norma M Keller, Akram Khan, Yuri Kim, Andrei L Kindzelski, Andrew J King, M Margaret Knudson, Aaron E Kornblith, Vidya Krishnan, Matthew E Kutcher, Michael A Laffan, Francois Lamontagne, Grégoire Le Gal, Christine M Leeper, Eric S Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Jose L Lopez-Sendon Moreno, Sylvain A Lother, Saurabh Malhotra, Miguel Marcos, Andréa Saud Marinez, John C Marshall, Nicole Marten, Michael A Matthay, Daniel F McAuley, Emily G McDonald, Anna McGlothlin, Shay P McGuinness, Saskia Middeldorp, Stephanie K Montgomery, Steven C Moore, Raquel Morillo Guerrero, Paul R Mouncey, Srinivas Murthy, Girish B Nair, Rahul Nair, Alistair D Nichol, Brenda Nunez-Garcia, Ambarish Pandey, Pauline K Park, Rachael L Parke, Jane C Parker, Sam Parnia, Jonathan D Paul, Yessica S Pérez González, Mauricio Pompilio, Matthew E Prekker, John G Quigley, Natalia S Rost, Kathryn Rowan, Fernanda O Santos, Marlene Santos, Mayler Olombrada Santos, Lewis Satterwhite, Christina T Saunders, Roger E G Schutgens, Christopher W Seymour, Deborah M Siegal, Delcio G Silva, Manu Shankar-Hari, John P Sheehan, Aneesh B Singhal, Dayna Solvason, Simon J Stanworth, Tobias Tritschler, Anne M Turner, Wilma van Bentum-Puijk, Frank L van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, Bryan J Wells, R Jay Widmer, Jennifer G Wilson, Eugene Yuriditsky, Fernando G Zampieri, Derek C Angus, Colin J McArthur, Steven A Webb, Michael E Farkouh, Judith S Hochman, Ryan Zarychanski,

<h4>Background</h4>Thrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve outcomes in noncritically ill patients who are hospitalized with Covid-19.<h4>Methods</h4>In this open-label, adaptive, multiplatform, controlled trial, we randomly assigned patients who were hospitalized with ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 385(9):790-802]

Cited: 17 times

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Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis.

, Manu Shankar-Hari, Claire L Vale, Peter J Godolphin, David Fisher, Julian P T Higgins, Francesca Spiga, Jelena Savovic, Jayne Tierney, Gabriel Baron, Julie S Benbenishty, Lindsay R Berry, Niklas Broman, Alexandre Biasi Cavalcanti, Roos Colman, Stefanie L De Buyser, Lennie P G Derde, Pere Domingo, Sharifah Faridah Omar, Ana Fernandez-Cruz, Thijs Feuth, Felipe Garcia, Rosario Garcia-Vicuna, Isidoro Gonzalez-Alvaro, Anthony C Gordon, Richard Haynes, Olivier Hermine, Peter W Horby, Nora K Horick, Kuldeep Kumar, Bart N Lambrecht, Martin J Landray, Lorna Leal, David J Lederer, Elizabeth Lorenzi, Xavier Mariette, Nicolas Merchante, Nor Arisah Misnan, Shalini V Mohan, Michael C Nivens, Jarmo Oksi, Jose A Perez-Molina, Reuven Pizov, Raphael Porcher, Simone Postma, Reena Rajasuriar, Athimalaipet V Ramanan, Philippe Ravaud, Pankti D Reid, Abraham Rutgers, Aranzazu Sancho-Lopez, Todd B Seto, Sumathi Sivapalasingam, Arvinder Singh Soin, Natalie Staplin, John H Stone, Garth W Strohbehn, Jonas Sunden-Cullberg, Julian Torre-Cisneros, Larry W Tsai, Hubert van Hoogstraten, Tom van Meerten, Viviane Cordeiro Veiga, Peter E Westerweel, Srinivas Murthy, Janet V Diaz, John C Marshall, Jonathan A C Sterne,

<h4>Importance</h4>Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized for COVID-19 have variously reported benefit, no effect, and harm.<h4>Objective</h4>To estimate the association between administration of IL-6 antagonists compared with usual care or placebo and 28-day all-cause mortality and other outcomes.<h4>Data sources</h4>Trials were identified through systematic searches of electronic ... Read more >>

JAMA (JAMA)
[2021, 326(6):499-518]

Cited: 11 times

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Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.

, , , Ewan C Goligher, Charlotte A Bradbury, Bryan J McVerry, Patrick R Lawler, Jeffrey S Berger, Michelle N Gong, Marc Carrier, Harmony R Reynolds, Anand Kumar, Alexis F Turgeon, Lucy Z Kornblith, Susan R Kahn, John C Marshall, Keri S Kim, Brett L Houston, Lennie P G Derde, Mary Cushman, Tobias Tritschler, Derek C Angus, Lucas C Godoy, Zoe McQuilten, Bridget-Anne Kirwan, Michael E Farkouh, Maria M Brooks, Roger J Lewis, Lindsay R Berry, Elizabeth Lorenzi, Anthony C Gordon, Tania Ahuja, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C Cheng, Tamta Chkhikvadze, Benjamin Coiffard, Aira Contreras, Todd W Costantini, Sophie de Brouwer, Michelle A Detry, Abhijit Duggal, Vladimír Džavík, Mark B Effron, Heather F Eng, Jorge Escobedo, Lise J Estcourt, Brendan M Everett, Dean A Fergusson, Mark Fitzgerald, Robert A Fowler, Joshua D Froess, Zhuxuan Fu, Jean P Galanaud, Benjamin T Galen, Sheetal Gandotra, Timothy D Girard, Andrew L Goodman, Herman Goossens, Cameron Green, Yonatan Y Greenstein, Peter L Gross, Rashan Haniffa, Sheila M Hegde, Carolyn M Hendrickson, Alisa M Higgins, Alexander A Hindenburg, Aluko A Hope, James M Horowitz, Christopher M Horvat, David T Huang, Kristin Hudock, Beverley J Hunt, Mansoor Husain, Robert C Hyzy, Jeffrey R Jacobson, Devachandran Jayakumar, Norma M Keller, Akram Khan, Yuri Kim, Andrei Kindzelski, Andrew J King, M Margaret Knudson, Aaron E Kornblith, Matthew E Kutcher, Michael A Laffan, Francois Lamontagne, Grégoire Le Gal, Christine M Leeper, Eric S Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Sylvain A Lother, Nicole Marten, Andréa Saud Marinez, Mary Martinez, Eduardo Mateos Garcia, Stavroula Mavromichalis, Daniel F McAuley, Emily G McDonald, Anna McGlothlin, Shay P McGuinness, Saskia Middeldorp, Stephanie K Montgomery, Paul R Mouncey, Srinivas Murthy, Girish B Nair, Rahul Nair, Alistair D Nichol, Jose C Nicolau, Brenda Nunez-Garcia, John J Park, Pauline K Park, Rachael L Parke, Jane C Parker, Sam Parnia, Jonathan D Paul, Mauricio Pompilio, John G Quigley, Robert S Rosenson, Natalia S Rost, Kathryn Rowan, Fernanda O Santos, Marlene Santos, Mayler O Santos, Lewis Satterwhite, Christina T Saunders, Jake Schreiber, Roger E G Schutgens, Christopher W Seymour, Deborah M Siegal, Delcio G Silva, Aneesh B Singhal, Arthur S Slutsky, Dayna Solvason, Simon J Stanworth, Anne M Turner, Wilma van Bentum-Puijk, Frank L van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, R Jay Widmer, Jennifer G Wilson, Eugene Yuriditsky, Yongqi Zhong, Scott M Berry, Colin J McArthur, Matthew D Neal, Judith S Hochman, Steven A Webb, Ryan Zarychanski,

<h4>Background</h4>Thrombosis and inflammation may contribute to morbidity and mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes in critically ill patients with Covid-19.<h4>Methods</h4>In an open-label, adaptive, multiplatform, randomized clinical trial, critically ill patients with severe Covid-19 were randomly assigned to a pragmatically defined ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 385(9):777-789]

Cited: 23 times

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Convalescent Plasma in Critically ill Patients with COVID-19

, Lise Estcourt,

BACKGROUND The evidence for benefit of convalescent plasma for critically ill patients with Covid–19 is inconsistent. We hypothesized that convalescent plasma would improve outcomes for critically ill adult patients with Covid–19. METHODS In an ongoing adaptive platform trial, critically ill patients with confirmed Covid–19, defined as receiving intensive care–level organ ... Read more >>

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Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke.

Richard P Whitlock, Emilie P Belley-Cote, Domenico Paparella, Jeff S Healey, Katheryn Brady, Mukul Sharma, Wilko Reents, Petr Budera, Andony J Baddour, Petr Fila, P J Devereaux, Alexander Bogachev-Prokophiev, Andreas Boening, Kevin H T Teoh, Georgios I Tagarakis, Mark S Slaughter, Alistair G Royse, Shay McGuinness, Marco Alings, Prakash P Punjabi, C David Mazer, Richard J Folkeringa, Andrea Colli, Álvaro Avezum, Juliet Nakamya, Kumar Balasubramanian, Jessica Vincent, Pierre Voisine, Andre Lamy, Salim Yusuf, Stuart J Connolly, ,

<h4>Background</h4>Surgical occlusion of the left atrial appendage has been hypothesized to prevent ischemic stroke in patients with atrial fibrillation, but this has not been proved. The procedure can be performed during cardiac surgery undertaken for other reasons.<h4>Methods</h4>We conducted a multicenter, randomized trial involving participants with atrial fibrillation and a CHA<sub>2</sub>DS<sub>2</sub>-VASc ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 384(22):2081-2091]

Cited: 7 times

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A Multicenter, Open-Label, Randomized Controlled Trial of a Conservative Fluid Management Strategy Compared With Usual Care in Participants After Cardiac Surgery: The Fluids After Bypass Study.

Rachael L Parke, Eileen Gilder, Michael J Gillham, Laurence J C Walker, Michael J Bailey, Shay P McGuinness, ,

<h4>Objectives</h4>There is little evidence to guide fluid administration to patients admitted to the ICU following cardiac surgery. This study aimed to determine if a protocolized strategy known to reduce fluid administration when compared with usual care reduced ICU length of stay following cardiac surgery.<h4>Design</h4>Prospective, multicenter, parallel-group, randomized clinical trial.<h4>Setting</h4>Five cardiac ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(3):449-461]

Cited: 0 times

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Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19.

, Anthony C Gordon, Paul R Mouncey, Farah Al-Beidh, Kathryn M Rowan, Alistair D Nichol, Yaseen M Arabi, Djillali Annane, Abi Beane, Wilma van Bentum-Puijk, Lindsay R Berry, Zahra Bhimani, Marc J M Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Adrian Buzgau, Allen C Cheng, Michelle A Detry, Eamon J Duffy, Lise J Estcourt, Mark Fitzgerald, Herman Goossens, Rashan Haniffa, Alisa M Higgins, Thomas E Hills, Christopher M Horvat, Francois Lamontagne, Patrick R Lawler, Helen L Leavis, Kelsey M Linstrum, Edward Litton, Elizabeth Lorenzi, John C Marshall, Florian B Mayr, Daniel F McAuley, Anna McGlothlin, Shay P McGuinness, Bryan J McVerry, Stephanie K Montgomery, Susan C Morpeth, Srinivas Murthy, Katrina Orr, Rachael L Parke, Jane C Parker, Asad E Patanwala, Ville Pettilä, Emma Rademaker, Marlene S Santos, Christina T Saunders, Christopher W Seymour, Manu Shankar-Hari, Wendy I Sligl, Alexis F Turgeon, Anne M Turner, Frank L van de Veerdonk, Ryan Zarychanski, Cameron Green, Roger J Lewis, Derek C Angus, Colin J McArthur, Scott Berry, Steve A Webb, Lennie P G Derde,

<h4>Background</h4>The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear.<h4>Methods</h4>We evaluated tocilizumab and sarilumab in an ongoing international, multifactorial, adaptive platform trial. Adult patients with Covid-19, within 24 hours after starting organ support in the intensive care unit (ICU), were randomly assigned to ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 384(16):1491-1502]

Cited: 233 times

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Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 – Preliminary report

, Anthony Gordon, Paul Mouncey, Farah Al-Beidh, Kathryn Rowan, Alistair Nichol, Yaseen Arabi, Djillali Annane, Abi Beane, Wilma van Bentum-Puijk, Lindsay Berry, Zahra Bhimani, Marc J.M. Bonten, Charlotte Bradbury, Frank Brunkhorst, Adrian Buzgau, Allen Cheng, Michelle Detry, Eamon Duffy, Lise Estcourt, Mark Fitzgerald, Herman Goossens, Rashan Haniffa, Alisa Higgins, Thomas Hills, Christopher Horvat, Francois Lamontagne, Patrick Lawler, Helen Leavis, Kelsey Linstrum, Edward Litton, Elizabeth Lorenzi, John Marshall, Florian Mayr, Danny McAuley, Anna McGlothlin, Shay McGuinness, Bryan McVerry, Stephanie Montgomery, Susan Morpeth, Srinivas Murthy, Katrina Orr, Rachael Parke, Jane Parker, Asad Patanwala, Ville Pettilä, Emma Rademaker, Marlene Santos, Christina Saunders, Christopher Seymour, Manu Shankar-Hari, Wendy Sligl, Alexis Turgeon, Anne Turner, Frank van de Veerdonk, Ryan Zarychanski, Cameron Green, Roger Lewis, Derek Angus, Colin McArthur, Scott Berry, Steve Webb, Lennie P.G. Derde,

<h4>Background</h4> The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear. <h4>Methods</h4> We evaluated tocilizumab and sarilumab in an ongoing international, multifactorial, adaptive platform trial. Adult patients with Covid-19, within 24 hours of commencing organ support in an intensive care unit, were randomized ... Read more >>

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A single-centre study of safety and efficacy of prone positioning for critically ill patients on veno-venous extracorporeal membrane oxygenation.

Hanna Chaplin, Shay McGuinness, Rachael Parke,

<h4>Background</h4>Veno-venous extracorporeal membrane oxygenation (VV-ECMO) may be used for patients with severe respiratory failure. Prone positioning may also be worthwhile using while patients are on VV-ECMO to promote return of native lung function.<h4>Objectives</h4>The aim of the study was to determine if the use of prone positioning in adult patients receiving ... Read more >>

Aust Crit Care (Australian critical care : official journal of the Confederation of Australian Critical Care Nurses)
[2021, 34(5):446-451]

Cited: 1 time

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Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Derek C Angus, Lennie Derde, Farah Al-Beidh, Djillali Annane, Yaseen Arabi, Abigail Beane, Wilma van Bentum-Puijk, Lindsay Berry, Zahra Bhimani, Marc Bonten, Charlotte Bradbury, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Allen C Cheng, Menno de Jong, Michelle Detry, Lise Estcourt, Mark Fitzgerald, Herman Goossens, Cameron Green, Rashan Haniffa, Alisa M Higgins, Christopher Horvat, Sebastiaan J Hullegie, Peter Kruger, Francois Lamontagne, Patrick R Lawler, Kelsey Linstrum, Edward Litton, Elizabeth Lorenzi, John Marshall, Daniel McAuley, Anna McGlothin, Shay McGuinness, Bryan McVerry, Stephanie Montgomery, Paul Mouncey, Srinivas Murthy, Alistair Nichol, Rachael Parke, Jane Parker, Kathryn Rowan, Ashish Sanil, Marlene Santos, Christina Saunders, Christopher Seymour, Anne Turner, Frank van de Veerdonk, Balasubramanian Venkatesh, Ryan Zarychanski, Scott Berry, Roger J Lewis, Colin McArthur, Steven A Webb, Anthony C Gordon, , Farah Al-Beidh, Derek Angus, Djillali Annane, Yaseen Arabi, Wilma van Bentum-Puijk, Scott Berry, Abigail Beane, Zahra Bhimani, Marc Bonten, Charlotte Bradbury, Frank Brunkhorst, Meredith Buxton, Allen Cheng, Menno De Jong, Lennie Derde, Lise Estcourt, Herman Goossens, Anthony Gordon, Cameron Green, Rashan Haniffa, Francois Lamontagne, Patrick Lawler, Edward Litton, John Marshall, Colin McArthur, Daniel McAuley, Shay McGuinness, Bryan McVerry, Stephanie Montgomery, Paul Mouncey, Srinivas Murthy, Alistair Nichol, Rachael Parke, Kathryn Rowan, Christopher Seymour, Anne Turner, Frank van de Veerdonk, Steve Webb, Ryan Zarychanski, Lewis Campbell, Andrew Forbes, David Gattas, Stephane Heritier, Lisa Higgins, Peter Kruger, Sandra Peake, Jeffrey Presneill, Ian Seppelt, Tony Trapani, Paul Young, Sean Bagshaw, Nick Daneman, Niall Ferguson, Cheryl Misak, Marlene Santos, Sebastiaan Hullegie, Mathias Pletz, Gernot Rohde, Kathy Rowan, Brian Alexander, Kim Basile, Timothy Girard, Christopher Horvat, David Huang, Kelsey Linstrum, Jennifer Vates, Richard Beasley, Robert Fowler, Steve McGloughlin, Susan Morpeth, David Paterson, Bala Venkatesh, Tim Uyeki, Kenneth Baillie, Eamon Duffy, Rob Fowler, Thomas Hills, Katrina Orr, Asad Patanwala, Steve Tong, Mihai Netea, Shilesh Bihari, Marc Carrier, Dean Fergusson, Ewan Goligher, Ghady Haidar, Beverley Hunt, Anand Kumar, Mike Laffan, Patrick Lawless, Sylvain Lother, Peter McCallum, Saskia Middeldopr, Zoe McQuilten, Matthew Neal, John Pasi, Roger Schutgens, Simon Stanworth, Alexis Turgeon, Alexandra Weissman, Neill Adhikari, Matthew Anstey, Emily Brant, Angelique de Man, Francois Lamonagne, Marie-Helene Masse, Andrew Udy, Donald Arnold, Phillipe Begin, Richard Charlewood, Michael Chasse, Mark Coyne, Jamie Cooper, James Daly, Iain Gosbell, Heli Harvala-Simmonds, Tom Hills, Sheila MacLennan, David Menon, John McDyer, Nicole Pridee, David Roberts, Manu Shankar-Hari, Helen Thomas, Alan Tinmouth, Darrell Triulzi, Tim Walsh, Erica Wood, Carolyn Calfee, Cecilia O’Kane, Murali Shyamsundar, Pratik Sinha, Taylor Thompson, Ian Young, Shailesh Bihari, Carol Hodgson, John Laffey, Danny McAuley, Neil Orford, Ary Neto, Michelle Detry, Mark Fitzgerald, Roger Lewis, Anna McGlothlin, Ashish Sanil, Christina Saunders, Lindsay Berry, Elizabeth Lorenzi, Eliza Miller, Vanessa Singh, Claire Zammit, Wilma van Bentum Puijk, Wietske Bouwman, Yara Mangindaan, Lorraine Parker, Svenja Peters, Ilse Rietveld, Kik Raymakers, Radhika Ganpat, Nicole Brillinger, Rene Markgraf, Kate Ainscough, Kathy Brickell, Aisha Anjum, Janis-Best Lane, Alvin Richards-Belle, Michelle Saull, Daisy Wiley, Julian Bion, Jason Connor, Simon Gates, Victoria Manax, Tom van der Poll, John Reynolds, Marloes van Beurden, Evelien Effelaar, Joost Schotsman, Craig Boyd, Cain Harland, Audrey Shearer, Jess Wren, Giles Clermont, William Garrard, Kyle Kalchthaler, Andrew King, Daniel Ricketts, Salim Malakoutis, Oscar Marroquin, Edvin Music, Kevin Quinn, Heidi Cate, Karen Pearson, Joanne Collins, Jane Hanson, Penny Williams, Shane Jackson, Adeeba Asghar, Sarah Dyas, Mihaela Sutu, Sheenagh Murphy, Dawn Williamson, Nhlanhla Mguni, Alison Potter, David Porter, Jayne Goodwin, Clare Rook, Susie Harrison, Hannah Williams, Hilary Campbell, Kaatje Lomme, James Williamson, Jonathan Sheffield, Willian van’t Hoff, Phobe McCracken, Meredith Young, Jasmin Board, Emma Mart, Cameron Knott, Julie Smith, Catherine Boschert, Julia Affleck, Mahesh Ramanan, Ramsy D’Souza, Kelsey Pateman, Arif Shakih, Winston Cheung, Mark Kol, Helen Wong, Asim Shah, Atul Wagh, Joanne Simpson, Graeme Duke, Peter Chan, Brittney Cartner, Stephanie Hunter, Russell Laver, Tapaswi Shrestha, Adrian Regli, Annamaria Pellicano, James McCullough, Mandy Tallott, Nikhil Kumar, Rakshit Panwar, Gail Brinkerhoff, Cassandra Koppen, Federica Cazzola, Matthew Brain, Sarah Mineall, Roy Fischer, Vishwanath Biradar, Natalie Soar, Hayden White, Kristen Estensen, Lynette Morrison, Joanne Smith, Melanie Cooper, Monash Health, Yahya Shehabi, Wisam Al-Bassam, Amanda Hulley, Christina Whitehead, Julie Lowrey, Rebecca Gresha, James Walsham, Jason Meyer, Meg Harward, Ellen Venz, Patricia Williams, Catherine Kurenda, Kirsy Smith, Margaret Smith, Rebecca Garcia, Deborah Barge, Deborah Byrne, Kathleen Byrne, Alana Driscoll, Louise Fortune, Pierre Janin, Elizabeth Yarad, Naomi Hammond, Frances Bass, Angela Ashelford, Sharon Waterson, Steve Wedd, Robert McNamara, Heidi Buhr, Jennifer Coles, Sacha Schweikert, Bradley Wibrow, Rashmi Rauniyar, Erina Myers, Ed Fysh, Ashlish Dawda, Bhaumik Mevavala, Ed Litton, Janet Ferrier, Priya Nair, Hergen Buscher, Claire Reynolds, John Santamaria, Leanne Barbazza, Jennifer Homes, Roger Smith, Lauren Murray, Jane Brailsford, Loretta Forbes, Teena Maguire, Vasanth Mariappa, Judith Smith, Scott Simpson, Matthew Maiden, Allsion Bone, Michelle Horton, Tania Salerno, Martin Sterba, Wenli Geng, Pieter Depuydt, Jan De Waele, Liesbet De Bus, Jan Fierens, Stephanie Bracke, Brenda Reeve, William Dechert, Michaël Chassé, François Martin Carrier, Dounia Boumahni, Fatna Benettaib, Ali Ghamraoui, David Bellemare, Ève Cloutier, Charles Francoeur, François Lamontagne, Frédérick D’Aragon, Elaine Carbonneau, Julie Leblond, Gloria Vazquez-Grande, Nicole Marten, Maggie Wilson, Martin Albert, Karim Serri, Alexandros Cavayas, Mathilde Duplaix, Virginie Williams, Bram Rochwerg, Tim Karachi, Simon Oczkowski, John Centofanti, Tina Millen, Erick Duan, Jennifer Tsang, Lisa Patterson, Shane English, Irene Watpool, Rebecca Porteous, Sydney Miezitis, Lauralyn McIntyre, Laurent Brochard, Karen Burns, Gyan Sandhu, Imrana Khalid, Alexandra Binnie, Elizabeth Powell, Alexandra McMillan, Tracy Luk, Noah Aref, Zdravko Andric, Sabina Cviljevic, Renata Đimoti, Marija Zapalac, Gordan Mirković, Bruno Baršić, Marko Kutleša, Viktor Kotarski, Ana Vujaklija Brajković, Jakša Babel, Helena Sever, Lidija Dragija, Ira Kušan, Suvi Vaara, Leena Pettilä, Jonna Heinonen, Anne Kuitunen, Sari Karlsson, Annukka Vahtera, Heikki Kiiski, Sanna Ristimäki, Amine Azaiz, Cyril Charron, Mathieu Godement, Guillaume Geri, Antoine Vieillard-Baron, Franck Pourcine, Mehran Monchi, David Luis, Romain Mercier, Anne Sagnier, Nathalie Verrier, Cecile Caplin, Shidasp Siami, Christelle Aparicio, Sarah Vautier, Asma Jeblaoui, Muriel Fartoukh, Laura Courtin, Vincent Labbe, Cécile Leparco, Grégoire Muller, Mai-Anh Nay, Toufik Kamel, Dalila Benzekri, Sophie Jacquier, Emmanuelle Mercier, Delphine Chartier, Charlotte Salmon, PierreFrançois Dequin, Francis Schneider, Guillaume Morel, Sylvie L’Hotellier, Julio Badie, Fernando Daniel Berdaguer, Sylvain Malfroy, Chaouki Mezher, Charlotte Bourgoin, Bruno Megarbane, Sebastian Voicu, Nicolas Deye, Isabelle Malissin, Laetitia Sutterlin, Christophe Guitton, Cédric Darreau, Mickaël Landais, Nicolas Chudeau, Alain Robert, Pierre Moine, Nicholas Heming, Virginie Maxime, Isabelle Bossard, Tiphaine Barbarin Nicholier, Gwenhael Colin, Vanessa Zinzoni, Natacham Maquigneau, André Finn, Gabriele Kreß, Uwe Hoff, Carl Friedrich Hinrichs, Jens Nee, Mathias Pletz, Stefan Hagel, Juliane Ankert, Steffi Kolanos, Frank Bloos, Sirak Petros, Bastian Pasieka, Kevin Kunz, Peter Appelt, Bianka Schütze, Stefan Kluge, Axel Nierhaus, Dominik Jarczak, Kevin Roedl, Dirk Weismann, Anna Frey, Vivantes Klinikum Neukölln, Lorenz Reill, Michael Distler, Astrid Maselli, János Bélteczki, István Magyar, Ágnes Fazekas, Sándor Kovács, Viktória Szőke, Gábor Szigligeti, János Leszkoven, Daniel Collins, Patrick Breen, Stephen Frohlich, Ruth Whelan, Bairbre McNicholas, Michael Scully, Siobhan Casey, Maeve Kernan, Peter Doran, Michael O’Dywer, Michelle Smyth, Leanne Hayes, Oscar Hoiting, Marco Peters, Els Rengers, Mirjam Evers, Anton Prinssen, Jeroen Bosch Ziekenhuis, Koen Simons, Wim Rozendaal, F Polderman, P de Jager, M Moviat, A Paling, A Salet, Emma Rademaker, Anna Linda Peters, E de Jonge, J Wigbers, E Guilder, M Butler, Keri-Anne Cowdrey, Lynette Newby, Yan Chen, Catherine Simmonds, Rachael McConnochie, Jay Ritzema Carter, Seton Henderson, Kym Van Der Heyden, Jan Mehrtens, Tony Williams, Alex Kazemi, Rima Song, Vivian Lai, Dinu Girijadevi, Robert Everitt, Robert Russell, Danielle Hacking, Ulrike Buehner, Erin Williams, Troy Browne, Kate Grimwade, Jennifer Goodson, Owen Keet, Owen Callender, Robert Martynoga, Kara Trask, Amelia Butler, Livia Schischka, Chelsea Young, Eden Lesona, Shaanti Olatunji, Yvonne Robertson, Nuno José, Teodoro Amaro dos Santos Catorze, Tiago Nuno Alfaro de Lima Pereira, Lucilia Maria Neves Pessoa, Ricardo Manuel Castro Ferreira, Joana Margarida Pereira Sousa Bastos, Simin Aysel Florescu, Delia Stanciu, Miahela Florentina Zaharia, Alma Gabriela Kosa, Daniel Codreanu, Yaseen Marabi, Eman Al Qasim, Mohamned Moneer Hagazy, Lolowa Al Swaidan, Hatim Arishi, Rosana Muñoz-Bermúdez, Judith Marin-Corral, Anna Salazar Degracia, Francisco Parrilla Gómez, Maria Isabel Mateo López, Jorge Rodriguez Fernandez, Sheila Cárcel Fernández, Rosario Carmona Flores, Rafael León López, Carmen de la Fuente Martos, Angela Allan, Petra Polgarova, Neda Farahi, Stephen McWilliam, Daniel Hawcutt, Laura Rad, Laura O’Malley, Jennifer Whitbread, Olivia Kelsall, Laura Wild, Jessica Thrush, Hannah Wood, Karen Austin, Adrian Donnelly, Martin Kelly, Sinéad O’Kane, Declan McClintock, Majella Warnock, Paul Johnston, Linda Jude Gallagher, Clare Mc Goldrick, Moyra Mc Master, Anna Strzelecka, Rajeev Jha, Michael Kalogirou, Christine Ellis, Vinodh Krishnamurthy, Vashish Deelchand, Jon Silversides, Peter McGuigan, Kathryn Ward, Aisling O’Neill, Stephanie Finn, Barbara Phillips, Dee Mullan, Laura Oritz-Ruiz de Gordoa, Matthew Thomas, Katie Sweet, Lisa Grimmer, Rebekah Johnson, Jez Pinnell, Matt Robinson, Lisa Gledhill, Tracy Wood, Matt Morgan, Jade Cole, Helen Hill, Michelle Davies, David Antcliffe, Maie Templeton, Roceld Rojo, Phoebe Coghlan, Joanna Smee, Euan Mackay, Jon Cort, Amanda Whileman, Thomas Spencer, Nick Spittle, Vidya Kasipandian, Amit Patel, Suzanne Allibone, Roman Mary Genetu, Mohamed Ramali, Alison Ghosh, Peter Bamford, Emily London, Kathryn Cawley, Maria Faulkner, Helen Jeffrey, Tim Smith, Chris Brewer, Jane Gregory, James Limb, Amanda Cowton, Julie O’Brien, Nikitas Nikitas, Colin Wells, Liana Lankester, Mark Pulletz, Patricia Williams, Jenny Birch, Sophie Wiseman, Sarah Horton, Ana Alegria, Salah Turki, Tarek Elsefi, Nikki Crisp, Louise Allen, Iain McCullagh, Philip Robinson, Carole Hays, Maite Babio-Galan, Hannah Stevenson, Divya Khare, Meredith Pinder, Selvin Selvamoni, Amitha Gopinath, Richard Pugh, Daniel Menzies, Callum Mackay, Elizabeth Allan, Gwyneth Davies, Kathryn Puxty, Claire McCue, Susanne Cathcart, Naomi Hickey, Jane Ireland, Hakeem Yusuff, Graziella Isgro, Chris Brightling, Michelle Bourne, Michelle Craner, Malcolm Watters, Rachel Prout, Louisa Davies, Suzannah Pegler, Lynsey Kyeremeh, Gill Arbane, Karen Wilson, Linda Gomm, Federica Francia, Stephen Brett, Sonia Sousa Arias, Rebecca Elin Hall, Joanna Budd, Charlotte Small, Janine Birch, Emma Collins, Jeremy Henning, Stephen Bonner, Keith Hugill, Emanuel Cirstea, Dean Wilkinson, Michal Karlikowski, Helen Sutherland, Elva Wilhelmsen, Jane Woods, Julie North, Dhinesh Sundaran, Laszlo Hollos, Susan Coburn, Joanne Walsh, Margaret Turns, Phil Hopkins, John Smith, Harriet Noble, Maria Theresa Depante, Emma Clarey, Shondipon Laha, Mark Verlander, Alexandra Williams, Abby Huckle, Andrew Hall, Jill Cooke, Caroline Gardiner-Hill, Carolyn Maloney, Hafiz Qureshi, Neil Flint, Sarah Nicholson, Sara Southin, Andrew Nicholson, Barbara Borgatta, Ian Turner-Bone, Amie Reddy, Laura Wilding, Loku Chamara Warnapura, Ronan Agno Sathianathan, David Golden, Ciaran Hart, Jo Jones, Jonathan Bannard-Smith, Joanne Henry, Katie Birchall, Fiona Pomeroy, Rachael Quayle, Arystarch Makowski, Beata Misztal, Iram Ahmed, Thyra KyereDiabour, Kevin Naiker, Richard Stewart, Esther Mwaura, Louise Mew, Lynn Wren, Felicity Willams, Richard Innes, Patricia Doble, Joanne Hutter, Charmaine Shovelton, Benjamin Plumb, Tamas Szakmany, Vincent Hamlyn, Nancy Hawkins, Sarah Lewis, Amanda Dell, Shameer Gopal, Saibal Ganguly, Andrew Smallwood, Nichola Harris, Stella Metherell, Juan Martin Lazaro, Tabitha Newman, Simon Fletcher, Jurgens Nortje, Deirdre Fottrell-Gould, Georgina Randell, Mohsin Zaman, Einas Elmahi, Andrea Jones, Kathryn Hall, Gary Mills, Kim Ryalls, Helen Bowler, Jas Sall, Richard Bourne, Zoe Borrill, Tracey Duncan, Thomas Lamb, Joanne Shaw, Claire Fox, Jeronimo Moreno Cuesta, Kugan Xavier, Dharam Purohit, Munzir Elhassan, Dhanalakshmi Bakthavatsalam, Matthew Rowland, Paula Hutton, Archana Bashyal, Neil Davidson, Clare Hird, Manish Chhablani, Gunjan Phalod, Amy Kirkby, Simon Archer, Kimberley Netherton, Henrik Reschreiter, Julie Camsooksai, Sarah Patch, Sarah Jenkins, David Pogson, Steve Rose, Zoe Daly, Lutece Brimfield, Helen Claridge, Dhruv Parekh, Colin Bergin, Michelle Bates, Joanne Dasgin, Christopher McGhee, Malcolm Sim, Sophie Kennedy Hay, Steven Henderson, Mandeep-Kaur Phull, Abbas Zaidi, Tatiana Pogreban, Lace Paulyn Rosaroso, Daniel Harvey, Benjamin Lowe, Megan Meredith, Lucy Ryan, Anil Hormis, Rachel Walker, Dawn Collier, Sarah Kimpton, Susan Oakley, Kevin Rooney, Natalie Rodden, Emma Hughes, Nicola Thomson, Deborah McGlynn, Andrew Walden, Nicola Jacques, Holly Coles, Emma Tilney, Emma Vowell, Martin Schuster-Bruce, Sally Pitts, Rebecca Miln, Laura Purandare, Luke Vamplew, Michael Spivey, Sarah Bean, Karen Burt, Lorraine Moore, Christopher Day, Charly Gibson, Elizabeth Gordon, Letizia Zitter, Samantha Keenan, Evelyn Baker, Shiney Cherian, Sean Cutler, Anna Roynon-Reed, Kate Harrington, Ajay Raithatha, Kris Bauchmuller, Norfaizan Ahmad, Irina Grecu, Dawn Trodd, Jane Martin, Caroline Wrey Brown, Ana-Marie Arias, Thomas Craven, David Hope, Jo Singleton, Sarah Clark, Nicola Rae, Ingeborg Welters, David Oliver Hamilton, Karen Williams, Victoria Waugh, David Shaw, Zudin Puthucheary, Timothy Martin, Filipa Santos, Ruzena Uddin, Alastair Somerville, Kate Colette Tatham, Shaman Jhanji, Ethel Black, Arnold Dela Rosa, Ryan Howle, Redmond Tully, Andrew Drummond, Joy Dearden, Jennifer Philbin, Sheila Munt, Alain Vuylsteke, Charles Chan, Saji Victor, Ramprasad Matsa, Minerva Gellamucho, Ben Creagh-Brown, Joe Tooley, Laura Montague, Fiona De Beaux, Laetitia Bullman, Ian Kersiake, Carrie Demetriou, Sarah Mitchard, Lidia Ramos, Katie White, Phil Donnison, Maggie Johns, Ruth Casey, Lehentha Mattocks, Sarah Salisbury, Paul Dark, Andrew Claxton, Danielle McLachlan, Kathryn Slevin, Stephanie Lee, Jonathan Hulme, Sibet Joseph, Fiona Kinney, Ho Jan Senya, Aneta Oborska, Abdul Kayani, Bernard Hadebe, Rajalakshmi Orath Prabakaran, Lesley Nichols, Matt Thomas, Ruth Worner, Beverley Faulkner, Emma Gendall, Kati Hayes, Colin Hamilton-Davies, Carmen Chan, Celina Mfuko, Hakam Abbass, Vineela Mandadapu, Susannah Leaver, Daniel Forton, Kamal Patel, Elankumaran Paramasivam, Matthew Powell, Richard Gould, Elizabeth Wilby, Clare Howcroft, Dorota Banach, Ziortza Fernández de Pinedo Artaraz, Leilani Cabreros, Ian White, Maria Croft, Nicky Holland, Rita Pereira, Ahmed Zaki, David Johnson, Matthew Jackson, Hywel Garrard, Vera Juhaz, Alistair Roy, Anthony Rostron, Lindsey Woods, Sarah Cornell, Suresh Pillai, Rachel Harford, Tabitha Rees, Helen Ivatt, Ajay Sundara Raman, Miriam Davey, Kelvin Lee, Russell Barber, Manish Chablani, Farooq Brohi, Vijay Jagannathan, Michele Clark, Sarah Purvis, Bill Wetherill, Ahilanandan Dushianthan, Rebecca Cusack, Kim de Courcy-Golder, Simon Smith, Susan Jackson, Ben Attwood, Penny Parsons, Valerie Page, Xiao Bei Zhao, Deepali Oza, Jonathan Rhodes, Tom Anderson, Sheila Morris, Charlotte Xia Le Tai, Amy Thomas, Alexandra Keen, Stephen Digby, Nicholas Cowley, Laura Wild, David Southern, Harsha Reddy, Andy Campbell, Claire Watkins, Sara Smuts, Omar Touma, Nicky Barnes, Peter Alexander, Tim Felton, Susan Ferguson, Katharine Sellers, Joanne Bradley-Potts, David Yates, Isobel Birkinshaw, Kay Kell, Nicola Marshall, Lisa Carr-Knott, Charlotte Summers,

<h4>Importance</h4>Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited.<h4>Objective</h4>To determine whether hydrocortisone improves outcome for patients with severe COVID-19.<h4>Design, setting, and participants</h4>An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, ... Read more >>

JAMA (JAMA)
[2020, 324(13):1317-1329]

Cited: 167 times

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Physical restraint of patients in Australia and New Zealand intensive care units.

Matthew J Maiden, Allison Bone, Megan Fitzpatrick, ,

Intensive Care Med (Intensive care medicine)
[2021, 47(2):234-236]

Cited: 0 times

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Avoidance of Routine Endotracheal Suction in Subjects Ventilated for ≤ 12 Hours Following Elective Cardiac Surgery.

Eileen Gilder, Shay P McGuinness, Alana Cavadino, Andrew Jull, Rachael L Parke,

<h4>Background</h4>Mechanical ventilation requires an endotracheal tube. Airway management includes endotracheal suctioning, a frequent procedure for patients in the ICU. Associated risks of endotracheal suctioning include hypoxia, atelectasis, and infection. There is currently no evidence about the safety of avoiding endotracheal suction. We aimed to assess the safety of avoiding endotracheal ... Read more >>

Respir Care (Respiratory care)
[2020, 65(12):1838-1846]

Cited: 0 times

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Conservative oxygen therapy for mechanically ventilated adults with suspected hypoxic ischaemic encephalopathy.

Paul Young, Diane Mackle, Rinaldo Bellomo, Michael Bailey, Richard Beasley, Adam Deane, Glenn Eastwood, Simon Finfer, Ross Freebairn, Victoria King, Natalie Linke, Edward Litton, Colin McArthur, Shay McGuinness, Rakshit Panwar, ,

<h4>Purpose</h4>Liberal use of oxygen may contribute to secondary brain injury in patients with hypoxic-ischaemic encephalopathy (HIE). However, there are limited data on the effect of different oxygen regimens on survival and neurological disability in HIE patients.<h4>Methods</h4>We undertook a post-hoc analysis of the 166 patients with suspected HIE enrolled in a ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(12):2411-2422]

Cited: 3 times

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A minimal common outcome measure set for COVID-19 clinical research.

,

Clinical research is necessary for an effective response to an emerging infectious disease outbreak. However, research efforts are often hastily organised and done using various research tools, with the result that pooling data across studies is challenging. In response to the needs of the rapidly evolving COVID-19 outbreak, the Clinical ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, 20(8):e192-e197]

Cited: 161 times

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The perceived barriers and facilitators to implementation of ECMO services in acute hospitals.

Bentley J Fulcher, Angus J Nicholson, Natalie J Linke, Danielle Berkovic, Carol L Hodgson, ,

Intensive Care Med (Intensive care medicine)
[2020, 46(11):2115-2117]

Cited: 0 times

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A survey of extracorporeal membrane oxygenation practice in 23 Australian adult intensive care units.

Natalie J Linke, Bentley J Fulcher, Daniel M Engeler, Shannah Anderson, Michael J Bailey, Stephen Bernard, Jasmin V Board, Daniel Brodie, Heidi Buhr, Aidan J C Burrell, David J Cooper, Eddy Fan, John F Fraser, David J Gattas, Alisa M Higgins, Ingrid K Hopper, Sue Huckson, Edward Litton, Shay P McGuinness, Priya Nair, Neil Orford, Rachael L Parke, Vincent A Pellegrino, David V Pilcher, Jayne Sheldrake, Benjamin A J Reddi, Dion Stub, Tony V Trapani, Andrew A Udy, Carol L Hodgson, ,

Crit Care Resusc (Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine)
[2020, 22(2):166-170]

Cited: 0 times

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Study protocol and statistical analysis plan for the Liberal Glucose Control in Critically Ill Patients with Pre-existing Type 2 Diabetes (LUCID) trial.

Alexis P Poole, Mark E Finnis, James Anstey, Rinaldo Bellomo, Shailesh Bihari, Vishwanath Biradar, Sarah Doherty, Glenn Eastwood, Simon Finfer, Craig J French, Angaj Ghosh, Simon Heller, Michael Horowitz, Palash Kar, Peter S Kruger, Matthew J Maiden, Johan Mårtensson, Colin J McArthur, Shay P McGuinness, Paul J Secombe, Antony E Tobin, Andrew A Udy, Paul J Young, Adam M Deane, , ,

BACKGROUND:Contemporary glucose management of intensive care unit (ICU) patients with type 2 diabetes is based on trial data derived predominantly from patients without type 2 diabetes. This is despite the recognition that patients with type 2 diabetes may be relatively more tolerant of hyperglycaemia and more susceptible to hypoglycaemia. It ... Read more >>

Crit Care Resusc (Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine)
[2020, 22(2):133-141]

Cited: 2 times

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Health-related quality of life in survivors of septic shock: 6-month follow-up from the ADRENAL trial.

Naomi E Hammond, Simon R Finfer, Qiang Li, Colman Taylor, Jeremy Cohen, Yaseen Arabi, Rinaldo Bellomo, Laurent Billot, Meg Harward, Christopher Joyce, Colin McArthur, John Myburgh, Anders Perner, Dorrilyn Rajbhandari, Andrew Rhodes, Kelly Thompson, Steve Webb, Balasubramanian Venkatesh, ,

<h4>Purpose</h4>To investigate the impact of hydrocortisone treatment and illness severity on health-related quality of life (HRQoL) at 6 months in septic shock survivors from the ADRENAL trial.<h4>Methods</h4>Using the EuroQol questionnaire (EQ-5D-5L) at 6 months after randomization we assessed HRQoL in patient subgroups defined by hydrocortisone or placebo treatment, gender, illness severity (APACHE II < or ≥ 25), ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(9):1696-1706]

Cited: 2 times

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