Full Text Journal Articles by
Author Shaun Blake

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Oncogene-induced senescence: From biology to therapy.

Haoran Zhu, Shaun Blake, Frances K Kusuma, Richard B Pearson, Jian Kang, Keefe T Chan,

Oncogene-induced senescence (OIS) is a powerful intrinsic tumor-suppressive mechanism, arresting cell cycle progression upon oncogene-activating genomic alterations. The discovery and characterization of the senescence-associated secretome unveiled a rich additional complexity to the senescence phenotype, including extrinsic impacts on the microenvironment and engagement of the immune response. Emerging evidence suggests that ... Read more >>

Mech. Ageing Dev. (Mechanisms of ageing and development)
[2020, 187:111229]

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A functional genetic screen defines the AKT-induced senescence signaling network.

Keefe T Chan, Shaun Blake, Haoran Zhu, Jian Kang, Anna S Trigos, Piyush B Madhamshettiwar, Jeannine Diesch, Lassi Paavolainen, Peter Horvath, Ross D Hannan, Amee J George, Elaine Sanij, Katherine M Hannan, Kaylene J Simpson, Richard B Pearson,

Exquisite regulation of PI3K/AKT/mTORC1 signaling is essential for homeostatic control of cell growth, proliferation, and survival. Aberrant activation of this signaling network is an early driver of many sporadic human cancers. Paradoxically, sustained hyperactivation of the PI3K/AKT/mTORC1 pathway in nontransformed cells results in cellular senescence, which is a tumor-suppressive mechanism ... Read more >>

Cell Death Differ. (Cell death and differentiation)
[2020, 27(2):725-741]

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Cystathionine β-Synthase in Physiology and Cancer.

Haoran Zhu, Shaun Blake, Keefe T Chan, Richard B Pearson, Jian Kang,

Cystathionine β-synthase (CBS) regulates homocysteine metabolism and contributes to hydrogen sulfide (H2S) biosynthesis through which it plays multifunctional roles in the regulation of cellular energetics, redox status, DNA methylation, and protein modification. Inactivating mutations in CBS contribute to the pathogenesis of the autosomal recessive disease CBS-deficient homocystinuria. Recent studies demonstrating ... Read more >>

Biomed Res Int (BioMed research international)
[2018, 2018:3205125]

Cited: 2 times

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