Full Text Journal Articles by
Author Shantibhusan Senapati

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Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host factors having implication in the disease pathogenesis and severity.

Voddu Suresh, Varshasnata Mohanty, Kiran Avula, Arup Ghosh, Bharati Singh, Rajendra Kumar Reddy, Deepti Parida, Amol Ratnakar Suryawanshi, Sunil Kumar Raghav, Soma Chattopadhyay, Punit Prasad, Rajeeb Kumar Swain, Rupesh Dash, Ajay Parida, Gulam Hussain Syed, Shantibhusan Senapati,

Syrian golden hamsters (Mesocricetus auratus) infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) manifests lung pathology. In this study, efforts were made to check the infectivity of a local SARS-CoV-2 isolate in a self-limiting and non-lethal hamster model and evaluate the differential expression of lung proteins during acute infection ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21713]

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Fusogenic Viral Protein-Based Near-Infrared Active Nanocarriers for Biomedical Imaging.

Suman Bishnoi, Anshu Kumari, Sheeba Rehman, Aliva Minz, Shantibhusan Senapati, Debasis Nayak, Sharad Gupta,

An effective drug delivery system (DDS) relies on an efficient cellular uptake and faster intracellular delivery of theranostic agents, bypassing the endosomal mediated degradation of the payload. The use of viral nanoparticles (VNPs) permits such advancement, as the viruses are naturally evolved to infiltrate the host cells to deliver their ... Read more >>

ACS Biomater Sci Eng (ACS biomaterials science & engineering)
[2021, :]

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Corrigendum to 'Overlapping targets exist between the Par-4 and miR-200c axis which regulate EMT and proliferation of pancreatic cancer cells' [Translational Oncology 14 (2021) 100879].

Archana Katoch, Vijay Lakshmi Jamwal, Mir Mohd Faheem, Sriram Kumar, Shantibhusan Senapati, Govind Yadav, Sumit G Gandhi, Anindya Goswami,

Transl Oncol (Translational oncology)
[2021, 14(8):101136]

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The Hha-TomB toxin-antitoxin module in Salmonella enterica serovar Typhimurium limits its intracellular survival profile and regulates host immune response.

Prajita Paul, Paritosh Patel, Suresh K Verma, Pragyan Mishra, Bikash R Sahu, Pritam Kumar Panda, Gajraj Singh Kushwaha, Shantibhusan Senapati, Namrata Misra, Mrutyunjay Suar,

The key to bacterial virulence relies on an exquisite balance of signals between microbe and hosts. Bacterial toxin-antitoxin (TA) system is known to play a vital role in response to stress adaptation, drug resistance, biofilm formation, intracellular survival, persistence as well as pathogenesis. In the present study, we investigated the ... Read more >>

Cell Biol Toxicol (Cell biology and toxicology)
[2021, :]

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Molecular detection of Theileria annulata infection in cattle by conventional PCR and quantitative real time PCR in India.

Ahmed Magdy Selim, Manoranjan Das, Santosh Kumar Senapati, Geeta Rani Jena, Chinmoy Mishra, Indramani Nath, Shantibhusan Senapati, Manisha Sethi,

<i>Theileria annulata</i> (<i>T. annulata</i>) is a tick-borne apicomplexan parasite that affects bovine. It is endemic in many tropical and subtropics areas, including Odisha, India. The objective of this study is to identify <i>T. annulata</i> infection in the peripheral blood of cattle as a biological sample by conventional PCR (cPCR) and ... Read more >>

J Parasit Dis (Journal of parasitic diseases : official organ of the Indian Society for Parasitology)
[2021, 45(1):72-77]

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Overlapping targets exist between the Par-4 and miR-200c axis which regulate EMT and proliferation of pancreatic cancer cells.

Archana Katoch, Vijay Lakshmi Jamwal, Mir Mohd Faheem, Sriram Kumar, Shantibhusan Senapati, Govind Yadav, Sumit G Gandhi, Anindya Goswami,

The last decade has witnessed a substantial expansion in the field of microRNA (miRNA) biology, providing crucial insights into the role of miRNAs in disease pathology, predominantly in cancer progression and its metastatic spread. The discovery of tumor-suppressing miRNAs represents a potential approach for developing novel therapeutics. In this context, ... Read more >>

Transl Oncol (Translational oncology)
[2021, 14(1):100879]

Cited: 1 time

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Immunological and functional aspects of MAGEA3 cancer/testis antigen.

Biswajit Das, Shantibhusan Senapati,

Identification of ectopic gene activation in cancer cells serves as a basis for both gene signature-guided tumor targeting and unearthing of oncogenic mechanisms to expand the understanding of tumor biology/oncogenic process. Proteins expressed only in germ cells of testis and/or placenta (immunoprivileged organs) and in malignancies are called cancer testis ... Read more >>

Adv Protein Chem Struct Biol (Advances in protein chemistry and structural biology)
[2021, 125:121-147]

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Escherichia coli, a common constituent of benign prostate hyperplasia-associated microbiota induces inflammation and DNA damage in prostate epithelial cells.

Sumeet Jain, Ajit Gopal Samal, Biswajit Das, Biswaranjan Pradhan, Nilanjan Sahu, Debasish Mohapatra, Prativa Kumari Behera, Partha Sarathi Satpathi, Akshaya K Mohanty, Sanghamitra Satpathi, Shantibhusan Senapati,

<h4>Background</h4>The role of microbiota in the pathophysiology of benign prostate hyperplasia (BPH), especially in creating an inflammatory milieu may not be avoided. The major objectives of this study were to investigate the microbial composition of BPH tissues, its association with inflammation and check the effect of clinically isolated bacteria on ... Read more >>

Prostate (The Prostate)
[2020, 80(15):1341-1352]

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Tissue distribution of ACE2 protein in Syrian golden hamster (Mesocricetus auratus) and its possible implications in SARS-CoV-2 related studies

Voddu Suresh, Deepti Parida, Aliva Minz, Shantibhusan Senapati,

Recently, the Syrian golden hamster ( Mesocricetus auratus ) has been demonstrated as a clinically relevant animal model for SARS-CoV-2 infection. However, lack of knowledge about the tissue-specific expression pattern of various proteins in these animals and the unavailability of reagents like antibodies against this species hampers optimal use of ... Read more >>

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Tissue Distribution of ACE2 Protein in Syrian Golden Hamster (Mesocricetus auratus) and Its Possible Implications in SARS-CoV-2 Related Studies.

Voddu Suresh, Deepti Parida, Aliva P Minz, Manisha Sethi, Bhabani S Sahoo, Shantibhusan Senapati,

The Syrian golden hamster (<i>Mesocricetus auratus</i>) has recently been demonstrated as a clinically relevant animal model for SARS-CoV-2 infection. However, lack of knowledge about the tissue-specific expression pattern of various proteins in these animals and the unavailability of reagents like antibodies against this species hampers these models' optimal use. The ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:579330]

Cited: 2 times

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Macrophage migration inhibitory factor of Syrian golden hamster shares structural and functional similarity with human counterpart and promotes pancreatic cancer.

Voddu Suresh, Rajivgandhi Sundaram, Pujarini Dash, Surendra Chandra Sabat, Debasish Mohapatra, Sneha Mohanty, Dileep Vasudevan, Shantibhusan Senapati,

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that increasingly is being studied in cancers and inflammatory diseases. Though murine models have been instrumental in understanding the functional role of MIF in different pathological conditions, the information obtained from these models is biased towards a specific species. In experimental ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):15507]

Cited: 2 times

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Probiotics L. acidophilus and B. clausii Modulate Gut Microbiota in Th1- and Th2-Biased Mice to Ameliorate Salmonella Typhimurium-Induced Diarrhea.

Biswaranjan Pradhan, Dipanjan Guha, Aman Kumar Naik, Arka Banerjee, Subodh Tambat, Saurabh Chawla, Shantibhusan Senapati, Palok Aich,

Gut microbiota play important role in maintaining health. Probiotics are believed to augment it further. We aimed at comparing effects of probiotics, Lactobacillus acidophilus (LA) and Bacillus clausii (BC) (a) on the gut microbiota abundance and diversity and (b) their contributions to control intestinal dysbiosis and inflammation in Th1- and ... Read more >>

Probiotics Antimicrob Proteins (Probiotics and antimicrobial proteins)
[2019, 11(3):887-904]

Cited: 8 times

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CID-6033590 inhibits p38MAPK pathway and induces S-phase cell cycle arrest and apoptosis in DU145 and PC-3 cells.

Guru Prasad Sharma, Sumiran Kumar Gurung, Afreen Inam, Lokesh Nigam, Archana Bist, Debasish Mohapatra, Shantibhusan Senapati, Naidu Subbarao, Amir Azam, Neelima Mondal,

Metastatic prostate cancer, with no effective treatment, is among the leading causes of cancer-associated deaths in men. Overexpression of p38αMAPK has been observed in neuroendocrine prostate cancer patients and in both DU145 and PC-3 cell lines and represents a good drug target. Sulfonamide derivatives have shown biological activities against many ... Read more >>

Toxicol In Vitro (Toxicology in vitro : an international journal published in association with BIBRA)
[2019, 60:420-436]

Cited: 1 time

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Macrophage migration inhibitory factor of Syrian golden hamster has similar structure and function as human MIF and promotes pancreatic tumor growth

Pujarini Dash, Rajivgandhi Sundaram, Voddu Suresh, Surendra Chandra Sabat, Debasish Mohapatra, Sneha Mohanty, Dileep Vasudevan, Shantibhusan Senapati,

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that increasingly is being studied in cancers and inflammatory diseases. Though murine models have been instrumental in understanding the functional role of MIF in different pathological conditions, the information obtained from these models is biased towards a specific species. In experimental ... Read more >>

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Lipopolysaccharide (LPS) enhances prostate cancer metastasis potentially through NF-κB activation and recurrent dexamethasone administration fails to suppress it in vivo.

Sumeet Jain, Pujarini Dash, Aliva P Minz, Sanghamitra Satpathi, Ajit G Samal, Prativa K Behera, Partha S Satpathi, Shantibhusan Senapati,

<h4>Background</h4>Previous studies have shown the effect of bacterial lipopolysaccharide (LPS) on enhanced cancer cells' growth and metastasis. However, the effect of LPS on prostate cancer (PCa) cells metastasis has not been investigated in details. This study aimed to investigate the functional role of LPS on PCa cells metastasis and determine ... Read more >>

Prostate (The Prostate)
[2019, 79(2):168-182]

Cited: 2 times

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TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy.

Kautilya Kumar Jena, Srinivasa Prasad Kolapalli, Subhash Mehto, Parej Nath, Biswajit Das, Pradyumna Kumar Sahoo, Abdul Ahad, Gulam Hussain Syed, Sunil K Raghav, Shantibhusan Senapati, Swati Chauhan, Santosh Chauhan,

Sequestration of protein aggregates in inclusion bodies and their subsequent degradation prevents proteostasis imbalance, cytotoxicity, and proteinopathies. The underlying molecular mechanisms controlling the turnover of protein aggregates are mostly uncharacterized. Herein, we show that a TRIM family protein, TRIM16, governs the process of stress-induced biogenesis and degradation of protein aggregates. ... Read more >>

EMBO J (The EMBO journal)
[2018, 37(18):]

Cited: 25 times

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Possible Autocrine Function of Galectin-3 in Pancreatic Stellate Cells.

Pujarini Dash, Aliva Prity Minz, Shantibhusan Senapati,

Gastroenterology (Gastroenterology)
[2018, 155(3):933-934]

Cited: 1 time

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Iron(III) Coordinated Polymeric Nanomaterial: A Next-Generation Theranostic Agent for High-Resolution T1-Weighted Magnetic Resonance Imaging and Anticancer Drug Delivery.

Diptendu Patra, Saikat Mukherjee, Ipsita Chakraborty, Tapan K Dash, Shantibhusan Senapati, Rangeet Bhattacharyya, Raja Shunmugam,

Theranostic-based nanomedicine plays a crucial role in the field of cancer therapy. This is due to having the capability to combine both therapy and diagnosis together in a single system. Herein a new class of metal-ligand-based nanocarrier in a norbornene backbone has been designed as a theranostic system. Fe<sup>3+</sup>-terpyridine complex ... Read more >>

ACS Biomater Sci Eng (ACS biomaterials science & engineering)
[2018, 4(5):1738-1749]

Cited: 0 times

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Dual role of Par-4 in abrogation of EMT and switching on Mesenchymal to Epithelial Transition (MET) in metastatic pancreatic cancer cells.

Archana Katoch, Sujit Suklabaidya, Souneek Chakraborty, Debasis Nayak, Reyaz U Rasool, Deepak Sharma, Debaraj Mukherjee, Mir M Faheem, Anmol Kumar, Parduman R Sharma, Shantibhusan Senapati, Lekha D Kumar, Anindya Goswami,

Epithelial-mesenchymal transition (EMT) is a critical event that occurs during the invasion and metastatic spread of cancer cells. Here, we conceive a dual mechanism of Par-4-mediated inhibition of EMT and induction of MET in metastatic pancreatic cancer cells. First, we demonstrate that 1,1'-β-D-glucopyranosyl-3,3'-bis(5-bromoindolyl)-octyl methane (NGD16), an N-glycosylated derivative of medicinally ... Read more >>

Mol Carcinog (Molecular carcinogenesis)
[2018, 57(9):1102-1115]

Cited: 6 times

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Nicotine associated breast cancer in smokers is mediated through high level of EZH2 expression which can be reversed by methyltransferase inhibitor DZNepA.

Kanchan Kumari, Biswajit Das, Amit Adhya, Sanjib Chaudhary, Shantibhusan Senapati, Sandip K Mishra,

Recent studies show substantial growth-promoting properties of nicotine (NIC) in cancer, which is a combined outcome of genetic and epigenetic alterations. However, the role of epigenetic modifiers in response to NIC in breast cancer is less studied. In the present study, for the first time we have shown NIC-induced enhanced ... Read more >>

Cell Death Dis (Cell death & disease)
[2018, 9(2):152]

Cited: 6 times

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Experimental models of pancreatic cancer desmoplasia.

Sujit Suklabaidya, Pujarini Dash, Biswajit Das, Voddu Suresh, Prakash K Sasmal, Shantibhusan Senapati,

Desmoplasia is a fibro-inflammatory process and a well-established feature of pancreatic cancer. A key contributor to pancreatic cancer desmoplasia is the pancreatic stellate cell. Various in vitro and in vivo methods have emerged for the isolation, characterization, and use of pancreatic stellate cells in models of cancer-associated fibrosis. In addition ... Read more >>

Lab Invest (Laboratory investigation; a journal of technical methods and pathology)
[2018, 98(1):27-40]

Cited: 9 times

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E2f8 mediates tumor suppression in postnatal liver development.

Lindsey N Kent, Jessica B Rakijas, Shusil K Pandit, Bart Westendorp, Hui-Zi Chen, Justin T Huntington, Xing Tang, Sooin Bae, Arunima Srivastava, Shantibhusan Senapati, Christopher Koivisto, Chelsea K Martin, Maria C Cuitino, Miguel Perez, Julian M Clouse, Veda Chokshi, Neelam Shinde, Raleigh Kladney, Daokun Sun, Antonio Perez-Castro, Ramadhan B Matondo, Sathidpak Nantasanti, Michal Mokry, Kun Huang, Raghu Machiraju, Soledad Fernandez, Thomas J Rosol, Vincenzo Coppola, Kamal S Pohar, James M Pipas, Carl R Schmidt, Alain de Bruin, Gustavo Leone,

E2F-mediated transcriptional repression of cell cycle-dependent gene expression is critical for the control of cellular proliferation, survival, and development. E2F signaling also interacts with transcriptional programs that are downstream of genetic predictors for cancer development, including hepatocellular carcinoma (HCC). Here, we evaluated the function of the atypical repressor genes E2f7 ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2016, 126(8):2955-2969]

Cited: 28 times

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Urinary bladder stone associated with seminal vesicle and prostate infection in a Copenhagen rat.

Shantibhusan Senapati, Sujit Suklabaidya, Hrudananda Mallik, Sabyasachi Panda, Datteswar Hota, Manas R Baisakh,

We report a very rare case of urinary bladder stone in a laboratory rat, which was associated with severe prostatitis and seminal vesiculitis. Importantly, the histopathological analysis revealed the rare variety of keratinizing desquamative squamous metaplasia of bladder, prostate, and seminal vesicle epithelium. Immunohistochemistry for alpha smooth muscle actin protein ... Read more >>

J Nat Sci Biol Med (Journal of natural science, biology, and medicine)
[2016, 7(2):193-197]

Cited: 0 times

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Magnetic Nanoparticles Labeled Mesenchymal Stem Cells: A Pragmatic Solution toward Targeted Cancer Theranostics.

Abhalaxmi Singh, Sumeet Jain, Shantibhusan Senapati, Rama Shanker Verma, Sanjeeb K Sahoo,

Mesenchymal stem cells (MSCs) have gained much interest to be used as targeting vehicle in cancer therapy due to the intrinsic tumor-homing behavior associated with them. In this scenario, superparamagnetic nanoparticles are emerging as an ideal probe for noninvasive cell tracking for different stem cell applications. In the study, it ... Read more >>

Adv Healthc Mater (Advanced healthcare materials)
[2015, 4(14):2078-2089]

Cited: 1 time

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TLR4 activation by lipopolysaccharide confers survival advantage to growth factor deprived prostate cancer cells.

Sumeet Jain, Sujit Suklabaidya, Biswajit Das, Sunil K Raghav, Surinder K Batra, Shantibhusan Senapati,

<h4>Background</h4>Prostate cancer (PCa) cells express Toll-like receptor-4 (TLR4), a known pro-tumorigenic molecule for different cancer cells. The cancer cells residing in the avascular region of the tumor confront various metabolic stresses and continuously adapt mechanisms to overcome them. We hypothesized that TLR4 activation might provide direct survival advantage to metabolically ... Read more >>

Prostate (The Prostate)
[2015, 75(10):1020-1033]

Cited: 15 times

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