Full Text Journal Articles by
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A comprehensive association analysis between homocysteine metabolic pathway gene methylation and ischemic stroke in a Chinese hypertensive population.

Bo Li, Yuying Li, Shan Xu, Hongen Chen, Shudong Dai, Xiaoling Peng, Li Wang, Yaping Liang, Cheng Li, Biwei Tang, Liqing Zhu, Tao Zhang, Chunfang Lv, Changyi Wang, Liyuan Han,

<h4>Background</h4>Ischemic stroke (IS) is a serious global health burden. In order to improve our understanding of the risk factors associated with IS, we investigated the combined effect of the methylation of five genes related to the metabolism of homocysteine on developing IS.<h4>Methods</h4>Quantitative methylation-specific PCR was used to measure the levels ... Read more >>

J Clin Lab Anal (Journal of clinical laboratory analysis)
[2020, :e23689]

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ITPR3 Facilitates Tumor Growth, Metastasis and Stemness by Inducing the NF-ĸB/CD44 Pathway in Urinary Bladder Carcinoma

Mengzhao Zhang, Lu Wang, Yangyang Yue, Lu Zhang, Tianjie Liu, Minxuan Jing, Xiao Liang, Minghai Ma, Shan Xu, Ke Wang, Xinyang Wang, Jinhai Fan,

<h4>Background: </h4> Bladder carcinoma is one of the most common urological cancers. ITPR3, as a ubiquitous endoplasmic reticulum calcium channel protein, was reported to be involved in the development and progression of various types of cancer. However, the potential roles and molecular mechanism of ITPR3 in bladder cancer are still ... Read more >>

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Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors for the treatment of non-small cell lung cancer: a patent review (2014-present).

Xin Sun, Shan Xu, Zunhua Yang, Pengwu Zheng, Wufu Zhu,

<b>Introduction</b>: EGFR is the receptor for epidermal growth factor (EGF) and belongs to the protein tyrosine kinase (PTK) receptor. It is closely related to the inhibition of tumor cell proliferation, invasion, and apoptosis. Overexpression or mutation activation of EGFR is involved in the development of many human malignancies, especially non-small cell ... Read more >>

Expert Opin Ther Pat (Expert opinion on therapeutic patents)
[2020, :1-16]

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Use of Cardiovascular Drugs for Primary and Secondary Prevention of Cardiovascular Disease Among Rural-Dwelling Older Chinese Adults.

Lin Cong, Yifei Ren, Tingting Hou, Xiaolei Han, Yi Dong, Yongxiang Wang, Qinghua Zhang, Rui Liu, Shan Xu, Lidan Wang, Yifeng Du, Chengxuan Qiu,

Cardiovascular risk factors and related disorders are common among older adults, and use of various classes of cardiovascular (CV) drugs could reduce the risk of cardiovascular disease (CVD). However, data are sparse with regard to the use of CV drugs among rural-dwelling older adults in China. Therefore, this population-based study ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:608136]

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Clinical and Imaging Prognosis in Patients with Delayed Encephalopathy after Acute Carbon Monoxide Poisoning.

Jinzhi Liu, Zhihua Si, Jie Liu, Yan Lin, Jing Yuan, Shan Xu, Yan He, Tao Zhang, Aihua Wang,

<h4>Objective</h4>To study the clinical manifestations, magnetic resonance imaging (MRI) findings, and prognosis of delayed encephalopathy after carbon monoxide poisoning (DEACMP).<h4>Methods</h4>The medical records of 20 patients with DEACMP were retrospectively reviewed. All the patients received hyperbaric oxygen treatment and other treatments as necessary.<h4>Results</h4>The patients had diverse clinical manifestations, including memory deficits, ... Read more >>

Behav Neurol (Behavioural neurology)
[2020, 2020:1719360]

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Depletion of insulin-like growth factor 1 receptor increases radiosensitivity in colorectal cancer

Yi Li, Kui Lu, Ben Zhao, Xiaokui Zeng, Shan Xu, Xin Ma, Yunqing Zhi,

<h4>Background</h4> Although radiation therapy for advanced colorectal cancer (CRC) is very effective in some patients, treatment resistance limits its efficacy. Insulin-like growth factor 1 receptor (IGF1R) can affect tumor responsiveness and sensitivity to radiation in several cancer types. Herein, we studied the underlying function of IGF1R in the resistance of ... Read more >>

J Gastrointest Oncol (Journal of gastrointestinal oncology)
[2020, 11(6):1135-1145]

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Does Inconsistent Social Support Matter? The Effects of Social Support on Work Absorption Through Relaxation at Work.

Shan Xu, Youxin Zhang, Bingran Zhang, Tao Qing, Jiafei Jin,

Drawing upon the conservation of resources theory and social exchange theory, we examined the effects of family supportive supervisor behavior (FSSB) and family support (FS) on work absorption at the within- and between-person levels. A 10-day study of 91 workers using 710 observations was employed. At the within-person level, the ... Read more >>

Front Psychol (Frontiers in psychology)
[2020, 11:555501]

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Innovative Method for Amplatzer Device Implantation in Patients With Bronchopleural Fistulas

Jisong Zhang, Huihui Hu, Li Xu, Shan Xu, Jihong Zhu, Fengjie Wu, Enguo Chen,

<h4>Background: </h4> Bronchopleural fistula (BPF) is a relatively rare complication after various types of pulmonary resection. The double-sided mushroom-shaped occluder (Amplatzer device, AD) has been gradually used for BPF blocking due to its reliable blocking effect. We have improved the existing AD implantation methods to facilitate clinical use and named ... Read more >>

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The new opportunities in medicinal chemistry of fourth-generation EGFR inhibitors to overcome C797S mutation.

Jie He, Zhihui Zhou, Xin Sun, Zunhua Yang, Pengwu Zheng, Shan Xu, Wufu Zhu,

Epidermal growth factor receptor (EGFR) is a receptor for epithelial growth factor (EGF) cell proliferation and signaling, which is related to the inhibition of tumor cell proliferation, angiogenesis, tumor invasion, metastasis, and apoptosis. Thus, it has become an important target for the treatment of non-small cell lung cancer (NSCLC). The ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2021, 210:112995]

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Automatic whole cell organelle segmentation in volumetric electron microscopy

Larissa Heinrich, Davis Bennett, David Ackerman, Woohyun Park, John Bogovic, Nils Eckstein, Alyson Petruncio, Jody Clements, Shan Xu, Jan Funke, Wyatt Korff, Harald Hess, Jennifer Lippincott-Schwartz, Stephan Saalfeld, Aubrey Weigel, ,

Cells contain hundreds of different organelle and macromolecular assemblies intricately organized relative to each other to meet any cellular demands. Obtaining a complete understanding of their organization is challenging and requires nanometer-level, threedimensional reconstruction of whole cells. Even then, the immense size of datasets and large number of structures to ... Read more >>

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High resolution 3D imaging of liver reveals a central role for subcellular architectural organization in metabolism

Güneş Parlakgül, Ana Paula Arruda, Erika Cagampan, Song Pang, Ekin Güney, Yankun Lee, Harald Hess, Shan Xu, Gökhan Hotamışlıgil,

Cells display complex intracellular organization through compartmentalization of metabolic processes into organelles, yet neither the resolution of these structures in the native tissue context nor its functional consequences are well understood. Here, we resolved the 3-dimensional organelle structural organization in large (>2.8×10 5 μm 3 ) volumes of intact liver ... Read more >>

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Species richness promotes ecosystem carbon storage: evidence from biodiversity-ecosystem functioning experiments.

Shan Xu, Nico Eisenhauer, Olga Ferlian, Jinlong Zhang, Guoyi Zhou, Xiankai Lu, Chengshuai Liu, Deqiang Zhang,

Plant diversity has a strong impact on a plethora of ecosystem functions and services, especially ecosystem carbon (C) storage. However, the potential context-dependency of biodiversity effects across ecosystem types, environmental conditions and carbon pools remains largely unknown. In this study, we performed a meta-analysis by collecting data from 95 biodiversity-ecosystem ... Read more >>

Proc Biol Sci (Proceedings. Biological sciences)
[2020, 287(1939):20202063]

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Isotropic 3D electron microscopy reference library of whole cells and tissues

Shan Xu, Song Pang, Gleb Shtengel, Andreas Müller, Alex Ritter, Huxley Hoffman, Shin-ya Takemura, Zhiyuan Lu, Amalia Pasolli, Nirmala Iyer, Jeeyun Chung, Davis Bennett, Aubrey Weigel, Tobias Walther, Robert Farese, Schuyler van Engelenburg, Ira Mellman, Michele Solimena, Harald Hess,

<h4>Summary</h4> Understanding cellular architecture is essential for understanding biology. Electron microscopy (EM) uniquely visualizes cellular structure with nanometer resolution. However, traditional methods, such as thin-section EM or EM tomography, have limitations inasmuch as they only visualize a single slice or a relatively small volume of the cell, respectively. Here, we ... Read more >>

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CCL5-dependent mast cell infiltration into the tumor microenvironment in clear cell renal cell carcinoma patients.

Tianjie Liu, Qing Xia, Haibao Zhang, Zixi Wang, Wenjie Yang, Xiaoyun Gu, Tao Hou, Yule Chen, Xinqi Pei, Guodong Zhu, Dalin He, Lei Li, Shan Xu,

We investigated the mechanisms affecting tumor progression and survival outcomes in <i>Polybromo-1</i>-mutated (<i>PBRM1</i><sup>MUT</sup>) clear cell renal cell carcinoma (ccRCC) patients. <i>PBRM1</i><sup>MUT</sup> ccRCC tissues contained higher numbers of mast cells and lower numbers of CD8<sup>+</sup> and CD4<sup>+</sup> T cells than tissues from <i>PBRM1</i><sup>WT</sup> ccRCC patients. Hierarchical clustering, pathway enrichment and GSEA ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(21):21809-21836]

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High MTHFR promoter methylation levels in men confer protection against ischemic stroke.

Shan Xu, Qianping Shi, Bo Li, Liyuan Han, Guodong Xu, Xiaolin Peng, Hongen Chen, Shuhong Dai, Wancheng Ma, Changyi Wang, Jianping Ma,

The MTHFR gene encodes methylenetetrahydrofolate reductase required for the metabolism of homocysteine (Hcy) - a previously reported independent risk factor for ischemic stroke (IS). In this study, we first aimed to clarify the association between DNA methylation levels in the MTHFR promoter and the risk of IS, followed by the ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):477-486]

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CD82 Suppresses ADAM17-Dependent E-Cadherin Cleavage and Cell Migration in Prostate Cancer.

Zhenkun Ma, Ye Gao, Wei Liu, Long Zheng, Ben Jin, Bei Duan, Hongjun Xie, Peng Guo, Jin Zeng, Ke Wang, Shan Xu, Xinyang Wang, Dalin He, Lei Li,

CD82 acts as a tumor suppressor in a series of steps in malignant progression. Here, we identified a novel function of CD82 on posttranslational regulating E-cadherin in prostate cancer. In our study, the declined expression of CD82 was verified in prostate cancer tissues and cell lines compared with normal tissue ... Read more >>

Dis Markers (Disease markers)
[2020, 2020:8899924]

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The Issue of Recurrently Positive Patients Who Recovered From COVID-19 According to the Current Discharge Criteria: Investigation of Patients from Multiple Medical Institutions in Wuhan, China.

You Zou, Bin-Ru Wang, Liu Sun, Shan Xu, Yong-Gang Kong, Li-Jun Shen, Geng-Tian Liang, Shi-Ming Chen,

The current discharge criteria for COVID-19 require that patients have 2 consecutive negative results for reverse transcription polymerase chain reaction (RT-PCR) detection. Here, we observed that recurrent positive RT-PCR test results in patients with 3 consecutive negative results (5.4%) were significantly decreased compared with those in patients with 2 consecutive ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, 222(11):1784-1788]

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Association of TG/HDLC ratio trajectory and risk of type 2 diabetes: A retrospective cohort study in China.

Yanyan Zhang, Pei Qin, Yanmei Lou, Ping Zhao, Xue Li, Ranran Qie, Xiaoyan Wu, Minghui Han, Shengbing Huang, Yang Zhao, Dechen Liu, Yuying Wu, Yang Li, Xingjin Yang, Yang Zhao, Yifei Feng, Changyi Wang, Jianping Ma, Xiaolin Peng, Hongen Chen, Dan Zhao, Shan Xu, Li Wang, Xinping Luo, Ming Zhang, Dongsheng Hu, Fulan Hu,

<h4>Background</h4>The association of ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C ratio) change trajectory with risk of type 2 diabetes mellitus (T2DM) remains unknown. The aim of this study was to evaluate the association between risk of T2DM and TG/HDL-C ratio change trajectory.<h4>Methods</h4>A total of 18 444 participants aged 18-80 years old ... Read more >>

J Diabetes (Journal of diabetes)
[2020, :]

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Probing Molecular Interactions between Surface-Immobilized Antimicrobial Peptides and Lipopolysaccharides In Situ.

Wen Guo, Shan Xu, Timothy M Reichart, Minyu Xiao, Tieyi Lu, Charlene Mello, Zhan Chen,

Lipopolysaccharide (LPS) is a component of the outer membrane of Gram-negative bacteria. Recently, a label-free immobilized antimicrobial peptide (AMP) surface plasmon resonance platform was developed to successfully distinguish LPS from multiple bacterial strains. Among the tested AMPs, SMAP29 exhibited excellent affinity with LPS and has two independent LPS-binding sites located ... Read more >>

Langmuir (Langmuir : the ACS journal of surfaces and colloids)
[2020, 36(41):12383-12393]

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3D FIB-SEM reconstruction of microtubule-organelle interaction in whole primary mouse beta cells

Andreas Müller, Deborah Schmidt, Shan Xu, Song Pang, Joyson Verner D’Costa, Susanne Kretschmar, Carla Münster, Thomas Kurth, Florian Jug, Martin Weigert, Harald Hess, Michele Solimena,

Microtubules play a major role in intracellular trafficking of vesicles in endocrine cells. Detailed knowledge of microtubule organization and their relation to other cell constituents is crucial for understanding cell function. However, their role in insulin transport and secretion is currently under debate. Here, we use F ib -S em ... Read more >>

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Electron Momentum Spectroscopy Study on the Valence Electronic Structure of Dimethyl Sulfide Considering Vibrational Effects.

ZhaoHui Liu, YaGuo Tang, ShanShan Niu, Xu Shan, ChunKai Xu, XiangJun Chen,

We report an electron momentum spectroscopy study on the valence electronic structure of dimethyl sulfide. The binding energy and electron momentum profiles are measured using a high-sensitivity (e, 2e) apparatus employing a symmetric non-coplanar geometry at an incident energy of 1200 eV plus binding energy. The measurements are compared with ... Read more >>

J Phys Chem A (The journal of physical chemistry. A)
[2020, 124(41):8551-8561]

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An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram-negative Pathogens and Reduced ex vivo Cochleotoxicity.

Amr Sonousi, Jonathan C K Quirke, Prabuddha Waduge, Tanja Janusic, Marina Gysin, Klara Haldimann, Shan Xu, Sven N Hobbie, Su-Hua Sha, Jochen Schacht, Christine S Chow, Andrea Vasella, Erik C Böttger, David Crich,

We describe the convergent synthesis of a 5-O-β-D-ribofuranosyl-based apramycin derivative (apralog) that displays significantly improved antibacterial activity over the parent apramycin against wild-type ESKAPE pathogens. In addition, the new apralog retains excellent antibacterial activity in the presence of the only aminoglycoside modifying enzyme (AAC(3)-IV) acting on the parent, without incurring ... Read more >>

ChemMedChem (ChemMedChem)
[2020, :]

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Dose-response association of the ZJU index and fatty liver disease risk: A large cohort in China.

Xue Li, Pei Qin, Liming Cao, Yanmei Lou, Jing Shi, Ping Zhao, Changyi Wang, Jianping Ma, Shan Xu, Xiaolin Peng, Hongen Chen, Dan Zhao, Fulan Hu, Yashuang Zhao,

<h4>Aims</h4>To investigate the sex-specific association between the ZJU index and risk of fatty liver disease in a large Chinese cohort.<h4>Methods</h4>Totally 28,729 adults without fatty liver disease at baseline and who completed at least one follow-up of annual examinations between 2009 and 2016 were included in this study. Cox proportional hazards ... Read more >>

J Gastroenterol Hepatol (Journal of gastroenterology and hepatology)
[2020, :]

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6-Gingerol suppresses tumor cell metastasis by increasing YAPser127 phosphorylation in renal cell carcinoma.

Shan Xu, Haibao Zhang, Tianjie Liu, Zixi Wang, Wenjie Yang, Tao Hou, Xinyang Wang, Dalin He, Pengsheng Zheng,

According to the World Health Organization, the incidence and mortality rates of renal cell carcinoma (RCC) are rapidly increasing worldwide. Serious side effects caused by immune therapy and resistance to targeted drug therapy are urgent clinical problems facing kidney treatment. There is increasing global interest in developing natural products with ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2021, 35(1):e22609]

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Coping strategies of students for anxiety during the COVID-19 pandemic in China: a cross-sectional study.

Mohammad Nurunnabi, Syed Far Abid Hossain Hossain, Karuthan Chinna, Sheela Sundarasen, Heba Bakr Khoshaim, Kamilah Kamaludin, Gul Mohammad Baloch, Areej Sukayt, Xu Shan,

<b>Background:</b> COVID-19 has severely affected university students everywhere in the world. Due to fear of infection, government and local authorities in China immediately closed academic institutions and tried to find survival techniques to cope with market turbulence. COVID-19 was present in China at the end of 2019. However, little attention ... Read more >>

F1000Res (F1000Research)
[2020, 9:1115]

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