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Potential mechanism of Ziyin Tongluo Formula in the treatment of postmenopausal osteoporosis: based on network pharmacology and ovariectomized rat model.

Rong-Bin Chen, Ying-Dong Yang, Kai Sun, Shan Liu, Wei Guo, Jin-Xin Zhang, Yong Li,

<h4>Background</h4>Amending from ancient classic, Ziyin Tongluo Formula (ZYTLF) has been prescribed to treat postmenopausal osteoporosis (PMOP) for decades with good curative effect. However, the possible mechanisms of it are still unknown.<h4>Methods</h4>Ovariectomized rat model was established to validate the therapeutic effect of ZYTLF on PMOP by Micro-CT bone analysis and pathological ... Read more >>

Chin Med (Chinese medicine)
[2021, 16(1):88]

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Powdered activated carbon doping improves the mechanical and adsorption properties of cementitious microfiltration membrane.

Jingyi Sun, Zhonglin Chen, Shan Liu, Jing Kang, Binyuan Wang, Jimin Shen, Shengxin Zhao, Xueyan Li, Zilong Song, Zhe Wang,

Cementitious membrane (CM) is a promising microfiltration membrane with low cost for raw materials and low energy consumption of non-sintering fabrication process. A novel carbon-cementitious microfiltration membrane (CCM) was fabricated with powdered activated carbon (PAC) as an additive based on CM, to solve the low mechanical strength of CM during ... Read more >>

Chemosphere (Chemosphere)
[2021, 287(Pt 3):132260]

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A TP53 mutation model for the prediction of prognosis and therapeutic responses in head and neck squamous cell carcinoma.

Congyu Shi, Shan Liu, Xudong Tian, Xiaoyi Wang, Pan Gao,

<h4>Background</h4>Tumor protein p53 (TP53) is the most frequently mutated gene in head and neck squamous cell carcinoma (HNSC), and TP53 mutations are associated with inhibited immune signatures and poor prognosis. We established a TP53 mutation associated risk score model to evaluate the prognosis and therapeutic responses of patients with HNSC.<h4>Methods</h4>Differentially ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1035]

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The Optimal Condition of Poly(I: C)-Induced Knockout of Cre Recombinase for Mx1-Cre/ Cre-loxP Mice

Bijie Yang, Haobiao Wang, Yuanyuan Liu, Feifei Xiao, Mei Kuang, Yi Shu, Shi Tang, Dan Zhu, Shan Liu, Tingting Jiang, Penghui Zhang, Lin Zou,

<h4>Background: </h4> The Cre- lox P system is widely applied for conditional knockout mice, commonly used to study the function of specific genes. Although some different promoters drive Cre expression, the poly(I: C)-inducible Mx1-Cre is the most commonly used to delete the target gene in experimental hematology. However, the optimal ... Read more >>

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MiR-216a-5p alleviates LPS-induced inflammation in the human bronchial epithelial cell by inhibition of TGF-β1 signaling via down-regulating TGFBR2.

Shan Liu, Jianjun Li, Liya Hu,

<h4>Objective</h4>Bronchopneumonia is a common respiratory infection disease and is the leading cause of hospitalization in children under 5 years of age. Inflammation is the primary response caused by bronchopneumonia. But the detailed underlying mechanism of inflammation in bronchopneumonia remains unclear. Therefore, this study focused on studying the effect of miR-216a-5p ... Read more >>

Allergol Immunopathol (Madr) (Allergologia et immunopathologia)
[2021, 49(5):64-71]

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Microbiota-gut-brain axis and Alzheimer's disease: Implications of the blood-brain barrier as an intervention target.

Shan Liu, Jiguo Gao, Kangding Liu, Hong-Liang Zhang,

The microbiota-gut-brain axis has emerged as a focal point of biomedical research. Alterations of gut microbiota are involved in not only various immune/inflammatory disorders but also neurological disorders including Alzheimer's disease (AD). The initial stage of the involvement of gut microbiota in the pathogenesis of AD may be the dysfunction ... Read more >>

Mech Ageing Dev (Mechanisms of ageing and development)
[2021, 199:111560]

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Exosomal lncRNA LINC01711 facilitates metastasis of esophageal squamous cell carcinoma via the miR-326/FSCN1 axis.

Mei-Ling Xu, Tian-Cheng Liu, Feng-Xiang Dong, Ling-Xin Meng, Ai-Xia Ling, Shan Liu,

Esophageal cancer is a malignant tumor with a five-year survival rate of less than 20%. Early diagnosis and exploration of esophageal cancer pathogenesis are of great significance for the treatment and prognosis of esophageal cancer. Long non-coding RNA (lncRNA) plays a vital role in the occurrence and development of different ... Read more >>

Aging (Albany NY) (Aging)
[2021, 13(15):19776-19788]

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Regulation of Myogenic Differentiation by Topologically Microgrooved Surfaces for Skeletal Muscle Tissue Engineering.

Huichang Gao, Jin Xiao, Yingqi Wei, Hao Wang, Hongxia Wan, Shan Liu,

Inspired by the natural topological structure of skeletal muscle tissue, the topological surface construction of bionic scaffolds for skeletal muscle repair has attracted great interest. Many previous studies have focused on the effects of the topological structure on myoblasts. However, these studies used only specific repeating sizes and shapes to ... Read more >>

ACS Omega (ACS omega)
[2021, 6(32):20931-20940]

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Characterization of novel gliotoxin biosynthesis-related genes from deep-sea-derived fungus Geosmithia pallida FS140.

Wei Ye, Saini Li, Shuai Liu, Yali Kong, Weiyang Zhang, Shan Liu, Taomei Liu, Weimin Zhang,

Gliotoxins are epipolythiodioxopiperazine toxins produced by the filamentous fungi, which show great potential in the treatment of liver and lung cancer because of its cytotoxicity. In this study, three novel genes related to gliotoxin biosynthesis, gliT, gliM and gliK encoding thioredoxin reductase, O-methyltransferase and gamma-glutamyl cyclotransferase, respectively, from the deep-sea-derived ... Read more >>

Biochimie (Biochimie)
[2021, 191:1-10]

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Reach and Adoption of a Geriatric Emergency Department Accreditation Program in the United States.

Maura Kennedy, Adriane Lesser, Juhi Israni, Shan W Liu, Ilianna Santangelo, Nicole Tidwell, Lauren T Southerland, Christopher R Carpenter, Kevin Biese, Surriya Ahmad, Ula Hwang,

<h4>Study objective</h4>The objectives of this study were to describe the reach and adoption of Geriatric Emergency Department Accreditation (GEDA) program and care processes instituted at accredited geriatric emergency departments (EDs).<h4>Methods</h4>We analyzed a cross-section of a cohort of US EDs that received GEDA from May 2018 to March 2021. We obtained ... Read more >>

Ann Emerg Med (Annals of emergency medicine)
[2021, :]

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Evaluating Heavy Metals Contamination in Campus Dust in Wuhan, the University Cluster in Central China: Distribution and Potential Human Health Risk Analysis

Shan Liu, Xihao Zhang, Changlin Zhan, Jiaquan Zhang, Jun Xu, Anglv Wang, Huidi Zhang, Jiangyan Xu, Jianlin Guo, Xianli Liu, Xinli Xing, Junji Cao, Yulun Xiao,

The potential health risk of heavy metals (HMs) in campus dust may threaten the health of thousands of students, teachers, and their families in Wuhan, the university cluster in Central China every day. In this research, the pollution characteristics and health risk with HMs was the first time presented in ... Read more >>

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Circ_0008673 regulates breast cancer malignancy by miR-153-3p/CFL2 axis.

Li Zhang, Wei Zhang, Zhigang Zuo, Jiying Tang, Ying Song, Fengjun Cao, Xiongjie Yu, Shan Liu, Xiaojun Cai,

<h4>Background</h4>Breast cancer is an aggressive tumor, which poses a heavy burden to human health. Circular RNAs have been involved in the pathogenesis of breast cancer. This study aims to investigate whether circ_0008673 mediates breast cancer malignant progression by microRNA-153-3p (miR-153-3p)/cofilin 2 (CFL2) pathway.<h4>Methods</h4>The RNA levels of circ_0008673, miR-153-3p and CFL2 ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2021, :]

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PD-1/PD-L1 Axis as a Potential Therapeutic Target for Multiple Sclerosis: A T Cell Perspective.

HaiXia Li, Chao Zheng, Jinming Han, Jie Zhu, Shan Liu, Tao Jin,

The programmed cell death protein-1/programmed death ligand-1 (PD-1/PD-L1) axis is a widely studied immune checkpoint that modulates signaling pathways related to T cell activation. The use of PD-1/PD-L1 inhibitors is a promising immune therapy strategy for cancer patients. However, individuals treated with PD-1/PD-L1 inhibitors may develop immune-related adverse events due ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:716747]

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LncRNA H19 Mitigates Oxidized Low-Density Lipoprotein Induced Pyroptosis via Caspase-1 in Raw 264.7 Cells.

Shan Liu, Dong-Sheng Xu, Jiu-Long Ma, Peng Huang, Di Wu, Li-Qun Ren,

Atherosclerosis (AS) is mainly characterized by the activation of inflammatory cells and chronic inflammatory responses after cell injury. Pyroptosis is a form of programmed cell death (PCD) accompanied by the release of inflammatory factors. Many studies have shown that pyroptosis plays an important role in AS. Increasing evidence also indicates ... Read more >>

Inflammation (Inflammation)
[2021, :]

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Pollution Characteristics and Associated Risk Assessment of Heavy Metals in Farmland Soils From a Typical County of Hubei Province, Central China.

Damao Xu, Zhishuang Zhou, Changlin Zhan, Shan Liu, Jiaquang Zhang, Hongxia Liu, Ziguo Liu, Xianli Liu,

Knowledge from the negative impacts of the counties' anthropogenic activities on soil pollution was of great significance in China, and valuable information was urgently needed for the control and remediation of soil pollution. The current pollution levels of heavy metals (Cu, Pb, Cd, Zn, Ni, and Cr) in farmland soils ... Read more >>

Bull Environ Contam Toxicol (Bulletin of environmental contamination and toxicology)
[2021, 107(2):327-335]

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Home hospital as a disposition for older adults from the emergency department: Benefits and opportunities.

Kei Ouchi, Shan Liu, Daniel Tonellato, Yonatan G Keschner, Maura Kennedy, David M Levine,

The $1 trillion industry of acute hospital care in the United States is shifting from inside the walls of the hospital to patient homes. To tackle the limitations of current hospital care in the United States, on November 25, 2020, the Center for Medicare & Medicaid Services announced that the ... Read more >>

J Am Coll Emerg Physicians Open (Journal of the American College of Emergency Physicians open)
[2021, 2(4):e12517]

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A Medical Image Registration Method Based on Progressive Images.

Qian Zheng, Qiang Wang, Xiaojuan Ba, Shan Liu, Jiaofen Nan, Shizheng Zhang,

<h4>Background</h4>Medical image registration is an essential task for medical image analysis in various applications. In this work, we develop a coarse-to-fine medical image registration method based on progressive images and SURF algorithm (PI-SURF) for higher registration accuracy.<h4>Methods</h4>As a first step, the reference image and the floating image are fused to ... Read more >>

Comput Math Methods Med (Computational and mathematical methods in medicine)
[2021, 2021:4504306]

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Patients With Deep Ovarian Suppression Following GnRH Agonist Long Protocol May Benefit From a Modified GnRH Antagonist Protocol: A Retrospective Cohort Study.

Shan Liu, Minghui Liu, Lingxiu Li, Huanhuan Li, Danni Qu, Haiying Ren, Hui Su, Yang Zhang, Yuan Li,

<h4>Objective</h4>To verify if patients with deep ovarian suppression following gonadotropin releasing hormone (GnRH) agonist long protocol may benefit from a modified GnRH antagonist protocol based on luteinizing hormone (LH) levels.<h4>Design</h4>Retrospective cohort study.<h4>Setting</h4>University-based hospital.<h4>Patients</h4>110 patients exhibited ultra-low LH levels during ovarian stimulation using GnRH agonist long protocol.<h4>Interventions</h4>As all the embryos in ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2021, 12:618580]

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Lessons Learned From Emergency Department Fall Assessment and Prevention Programs.

Phraewa Thatphet, Fae B Kayarian, Kei Ouchi, Teresita Hogan, John G Schumacher, Maura Kennedy, Shan W Liu,

Objectives This research describes the experiences of emergency departments (EDs) with geriatric fall programs and qualitatively synthesizes lessons learned to inform other EDs planning new fall program implementation. Methods By using grounded theory, we conducted semi-structured, open-ended telephone/skype interviews of emergency physicians and geriatric providers recruited from a purposeful sampling ... Read more >>

Cureus (Cureus)
[2021, 13(7):e16526]

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Prognostic Value of Perineural Invasion in Oral Tongue Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.

Jiajia Li, Shan Liu, Zhangao Li, Xinxin Han, Lin Que,

<h4>Objectives</h4>A significant number of recently published research has outlined the contribution of perineural invasion (PNI) to clinical outcomes in oral tongue squamous cell carcinoma (OTSCC), but some results remain conflicting. This study aimed to determine whether patients with OTSCC with PNI have a worse prognosis than those without PNI.<h4>Materials and ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:683825]

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Dielectric constants of organic pollutants determine their strength for enhancing microbial iron reduction.

Shan Liu, Hui Liu, Yao Huang, Jie Ma, Zhu Wang, Rong Chen,

Physicochemical properties are essential characteristics of organic compounds, which not only impact the fate of organic pollutants but also determine their application in biological processes. Here, we first found that the dielectric constants (ɛ) of organic pollutants negatively correlated to their strength for enhancing microbial Fe(III) reduction. Those with lower ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2021, :]

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[Gene editing for the treatment of primary immunodeficiency disease].

Shan Liu, Shu-Yu Fang, Yun-Fei An,

Gene editing is an advanced technique based on artificial nucleases and can precisely modify genome sequences. It has shown great application prospects in the field of medicine and has provided a new precision therapy for diseases. Primary immunodeficiency disease is a group of diseases caused by single gene mutation and ... Read more >>

Zhongguo Dang Dai Er Ke Za Zhi (Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics)
[2021, 23(7):743-748]

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Potential Mechanism of Ziyin Tongluo Formula in the Treatment of Postmenopausal Osteoporosis:based on Network Pharmacology and Ovariectomized Rat Model

Chen Rongbin, Yang Yingdong, Sun Kai, Liu Shan, Guo Wei, Zhang Jinxin, Li Yong,

<h4>Background: </h4> Amending from ancient classic, Ziyin Tongluo Formula (ZYTLF) has been prescribed to treat Postmenopausal osteoporosis (PMOP) for decades and obtained beneficial effect. However, the possible mechanisms of it are still unknown. MethodsOvariectomized rat model were established to validate the therapeutic effect of ZYTLF on PMOP by Micro-CT bone ... Read more >>

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Efficacy and Safety of Thread Embedding Acupuncture for Facial Expression Muscles Atrophy After Peripheral Facial Paralysis: Study Protocol for a Randomized Controlled Trial

Binyan Yu, Lihua Xuan, Yutong Jin, Shan Chen, Shan Liu, Yijia Wan,

<h4>Background: </h4> Facial expression muscles atrophy is one kind of sequelae after peripheral facial paralysis. It causes critical problems in facial appearance of patient as well as social and psychological problems. This study aims to evaluate the efficacy and safety of Thread-embedding acupuncture (TEA) for the management of facial expression ... Read more >>

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Shape-Preserving Stereo Object Remapping via Object-Consistent Grid Warping.

Bing Li, Chia-Wen Lin, Cheng Zheng, Shan Liu, Bernard Ghanem, Wen Gao, C-C Jay Kuo,

Viewing various stereo images under different viewing conditions has escalated the need for effective object-level remapping techniques. In this paper, we propose a new object spatial mapping scheme, which adjusts the depth and size of the selected object to match user preference and viewing conditions. Existing warping-based methods often distort ... Read more >>

IEEE Trans Image Process (IEEE transactions on image processing : a publication of the IEEE Signal Processing Society)
[2021, 30:5889-5904]

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