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MicroRNA-506-3p inhibits colorectal cancer cell proliferation through targeting enhancer of zeste homologue 2.

Liang Ai, Xiaojun Luo, Xiong Yan, Shan Jiang,

A large number of studies have shown that microRNA (miRNA) has an important relationship with the occurrence and development of colorectal cancer (CRC), but its specific molecular mechanism has not been fully elucidated. This study is to explore the influence of miR-506-3p on the malignant behavior of CRC and its ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):4044-4053]

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The development of a blended emergent research training program for clinical nurses (Part 1)

Qirong Chen, Zeen Li, Siyuan Tang, Chuyi Zhou, Aimee Castro, Shan Jiang, Chongmei Huang, Jinnan Xiao,

<h4>Background: </h4> Nursing research training is important for the improvement of nursing research competence of clinical nurses. High-quality development is crucial for a good nursing research training program. Therefore, the objectives of this study are: (1) To develop a blended emergent research training program for clinical nurses based on a ... Read more >>

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Pirfenidone is a renal protective drug: Mechanisms, signalling pathways, and preclinical evidence.

Xue Bai, Ping Nie, Yan Lou, Yuexin Zhu, Shan Jiang, Bing Li, Ping Luo,

Renal fibrosis, a characteristic of all chronic kidney diseases, lacks effective therapeutic drugs currently. Pirfenidone (PFD), a small molecule drug with good oral bioavailability, is widely used in idiopathic pulmonary fibrosis and exerts anti-fibrotic, anti-inflammatory, antioxidant, and anti-apoptotic effects. These effects have been attributed to the suppression of cell growth ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2021, :174503]

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USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer.

Pingping Hou, Xingdi Ma, Zecheng Yang, Qiang Zhang, Chang-Jiun Wu, Jun Li, Lin Tan, Wantong Yao, Liang Yan, Xin Zhou, Alec C Kimmelman, Philip L Lorenzi, Jianhua Zhang, Shan Jiang, Denise Spring, Y Alan Wang, Ronald A DePinho,

Activating mutations in KRAS (KRAS*) are present in nearly all pancreatic ductal adenocarcinoma (PDAC) cases and critical for tumor maintenance. By using an inducible KRAS* PDAC mouse model, we identified a deubiquitinase USP21-driven resistance mechanism to anti-KRAS* therapy. USP21 promotes KRAS*-independent tumor growth via its regulation of MARK3-induced macropinocytosis, which ... Read more >>

Genes Dev (Genes & development)
[2021, :]

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Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis.

Edoardo Del Poggetto, I-Lin Ho, Chiara Balestrieri, Er-Yen Yen, Shaojun Zhang, Francesca Citron, Rutvi Shah, Denise Corti, Giuseppe R Diaferia, Chieh-Yuan Li, Sara Loponte, Federica Carbone, Yoku Hayakawa, Giovanni Valenti, Shan Jiang, Luigi Sapio, Hong Jiang, Prasenjit Dey, Sisi Gao, Angela K Deem, Stefan Rose-John, Wantong Yao, Haoqiang Ying, Andrew D Rhim, Giannicola Genovese, Timothy P Heffernan, Anirban Maitra, Timothy C Wang, Linghua Wang, Giulio F Draetta, Alessandro Carugo, Gioacchino Natoli, Andrea Viale,

[Figure: see text]. ... Read more >>

Science (Science (New York, N.Y.))
[2021, 373(6561):eabj0486]

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KMT2D Loss Promotes Head and Neck Squamous Cell Carcinoma Through Enhancer Reprogramming and Modulation of Immune Microenvironment

Carson Callahan, Margarita Divenko, Praveen Barrodia, Anand Singh, Emre Arslan, Zhiyi Liu, Jiah Yang, Nazanin Anvar, Moran Amit, Tongxin Xie, Shan Jiang, Jonathan Schulz, Ming Tang, Jeffrey Myers, Kunal Rai,

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide with 5-year survival of approximately 50%. Genomic profiling studies have identified important somatic mutations in this disease which presents an opportunity for precision medicine. We demonstrate that KMT2D, a histone methyltransferase harbors somatic mutations in approximately ... Read more >>

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Fabrication of a honeycomb-like bimetallic SERS substrate for the detection of triphenyltin chloride.

Shan Jiang, Lin Chang, Jie Luo, Jianfa Zhang, Xiaohong Liu, Chong-Yew Lee, Wei Zhang,

Triphenyltin chloride (TPhT) is an organotin compound that causes intensive toxicological risk to the environment and humans. A detection method with high sensitivity and stability is therefore desired to better detect TPhT. In this study, a novel SERS substrate was prepared by sputtering an ultra-thin Au layer on a honeycomb-like ... Read more >>

Analyst (The Analyst)
[2021, :]

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A survey of a COVID-19 cluster of charter flight importation

Yong Yue, Yuezhu Chen, Xunbo Du, Yijie Jin, Min Hu, Xiaoman Jiang, Cheng Wang, Zhenhua Chen, Liyuan Su, Chao Chen, Shan Jiang, Xiaoli Tuo,

<h4>Objectives</h4> Although a number of cases of importation with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported, there are still no data available concerning the characteristics in the coronavirus disease 2019 (COVID-19) cluster of charter flight importation. Here, we provide an analysis of COVID-19 cases and their ... Read more >>

Public Health (Public health)
[2021, :]

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Effects of structural-economic and socio-relational exclusion on well-being of Chinese migrant children.

Shan Jiang, Steven Sek-Yum Ngai,

Social exclusion is a widely accepted risk factor for child well-being, but relatively little is known about its dynamics and effect on multiple well-being domains. This study aims to extend prior research by examining the influencing mechanisms of structural-economic and socio-relational exclusion on the physical, psychological, behavioural and educational well-being ... Read more >>

Health Soc Care Community (Health & social care in the community)
[2021, :]

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Maturation of Nephrons by Implanting hPSC-Derived Kidney Progenitors Under Kidney Capsules of Unilaterally Nephrectomized Mice

Xin Yu, Shan Jiang, Kailin Li, Xianzhen Yang, Zhihe Xu, Xiaohang Du, Feng Kong, Shengtian Zhao,

<h4>Background: </h4> Human pluripotent stem cell (hPSCs)-derived kidney organoids may contribute to disease modeling and generation of kidney replacement tissues. However, realization of such applications requires the induction of hPSCs into functional mature organoids. One of the key questions for this process is whether a specific vascular system exists for ... Read more >>

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Elder mistreatment and life satisfaction of older adults: mediating roles of emotional closeness with children and loneliness.

Chaoxin Jiang, Shan Jiang,

Elder mistreatment is a risk factor in the life satisfaction of older adults, yet understanding of its underlying mechanisms remains limited. This study investigates the mediating role of emotional closeness and loneliness in the association between elder mistreatment and life satisfaction. A sample of 8,717 Chinese older adults is obtained ... Read more >>

J Elder Abuse Negl (Journal of elder abuse & neglect)
[2021, :1-17]

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An optimized protocol for a standardized, femoral osteotomy model to study fracture healing in mice.

Shan Jiang, Paul Knapstein, Antonia Donat, Serafeim Tsitsilonis, Johannes Keller,

Fracture healing represents a dynamic and complex process which depends on the balanced activities of a broad array of different cell types and signaling pathways. Here, we describe a femoral osteotomy protocol for mice, using an external fixator to stabilize the fractured bone. Depending on experimental requirements, the size of ... Read more >>

STAR Protoc (STAR protocols)
[2021, 2(3):100798]

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Isolation, identification and genetic characterization analysis of a fowl aviadenovirus serotype 4 strain from Tianjin, China.

Lili Wang, Li Zheng, Shan Jiang, Xiuli Li, Chao Lu, Li Zhang, Weike Ren, Cheng Li, Xiangxue Tian, Fuqiang Li, Minghua Yan,

A fowl aviadenovirus serotype 4 (FAdV-4), Y17215-1, was isolated from the liver of chickens with Hydropericardium-hepatitissyndrome(HHS) in a chicken farm of Tianjin, China. Obvious cytopathic effects were observed in the infected chicken liver hepatocellular carcinoma cell line (LMH cells) at 24 h post infection (hpi), which consisted of enlarger and rounder ... Read more >>

Infect Genet Evol (Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases)
[2021, :105078]

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Deformable registration of chest CT images using a 3D convolutional neural network based on unsupervised learning.

Yongnan Zheng, Shan Jiang, Zhiyong Yang,

<h4>Purpose</h4>The deformable registration of 3D chest computed tomography (CT) images is one of the most important tasks in the field of medical image registration. However, the nonlinear deformation and large-scale displacement of lung tissues caused by respiratory motion cause great challenges in the deformable registration of 3D lung CT images.<h4>Materials ... Read more >>

J Appl Clin Med Phys (Journal of applied clinical medical physics)
[2021, :]

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Saikosaponin a promotes sleep by decreasing neuronal activities in the lateral hypothalamus.

Yu-Heng Zhong, Shan Jiang, Wei-Min Qu, Wen Zhang, Zhi-Li Huang, Chang-Rui Chen,

Insomnia is one of the most prevalent sleep disorders, which imparts tremendous societal and economic impact. However, the present pharmacotherapy is greatly limited by adverse effects, so it is necessary to explore new drugs for the treatment of insomnia. Radix Bupleuri (RB) has been widely used in traditional Chinese medicine ... Read more >>

J Sleep Res (Journal of sleep research)
[2021, :e13484]

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Academic stress and depression of Chinese adolescents in junior high schools: Moderated mediation model of school burnout and self-esteem.

Shan Jiang, Qiang Ren, Chaoxin Jiang, Lin Wang,

Background Despite previous research indicates that academic stress is a risk factor for students' mental health, the mediating and moderating mechanisms underlying this relationship are less known. This study tests the mediation effect of school burnout in the association between academic stress and adolescent depression, and whether this mediation is ... Read more >>

J Affect Disord (Journal of affective disorders)
[2021, 295:384-389]

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Pro-pigmentary action of 5-fluorouracil through the stimulated secretion of CXCL12 by dermal fibroblasts.

Zhi-Kai Liao, Shuang-Hai Hu, Bin-Yu Han, Xie Qiu, Shan Jiang, Tie-Chi Lei,

<h4>Background</h4>There is growing evidence that 5-fluorouracil (5-FU) combined with therapeutic trauma can effectively induce skin repigmentation in vitiligo patients who are unresponsive to conventional treatments. Previous studies have mainly focused on identifying the antimitotic activity of 5-FU for the treatment of skin cancer, but few studies have investigated its extra-genotoxic ... Read more >>

Chin Med J (Engl) (Chinese medical journal)
[2021, :]

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TIPS: trajectory inference of pathway significance through pseudotime comparison for functional assessment of single-cell RNAseq data.

Zihan Zheng, Xin Qiu, Haiyang Wu, Ling Chang, Xiangyu Tang, Liyun Zou, Jingyi Li, Yuzhang Wu, Jianzhi Zhou, Shan Jiang, Ying Wan, Qingshan Ni,

Recent advances in bioinformatics analyses have led to the development of novel tools enabling the capture and trajectory mapping of single-cell RNA sequencing (scRNAseq) data. However, there is a lack of methods to assess the contributions of biological pathways and transcription factors to an overall developmental trajectory mapped from scRNAseq ... Read more >>

Brief Bioinform (Briefings in bioinformatics)
[2021, 22(5):]

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Equity in science: advocating for a triple-blind review system.

Stephanie Brodie, André Frainer, Maria Grazia Pennino, Shan Jiang, Laura Kaikkonen, Jon Lopez, Kelly Ortega-Cisneros, Carl A Peters, Samiya A Selim, Nataşa Văidianu,

We propose 'triple-blind review' for peer-reviewed journals - a process that keeps author identities and affiliations blind to manuscript editors until after first appraisal. Blinded appraisal will help to reduce the biases that negatively affect under-represented and minority scientists, ultimately better supporting equity in scientific publishing. ... Read more >>

Trends Ecol Evol (Trends in ecology & evolution)
[2021, :]

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Implantable optical fibers for immunotherapeutics delivery and tumor impedance measurement.

Ai Lin Chin, Shan Jiang, Eungyo Jang, Liqian Niu, Liwu Li, Xiaoting Jia, Rong Tong,

Immune checkpoint blockade antibodies have promising clinical applications but suffer from disadvantages such as severe toxicities and moderate patient-response rates. None of the current delivery strategies, including local administration aiming to avoid systemic toxicities, can sustainably supply drugs over the course of weeks; adjustment of drug dose, either to lower ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):5138]

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Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II-induced hypertension.

Shan Jiang, Yongjie Shui, Yu Cui, Chun Tang, Xiaohua Wang, Xingyu Qiu, Weipeng Hu, Lingyan Fei, Yun Li, Suping Zhang, Liang Zhao, Nan Xu, Fang Dong, Xiaoqiu Ren, Ruisheng Liu, Pontus B Persson, Andreas Patzak, En Yin Lai, Qichun Wei, Zhihua Zheng,

Gut microbiota produce Trimethylamine N-oxide (TMAO) by metabolizing dietary phosphatidylcholine, choline, l-carnitine and betaine. TMAO is implicated in the pathogenesis of chronic kidney disease (CKD), diabetes, obesity and atherosclerosis. We test, whether TMAO augments angiotensin II (Ang II)-induced vasoconstriction and hence promotes Ang II-induced hypertension. Plasma TMAO levels were indeed ... Read more >>

Redox Biol (Redox biology)
[2021, 46:102115]

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Prioritizing Susceptible Genes for Thyroid Cancer Based on Gene Interaction Network.

Lin-Kun Zhong, Chang-Lian Xie, Shan Jiang, Xing-Yan Deng, Xiao-Xiong Gan, Jian-Hua Feng, Wen-Song Cai, Chi-Zhuai Liu, Fei Shen, Jian-Hang Miao, Bo Xu,

Thyroid cancer ranks second in the incidence rate of endocrine malignant cancer. Thyroid cancer is usually asymptomatic at the initial stage, which makes patients easily miss the early treatment time. Combining genetic testing with imaging can greatly improve the diagnostic efficiency of thyroid cancer. Researchers have discovered many genes related ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2021, 9:740267]

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An inverse planning simulated annealing algorithm with adaptive weight adjustment for LDR pancreatic brachytherapy.

Ruijin Zhang, Zhiyong Yang, Shan Jiang, Xiaoling Yu, Erpeng Qi, Zeyang Zhou, Guobin Zhang,

<h4>Purpose</h4>The inverse planning simulated annealing (IPSA) algorithm has shown good results in cancer surgical treatment planning. However, an adaptive approach has not well been proposed for different shapes and sizes of tumors. The purpose of this study was to propose an adaptive, efficient and safe algorithm to get high-quality treatment ... Read more >>

Int J Comput Assist Radiol Surg (International journal of computer assisted radiology and surgery)
[2021, :]

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Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level.

Yingcheng Wu, Shuaixi Yang, Jiaqiang Ma, Zechuan Chen, Guohe Song, Dongning Rao, Yifei Cheng, Siyuan Huang, Yifei Liu, Shan Jiang, Jinxia Liu, Xiaowu Huang, Xiaoying Wang, Shuangjian Qiu, Jianmin Xu, Ruibin Xi, Fan Bai, Jian Zhou, Jia Fan, Xiaoming Zhang, Qiang Gao,

Liver metastasis, the leading cause of colorectal cancer mortality, exhibits a highly heterogeneous and suppressive immune microenvironment. Here, we sequenced 97 matched samples by using single-cell RNA-seq and Spatial Transcriptomics. Strikingly, metastatic microenvironment underwent remarkable spatial reprogramming of immunosuppressive cells such as MRC1+ CCL18+ M2-like macrophages. We further developed scMetabolism, ... Read more >>

Cancer Discov (Cancer discovery)
[2021, :]

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Isolation, Identification, and Characterization of Polystyrene-Degrading Bacteria From the Gut of Galleria Mellonella (Lepidoptera: Pyralidae) Larvae.

Shan Jiang, Tingting Su, Jingjing Zhao, Zhanyong Wang,

Polystyrene (PS) is a widely used petroleum-based plastic, that pollutes the environment because it is difficult to degrade. In this study, a PS degrading bacterium identified as <i>Massilia</i> sp. FS1903 was successfully isolated from the gut of <i>Galleria mellonella</i> (Lepidoptera: Pyralidae) larvae that were fed with PS foam. Scanning electron ... Read more >>

Front Bioeng Biotechnol (Frontiers in bioengineering and biotechnology)
[2021, 9:736062]

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