Full Text Journal Articles by
Author Shan He Yu


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Reinforced erythroid differentiation inhibits leukemogenic potential of t(8;21) leukemia.

Meng-Xi Wang, Li Yan, Juan Chen, Jun-Mei Zhao, Jiang Zhu, Shan-He Yu,

Oncoprotein AML1-ETO (AE) derived from t(8;21)(q22;q22) translocation is typically present in a portion of French-American-British-M2 subtype of acute myeloid leukemia (AML). Although these patients have relatively favorable prognoses, substantial numbers of them would relapse after conventional therapy. Here, we explored whether reinforcing the endogenous differentiation potential of t(8;21) AML cells ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2022, 36(10):e22562]

Cited: 0 times

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Leukemic progenitor cells enable immunosuppression and post-chemotherapy relapse via IL-36-inflammatory monocyte axis.

He-Zhou Guo, Zi-Hua Guo, Shan-He Yu, Li-Ting Niu, Wan-Ting Qiang, Meng-Meng Huang, Yuan-Yuan Tian, Juan Chen, Hui Yang, Xiang-Qin Weng, Yi Zhang, Wu Zhang, Shao-Yan Hu, Jun Shi, Jiang Zhu,

Chemotherapy can effectively reduce the leukemic burden and restore immune cell production in most acute myeloid leukemia (AML) cases. Nevertheless, endogenous immunosurveillance usually fails to recover after chemotherapy, permitting relapse. The underlying mechanisms of this therapeutic failure have remained poorly understood. Here, we show that abnormal IL-36 production activated by ... Read more >>

Sci Adv (Science advances)
[2021, 7(41):eabg4167]

Cited: 1 time

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