Full Text Journal Articles by
Author Shambhuprasad K Togarsimalemath


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Detection of Autoantibodies to Complement Components by Surface Plasmon Resonance-Based Technology.

Remi Noe, Sophie Chauvet, Shambhuprasad K Togarsimalemath, Maria Chiara Marinozzi, Maria Radanova, Vasil V Vasilev, Veronique Fremeaux-Bacchi, Marie-Agnes Dragon-Durey, Lubka T Roumenina,

The innate immune complement system is a powerful defense cascade against pathogens, but can induce host tissue damage when overactivated. In pathological conditions, mainly but not restricted to renal diseases, such as lupus nephritis, atypical hemolytic uremic syndrome, and C3 glomerulopathies, complement is overactivated or dysregulated by autoantibodies directed against ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2019, 1901:271-280]

Cited: 1 time

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Gastrointestinal pathogens in anti-FH antibody positive and negative Hemolytic Uremic Syndrome.

Shambhuprasad K Togarsimalemath, Ali Si-Mohammed, Mamta Puraswani, Aarti Gupta, Astrid Vabret, Sandrine Liguori, Patricia Mariani-Kurkdjian, Arvind Bagga, Marie-Agnes Dragon-Durey,

BACKGROUND:Prodromal symptoms are frequently reported in the atypical form of Hemolytic uremic syndrome (aHUS) suggesting implication of infectious triggers. Some pathogens may also play a role in the mechanisms of production of autoantibody directed against Factor H (FH), a complement regulator, leading to aHUS. METHODS:The presence of 15 gastrointestinal (GI) ... Read more >>

Pediatr Res (Pediatric research)
[2018, 84(1):118-124]

Cited: 4 times

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A novel CFHR1-CFHR5 hybrid leads to a familial dominant C3 glomerulopathy.

Shambhuprasad K Togarsimalemath, Sidharth K Sethi, Rajan Duggal, Moglie Le Quintrec, Pranaw Jha, RĂ©gis Daniel, Florence Gonnet, Shyam Bansal, Lubka T Roumenina, Veronique Fremeaux-Bacchi, Vijay Kher, Marie-Agnes Dragon-Durey,

The intrinsic similarity shared between the members of the complement factor H family, which comprises complement factor H and five complement factor H-related (CFHR) genes, leads to various recombination events. In turn these events lead to deletions of some genes or abnormal proteins, which are found in patients with atypical ... Read more >>

Kidney Int (Kidney international)
[2017, 92(4):876-887]

Cited: 12 times

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