Full Text Journal Articles by
Author Shailender S Chauhan

Advertisement

Find full text journal articles








Targeting dual signalling pathways in concert with immune checkpoints for the treatment of pancreatic cancer.

Erik S Knudsen, Vishnu Kumarasamy, Sejin Chung, Amanda Ruiz, Paris Vail, Stephanie Tzetzo, Jin Wu, Ram Nambiar, Jared Sivinski, Shailender S Chauhan, Mukund Seshadri, Scott I Abrams, Jianmin Wang, Agnieszka K Witkiewicz,

OBJECTIVE:This study exploits the intersection between molecular-targeted therapies and immune-checkpoint inhibition to define new means to treat pancreatic cancer. DESIGN:Patient-derived cell lines and xenograft models were used to define the response to CDK4/6 and MEK inhibition in the tumour compartment. Impacts relative to immunotherapy were performed using subcutaneous and orthotopic ... Read more >>

Gut (Gut)
[2020, :]

Cited: 0 times

View full text PDF listing >>



PIM kinases alter mitochondrial dynamics and chemosensitivity in lung cancer.

Shailender S Chauhan, Rachel K Toth, Corbin C Jensen, Andrea L Casillas, David F Kashatus, Noel A Warfel,

Resistance to chemotherapy represents a major obstacle to the successful treatment of non-small-cell lung cancer (NSCLC). The goal of this study was to determine how PIM kinases impact mitochondrial dynamics, ROS production, and response to chemotherapy in lung cancer. Live-cell imaging and microscopy were used to determine the effect of ... Read more >>

Oncogene (Oncogene)
[2020, 39(12):2597-2611]

Cited: 1 time

View full text PDF listing >>



Advertisement

Cell cycle plasticity driven by MTOR signaling: integral resistance to CDK4/6 inhibition in patient-derived models of pancreatic cancer.

Erik S Knudsen, Vishnu Kumarasamy, Amanda Ruiz, Jared Sivinski, Sejin Chung, Adam Grant, Paris Vail, Shailender S Chauhan, Tun Jie, Taylor S Riall, Agnieszka K Witkiewicz,

Pancreatic ductal adenocarcinoma (PDAC), like many KRAS-driven tumors, preferentially loses CDKN2A that encodes an endogenous CDK4/6 inhibitor to bypass the RB-mediated cell cycle suppression. Analysis of a panel of patient-derived cell lines and matched xenografts indicated that many pancreatic cancers have intrinsic resistance to CDK4/6 inhibition that is not due ... Read more >>

Oncogene (Oncogene)
[2019, 38(18):3355-3370]

Cited: 4 times

View full text PDF listing >>



Targeting PIM kinases to oppose hypoxia-mediated therapeutic resistance.

Shailender S Chauhan, Noel A Warfel,

(Oncoscience)
[2018, 5(9-10):254-255]

Cited: 0 times

View full text PDF listing >>





Advertisement

Disclaimer
0.5224 s