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Author Shahrokh F Shariat

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Acute kidney injury in COVID-19: are kidneys the target or just collateral damage? A comprehensive assessment of viral RNA and AKI rate in patients with COVID-19.

Dmitry Enikeev, Mark Taratkin, Sergey Efetov, Alexandra Shlomina, Margarita Boldyreva, Irina Galkina, Leonid Spivak, Evgeniy Gitel, Agunda Kuchieva, Vasiliy Mikhailov, Jeremy Yuen-Chun Teoh, Thomas R W Herrmann, Željko Kikic, Viktor Fomin, Shahrokh F Shariat, Petr Glybochko,

<h4>Purpose of review</h4>To investigate the possible effects of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) on kidney function and assess the rate of viral ribonucleic acid (RNA) shedding/detection in urine.<h4>Recent findings</h4>Most of the research on the topic suggests that for the moment our ability to estimate whether SARS-CoV-2 is a ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(4):363-368]

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Health-related quality of life in bladder cancer patients: bladder cancer-specific instruments and domains. Part 2.

Kristin Zimmermann, Hadi Mostafaei, Axel Heidenreich, Hans U Schmelz, Shahrokh F Shariat, Keiichiro Mori,

<h4>Purpose of review</h4>Several instruments have been designed to evaluate health-related quality of life (HRQoL) in patients with bladder cancer (BC). However, they vary in purpose, domains, and quality. To identify QoL instruments that have been validated for BC patients and to critically assess their domains and limitations.<h4>Recent findings</h4>Of the 11 ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(4):304-314]

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The prognostic value of sarcopenia in patients with prostate cancer: a systematic review.

Victoria Jahrreiss, Ekaterina Laukhtina, David D'Andrea, Shahrokh F Shariat,

<h4>Purpose of review</h4>Sarcopenia is known to affect perioperative and oncologic outcomes in patients with different urological malignancies. Nevertheless, the use of pretreatment sarcopenia as a predictor of clinical outcomes in patients with prostate cancer is still poorly studied. Therefore, we aimed to conduct a systematic review summarizing the available evidence ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(4):315-323]

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Artificial intelligence in prostate histopathology: where are we in 2021?

André Oszwald, Gabriel Wasinger, Benjamin Pradere, Shahrokh F Shariat, Eva M Compérat,

<h4>Purpose of review</h4>Artificial intelligence has made an entrance into mainstream applications of daily life but the clinical deployment of artificial intelligence-supported histological analysis is still at infancy. Recent years have seen a surge in technological advance regarding the use of artificial intelligence in pathology, in particular in the diagnosis of ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(4):430-435]

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Association between male infertility and prostate cancer: a systematic review and meta-analysis.

Ekaterina Laukhtina, Keiichiro Mori, Benjamin Pradere, Shahrokh F Shariat,

<h4>Purpose of review</h4>Male infertility has been shown to be associated with different maladies. The present systematic review and meta-analysis aimed to summarize the available evidence on the association between male infertility or childlessness and prostate cancer.<h4>Recent findings</h4>The PubMed, Web of Science, and Scopus databases were searched according to the Preferred ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(4):346-353]

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Contemporary patterns of presentation, diagnostics and management of upper tract urothelial cancer in 101 centres: the Clinical Research Office of the Endourological Society Global upper tract urothelial carcinoma registry.

Joyce Baard, Luigi Cormio, Vitor Cavadas, Antonio Alcaraz, Shahrokh F Shariat, Jean de la Rosette, Maria P Laguna,

<h4>Purpose of review</h4>To assess patterns of presentation, diagnostics and treatment in patients with upper tract urothelial carcinoma (UTUC), a multicentre registry was launched. Clinical data of UTUC patients were prospectively collected over a 5-year period.<h4>Recent findings</h4>Data from 2380 patients were included from 2014 to 2019 (101 centres in 29 countries). ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(4):354-362]

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Quality indicators for the management of high-risk upper tract urothelial carcinoma requiring radical nephroureterectomy.

Frederik König, Shahrokh F Shariat, Pierre I Karakiewicz, Dong-Ho Mun, Michael Rink, Benjamin Pradere,

<h4>Purpose of review</h4>The purpose of this article was to identify quality indicators for an optimized management of high-risk upper tract urothelial carcinoma (UTUC) requiring radical nephroureterectomy (RNU).<h4>Recent findings</h4>RNU with bladder cuff resection is the standard treatment of high-risk UTUC. For the bladder cuff resection, two main approaches are accepted: transvesical ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(4):291-296]

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Adverse events of systemic immune-based combination therapies in the first-line treatment of patients with metastatic renal cell carcinoma: systematic review and network meta-analysis.

Fahad Quhal, Keiichiro Mori, Mesut Remzi, Harun Fajkovic, Shahrokh F Shariat, Manuela Schmidinger,

<h4>Purpose of review</h4>To compare the safety profiles of systemic immune checkpoint inhibitor-based combination therapies that were evaluated in the first-line setting of the management of patients with advanced or metastatic renal cell carcinoma (mRCC).<h4>Recent findings</h4>Six phase III randomized control trials comparing first-line immune-based combination therapies to sunitinib in previously untreated ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(4):332-339]

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Novel transurethral resection technologies and training modalities in the management of nonmuscle invasive bladder cancer: a comprehensive review.

Victor M Schuettfort, Benjamin Pradere, Eva Compérat, Mohammad Abufaraj, Shahrokh F Shariat,

<h4>Purpose of review</h4>Conventional transurethral resection (TURBT) with tumor fragmentation is the primary step in the surgical treatment of nonmuscle invasive bladder cancer. Recently, new surgical techniques and training modalities have emerged with the aim to overcome short-comings of TURBT and improve oncologic outcomes. In this review, we provide a comprehensive ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(4):324-331]

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Health-related quality of life in bladder cancer patients: general and cancer-specific instruments. Part 1.

Kristin Zimmermann, Hadi Mostafaei, Axel Heidenreich, Hans U Schmelz, Shahrokh F Shariat, Keiichiro Mori,

<h4>Purpose of review</h4>Although survival outcomes are the primary outcomes to determine the effectiveness of treatment options, quality of life (QoL) is gaining in importance in addition to classic oncological outcomes. The present review aims to state and critically assess the challenges in health-related QoL (HRQoL) assessment especially in bladder cancer ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(4):297-303]

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Impact of the preoperative modified glasgow prognostic score on disease outcome after radical cystectomy for urothelial carcinoma of the bladder.

Victor M Schuettfort, Kilian Gust, David D'Andrea, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Michael Rink, Mohammad Abufaraj, Pierre I Karakiewicz, Stefano Luzzago, Morgan Rouprêt, Dmitry Enikeev, Kristin Zimmermann, Marina Deuker, Marco Moschini, Reza Sari Motlagh, Nico C Grossmann, Satoshi Katayama, Benjamin Pradere, Shahrokh F Shariat,

<h4>Background</h4>To investigate the predictive and prognostic value of the preoperative modified Glasgow Prognostic Score (mGPS) in patients with urothelial carcinoma of the bladder (UCB) treated with radical cystectomy (RC).<h4>Methods</h4>We conducted a retrospective analysis of an established multicenter database consisting of 4,335 patients who were treated with RC +/- adjuvant chemotherapy ... Read more >>

Minerva Urol Nephrol (Minerva urology and nephrology)
[2021, :]

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Impact of systemic Immune-inflammation Index on oncologic outcomes in patients treated with radical prostatectomy for clinically nonmetastatic prostate cancer.

Pawel Rajwa, Victor M Schuettfort, David D'Andrea, Fahad Quhal, Keiichiro Mori, Satoshi Katayama, Ekaterina Laukhtina, Benjamin Pradere, Reza Sari Motlagh, Hadi Mostafaei, Nico C Grossmann, Nicolai Huebner, Andreas Aulitzky, Dong-Ho Mun, Alberto Briganti, Pierre I Karakiewicz, Harun Fajkovic, Shahrokh F Shariat,

<h4>Purpose</h4>To evaluate the predictive and prognostic value of the Systemic Immune-inflammation Index (SII) in a large cohort of patients treated with radical prostatectomy (RP) for clinically non-metastatic prostate cancer (PCa).<h4>Methods</h4>We retrospectively analyzed our multicenter database comprising 6,039 consecutive patients. The optimal preoperative SII cut-off value was assessed with the Youden ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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The role of lymph node dissection in salvage radical prostatectomy for patients with radiation recurrent prostate cancer.

Fahad Quhal, Pawel Rajwa, Keiichiro Mori, Ekaterina Laukhtina, Nico C Grossmann, Victor M Schuettfort, Frederik König, Abdulmajeed Aydh, Reza S Motlagh, Satoshi Katayama, Hadi Mostafai, Benjamin Pradere, Giancarlo Marra, Paolo Gontero, Romain Mathieu, Pierre I Karakiewicz, Alberto Briganti, Shahrokh F Shariat, Axel Heidenreich,

<h4>Purpose</h4>To examine the effect of lymph node dissection on the outcomes of patients who underwent salvage radical prostatectomy (SRP).<h4>Material and methods</h4>We retrospectively reviewed data from radiation-recurrent patients with prostate cancer (PCa) who underwent SRP from 2000-2016. None of the patients had clinical lymph node involvement before SRP. The effect of ... Read more >>

Prostate (The Prostate)
[2021, :]

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Role of Radiomics in the Prediction of Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis.

Mieszko Kozikowski, Rodrigo Suarez-Ibarrola, Rafał Osiecki, Konrad Bilski, Christian Gratzke, Shahrokh F Shariat, Arkadiusz Miernik, Jakub Dobruch,

<h4>Context</h4>Radiomics is a field of science that aims to develop improved methods of medical image analysis by extracting a large number of quantitative features. New data have emerged on the successful application of radiomics and machine-learning techniques to the prediction of muscle-invasive bladder cancer (MIBC).<h4>Objective</h4>To systematically review the diagnostic performance ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Contemporary analysis of the effect of marital status on survival in upper tract urothelial carcinoma patients treated with radical nephroureterectomy: A population-based study.

Claudia Collà Ruvolo, Luigi Nocera, Franziska L Stolzenbach, Mike Wenzel, Christoph Würnschimmel, Ferdinando Fusco, Alessandro Palmieri, Zhe Tian, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Ciro Imbimbo, Vincenzo Mirone, Pierre I Karakiewicz,

<h4>Purpose</h4>Unmarried status is an established risk factor for worse cancer control outcomes in various malignancies. Moreover, several investigators observed worse outcomes in unmarried males, but not in females. This concept has not been tested in upper tract urothelial carcinoma and represents the topic of the study.<h4>Methods</h4>Within Surveillance, Epidemiology and End ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Comparison between 1973 and 2004/2016 World Health Organization grading in upper tract urothelial carcinoma treated with radical nephroureterectomy.

Claudia Collà Ruvolo, Christoph Würnschimmel, Mike Wenzel, Luigi Nocera, Giuseppe Celentano, Francesco Mangiapia, Zhe Tian, Shahrokh F Shariat, Fred Saad, Felix H C Chun, Alberto Briganti, Nicola Longo, Vincenzo Mirone, Pierre I Karakiewicz,

<h4>Aims</h4>The European Association of Urology guideline for upper tract urothelial carcinoma (UTUC) relies on two grading system: 1973 World Health Organization (WHO) and 2004/2016 WHO. No consensus has been made which classification should supersede the other and both are recommended in clinical practice. We hypothesized that one may be superior ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2021, :]

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Prognostic Impact of Different Gleason Patterns on Biopsy Within Grade Group 4 Prostate Cancer.

Keiichiro Mori, Vidit Sharma, Eva M Comperat, Shun Sato, Ekaterina Laukhtina, Victor M Schuettfort, Benjamin Pradere, Reza Sari Motlagh, Hadi Mostafaei, Fahad Quhal, Mehdi Kardoust Parizi, Mohammad Abufaraj, Pierre I Karakiewicz, Shin Egawa, Derya Tilki, Stephen A Boorjian, Shahrokh F Shariat,

<h4>Background</h4>Grade group (GG) 4 prostate cancer (PC) is considered a single entity; however, there are questions regarding prognostic heterogeneity. This study assessed the prognostic differences among various Gleason scores (GSs) classified as GG 4 PC on biopsy before radical prostatectomy (RP).<h4>Methods</h4>We conducted a multicenter retrospective study, and a total of ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2021, :]

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Oncologic impact of delaying radical prostatectomy in men with intermediate- and high-risk prostate cancer: a systematic review.

Ekaterina Laukhtina, Reza Sari Motlagh, Keiichiro Mori, Fahad Quhal, Victor M Schuettfort, Hadi Mostafaei, Satoshi Katayama, Nico C Grossmann, Guillaume Ploussard, Pierre I Karakiewicz, Alberto Briganti, Mohammad Abufaraj, Dmitry Enikeev, Benjamin Pradere, Shahrokh F Shariat,

<h4>Purpose</h4>To summarize the available evidence on the survival and pathologic outcomes after deferred radical prostatectomy (RP) in men with intermediate- and high-risk prostate cancer (PCa).<h4>Methods</h4>The PubMed database and Web of Science were searched in November 2020 according to the PRISMA statement. Studies were deemed eligible if they reported the survival ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Overall survival and adverse events after treatment with darolutamide vs. apalutamide vs. enzalutamide for high-risk non-metastatic castration-resistant prostate cancer: a systematic review and network meta-analysis.

Mike Wenzel, Luigi Nocera, Claudia Collà Ruvolo, Christoph Würnschimmel, Zhe Tian, Shahrokh F Shariat, Fred Saad, Derya Tilki, Markus Graefen, Luis A Kluth, Alberto Briganti, Philipp Mandel, Francesco Montorsi, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>The most recent overall survival (OS) and adverse event (AE) data have not been compared for the three guideline-recommended high-risk non-metastatic castration-resistant prostate cancer (nmCRPC) treatment alternatives.<h4>Methods</h4>We performed a systematic review and network meta-analysis focusing on OS and AE according to the most recent apalutamide, enzalutamide, and darolutamide reports. We ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2021, :]

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Deep Learning-based Recalibration of the CUETO and EORTC Prediction Tools for Recurrence and Progression of Non-muscle-invasive Bladder Cancer.

Mateusz Jobczyk, Konrad Stawiski, Marcin Kaszkowiak, Paweł Rajwa, Waldemar Różański, Francesco Soria, Shahrokh F Shariat, Wojciech Fendler,

Despite being standard tools for decision-making, the European Organisation for Research and Treatment of Cancer (EORTC), European Association of Urology (EAU), and Club Urologico Espanol de Tratamiento Oncologico (CUETO) risk groups provide moderate performance in predicting recurrence-free survival (RFS) and progression-free survival (PFS) in non-muscle-invasive bladder cancer (NMIBC). In this ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, :]

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Adjuvant Nivolumab versus Placebo in Muscle-Invasive Urothelial Carcinoma.

Dean F Bajorin, J Alfred Witjes, Jürgen E Gschwend, Michael Schenker, Begoña P Valderrama, Yoshihiko Tomita, Aristotelis Bamias, Thierry Lebret, Shahrokh F Shariat, Se Hoon Park, Dingwei Ye, Mads Agerbaek, Deborah Enting, Ray McDermott, Pablo Gajate, Avivit Peer, Matthew I Milowsky, Alexander Nosov, João Neif Antonio, Krzysztof Tupikowski, Laurence Toms, Bruce S Fischer, Anila Qureshi, Sandra Collette, Keziban Unsal-Kacmaz, Edward Broughton, Dimitrios Zardavas, Henry B Koon, Matthew D Galsky,

<h4>Background</h4>The role of adjuvant treatment in high-risk muscle-invasive urothelial carcinoma after radical surgery is not clear.<h4>Methods</h4>In a phase 3, multicenter, double-blind, randomized, controlled trial, we assigned patients with muscle-invasive urothelial carcinoma who had undergone radical surgery to receive, in a 1:1 ratio, either nivolumab (240 mg intravenously) or placebo every ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 384(22):2102-2114]

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Adverse events of the second-line treatment for patients with locally advanced or metastatic urothelial carcinoma of the bladder: network meta-analysis.

Ekaterina Laukhtina, Keiichiro Mori, Hadi Mostafaei, Axel S Merseburger, Peter Nyirady, Marco Moschini, Fahad Quhal, Victor M Schuettfort, Benjamin Pradere, Reza Sari Motlagh, Dmitry Enikeev, Shahrokh F Shariat, European Association Of Urology-Young Academic Urologists Eau-Yau Urothelial Carcinoma Working Group,

<b>Aim:</b> We aimed to compare the mortality rates related to adverse events (AEs) and discontinuation of treatment due to toxicity as well as all AEs of currently used regimens of second-line treatment strategies for advanced or metastatic urothelial carcinoma of the bladder. <b>Methods:</b> The MEDLINE and EMBASE databases were searched ... Read more >>

Immunotherapy (Immunotherapy)
[2021, :]

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Non-cancer mortality in elderly prostate cancer patients treated with combination of radical prostatectomy and external beam radiation therapy.

Mike Wenzel, Christoph Würnschimmel, Francesco Chierigo, Zhe Tian, Shahrokh F Shariat, Carlo Terrone, Fred Saad, Derya Tilki, Markus Graefen, Philipp Mandel, Luis A Kluth, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>To test for rates of other cause mortality (OCM) and cancer-specific mortality (CSM) in elderly prostate cancer (PCa) patients treated with the combination of radical prostatectomy (RP) and external beam radiation therapy (EBRT) versus RP alone, since elderly PCa patients may be over-treated.<h4>Methods</h4>Within the Surveillance, Epidemiology and End Results database ... Read more >>

Prostate (The Prostate)
[2021, :]

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Presence of biopsy Gleason pattern 5 + 3 is associated with higher mortality after radical prostatectomy but not after external beam radiotherapy compared to other Gleason Grade Group IV patterns.

Christoph Würnschimmel, Mike Wenzel, Francesco Chierigo, Rocco S Flammia, Keiichiro Mori, Zhe Tian, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Nazareno Suardi, Carlo Terrone, Michele Gallucci, Felix K H Chun, Derya Tilki, Markus Graefen, Pierre I Karakiewicz,

<h4>Background</h4>We hypothesized that Gleason Grade Group (GGG) IV patients treated with radical prostatectomy (RP) or external beam radiotherapy (EBRT) exhibit different cancer-specific mortality (CSM) rates according to underlying Gleason patterns (GP): 4 + 4 versus 3 + 5 versus 5 + 3.<h4>Materials and methods</h4>We identified all GGG IV patients treated with either RP or EBRT within ... Read more >>

Prostate (The Prostate)
[2021, :]

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Differential Prognosis and Response of Denovo vs. Secondary Muscle-Invasive Bladder Cancer: An Updated Systematic Review and Meta-Analysis.

Mario Pones, David D'Andrea, Keiichiro Mori, Mohammad Abufraj, Marco Moschini, Eva Comperat, Shahrokh F Shariat,

To evaluate oncological outcomes of primary versus secondary muscle-invasive bladder cancer treated with radical cystectomy. Medline, Embase, Scopus and Cochrane Library were searched for eligible studies. Hazard ratios for overall survival (OS), cancer specific survival (CSS) and progression free survival (PFS) were calculated using survival data extracted from Kaplan-Meier curves. ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(10):]

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