Full Text Journal Articles by
Author Shaheen Sharafat

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HBV S antigen evolution in the backdrop of HDV infection affects epitope processing and presentation.

Mehwish Sajjad, Syed Ali, Samina Baig, Shaheen Sharafat, Bilal Ahmed Khan, Saeed Khan, Muhammad Nouman Mughal, Syed Hani Abidi,

<h4>Introduction</h4>HBV can evolve under selection pressure exerted by drugs and/or host immunity, resulting in accumulation of escape mutations that can affect the drug or the immune activity. Hepatitis delta virus (HDV) coinfection is also known to exert selection pressure on HBV, which leads to selective amplification of certain mutations, especially ... Read more >>

J Med Virol (Journal of medical virology)
[2020, :]

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Common Cancers in Karachi, Pakistan: 2010-2019 Cancer Data from the Dow Cancer Registry.

Muhammad Asif Qureshi, Saeed Khan, Shaheen Sharafat, Mohammed Saeed Quraishy,

<h4>Objectives</h4>To present 2010-2019 cancer data from the Dow Cancer Registry representing all districts of Karachi (~17.4 million).<h4>Methods</h4>The study was conducted at the Dow University of Health Sciences. After ethical approval, the Dow Cancer Registry was established at the largest government-run diagnostic and reference center of Karachi (Dow Labs). All cancers ... Read more >>

Pak J Med Sci (Pakistan journal of medical sciences)
[2020, 36(7):1572-1578]

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Pan-Cancer Multiomics Analysis of TC2N Gene Suggests its Important Role(s) in Tumourigenesis of Many Cancers.

Muhammad Asif Qureshi, Saeed Khan, Muhammad Sohaib Tauheed, Sofia Ali Syed, Ikram Din Ujjan, Amanullah Lail, Shaheen Sharafat,

<h4>Background</h4>Role of TC2N in carcinogenesis has been largely unfathomed until recently when it was identified as a novel oncogene in lung cancer. Subsequently, a tumour suppressor role of TC2N was reported in breast cancer. It is therefore highly relevant to investigate TC2N molecular partners/mechanisms on a larger scale including a ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(11):3199-3209]

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Non-albicans Candida species: Emergence of neglected pathogens among population of Karachi.

Gul Jabeen, Sehar Afshan Naz, Nusrat Jabeen, Maryam Shafique, Shaheen Sharafat, Samina Baig, Sadia Nazeer,

Candida albicans was considered as the principal cause of opportunistic candidiasis but nowadays, neglected non-albicans Candida (NAC) species are evolving as more virulent and drug resistant strains. This research was intended to assess pervasiveness of candidiasis mainly caused by NAC species in Karachi city. A total of 562 clinical isolates ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(3 (Supplementary)):1185-1192]

Cited: 1 time

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Bergenin loaded gum xanthan stabilized silver nanoparticles suppress synovial inflammation through modulation of the immune response and oxidative stress in adjuvant induced arthritic rats.

Komal Rao, Talat Roome, Sabahat Aziz, Anam Razzak, Ghulam Abbas, Muhammad Imran, Tooba Jabri, Jasra Gul, Munawar Hussain, Bushra Sikandar, Shaheen Sharafat, Muhammad Raza Shah,

Bergenin (BG) is a naturally occurring C-glycoside with demonstrated anti-arthritic potential. Its therapeutic efficacy is compromised due to its lower absorption and instability at neutral-basic pH. The present study reports fabrication of gum xanthan (GX) stabilized silver nanoparticles (AgNPs) with BG for anti-arthritic activity in a CFA-induced arthritis model targeting ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2018, 6(27):4486-4501]

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Comparison Of Ziehl-Neelsen Based Light Microscopy With Led Fluorescent Microscopy For Tuberculosis Diagnosis: An Insight From A Limited Resource-High Burden setting.

Muhammad Yahya Noori, Faiza Ali, Zaheer Ali, Shaheen Sharafat,

Microscopy is the most widely used tool for Tuberculosis screening. Conventionally, Ziehl-Neelsen (ZN) staining has been the widely used for staining Acid-Fast Bacilli (AFB) but with the advent of Fluorescent staining, Auramine O stain is now being adapted as the preferred method for setups with high workload as it has ... Read more >>

J Ayub Med Coll Abbottabad (Journal of Ayub Medical College, Abbottabad : JAMC)
[2017, 29(4):577-579]

Cited: 1 time

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Estimation of uncertainty measurement - A prerequisite of ISO1589 accreditation for clinical laboratories.

Sahar Iqbal, Aamir Ijaz, Shaheen Sharafat,

<h4>Objective</h4>To estimate relative expanded uncertainty measurement of routine clinical chemistry analytes for international organisation for standardisation 15189 accreditation.<h4>Methods</h4>This cross-sectional study was conducted at Dow International Medical College, Karachi, from September 2013 to May 2014. During the process of international organisation for standardisation 15189 accreditation, measurement uncertainty was estimated for 13 ... Read more >>

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2017, 67(5):701-705]

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False negativity in AFB Smear microscopy: An insight into the caveats of the most widely used screening tool for tuberculosis.

Muhammad Yahya Noori, Zaheer Ali, Syed Adnan Ali Wahidi, Muhammad Nouman Mughal, Shaheen Sharafat, Muhammad Masroor, Muhammad Rafiq Khanani,

<h4>Objective</h4>To study the ratio of false negativity in sputum samples in diagnostic smears received for acid fast bacilli smear microscopy.<h4>Methods</h4>The retrospective cross-sectional study was conducted at the Ojha Institute of Chest Diseases, Karachi, and comprised specimens for microscopy and culture from presumptive tuberculosis patients for 38 months starting from November ... Read more >>

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2016, 66(9):1116-1119]

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Cancer patterns in Karachi (all districts), Pakistan: First results (2010-2015) from a Pathology based cancer registry of the largest government-run diagnostic and reference center of Karachi.

Muhammad Asif Qureshi, Talat Mirza, Saeed Khan, Bushra Sikandar, Maria Zahid, Marium Aftab, Sehrish Mohsin, Shaheen Sharafat, Lubna Avesi, Saba Hassan,

National level population-based cancer data have never been published from Pakistan in seven decades since independence (1947). Therefore, generation of high-quality regional data becomes highly relevant. Cancer data for the period of 2010-2015 representing the population from all districts of Karachi (14.6 million) are presented herein. After institutional approval (Ref ... Read more >>

Cancer Epidemiol (Cancer epidemiology)
[2016, 44:114-122]

Cited: 7 times

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DIFFERENCES IN CULTURAL YIELD OF MYCOBACTERIUM TUBERCULOSIS ON MEDIA PREPARED USING COMMERCIAL AND HOUSEHOLD EGGS.

Muhammad Yahya Noori, Zaheer AJi, Ghazala Khan, Shaheen Sharafat, Muhammad Masroor,

<h4>Background</h4>Mycobacterial culture is considered as the gold standard for TB diagnosis. It is performed on egg-based media using commercially available eggs to grow Mycobacteria from clinical samples. These eggs are known to contain high concentration of antibiotics, including fluoroquinolones, given to chicken to prevent early mortality. This study was performed ... Read more >>

J Ayub Med Coll Abbottabad (Journal of Ayub Medical College, Abbottabad : JAMC)
[2015, 27(4):764-766]

Cited: 0 times

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Prevalence and clinical profile of insulin resistance in young women of poly cystic ovary syndrome: A study from Pakistan.

Rumina Tabassum, Fouzia Imtiaz, Shaheen Sharafat, Shazia Shukar-Ud-Din, Uzma Nusrat,

<h4>Objective</h4>The aim was to estimate the prevalence of Insulin Resistance (IR) in Poly Cystic Ovary Syndrome (PCOS) and analyze its clinical parameters.<h4>Methodology</h4>This observational study was conducted at Dow University Hospital during June 2011 till May 2012. Patients of PCOS were selected, an anthropometric measurement, examination and fasting blood test for ... Read more >>

Pak J Med Sci (Pakistan journal of medical sciences)
[2013, 29(2):593-596]

Cited: 3 times

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