Full Text Journal Articles by
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Molecular Subgroup Classification in Alzheimer's Disease by Transcriptomic Profiles.

Sha Liu, Yan Lu, Deqin Geng,

Alzheimer's disease (AD) is a progressive cognitive disorder that occurs worldwide, and the lack of disease-modifying targets and pathways is a pressing issue. This study aimed to provide new targets and pathways by performing molecular subgroup classification. After normalizing the collected data, the subgroup number was confirmed with consensus clustering. ... Read more >>

J Mol Neurosci (Journal of molecular neuroscience : MN)
[2022, :]

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Discovery of a novel megakaryopoiesis enhancer, ingenol, promoting thrombopoiesis through PI3K-Akt signaling independent of thrombopoietin.

Long Wang, Ting Zhang, Sha Liu, Qi Mo, Nan Jiang, Qi Chen, Jing Yang, Yun-Wei Han, Jian-Ping Chen, Fei-Hong Huang, Hua Li, Jie Zhou, Jie-Si Luo, Jian-Ming Wu,

Thrombocytopenia, a most common complication of radiotherapy and chemotherapy, is an important cause of morbidity and mortality in cancer patients. However, there are still no approved agents for the treatment of radiation- and chemotherapy-induced thrombocytopenia (RIT and CIT, respectively). In this study, a drug screening model for predicting compounds with ... Read more >>

Pharmacol Res (Pharmacological research)
[2022, :106096]

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Correction to: Attenuated expression of SNF5 facilitates progression of bladder cancer via STAT3 activation.

Hua Ding, Yaqin Huang, Jiazhong Shi, Liwei Wang, Sha Liu, Baixiong Zhao, Yuting Liu, Jin Yang, Zhiwen Chen,

Cancer Cell Int (Cancer cell international)
[2022, 22(1):20]

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YEATS Domains as Novel Epigenetic Readers: Structures, Functions, and Inhibitor Development.

Xin Li, Sha Liu, Xiang Li, Xiang David Li,

Interpretation of the histone posttranslational modifications (PTMs) by effector proteins, or readers, is an important epigenetic mechanism to regulate gene function. YEATS domains have been recently identified as novel readers of histone lysine acetylation and a variety of nonacetyl acylation marks. Accumulating evidence has revealed the association of dysregulated interactions ... Read more >>

ACS Chem Biol (ACS chemical biology)
[2022, :]

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APTC-EC-2A: A Lytic Phage Targeting Multidrug Resistant E. coli Planktonic Cells and Biofilms.

Karen Hon, Sha Liu, Sophie Camens, George Spyro Bouras, Alkis James Psaltis, Peter-John Wormald, Sarah Vreugde,

<i>Escherichia coli</i> (<i>E. coli</i>) are common bacteria that colonize the human and animal gastrointestinal tract, where they help maintain a balanced microbiome. However, some <i>E. coli</i> strains are pathogenic and can cause serious infectious diseases and life-threatening complications. Due to the overuse of antibiotics and limited development of novel antibiotics, ... Read more >>

Microorganisms (Microorganisms)
[2022, 10(1):]

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Correction: Combining PD-L1 inhibitors with immunogenic cell death triggered by chemo-photothermal therapy via a thermosensitive liposome system to stimulate tumor-specific immunological response.

Jie Yu, Xidong He, Zigui Wang, Yupeng Wang, Sha Liu, Zhigang Xie, Xiaoyuan Li, Yubin Huang,

Correction for 'Combining PD-L1 inhibitors with immunogenic cell death triggered by chemo-photothermal therapy via a thermosensitive liposome system to stimulate tumor-specific immunological response' by Jie Yu et al., Nanoscale, 2021, DOI: . ... Read more >>

Nanoscale (Nanoscale)
[2021, 13(32):13907]

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Long-Term Dechlorination of Polychlorinated Biphenyls (PCBs) in Taihu Lake Sediment Microcosms: Identification of New Pathways, PCB-Driven Shifts of Microbial Communities, and Insights into Dechlorination Potential.

Lei Xu, Sha Liu, Yanqiang Tang, Xuexin Han, Ying Wang, Dafang Fu, Qingdong Qin, Yan Xu,

Microbial reductive dechlorination of polychlorinated biphenyls (PCBs) is regarded as an alternative approach for <i>in situ</i> remediation and detoxification in the environment. To better understand the process of PCB dechlorination in freshwater lake sediment, a long-term (108 weeks) dechlorination study was performed in Taihu Lake sediment microcosms with nine parent ... Read more >>

Environ Sci Technol (Environmental science & technology)
[2022, 56(2):938-950]

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Noninvasive Prenatal Screening Based on Second-Trimester Ultrasonographic Soft Markers in Low-Risk Pregnant Women.

Yunyun Liu, Xiaosha Jing, Lingling Xing, Sha Liu, Jianlong Liu, Jing Cheng, Cechuan Deng, Ting Bai, Tianyu Xia, Xiang Wei, Yuan Luo, Quanfang Zhou, Qian Zhu, Hongqian Liu,

<b>Background:</b> We aimed to assess the clinical application of noninvasive prenatal screening (NIPS) based on second-trimester ultrasonographic soft markers (USMs) in low-risk pregnant women. <b>Methods:</b> Data of pregnant women between April 2015 and December 2019 were retrospectively analyzed. Pregnant women [age at expected date of confinement (EDC) of <35 years; low ... Read more >>

Front Genet (Frontiers in genetics)
[2021, 12:793894]

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Molecular characterization and tissue distribution of nine selenoprotein genes in grass carp Ctenopharyngodon idella and their mRNA expressions in response to high-fat diet and high-fat diet supplemented with selenium.

Pan He, Xiaotian Zhang, Wenyi Wu, Guohao Liu, Sha Liu, Chi Wang, Haibo Yu,

Our previous study has found that selenium (Se) can alleviate lipid accumulation caused by high-fat diet (HFD) in fish. This study aims to explore the selenoproteins (SePs) in grass carp Ctenopharyngodon idella by characterizing cDNAs of nine SeP genes (SELENOF, SELENOM, SELENOS, SELENOP1, SELENOP2, SELENOE, SELENOL, SELENOU1a and SELENOU1b) and ... Read more >>

Comp Biochem Physiol B Biochem Mol Biol (Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology)
[2021, 259:110706]

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Combining PD-L1 inhibitors with immunogenic cell death triggered by chemo-photothermal therapy via a thermosensitive liposome system to stimulate tumor-specific immunological response.

Jie Yu, Xidong He, Zigui Wang, Yupeng Wang, Sha Liu, Xiaoyuan Li, Yubin Huang,

Immune checkpoint blockade (ICB) therapy in combination with immunogenic death (ICD) triggered by photothermal therapy (PTT) and oxaliplatin (OXA) treatment was expected to elicit both innate and adaptive immune responses for tumor control and metastasis prevention. In this study, a photothermal agent (IR780), a folic acid (FA) linked oxaliplatin (OXA) ... Read more >>

Nanoscale (Nanoscale)
[2021, 13(30):12966-12978]

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The effectiveness of computer-assisted Cognitive Behavioral Therapy (cCBT) for psychological outcomes in patients with laryngectomy: Randomized controlled trial.

Yang Yang, Haibin Zhang, Yuling Li, Zhifen Liu, Sha Liu, Xinrong Li, Gaiping Fan, Yong Xu, Bin-Quan Wang,

<h4>Background</h4>The symptom burden was tremendous and rates of psychological distress were high because of laryngectomy in Laryngeal carcinoma. Anxiety and depression as mainly psychological distress influenced their sleep, pain, and the quality of life (QOL). This study aimed to assess the effiacy of computer-assisted Cognitive Behavioral Therapy (cCBT) for psychological ... Read more >>

J Affect Disord (Journal of affective disorders)
[2021, 300:59-65]

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Sustainable hydrophilic ultrasmall carbonaceous spheres modified by click reaction for high-performance polymeric ion chromatographic stationary phase.

Yuqing Li, Sha Liu, Qiaoyan Zhang, Wan Gong, Hua Yin, Bo Yang, Luping Qin, Qiming Zhao, Yan Zhu,

Novel poly(ethylvinylbenzene-divinylbenzene) (EVB-DVB) agglomerated with ultrasmall carbonaceous spheres (UCSs) anion-exchange packings for ion chromatography (IC) were constructed. Hydrophilic UCSs with mean sizes of 62-98 nm were synthesized in quantity by the polydiallyl dimethyl ammonium chloride aided hydrothermal carbonization of fructose. The green strategy based on the thiol-ene click reaction with cysteamine ... Read more >>

J Chromatogr A (Journal of chromatography. A)
[2022, 1663:462762]

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A facile dual-mode aptasensor based on [email protected] nanohybrids for ultrasensitive fluorescence and surface-enhanced Raman spectroscopy detection of tetrodotoxin.

Sha Liu, Yapeng Huo, Sumei Deng, Guanghua Li, Shuang Li, Lei Huang, Shuyue Ren, Zhixian Gao,

The development of ultrasensitive, reliable, and facile detection technologies for trace tetrodotoxin (TTX) is challenging. We presented a facile dual-mode aptamer-based biosensor (aptasensor) for ultrasensitive fluorescence and surface-enhanced Raman spectroscopy (SERS) detection of TTX by using gold nanoparticles (AuNPs)-embedded metal-organic framework (MOF) nanohybrids ([email protected]) because of their superior properties. A ... Read more >>

Biosens Bioelectron (Biosensors & bioelectronics)
[2021, 201:113891]

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Diagnostic and Therapeutic Potential of Exosomes in Neurodegenerative Diseases.

Panyue Gao, Xinrong Li, Xinzhe Du, Sha Liu, Yong Xu,

Neurodegenerative diseases are closely related to brain function and the progression of the diseases are irreversible. Due to brain tissue being not easy to acquire, the study of the pathophysiology of neurodegenerative disorders has many limitations-lack of reliable early biomarkers and personalized treatment. At the same time, the blood-brain barrier ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2021, 13:790863]

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Mitochondrial Deficits With Neural and Social Damage in Early-Stage Alzheimer's Disease Model Mice.

Afzal Misrani, Sidra Tabassum, Qingwei Huo, Sumaiya Tabassum, Jinxiang Jiang, Adeel Ahmed, Xiangmao Chen, Jianwen Zhou, Jiajia Zhang, Sha Liu, Xiaoyi Feng, Cheng Long, Li Yang,

Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide. Mitochondrial dysfunction is thought to be an early event in the onset and progression of AD; however, the precise underlying mechanisms remain unclear. In this study, we investigated mitochondrial proteins involved in organelle dynamics, morphology and energy production in the ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2021, 13:748388]

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Attenuated expression of SNF5 facilitates progression of bladder cancer via STAT3 activation.

Hua Ding, Yaqin Huang, Jiazhong Shi, Liwei Wang, Sha Liu, Baixiong Zhao, Yuting Liu, Jin Yang, Zhiwen Chen,

<h4>Background</h4>SWI/SNF, a well-known ATP-dependent chromatin-remodeling complex, plays an essential role in several biological processes. SNF5, the core subunit of the SWI/SNF remodeling complex, inactivated in 95% of malignant rhabdoid tumors (MRT), highlighting its significance in tumorigenesis. However, the role of SNF5 in bladder cancer (BC) remains unknown. In this study, ... Read more >>

Cancer Cell Int (Cancer cell international)
[2021, 21(1):655]

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DMAG, a novel countermeasure for the treatment of thrombocytopenia.

Jing Lin, Jing Zeng, Sha Liu, Xin Shen, Nan Jiang, Yue-Song Wu, Hong Li, Long Wang, Jian-Ming Wu,

<h4>Background</h4>Thrombocytopenia is one of the most common hematological disease that can be life-threatening caused by bleeding complications. However, the treatment options for thrombocytopenia remain limited.<h4>Methods</h4>In this study, giemsa staining, phalloidin staining, immunofluorescence and flow cytometry were used to identify the effects of 3,3'-di-O-methylellagic acid 4'-glucoside (DMAG), a natural ellagic acid ... Read more >>

Mol Med (Molecular medicine (Cambridge, Mass.))
[2021, 27(1):149]

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Rapid and ultrasensitive detection of DNA and microRNA-21 using a zirconium porphyrin metal-organic framework-based switch fluorescence biosensor.

Sha Liu, Yapeng Huo, Longxing Fan, Baoan Ning, Tieqiang Sun, Zhixian Gao,

Sensitive and accurate detection of nucleic acid biomarkers is critical for early cancer diagnosis, disease monitoring, and clinical treatment. In this study, we developed a switch fluorescence biosensor for simple and high-efficient detection of nucleic acid biomarkers using 6-carboxyfluorescein (FAM)-modified single-stranded DNA (ssDNA) probes (FAM-P1/P2), and zirconium porphyrin metal-organic framework ... Read more >>

Anal Chim Acta (Analytica chimica acta)
[2022, 1192:339340]

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Identifying the Subtypes and Characteristics of Mental Workload Among Chinese Physicians in Outpatient Practice: A Latent Profile Analysis.

Dehe Li, Yinhuan Hu, Hao Chen, Ximin Zhu, Xiaoyue Wu, Jiayi Li, Zemiao Zhang, Sha Liu,

<b>Objective:</b> The purpose of this study is to investigate the mental workload level of physicians in outpatient practice since the normalization of prevention and control of the COVID-19 pandemic in China and explore the subtypes of physicians regarding their mental workload. <b>Methods:</b> A cross-sectional survey of 1,934 physicians primarily in ... Read more >>

Front Public Health (Frontiers in public health)
[2021, 9:779262]

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The screening value of RT-LAMP and RT-PCR in the diagnosis of COVID-19: systematic review and meta-analysis.

Ruiyang Pu, Sha Liu, Xiaoyu Ren, Dian Shi, Yupei Ba, Yanbei Huo, Wenling Zhang, Lingling Ma, Yanyan Liu, Yan Yang, Ning Cheng,

The purpose of this systematic review is to evaluate the test accuracy of reverse-transcription loop-mediated isothermal amplification (RT-LAMP) and reverse transcription-PCR (RT-PCR) for the diagnosis of coronavirus disease 2019 (COVID-19). We comprehensively searched PUBMED, Web of Science, the Cochrane Library, the Chinese National Knowledge Infrastructure, and the Chinese Biomedical Literature ... Read more >>

J Virol Methods (Journal of virological methods)
[2022, 300:114392]

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Rapid testing of candidate oncogenes and tumour suppressor genes in signal transduction and neoplastic transformation.

Sha Liu, Paula Medina-Perez, Minh-Cam Ha-Thi, Anja Wieland, Maria Stecklum, Jens Hoffmann, Oleg Tchernitsa, Christine Sers, Reinhold Schäfer,

The COSMIC database (version 94) lists 576 genes in the Cancer Gene Census which have a defined function as drivers of malignancy (oncogenes) or as tumour suppressors (Tier 1). In addition, there are 147 genes with similar functions, but which are less well characterised (Tier 2). Furthermore, next-generation sequencing projects ... Read more >>

Adv Biol Regul (Advances in biological regulation)
[2021, :100841]

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Transforming growth factor-β blockade modulates tumor mechanical microenvironments for enhanced antitumor efficacy of photodynamic therapy.

Jitang Chen, Si Li, Xin Liu, Sha Liu, Chen Xiao, Zhijie Zhang, Shiyou Li, Zifu Li, Xiangliang Yang,

Photodynamic therapy (PDT) is frequently used in cancer treatment in clinical settings. However, its applications in stroma-rich solid tumors, e.g., triple negative breast cancer, are limited by abnormal mechanical microenvironments. Solid stress accumulated in stroma-rich solid tumors compresses tumor blood vessels, hampers the delivery of photosensitizers (PSs) in tumor tissues, ... Read more >>

Nanoscale (Nanoscale)
[2021, 13(22):9989-10001]

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Clinical Utility of Noninvasive Prenatal Screening for Rare Chromosome Abnormalities in Singleton Pregnancies

Ting Hu, Jiamin Wang, Qian Zhu, zhu zhang, Rui Hu, Like Xiao, Yunyuan Yang, Na Liao, Sha Liu, He Wang, Xiaoyu Niu, Shanling Liu,

<h4>Objective: </h4> To systematically investigate the clinical utility of noninvasive prenatal screening (NIPS) commercially used for the common fetal aneuploidies as a prenatal screening tool for rare chromosome abnormalities (RCAs). <h4>Design:</h4> Prospective study. <h4>Setting:</h4> Hospital-based. Population or Sample: 528 gravidas with positive NIPS results for RCAs. <h4>Methods:</h4> Gravidas with positive ... Read more >>

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Lard-Blended Vegetable Oil Diet Alleviates Metabolic Syndrome in Mice

Sisi Yan, Jianyu Qu, Xiangyan Liu, Sha Liu, Yu Zeng, Huijuan Zhou, Froilan Bernard Matias, Lixin Wen, Ji Wang,

<h4>Background: </h4> Our previous work has suggested that the balance fatty acid diet, blending lard with soybean oil, could reduce adipose tissue accumulation by decreasing adipogenesis and lipogenesis while increasing the hydrolysis of triglycerides. The aim of present study is to investigate whether the fat reducing function of balanced fatty ... Read more >>

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A new mouse model of type 2 diabetes mellitus established through combination of high-fat diet, streptozotocin and glucocorticoid.

Sha Liu, Lingling Ma, Xiaoyu Ren, Wenling Zhang, Dian Shi, Yanbei Huo, Yupei Ba, Yana Bai, Ning Cheng,

<h4>Aim</h4>A stable induced type 2 diabetes model (T2DM) still needs to be explored for basic and clinical research, due to nonuniform model methods and unstable consequences. Our aims were to explore and establish an optimized induced T2DM model in mice that exhibits insulin resistance and β-cell damage.<h4>Materials and methods</h4>C57BL/6 mice ... Read more >>

Life Sci (Life sciences)
[2021, 286:120062]

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