Full Text Journal Articles by
Author Sevki Cetinkalp

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Turkish Adaptation of Diabetic Foot Ulcer Scale-Short Form.

İsmail Toygar, Sadık Hançerlioğlu, Selden Gül, Tülün Utku, Ilgın Yıldırım Şimşir, Şevki Çetinkalp,

The purpose of this study was to evaluate the validity and reliability of the Turkish version of the Diabetic Foot Scale-Short Form (DFS-SF). The study was cross-sectional and conducted between January and October 2019 in a diabetic foot council of a university hospital. A total of 194 diabetic foot patients ... Read more >>

Int J Low Extrem Wounds (The international journal of lower extremity wounds)
[2020, :1534734620921036]

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Comparative Evaluation of Clinical Efficacy and Safety of Collagen Laminin-Based Dermal Matrix Combined With Resveratrol Microparticles (Dermalix) and Standard Wound Care for Diabetic Foot Ulcers.

Şevki Çetinkalp, Evren Homan Gökçe, IlgınYıldırım Şimşir, Sakine Tuncay Tanrıverdi, Fatma Doğan, Çığır Biray Avcı, İpek Eroğlu, Tülün Utku, Cumhur Gündüz, Özgen Özer,

This is an open, prospective, comparative parallel-arm medical device clinical study of Dermalix (Dx) in diabetic foot wounds. Dx is a 3-dimensional collagen-laminin porous-structured dermal matrix prepared and additionally impregnated with resveratrol-loaded hyaluronic acid and dipalmitoylphosphatidylcholine-based microparticles. The aim was to evaluate the efficacy and safety of Dx, an investigational ... Read more >>

Int J Low Extrem Wounds (The international journal of lower extremity wounds)
[2020, :1534734620907773]

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Therapeutic plasma exchange in hypertriglyceridemic patients

Ilgın Yıldırım Şimşir, Utku Erdem Soyaltın, Banu Sarer Yürekli, Mehmet Erdoğan, Şevki Çetinkalp, Füsun Saygılı, Ayhan Dönmez, Ahmet Gökhan Özgen,

Background/aim:High triglyceride (TG) levels are associated with increases in atherosclerotic cardiovascular disease (CVD), hepatic steatosis, and pancreatitis. Acute pancreatitis is a condition with high mortality. Therapeutic plasma exchange (TPE) in the treatment of hypertriglyceridemic pancreatitis (HTGP) is a rapid and effective treatment modality. In this study, the results of TPE ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2019, 49(3):872-878]

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Langerhans cell histiocytosis of the thyroid together with papillary thyroid carcinoma.

Hatice Ozisik, Banu Sarer Yurekli, Derya Demir, Yesim Ertan, Ilgın Yildirim Simsir, Murat Ozdemir, Mehmet Erdogan, Sevki Cetinkalp, Gokhan Ozgen, Fusun Saygili,

Hormones (Athens) (Hormones (Athens, Greece))
[2020, 19(2):253-259]

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A Cross-Sectional Study of Overtreatment and Deintensification of Antidiabetic and Antihypertensive Medications in Diabetes Mellitus: The TEMD Overtreatment Study.

Alper Sonmez, Ilker Tasci, Ibrahim Demirci, Cem Haymana, Cem Barcin, Hasan Aydin, Sevki Cetinkalp, Feyza Yener Ozturk, Kamile Gul, Tevfik Sabuncu, Ilhan Satman, Fahri Bayram, ,

INTRODUCTION:Targeting better glycated hemoglobin (HbA1c) and blood pressure (BP) goals may endanger older adults with type 2 diabetes mellitus (T2DM). Overtreatment of T2DM and hypertension is a trending issue, although undertreatment is still common. We investigated the rates and predictors of overtreatment and undertreatment of glycemia and BP in older ... Read more >>

Diabetes Ther (Diabetes therapy : research, treatment and education of diabetes and related disorders)
[2020, 11(5):1045-1059]

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A neglected causative agent in diabetic foot infection: a retrospective evaluation of 13 patients with fungal etiology

Anıl Murat Öztürk, Meltem Taşbakan, Dilek Yeşim Metin, Can Yener, Serhat Uysal, Ilgın Yıldırım Şımşır, İlgen Ertam, Hüsnü Pullukçu, Bilgin Arda, Şevki Çetinkalp,

Background/aim:Clinicians often neglect fungal infections and do not routinely investigate deep tissue from the wound for fungal culture and sensitivity due to insufficient information in the literature. In this study, we aimed to ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2019, 49(1):81-86]

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Review of Factors Contributing to Nodular Goiter and Thyroid Carcinoma.

Ilgin Yildirim Simsir, Sevki Cetinkalp, Taylan Kabalak,

There is an increased incidence of thyroid nodules and cancer. In this article, the reasons for this increase are evaluated and discussed. The factors causing increases in the incidence of nodules are the same as those causing increases in thyroid cancer. There are publications from all over the world regarding ... Read more >>

Med Princ Pract (Medical principles and practice : international journal of the Kuwait University, Health Science Centre)
[2020, 29(1):1-5]

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Continuation of evolution: Headliner glargine U300.

Utku Erdem Soyaltin, Ilgın Yildirim Şimşir, Şevki Çetinkalp,

Med. Hypotheses (Medical hypotheses)
[2018, 119:24-25]

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Prolactin effect on blood glucose and insülin in breastfeeding women.

Hatice Ozisik, Aslı Suner, Sevki Cetinkalp,

INTRODUCTION:Prolactin plays a significant role in lactation and prolactin levels are increasing physiologically in pregnancy and breastfeeding period. There might be different mechanisms during breastfeeding between prolactin and insülin levels. In order to highlighten this mechanisms we compared the plasma levels of glucose, insülin, prolactin, C-peptid in basal situations and ... Read more >>

Diabetes Metab Syndr (Diabetes & metabolic syndrome)
[2019, 13(3):1765-1767]

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Analysis of the GCK gene in 79 MODY type 2 patients: A multicenter Turkish study, mutation profile and description of twenty novel mutations.

Ayça Aykut, Emin Karaca, Hüseyin Onay, Damla Gökşen, Şevki Çetinkalp, Erdal Eren, Betül Ersoy, Esra Papatya Çakır, Muammer Büyükinan, Cengiz Kara, Ahmet Anık, Birgül Kırel, Samim Özen, Tahir Atik, Şükran Darcan, Ferda Özkınay,

Maturity onset diabetes is a genetic form of diabetes mellitus characterized by an early age at onset and several etiologic genes for this form of diabetes have been identified in many patients. Maturity onset diabetes type 2 [MODY2 (#125851)] caused by mutations in the glucokinase gene (GCK). Although its prevalence ... Read more >>

Gene (Gene)
[2018, 641:186-189]

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Intralesional epidermal growth factor therapy fordiabetic foot ulcers: an evaluation of 15 cases

Meltem Işıkgöz Taşbakan, Ilgın Yıldırım Şimşir, Sinan Mermer, Serhat Uysal, Murat Öztürk, Şevki Çetinkalp,

Background/aim: Intralesional recombinant epidermal growth factor (EGF) is a new treatment approach for diabetic foot ulcer, approved in 2006. EGF therapy is given as an adjunct to the standard treatment regimen of antibiotics, surgery, and hyperbaric oxygen. EGF accelerates the healing of diabetic foot ulcers and reduces healing time. This ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2017, 47(5):1500-1504]

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Risk factors for amputation in patients with diabetic foot infection: a prospective study.

Serhat Uysal, Bilgin Arda, Meltem I Taşbakan, Şevki Çetinkalp, Ilgın Y Şimşir, Anıl M Öztürk, Ayşe Uysal, İlgen Ertam,

There is a variety of diagnostic and therapeutic algorithms for diabetic foot infections (DFIs). Some of them are too difficult to be applied in routine clinical approach. In the routine clinical approach, it is necessary to find new risk factors and end up with a quick and easy assessment of ... Read more >>

Int Wound J (International wound journal)
[2017, 14(6):1219-1224]

Cited: 3 times

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Turkish nationwide survEy of glycemic and other Metabolic parameters of patients with Diabetes mellitus (TEMD study).

Alper Sonmez, Cem Haymana, Fahri Bayram, Serpil Salman, Oguzhan Sitki Dizdar, Eren Gurkan, Ayse Kargili Carlıoglu, Cem Barcin, Tevfik Sabuncu, Ilhan Satman, ,

AIMS:Turkey has the highest prevalence of diabetes in Europe. It is therefore essential to know the overall cardiovascular risk and reveal the predictors of metabolic control in Turkish adults with diabetes mellitus. METHODS:A nationwide, multicenter survey consecutively enrolled patients who were under follow up for at least a year. Optimal ... Read more >>

Diabetes Res. Clin. Pract. (Diabetes research and clinical practice)
[2018, 146:138-147]

Cited: 1 time

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[33 Questions about Triglycerides and Cardiovascular Effects: Expert Answers].

Şevki Çetinkalp, Nevrez Koylan, Necla Özer, Altan Onat, A Gökhan Özgen, Z Lale Koldaş, Gülay Sain Güven, Öner Özdoğan, Kubilay Karşıdağ, Zerrin Yiğit, Meral Kayıkçıoğlu, Lale Tokgözoğlu, Levent H Can, Zeynep Tartan, Hakan Kültürsay, Barış Karpuz, Bahadır Kırılmaz, Murat Ersanlı, Dilek Ural, Ayşe Naciye Erbakan, Aytekin Oğuz, Özcan R Kayıkçıoğlu, Ahmet Temizhan, Vedat Sansoy, Ceyhun Ceyhan, Zeki Öngen, Fahri Bayram, Cihan Örem, Alper Sönmez, Şengül Beyaz, Kubilay Ükinç, Banu Şarer Yürekli, Mahmut Çoker, Ebru Canda, Ilgın Yıldırım Şimşir,

Turk Kardiyol Dern Ars (Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir)
[2017, 45(Suppl 1):1-63]

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The low levels of bone morphogenic protein-4 and its antagonist noggin in type 2 diabetes.

Banu Sarer Yurekli, Gokcen Unal Kocabas, Murat Aksit, Nilufer Ozdemir Kutbay, Aslı Suner, Ismail Yurekli, Habib Cakir, Giray Bozkaya, Sevki Cetinkalp,

OBJECTIVE:Bone morphogenic protein-4 (BMP-4) is a proinflammatory cytokine which is controlled by BMP-4 antagonists. Our aim was to investigate the levels of BMP-4 and its antagonists, noggin and matrix Gla protein (MGP), in prediabetes and diabetes. DESIGN:One hundred and forty-two type 2 diabetic, 32 prediabetic, and 58 control subjects participated ... Read more >>

Hormones (Athens) (Hormones (Athens, Greece))
[2018, 17(2):247-253]

Cited: 1 time

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Glucagon like peptide-1 (GLP-1) likes Alzheimer's disease.

Ilgin Yildirim Simsir, Utku Erdem Soyaltin, Sevki Cetinkalp,

Glucagon-like peptide-1 (GLP-1) is a 30 amino acid long peptide hormone derived from the proglucagon gene and secreted in the distal small intestine when food enters the duodenum. GLP-1 is also produced in the central nervous system (CNS), predominantly in the brainstem, and subsequently transported to a large number of ... Read more >>

Diabetes Metab Syndr (Diabetes & metabolic syndrome)
[2018, 12(3):469-475]

Cited: 4 times

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Monocyte chemotactic protein-1, RANTES and macrophage migration inhibitory factor levels in gingival crevicular fluid of metabolic syndrome patients with gingivitis.

Ali Gürkan, Gülnihal Eren, Şevki Çetinkalp, Yasemin Delen Akçay, Gülnur Emingil, Gül Atilla,

The aim of the present study was to determine gingival crevicular fluid (GCF) levels of monocyte chemotactic protein-1 (MCP-1), regulated on activation, normal T-cell expressed and secreted protein (RANTES) and macrophage migration inhibitory factor (MIF) in metabolic syndrome patients with gingivitis.Twenty metabolic syndrome patients with gingivitis (MSG), 20 MetS patients ... Read more >>

Arch. Oral Biol. (Archives of oral biology)
[2016, 69:82-88]

Cited: 1 time

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The spectrum of HNF1A gene mutations in patients with MODY 3 phenotype and identification of three novel germline mutations in Turkish Population.

Emin Karaca, Huseyin Onay, Sevki Cetinkalp, Ayca Aykut, Damla Göksen, Samim Ozen, Tahir Atik, Sukran Darcan, Ismihan Merve Tekin, Ferda Ozkınay,

Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes mellitus characterized by autosomal dominant inheritance, early age of onset, and pancreatic beta cell dysfunction. Heterozygous mutations in several genes may cause MODY.In the present study, we investigated the molecular spectrum of HNF1A (hepatocyte nuclear factor 1a) mutations, ... Read more >>

Diabetes Metab Syndr (Diabetes & metabolic syndrome)
[2017, 11 Suppl 1:S491-S496]

Cited: 1 time

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Cortisol response patterns in depressed women and their healthy daughters at risk: Comparison with healthy women and their daughters.

Ali Saffet Gonul, Sevki Cetinkalp, Sebnem Tunay, Irmak Polat, Fatma Simsek, Burcu Aksoy, Gozde Kizilates, Yigit Erdogan, Kerry L Coburn,

A dysfunctional hypothalamic pituitary adrenal (HPA) axis is widely accepted as a significant pathophysiological aspect of Major Depressive Disorder (MDD). Despite studies suggesting that a dysfunctional HPA axis might be present before the clinical syndrome becomes apparent, the functioning of the HPA axis in high-risk populations has not been well ... Read more >>

J Psychiatr Res (Journal of psychiatric research)
[2017, 85:66-74]

Cited: 1 time

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A novel CYP11B1 mutation in a Turkish patient with 11β-hydroxylase deficiency: An association with the severe hypokalemia leading to rhabdomyolysis.

Banu Sarer Yurekli, Nilufer Ozdemir Kutbay, Huseyin Onay, Ilgin Yildirim Simsir, Gokcen Unal Kocabas, Mehmet Erdogan, Sevki Cetinkalp, Gokhan Ozgen, Fusun Saygili,

Hormones (Athens) (Hormones (Athens, Greece))
[2016, 15(2):300-302]

Cited: 2 times

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Comparison of the effects of intensive insulin treatment modalities on cardiovascular biomarkers in type 1 diabetes mellitus.

Sevki Cetinkalp, Canan Felekoglu, Muammer Karadeniz, Hayal Boyacıoglu, Yasemin Delen, Eser Yildirim, Candeger Yilmaz,

To evaluate effects of intensive insulin treatment modalities on cardiovascular biomarkers in patients with type 1 diabetes mellitus (T1DM).A total of 25 patients with T1DM receiving intensive insulin therapy either in the form of continuous insulin pump (IP group; n=13) or as multiple daily injections (MDI group; n=12) and 13 ... Read more >>

Diabetes Metab Syndr (Diabetes & metabolic syndrome)
[2015, 9(3):157-162]

Cited: 1 time

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The relationship of the apolipoprotein E gene polymorphism in Turkish Type 2 Diabetic Patients with and without diabetic foot ulcers.

Erdogan Mehmet, Eroglu Zuhal, Kulaksizoglu Mustafa, Solmaz Soner, Tetik Aslı, Cetinkalp Sevki,

The aim of this study was to investigate the association between Apolipoprotein E (ApoE) gene polymorphism in the development of diabetic foot ulcers in Type 2 diabetes Turkish patients.The ApoE genotypes were determined retrospectively in 50 patients with diabetic foot and 50 without diabetic foot and a control group of ... Read more >>

Diabetes Metab Syndr (Diabetes & metabolic syndrome)
[2016, 10(1 Suppl 1):S30-3]

Cited: 0 times

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Can an oral antidiabetic (rosiglitazone) be of benefit in leukemia treatment?

Sevki Cetinkalp, Ilgın Yildirim Simsir, Fahri Sahin, Guray Saydam, Ali Ugur Ural, Candeger Yilmaz,

PPARs are ligand-regulated transcription factors and regulate expression of several gene products. Therefore, PPARs are being studied for their possible contribution to the treatment of cancer, atherosclerosis, inflammation, infertility and demyelinating diseases. Primary AML patients were observed to have significantly elevated PPARγ mRNA expression compared to normal peripheral blood or ... Read more >>

Saudi Pharm J (Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society)
[2015, 23(1):14-21]

Cited: 2 times

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Insulin resistance in brain and possible therapeutic approaches.

Sevki Cetinkalp, Ilgin Y Simsir, Sibel Ertek,

Although the brain has long been considered an insulin-independent organ, recent research has shown that insulin has significant effects on the brain, where it plays a role in maintaining glucose and energy homeostasis. To avoid peripheral insulin resistance, the brain may act via hypoinsulinemic responses, maintaining glucose metabolism and insulin ... Read more >>

Curr Vasc Pharmacol (Current vascular pharmacology)
[2014, 12(4):553-564]

Cited: 5 times

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Is there U-turn from insulin back to pills in diabetes?

Sibel Ertek, Sevki Cetinkalp,

Type 2 diabetes is characterized by insulin resistance together with progressive loss of beta-cell function. After recognition of gluco- and lipo-toxicity, attention was focused on the preservation and/or restoration of beta cell function, especially at the early stages of the diabetes, with better beta-cell reserve and in the absence of ... Read more >>

Curr Vasc Pharmacol (Current vascular pharmacology)
[2014, 12(4):617-626]

Cited: 3 times

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