Full Text Journal Articles by
Author Seri Jo

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Inhibition of SARS-CoV 3CL protease by flavonoids.

Seri Jo, Suwon Kim, Dong Hae Shin, Mi-Sun Kim,

There were severe panics caused by Severe Acute Respiratory Syndrome (SARS) and Middle-East Respiratory Syndrome-Coronavirus. Therefore, researches targeting these viruses have been required. Coronaviruses (CoVs) have been rising targets of some flavonoids. The antiviral activity of some flavonoids against CoVs is presumed directly caused by inhibiting 3C-like protease (3CLpro). Here, ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):145-151]

Cited: 58 times

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A study of Rose Bengal against a 2-keto-3-deoxy-d-manno-octulosonate cytidylyltransferase as an antibiotic candidate.

Suwon Kim, Seri Jo, Mi-Sun Kim, Dong Hae Shin,

Frequent occurrences of multi-drug resistance of pathogenic Gram-negative bacteria threaten human beings. The CMP-2-keto-3-deoxy-d-<i>manno</i>-octulosonic acid biosynthesis pathway is one of the new targets for antibiotic design. 2-Keto-3-deoxy-d-<i>manno</i>-octulosonate cytidylyltransferase (KdsB) is the key enzyme in this pathway. KdsB proteins from <i>Burkholderia pseudomallei</i> (<i>Bp</i>), <i>B. thailandensis</i> (<i>Bt</i>), <i>Pseudomonas aeruginosa</i> (<i>Pa</i>), and <i>Chlamydia ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):1414-1421]

Cited: 0 times

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Inhibition of d-glycero-β-d-manno-heptose 1-phosphate adenylyltransferase from Burkholderia pseudomallei by epigallocatechin gallate and myricetin.

Suwon Kim, Seri Jo, Mi-Sun Kim, Heejin Kam, Dong Hae Shin,

Flavonoids play beneficial roles in various human diseases. In this study, a flavonoid library was employed to probe inhibitors of d-glycero-β-d-manno-heptose-1-phosphate adenylyltransferase from Burkholderia pseudomallei (BpHldC) and two flavonoids, epigallocatechin gallate (EGCG) and myricetin, have been discovered. BpHldC is one of the essential enzymes in the ADP-l-glycero-β-d-manno-heptose biosynthesis pathway constructing ... Read more >>

Biochem J (The Biochemical journal)
[2020, :]

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Flavonoids with inhibitory activity against SARS-CoV-2 3CLpro.

Seri Jo, Suwon Kim, Dae Yong Kim, Mi-Sun Kim, Dong Hae Shin,

Coronavirus disease 2019 (COVID-19) has been a pandemic disease of which the termination is not yet predictable. Currently, researches to develop vaccines and treatments is going on globally to cope with this disastrous disease. Main protease (3CLpro) from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the good targets ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):1539-1544]

Cited: 1 time

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A Tryptophan-based Assay Method to Search Regulatory Compounds for TCTP

Seri Jo, Eun-Wha Jang, Mi-Sun Kim, Suwon Kim, Kyunglim Lee, Dong Hae Shin,

Transcriptionally controlled tumor protein (TCTP) is a highly conserved protein performing a large number of cellular functions by binding with various partner proteins. The importance of its roles in many diseases requires an assay method to find regulatory compounds. However, the molecular characteristics of TCTP made it difficult to search ... Read more >>

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A Study of a Potent Inhibitor Against a GDP-6-Deoxy-α-d-Manno-Heptose Biosynthesis Pathway as Antibiotic Candidates.

Suwon Kim, Seri Jo, Mi-Sun Kim, Dong Hae Shin,

The GDP-6-deoxy-α-d-<i>manno</i>-heptose is a key building block molecule in constructing lipopolysaccharide of Gram-negative bacteria. Therefore, blockage of the biosynthesis pathway of GDP-6-deoxy-α-d-<i>manno</i>-heptose is lethal or increases antibiotics susceptibility to pathogens. In this study, we assayed d-<i>glycero</i>-α-d-<i>manno</i>-heptose-1-phosphate guanylyltransferase (HddC) from <i>Yersinia pseudotuberculosis</i> (<i>Yp</i>) using an efficient assay method supplying its natural ... Read more >>

Microb Drug Resist (Microbial drug resistance (Larchmont, N.Y.))
[2020, 26(4):385-390]

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GTP Preference of d-Glycero-α-d-manno-Heptose-1-Phosphate Guanylyltransferase from Yersinia pseudotuberculosis.

Suwon Kim, Mi-Sun Kim, Seri Jo, Dong Hae Shin,

d-glycero-α-d-manno-heptose-1-phosphate guanylyltransferase (HddC) is the fourth enzyme synthesizing a building component of lipopolysaccharide (LPS) of Gram-negative bacteria. Since HddC is a potential new target to develop antibiotics, the analysis of the structural and functional relationship of the complex structure will lead to a better idea to design inhibitory compounds. X-ray ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 21(1):]

Cited: 0 times

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