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Author Sergio Manzano

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Oropharyngeal Carriage of Kingella kingae and Transient Synovitis of the Hip in Young Children: A Case-Control Study.

Jocelyn Gravel, Sergio Manzano, Marie-Lyne Nault, Émilie Vallières, Fabien Rallu, Christian Renaud,

<h4>Background</h4>Transient synovitis of the hip affects mostly preschool children, and its etiology is unknown. Kingella kingae has been identified recently as a common etiologic agent of osteoarticular infections (OAI) in young children and could potentially be associated to transient synovitis of the hip. The main objective of this study was ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, Publish Ahead of Print:]

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Factors associated with parents' willingness to enroll their children in trials for COVID-19 vaccination.

Ran D Goldman, Georg Staubli, Cristina Parra Cotanda, Julie C Brown, Julia Hoeffe, Michelle Seiler, Renana Gelernter, Jeanine E Hall, Mark A Griffiths, Adrienne L Davis, Sergio Manzano, Ahmed Mater, Sara Ahmed, David Sheridan, Matt Hansen, Samina Ali, Graham C Thompson, Naoki Shimizu, Eileen J Klein,

The coronavirus disease 2019 (COVID-19) pandemic has taken an unprecedented global toll and vaccination is needed to restore healthy living. Timely inclusion of children in vaccination trials is critical. We surveyed caregivers of children seeking care in 17 Emergency Departments (ED) across 6 countries during the peak of the pandemic ... Read more >>

Hum Vaccin Immunother (Human vaccines & immunotherapeutics)
[2020, :1-5]

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Febrile young infants with abnormal urine dipstick at low risk of invasive bacterial infection.

Roberto Velasco, Ainara Lejarzegi, Borja Gomez, Mercedes de la Torre, Isabel Duran, Amaia Camara, Daniel de la Rosa, Sergio Manzano, Jose Rodriguez, Andres González, Anne-Aurelie Lopes, Aristides Rivas, Isabel Martinez, Carlos Miguel Angelats, Sandra Moya, Sonia Corral, Juan Alonso, Patricia Del Rio, Elena Sancho, Ignacio Ruiz Del Olmo, Inmaculada Nieto, Beatriz Vega, Santiago Mintegi, ,

<h4>Objectives</h4>To develop and validate a prediction rule to identify well-appearing febrile infants aged ≤90 days with an abnormal urine dipstick at low risk of invasive bacterial infections (IBIs, bacteraemia or bacterial meningitis).<h4>Design</h4>Ambispective, multicentre study.<h4>Setting</h4>The derivation set in a single paediatric emergency department (ED) between 2003 and 2017. The validation set ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2020, :]

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Caregiver willingness to vaccinate their children against COVID-19: Cross sectional survey.

Ran D Goldman, Tyler D Yan, Michelle Seiler, Cristina Parra Cotanda, Julie C Brown, Eileen J Klein, Julia Hoeffe, Renana Gelernter, Jeanine E Hall, Adrienne L Davis, Mark A Griffiths, Ahmed Mater, Sergio Manzano, Gianluca Gualco, Naoki Shimizu, Thomas L Hurt, Sara Ahmed, Matt Hansen, David Sheridan, Samina Ali, Graham C Thompson, Nathalie Gaucher, Georg Staubli, ,

<h4>Background</h4>More than 100 COVID-19 vaccine candidates are in development since the SARS-CoV-2 genetic sequence was published in January 2020. The uptake of a COVID-19 vaccine among children will be instrumental in limiting the spread of the disease as herd immunity may require vaccine coverage of up to 80% of the ... Read more >>

Vaccine (Vaccine)
[2020, 38(48):7668-7673]

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Caregivers' Willingness to Accept Expedited Vaccine Research During the COVID-19 Pandemic: A Cross-sectional Survey.

Ran D Goldman, Shashidhar R Marneni, Michelle Seiler, Julie C Brown, Eileen J Klein, Cristina Parra Cotanda, Renana Gelernter, Tyler D Yan, Julia Hoeffe, Adrienne L Davis, Mark A Griffiths, Jeanine E Hall, Gianluca Gualco, Ahmed Mater, Sergio Manzano, Graham C Thompson, Sara Ahmed, Samina Ali, Naoki Shimizu, ,

<h4>Purpose</h4>This study determined the predictors of caregivers' willingness to accept an accelerated regulatory process for the development of vaccines against coronavirus disease 2019 (COVID-19).<h4>Methods</h4>An international cross-sectional survey was administered to 2557 caregivers of children in 17 pediatric emergency departments (EDs) across 6 countries from March 26, 2020, to June 30, ... Read more >>

Clin Ther (Clinical therapeutics)
[2020, 42(11):2124-2133]

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Willingness to Vaccinate Children against Influenza after the Coronavirus Disease 2019 Pandemic.

Ran D Goldman, Sophie McGregor, Shashidhar R Marneni, Tomohiro Katsuta, Mark A Griffiths, Jeanine E Hall, Michelle Seiler, Eileen J Klein, Cristina Parra Cotanda, Renana Gelernter, Julia Hoeffe, Adrienne L Davis, Gianluca Gualco, Ahmed Mater, Sergio Manzano, Graham C Thompson, Sara Ahmed, Samina Ali, Julie C Brown, ,

<h4>Objectives</h4>To determine factors associated with parents who plan to vaccinate their children against influenza next year, especially those who did not vaccinate against influenza last year using a global survey.<h4>Study design</h4>A survey of caregivers accompanying their children aged 1-19 years old in 17 pediatric emergency departments in 6 countries at the ... Read more >>

J Pediatr (The Journal of pediatrics)
[2021, 228:87-93.e2]

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The Impact of a Tablet App on Adherence to American Heart Association Guidelines During Simulated Pediatric Cardiopulmonary Resuscitation: Randomized Controlled Trial.

Johan N Siebert, Laurence Lacroix, Aymeric Cantais, Sergio Manzano, Frederic Ehrler,

BACKGROUND:Evidence-based best practices are the cornerstone to guide optimal cardiopulmonary arrest resuscitation care. Adherence to the American Heart Association (AHA) guidelines for cardiopulmonary resuscitation (CPR) optimizes the management of critically ill patients and increases their chances of survival after cardiac arrest. Despite advances in resuscitation science and survival improvement over ... Read more >>

J Med Internet Res (Journal of medical Internet research)
[2020, 22(5):e17792]

Cited: 0 times

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A Mobile Health Platform to Disseminate Validated Institutional Measurements During the COVID-19 Outbreak: Utilization-Focused Evaluation Study.

Ido Zamberg, Sergio Manzano, Klara Posfay-Barbe, Olivier Windisch, Thomas Agoritsas, Eduardo Schiffer,

<h4>Background</h4>As part of the response plans for the current outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), authorities are drafting and implementing containment measures across jurisdictions worldwide in the effort to slow down transmission and reduce the infection rate. A solid communication strategy is needed to increase the reach ... Read more >>

JMIR Public Health Surveill (JMIR public health and surveillance)
[2020, 6(2):e18668]

Cited: 4 times

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Incidence and causes of pacemaker implantation during postoperative period of aortic valve replacement with rapid deployment prosthesis.

José María Arribas, Laura Soriano, José Miguel Rivera-Caravaca, Maydelin Lorenzo, Carmen Muñoz, Rubén Taboada, Antonio Jiménez, Juan Martínez, Julio García-Puente, Francisco Gutiérrez, Sergio Manzano, Sergio Cánovas,

<h4>Background</h4>Aortic stenosis is currently the most frequently occurring valve pathology. Developments, such as transcatheter prostheses and rapid deployment prostheses, allow for the offer of a valve replacement to higher risk patients, but these techniques are linked with a higher need for a permanent pacemaker during the immediate postoperative period.<h4>Methods</h4>We studied ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2019, 42(12):1534-1540]

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A mobile device app to reduce prehospital medication errors and time to drug preparation and delivery by emergency medical services during simulated pediatric cardiopulmonary resuscitation: study protocol of a multicenter, prospective, randomized controlled trial.

Johan N Siebert, Laurie Bloudeau, Frédéric Ehrler, Christophe Combescure, Kevin Haddad, Florence Hugon, Laurent Suppan, Frédérique Rodieux, Christian Lovis, Alain Gervaix, Sergio Manzano,

<h4>Background</h4>Emergency drug preparation and administration in children is both complex and time-consuming and places this population at a higher risk than adults for medication errors. Moreover, survival and a favorable neurological outcome from cardiopulmonary resuscitation are inversely correlated to drug preparation time. We developed a mobile device application (the pediatric ... Read more >>

Trials (Trials)
[2019, 20(1):634]

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Kingella kingae and Osteoarticular Infections.

Eleftheria Samara, Vasiliki Spyropoulou, Anne Tabard-Fougère, Laura Merlini, Raimonda Valaikaite, Amira Dhouib, Sergio Manzano, Céline Juchler, Romain Dayer, Dimitri Ceroni,

OBJECTIVES:In this study, we aimed to contrast the bacteriologic epidemiology of osteoarticular infections (OAIs) between 2 patient groups in successive 10-year periods, before and after the extensive use of nucleic acid amplification assays in the diagnostic process. METHODS:Epidemiologic data and bacteriologic etiologies of all children presenting with OAIs on admission ... Read more >>

Pediatrics (Pediatrics)
[2019, 144(6):]

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Effects of Blindfold on Leadership in Pediatric Resuscitation Simulation: A Randomized Trial.

Michael Buyck, Sergio Manzano, Kevin Haddad, Anne-Catherine Moncousin, Annick Galetto-Lacour, Katherine Blondon, Oliver Karam,

Background: Pediatric resuscitations are rare events. Simulation-based training improves clinical and non-clinical skills, as well as survival rate. We assessed the effectiveness of using blindfolds to further improve leadership skills in pediatric simulation-based training. Methods: Twelve teams, each composed of 1 pediatric emergency fellow, 1 pediatric resident, and 2 pediatric ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:10]

Cited: 1 time

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A mobile device application to reduce medication errors and time to drug delivery during simulated paediatric cardiopulmonary resuscitation: a multicentre, randomised, controlled, crossover trial.

Johan N Siebert, Frédéric Ehrler, Christophe Combescure, Christian Lovis, Kevin Haddad, Florence Hugon, Fanny Luterbacher, Laurence Lacroix, Alain Gervaix, Sergio Manzano, ,

<h4>Background</h4>Vasoactive drug preparation for continuous infusion in children is both complex and time consuming and places the paediatric population at higher risk than adults for medication errors. We developed a mobile device application (app) as a step-by-step guide for the preparation to delivery of drugs requiring continuous infusion. The app ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2019, 3(5):303-311]

Cited: 3 times

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Inappropriate doses of direct oral anticoagulants in real-world clinical practice: prevalence and associated factors. A subanalysis of the FANTASIIA Registry.

Martín Ruiz Ortiz, Javier Muñiz, Paula Raña Míguez, Inmaculada Roldán, Francisco Marín, María Asunción Esteve-Pastor, Angel Cequier, Manuel Martínez-Sellés, Vicente Bertomeu, Manuel Anguita, ,

Aims:To describe the prevalence and associated factors of inappropriate doses of direct oral anticoagulants (DOAC) in a national registry of patients of real clinical practice. Methods and results:Five hundred and thirty outpatients with atrial fibrillation treated with DOAC were included in a prospective, national, multicentre study. The appropriateness of the ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2018, 20(10):1577-1583]

Cited: 8 times

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The Biomarker S100B and Mild Traumatic Brain Injury: A Meta-analysis.

Charlotte Oris, Bruno Pereira, Julie Durif, Jeanne Simon-Pimmel, Christoph Castellani, Sergio Manzano, Vincent Sapin, Damien Bouvier,

CONTEXT:The usefulness of S100B has been noted as a biomarker in the management of mild traumatic brain injury (mTBI) in adults. However, S100B efficacy as a biomarker in children has previously been relatively unclear. OBJECTIVE:A meta-analysis is conducted to assess the prognostic value of S100B in predicting intracerebral lesions in ... Read more >>

Pediatrics (Pediatrics)
[2018, 141(6):]

Cited: 4 times

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Refined Lab-score, a Risk Score Predicting Serious Bacterial Infection in Febrile Children Less Than 3 Years of Age.

Sandrine Leroy, Silvia Bressan, Laurence Lacroix, Barbara Andreola, Samuel Zamora, Benoit Bailey, Liviana Da Dalt, Sergio Manzano, Alain Gervaix, Annick Galetto-Lacour,

<h4>Background</h4>The identification of serious bacterial infection (SBI) in children with fever without source remains a challenge. A risk score called Lab-score, based on C-reactive protein, procalcitonin and urinary dipstick results was derived to predict SBI. However, all biomarkers were initially dichotomized, leading to weak statistical reliability and lack of transportability ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2018, 37(5):387-393]

Cited: 3 times

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Improved Diagnostic Performance of an Immunofluorescence-based Rapid Antigen Detection Test for Group A Streptococci in Children With Pharyngitis.

Laurence Lacroix, Abdessalam Cherkaoui, Diane Schaller, Sergio Manzano, Annick Galetto-Lacour, Ulrich Pfeifer, René Tabin, Alain Gervaix,

BACKGROUND:Accurate diagnosis and appropriate treatment of group A streptococcal (GAS) pharyngitis are important to prevent complications. Most available rapid antigen detection tests (RADTs) have shown excellent specificity but often lack sensitivity. Our objective was to compare the diagnostic performances of a new fluorescence-based immunoassay and a classic immunochromatographic RADT using ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2018, 37(3):206-211]

Cited: 1 time

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The Contemporary Bacteriologic Epidemiology of Osteoarticular Infections in Children in Switzerland.

Céline Juchler, Vasiliki Spyropoulou, Noémie Wagner, Laura Merlini, Amira Dhouib, Sergio Manzano, Anne Tabard-Fougère, Eleftheria Samara, Dimitri Ceroni,

OBJECTIVES:To assess the contemporary bacteriologic epidemiology of pediatric osteoarticular infection with particular regard to children's ages, because Kingella kingae has gained increasing recognition as the predominant pathogen for osteoarticular infection in young children. STUDY DESIGN:Retrospective file review of enrolled children from 0 to 15 years of age, admitted to our ... Read more >>

J Pediatr (The Journal of pediatrics)
[2018, 194:190-196.e1]

Cited: 7 times

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A transversal pilot study of oropharyngeal carriage of Kingella kingae in healthy children younger than 6 months.

Vasiliki Spyropoulou, Gabriel Brändle, Albane Bertha Rosa Maggio, Rebecca Anderson Della Llana, Abdessalam Cherkaoui, Gesuele Renzi, Jacques Schrenzel, Sergio Manzano, Dimitri Ceroni,

The aim of this pilot study was to investigate the extent of oropharyngeal Kingella kingae carriage during the first 6 months of life.We conducted a monocentric transversal pilot study on healthy children younger than 6 months in order to define the oropharyngeal carriage rate. Participants were recruited between December 2013 ... Read more >>

World J Pediatr (World journal of pediatrics : WJP)
[2017, 13(6):615-617]

Cited: 1 time

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Association between oropharyngeal carriage of Kingella kingae and osteoarticular infection in young children: a case-control study.

Jocelyn Gravel, Dimitri Ceroni, Laurence Lacroix, Christian Renaud, Guy Grimard, Eleftheria Samara, Abdessalam Cherkaoui, Gesuele Renzi, Jacques Schrenzel, Sergio Manzano,

<h4>Background</h4><i>Kingella kingae</i> has been increasingly identified in patients with osteoarticular infections. Our main objective was to evaluate the association between carriage of <i>K. kingae</i> in the oropharynx of preschool children and osteoarticular infections.<h4>Methods</h4>We conducted this prospective case-control study in 2 tertiary care pediatric hospitals (Canada and Switzerland) between 2014 and ... Read more >>

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2017, 189(35):E1107-E1111]

Cited: 8 times

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A Mobile Device App to Reduce Medication Errors and Time to Drug Delivery During Pediatric Cardiopulmonary Resuscitation: Study Protocol of a Multicenter Randomized Controlled Crossover Trial.

Johan N Siebert, Frederic Ehrler, Christian Lovis, Christophe Combescure, Kevin Haddad, Alain Gervaix, Sergio Manzano,

<h4>Background</h4>During pediatric cardiopulmonary resuscitation (CPR), vasoactive drug preparation for continuous infusions is complex and time-consuming. The need for individual specific weight-based drug dose calculation and preparation places children at higher risk than adults for medication errors. Following an evidence-based and ergonomic driven approach, we developed a mobile device app called ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2017, 6(8):e167]

Cited: 1 time

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Acute scrotal idiopathic edema: A misleading erythema.

Fabiana Esposito, Oliver Sanchez, Johan N Siebert, Sergio Manzano,

CJEM (CJEM)
[2018, 20(S2):S37]

Cited: 0 times

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Adherence to AHA Guidelines When Adapted for Augmented Reality Glasses for Assisted Pediatric Cardiopulmonary Resuscitation: A Randomized Controlled Trial.

Johan N Siebert, Frederic Ehrler, Alain Gervaix, Kevin Haddad, Laurence Lacroix, Philippe Schrurs, Ayhan Sahin, Christian Lovis, Sergio Manzano,

<h4>Background</h4>The American Heart Association (AHA) guidelines for cardiopulmonary resuscitation (CPR) are nowadays recognized as the world's most authoritative resuscitation guidelines. Adherence to these guidelines optimizes the management of critically ill patients and increases their chances of survival after cardiac arrest. Despite their availability, suboptimal quality of CPR is still common. ... Read more >>

J Med Internet Res (Journal of medical Internet research)
[2017, 19(5):e183]

Cited: 7 times

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A three-step diagnosis of pediatric pneumonia at the emergency department using clinical predictors, C-reactive protein, and pneumococcal PCR.

Gabriel Alcoba, Kristina Keitel, Veronica Maspoli, Laurence Lacroix, Sergio Manzano, Mario Gehri, René Tabin, Alain Gervaix, Annick Galetto-Lacour,

Recommendations for the management of community-acquired pneumonia (CAP) advocate that, in the absence of the clinical and laboratory findings typical of bacterial CAP, antibiotics are not required. However, the true value of the clinical and laboratory predictors of pediatric CAP still needs to be assessed. This prospective cohort study in ... Read more >>

Eur J Pediatr (European journal of pediatrics)
[2017, 176(6):815-824]

Cited: 4 times

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A Mobile Device App to Reduce Time to Drug Delivery and Medication Errors During Simulated Pediatric Cardiopulmonary Resuscitation: A Randomized Controlled Trial.

Johan N Siebert, Frederic Ehrler, Christophe Combescure, Laurence Lacroix, Kevin Haddad, Oliver Sanchez, Alain Gervaix, Christian Lovis, Sergio Manzano,

<h4>Background</h4>During pediatric cardiopulmonary resuscitation (CPR), vasoactive drug preparation for continuous infusion is both complex and time-consuming, placing children at higher risk than adults for medication errors. Following an evidence-based ergonomic-driven approach, we developed a mobile device app called Pediatric Accurate Medication in Emergency Situations (PedAMINES), intended to guide caregivers step-by-step ... Read more >>

J Med Internet Res (Journal of medical Internet research)
[2017, 19(2):e31]

Cited: 6 times

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