Full Text Journal Articles by
Author Sergey Leonov

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Highly Pathogenic Avian Influenza A(H5N8) Virus Clade 2.3.4.4b, Western Siberia, Russia, 2020.

Ivan Sobolev, Kirill Sharshov, Nikita Dubovitskiy, Olga Kurskaya, Alexander Alekseev, Sergey Leonov, Yuriy Yushkov, Victor Irza, Andrey Komissarov, Artem Fadeev, Daria Danilenko, Junki Mine, Ryota Tsunekuni, Yuko Uchida, Takehiko Saito, Alexander Shestopalov,

Two variants of highly pathogenic avian influenza A(H5N8) virus were detected in dead poultry in Western Siberia, Russia, during August and September 2020. One variant was represented by viruses of clade 2.3.4.4b and the other by a novel reassortant between clade 2.3.4.4b and Eurasian low pathogenicity avian influenza viruses circulating ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2021, 27(8):2224-2227]

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IR-Surviving NSCLC Cells Exhibit Different Patterns of Molecular and Cellular Reactions Relating to the Multifraction Irradiation Regimen and p53-Family Proteins Expression.

Lina Alhaddad, Margarita Pustovalova, Taisia Blokhina, Roman Chuprov-Netochin, Andreyan N Osipov, Sergey Leonov,

Radiotherapy is a primary treatment modality for patients with unresectable non-small cell lung cancer (NSCLC). Tumor heterogeneity still poses the central question of cancer radioresistance, whether the presence of a particular cell population inside a tumor undergoing a selective outgrowth during radio- and chemotherapy give rise to metastasis and tumor ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(11):]

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Type of Physical Activity, Diet, BMI and Tobacco/Alcohol Consumption Relationship: How They are Associated with Our Health?

Liudmila Liutsko, Alexander Veraksa, Irina Polikanova, Sergey Leonov,

The purpose of this article was to check the effects on health of various types of physical activities, diet, BMI, smoking and alcohol consumption and their interrelationships with control for age, sex and level of education. The study was based on epidemiological data (9617 participants from 19 to 81 years ... Read more >>

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Study of Differences in Motor Reactions and Performances in Professional Ice Hockey Players and not Experienced Participants Using Virtual Reality (VR) Technology

Irina Polikanova, Anastasiya Yakushina, Sergey Leonov, Anna Kruchinina, Victor Chertopolokhov, Liudmila Liutsko,

The efficiency of performance in various sports has the development of certain specific skills at its core. In ice hockey, both the technical aspects (techniques, stance) and the cognitive ones (keeping attention on the puck, game strategy, etc.) are highly important. This study is aimed at the identification of specific ... Read more >>

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Comprehensive patient-level classification and quantification of driver events in TCGA PanCanAtlas cohorts

Alexey Vyatkin, Danila Otnyukov, Sergey Leonov, Aleksey Belikov,

<h4>Background</h4> There is a growing need to develop novel therapeutics for targeted treatment of cancer. The prerequisite to success is the knowledge about which types of molecular alterations are predominantly driving tumorigenesis – single nucleotide (SNA) or copy number (CNA), in oncogenes or in tumour suppressors, gains or losses of ... Read more >>

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The CD44high Subpopulation of Multifraction Irradiation-Surviving NSCLC Cells Exhibits Partial EMT-Program Activation and DNA Damage Response Depending on Their p53 Status.

Margarita Pustovalova, Lina Alhaddad, Taisia Blokhina, Nadezhda Smetanina, Anna Chigasova, Roman Chuprov-Netochin, Petr Eremin, Ilmira Gilmutdinova, Andreyan N Osipov, Sergey Leonov,

Ionizing radiation (IR) is used for patients diagnosed with unresectable non-small cell lung cancer (NSCLC). However, radiotherapy remains largely palliative due to the survival of specific cell subpopulations. In the present study, the sublines of NSCLC cells, A549IR (p53wt) and H1299IR (p53null) survived multifraction X-ray radiation exposure (MFR) at a ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(5):]

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Synthesis and biological evaluation of indolylglyoxylamide bisphosphonates, antimitotic microtubule-targeting derivatives of indibulin with improved aqueous solubility.

Valery K Brel, Oleg I Artyushin, Roman N Chuprov-Netochin, Sergey V Leonov, Marina N Semenova, Victor V Semenov,

Indibulin (D-24851) derivatives with bisphosphonate fragment connected to the N1 atom of imidazole ring were synthesized by alkylation of (indolyl-3)methylglyoxylates with ethylenebisphosphonate. Biological evaluation of targeted compounds 4a-d using the phenotypic sea urchin embryo assay provided evidence that replacing of p-chlorobenzene ring in indibulin by bisphosphonate group did not eliminate ... Read more >>

Bioorg Med Chem Lett (Bioorganic & medicinal chemistry letters)
[2020, 30(23):127635]

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Fatty Acids from Hermetia illucens Larvae Fat Inhibit the Proliferation and Growth of Actual Phytopathogens.

Elena Marusich, Heakal Mohamed, Yuriy Afanasev, Sergey Leonov,

The rapid increase of plant diseases caused by bacterial phytopathogens calls for an urgent search for new antibacterials. Antimicrobial compounds of natural origin stand up as frontiers in the attempts of the antibiotic overuse replacement. With this in mind, the <i>Hermetia illucens (H. illucens)</i> larvae have recently gained attention as ... Read more >>

Microorganisms (Microorganisms)
[2020, 8(9):]

Cited: 2 times

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Individual Features in the Typology of the Nervous System and the Brain Activity Dynamics of Freestyle Wrestlers Exposed to a Strong Physical Activity (A Pilot Study).

Irina Polikanova, Sergey Leonov, Aleksey Isaev, Liudmila Liutsko,

Nowadays, knowledge of psychophysiological features, particularly on the nervous system's characteristics, is essential in the sporting context, particularly for freestyle wrestling. The study aimed to investigate the peculiarities of the wrestlers' nervous system-on the individual and electrophysiological levels in two functional states-in calm wakefulness and during intense physical fatigue. Psychological ... Read more >>

Behav Sci (Basel) (Behavioral sciences (Basel, Switzerland))
[2020, 10(4):]

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Protective effects of carotenoid fucoxanthin in fibroblasts cellular senescence.

Zulfiia Guvatova, Alexandra Dalina, Elena Marusich, Elena Pudova, Anastasiya Snezhkina, George Krasnov, Anna Kudryavtseva, Sergey Leonov, Alexey Moskalev,

Fucoxanthin, as a main marine carotenoid, exhibit a wide variety of bioactivities, including antioxidant activity. Previously, we have shown the geroprotective activity of fucoxanthin on Drosophila and C. elegans. Our new study aimed to compare the antioxidant activity of fucoxanthin in early and late passage normal human cells LECh4(81) in ... Read more >>

Mech Ageing Dev (Mechanisms of ageing and development)
[2020, 189:111260]

Cited: 3 times

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The p53-53BP1-Related Survival of A549 and H1299 Human Lung Cancer Cells after Multifractionated Radiotherapy Demonstrated Different Response to Additional Acute X-ray Exposure.

Margarita Pustovalova, Lina Alhaddad, Nadezhda Smetanina, Anna Chigasova, Taisia Blokhina, Roman Chuprov-Netochin, Andreyan N Osipov, Sergey Leonov,

Radiation therapy is one of the main methods of treating patients with non-small cell lung cancer (NSCLC). However, the resistance of tumor cells to exposure remains the main factor that limits successful therapeutic outcome. To study the molecular/cellular mechanisms of increased resistance of NSCLC to ionizing radiation (IR) exposure, we ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(9):]

Cited: 3 times

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Reproductive Characteristics of Thawed Stallion Sperm.

Mikhail M Atroshchenko, Ekaterina Arkhangelskaya, Dmitry A Isaev, Sergey B Stavitsky, Alexander M Zaitsev, Valery V Kalaschnikov, Sergey Leonov, Andreyan N Osipov,

The main goal of our study was to determine a set of thawed stallion sperm characteristics that have predictive value for the pregnancy rate (PR) of mares after artificial insemination (AI). DNA fragmentation and survival of sperm during hypothermic storage were studied in addition to routinely determined semen characteristics such ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2019, 9(12):]

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Analysis of novel hyperosmotic shock response suggests 'beads in liquid' cytosol structure.

Alexander I Alexandrov, Erika V Grosfeld, Alexander A Dergalev, Vitaly V Kushnirov, Roman N Chuprov-Netochin, Pyotr A Tyurin-Kuzmin, Igor I Kireev, Michael D Ter-Avanesyan, Sergey V Leonov, Michael O Agaphonov,

Proteins can aggregate in response to stresses, including hyperosmotic shock. Formation and disassembly of aggregates is a relatively slow process. We describe a novel instant response of the cell to hyperosmosis, during which chaperones and other proteins form numerous foci with properties uncharacteristic of classical aggregates. These foci appeared/disappeared seconds ... Read more >>

Biol Open (Biology open)
[2019, 8(7):]

Cited: 4 times

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Spontaneous γH2AX foci in human dermal fibroblasts in relation to proliferation activity and aging.

Vadim Zorin, Anna Grekhova, Margarita Pustovalova, Alla Zorina, Nadezhda Smetanina, Natalia Vorobyeva, Pavel Kopnin, Ilmira Gilmutdinova, Alexey Moskalev, Andreyan N Osipov, Sergey Leonov,

We assessed the effects of donor age on clonogenicity, proliferative potential, and spontaneous γH2AX foci in the proliferating (Ki67 +) and senescent (SA β-gal +) cultures of skin fibroblasts isolated from 34 donors of different age (23-82 years). Here, we demonstrated that neither the colony forming effectiveness of proliferating (Ki67+) ... Read more >>

Aging (Albany NY) (Aging)
[2019, 11(13):4536-4546]

Cited: 1 time

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Formation of γH2AX and pATM Foci in Human Mesenchymal Stem Cells Exposed to Low Dose-Rate Gamma-Radiation.

Stepan Ulyanenko, Margarita Pustovalova, Sergey Koryakin, Evgenii Beketov, Anatolii Lychagin, Liliya Ulyanenko, Andrey Kaprin, Anna Grekhova, Alexandra M Ozerova, Ivan V Ozerov, Natalia Vorobyeva, Peter Shegay, Sergey Ivanov, Sergey Leonov, Dmitry Klokov, Andreyan N Osipov,

DNA double-strand breaks (DSB) are among the most harmful DNA lesions induced by ionizing radiation (IR). Although the induction and repair of radiation-induced DSB is well studied for acute irradiation, responses to DSB produced by chronic IR exposures are poorly understood, especially in human stem cells. The aim of this ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(11):]

Cited: 8 times

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The Poisson process is the universal law of cancer development: driver mutations accumulate randomly, silently, at constant average rate and for many decades, likely in stem cells

Aleksey Belikov, Alexey Vyatkin, Sergey Leonov,

<h4>Background</h4> It is assumed that cancers develop upon acquiring a particular number of (epi)mutations in driver genes, but the law governing the kinetics of this process is not known. We have recently shown that the age distribution of incidence for 20 most prevalent cancers of old age is best approximated ... Read more >>

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Method for Ultrarapid High-Content Screening for Biologically Active Chemicals Using Plant Pollen.

Roman Chuprov-Netochin, Elena Marusich, Yaroslav Neskorodov, Yana Mishutkina, Polina Volynchuk, Yan Ivanenkov, Alisher Touraev, Sergey Leonov, Klaus Palme,

Chemical genomics attracts considerable attention by offering crucial tools for plant biology to regulate plant growth and development. However, most chemical screens are time consuming and laborious, and require a high input of resources. Here we describe a broadly applicable method for the ultrarapid high-content phenotypic screening of small chemical ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2018, 1795:27-37]

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The Evaluation of Geroprotective Effects of Selected Flavonoids in Drosophila melanogaster and Caenorhabditis elegans.

Ekaterina Lashmanova, Nadezhda Zemskaya, Ekaterina Proshkina, Anna Kudryavtseva, Marina Volosnikova, Elena Marusich, Sergey Leonov, Alex Zhavoronkov, Alexey Moskalev,

Flavonoids is an intensively studied group of natural compounds with antioxidant, antineoplastic, antihyperglycemic, cardioprotective, and neuroprotective properties. The present study intends to investigate the geroprotective action of three selected flavonoids (naringin, luteolin, chrysin) in two model organisms, <i>Caenorhabditis elegans</i> and <i>Drosophila melanogaster</i>. Luteolin and chrysin were shown to improve lifespan ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2017, 8:884]

Cited: 4 times

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Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach.

Upendra Rao Anumala, Jo Waaler, Yves Nkizinkiko, Alexander Ignatev, Katina Lazarow, Peter Lindemann, Petter Angell Olsen, Sudarshan Murthy, Ezeogo Obaji, Alexander G Majouga, Sergey Leonov, Jens Peter von Kries, Lari Lehtiö, Stefan Krauss, Marc Nazaré,

A structure-guided hybridization approach using two privileged substructures gave instant access to a new series of tankyrase inhibitors. The identified inhibitor 16 displays high target affinity on tankyrase 1 and 2 with biochemical and cellular IC50 values of 29 nM, 6.3 nM and 19 nM, respectively, and high selectivity toward ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2017, 60(24):10013-10025]

Cited: 5 times

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γH2AX, 53BP1 and Rad51 protein foci changes in mesenchymal stem cells during prolonged X-ray irradiation.

Anastasia Tsvetkova, Ivan V Ozerov, Margarita Pustovalova, Anna Grekhova, Petr Eremin, Natalia Vorobyeva, Ilya Eremin, Andrey Pulin, Vadim Zorin, Pavel Kopnin, Sergey Leonov, Alex Zhavoronkov, Dmitry Klokov, Andreyan N Osipov,

At high exposure levels ionizing radiation is a carcinogen. Little is known about how human stem cells, which are known to contribute to tumorigenesis, respond to prolonged radiation exposures. We studied formation of DNA double strand breaks, accessed as γH2AX and 53BP1 foci, in human mesenchymal stem cells (MSCs) exposed ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(38):64317-64329]

Cited: 12 times

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Residual γH2AX foci induced by low dose x-ray radiation in bone marrow mesenchymal stem cells do not cause accelerated senescence in the progeny of irradiated cells.

Margarita Pustovalova, Тatiana A Astrelina, Anna Grekhova, Natalia Vorobyeva, Anastasia Tsvetkova, Taisia Blokhina, Victoria Nikitina, Yulia Suchkova, Daria Usupzhanova, Vitalyi Brunchukov, Irina Kobzeva, Тatiana Karaseva, Ivan V Ozerov, Aleksandr Samoylov, Andrey Bushmanov, Sergey Leonov, Evgeny Izumchenko, Alex Zhavoronkov, Dmitry Klokov, Andreyan N Osipov,

Mechanisms underlying the effects of low-dose ionizing radiation (IR) exposure (10-100 mGy) remain unknown. Here we present a comparative study of early (less than 24h) and delayed (up to 11 post-irradiation passages) radiation effects caused by low (80 mGy) vs intermediate (1000 mGy) dose X-ray exposure in cultured human bone ... Read more >>

Aging (Albany NY) (Aging)
[2017, 9(11):2397-2410]

Cited: 6 times

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Genome Sequence of an Unusual Reassortant H1N1 Swine Influenza Virus Isolated from a Pig in Russia, 2016.

Ivan Sobolev, Olga Kurskaya, Tatyana Murashkina, Sergey Leonov, Kirill Sharshov, Marsel Kabilov, Tatyana Alikina, Natalia Tolstykh, Vladimir Gorodov, Alexander Alekseev, Alexander Shestopalov,

We report here the genome sequence of the influenza A virus strain A/swine/Siberia/1sw/2016, isolated from a swine in Russia. On the basis of sequence analysis, A/swine/Siberia/1sw/2016 is characterized by unusual surface glycoproteins phylogenetically distinct from those of swine A(H1N1)pdm09 influenza virus. ... Read more >>

Genome Announc (Genome announcements)
[2017, 5(36):]

Cited: 1 time

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Diffuse colonies of human skin fibroblasts in relation to cellular senescence and proliferation.

Vadim Zorin, Alla Zorina, Nadezhda Smetanina, Pavel Kopnin, Ivan V Ozerov, Sergey Leonov, Artur Isaev, Dmitry Klokov, Andreyan N Osipov,

Development of personalized skin treatment in medicine and skin care may benefit from simple and accurate evaluation of the fraction of senescent skin fibroblasts that lost their proliferative capacity. We examined whether enriched analysis of colonies formed by primary human skin fibroblasts, a simple and widely available cellular assay, could ... Read more >>

Aging (Albany NY) (Aging)
[2017, 9(5):1404-1413]

Cited: 11 times

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Accumulation of spontaneous γH2AX foci in long-term cultured mesenchymal stromal cells.

Margarita Pustovalova, Anna Grekhova, Тatiana Astrelina, Viktoria Nikitina, Ekaterina Dobrovolskaya, Yulia Suchkova, Irina Kobzeva, Darya Usupzhanova, Natalia Vorobyeva, Aleksandr Samoylov, Andrey Bushmanov, Ivan V Ozerov, Alex Zhavoronkov, Sergey Leonov, Dmitry Klokov, Andreyan N Osipov,

Expansion of mesenchymal stromal/stem cells (MSCs) used in clinical practices may be associated with accumulation of genetic instability. Understanding temporal and mechanistic aspects of this process is important for improving stem cell therapy protocols. We used γH2AX foci as a marker of a genetic instability event and quantified it in ... Read more >>

Aging (Albany NY) (Aging)
[2016, 8(12):3498-3506]

Cited: 9 times

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Novel small molecule modulators of plant growth and development identified by high-content screening with plant pollen.

Roman Chuprov-Netochin, Yaroslav Neskorodov, Elena Marusich, Yana Mishutkina, Polina Volynchuk, Sergey Leonov, Konstantin Skryabin, Andrey Ivashenko, Klaus Palme, Alisher Touraev,

<h4>Background</h4>Small synthetic molecules provide valuable tools to agricultural biotechnology to circumvent the need for genetic engineering and provide unique benefits to modulate plant growth and development.<h4>Results</h4>We developed a method to explore molecular mechanisms of plant growth by high-throughput phenotypic screening of haploid populations of pollen cells. These cells rapidly germinate ... Read more >>

BMC Plant Biol (BMC plant biology)
[2016, 16(1):192]

Cited: 6 times

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