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The Cardiac Injury in Hospitalized Patients with Severe COVID-19 in Wuhan, China

Sen Lu, Hongli He, Rong an Liu, Yaqiu Wu, Lei Deng, Pin Wang, Weiwei Huang, Yong Peng, Hongwen Xiao, Gang Li, Xiaobo Huang,

Abstract Background: The Coronavirus disease 2019 (COVID-19) has caused a global pandemic since December 2019, while the date on the relationship between cardiac injury and mortality in patients with COVID-19 is limited. Methods: All consecutive lab-confirmed critically ill COVID-19 patients in intensive care unit of Wuhan Red Cross Hospital from ... Read more >>

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Exploring the Connection Between Binary and Spiking Neural Networks.

Sen Lu, Abhronil Sengupta,

On-chip edge intelligence has necessitated the exploration of algorithmic techniques to reduce the compute requirements of current machine learning frameworks. This work aims to bridge the recent algorithmic progress in training Binary Neural Networks and Spiking Neural Networks-both of which are driven by the same motivation and yet synergies between ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:535]

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Liver damage in severe COVID-19 patients from Sichuan area

Tianlong Li, Chao Deng, Qing Du, Hong Chen, Sen Lu, Ruiming Yue, Yang Guo, Xiaobo Huang, Lingai Pan,

Abstract Background: COVID-19 has spread worldwide, which becomes a huge threat to human beings. Materials: Severe COVID-19 patients from Sichuan area admitted to department of critical care medicine in Chengdu Public Health Clinical Medical Center were retrospectively enrolled. The liver function during the ICU hospitalization were record and analyzed. Results: ... Read more >>

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Expression and clinical significance of miR-4516 and miR-21-5p in serum of patients with colorectal cancer.

Xi-Han Jin, Sen Lu, Ai-Fen Wang,

BACKGROUND:This study sought to detect the expression and clinical significance of miR-4516 and miR-21-5p in serum of patients with colorectal cancer. METHODS:Bioinformatics methods were used to analyze the expression patterns of miR-4516 and miR-21-5p in colorectal cancer. A total of 80 patients with colorectal cancer, 65 patients with benign colorectal ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):241]

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Circular RNA hsa_circRNA_002178 silencing retards breast cancer progression via microRNA-328-3p-mediated inhibition of COL1A1.

Ting Liu, Ping Ye, Yuanyuan Ye, Sen Lu, Baosan Han,

Circular RNAs (circRNAs) are a group of non-coding RNAs implicated in the pathogenesis of cancer progression, which exert their functions via regulation of microRNAs (miRNAs) and genes. The present study uses gain- and loss-of-function approaches to evaluate the functions of hsa_circRNA_002178 in angiogenesis along with energy metabolism and underlying downstream ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2020, 24(3):2189-2201]

Cited: 2 times

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Physicochemical Properties and Protein Denaturation of Pork Longissimus Dorsi Muscle Subjected to Six Microwave-Based Thawing Methods.

Ming-Ming Zhu, Ze-Yu Peng, Sen Lu, Hong-Ju He, Zhuang-Li Kang, Han-Jun Ma, Sheng-Ming Zhao, Zheng-Rong Wang,

Physicochemical changes and protein denaturation were evaluated for pork longissimus dorsi muscle subjected to different thawing methods. Fresh pork longissimus dorsi muscle served as a control. Microwave (MT), microwave combined with ultrasonic (MUT), microwave combined with 35 °C water immersion (MIT), microwave combined with 4 °C refrigeration (MRT), microwave combined ... Read more >>

Foods (Foods (Basel, Switzerland))
[2019, 9(1):]

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Discovery of the Migraine Prevention Therapeutic Aimovig (Erenumab), the First FDA-Approved Antibody against a G-Protein-Coupled Receptor.

Chadwick Terence King, Colin V Gegg, Sylvia Nai-Yu Hu, Hsieng Sen Lu, Brian M Chan, Kelly A Berry, David W Brankow, Tom J Boone, Nebojsa Kezunovic, Matt R Kelley, Licheng Shi, Cen Xu,

In 2018, the United States Food and Drug Administration (FDA) approved Aimovig (erenumab) for the prevention of migraine. Erenumab is the first FDA approved antibody therapeutic against a G-protein-coupled receptor, the canonical receptor of calcitonin gene related peptide (CGRP-R). A novel, epitope-focused antigen was created to reconstruct the extracellular domains ... Read more >>

ACS Pharmacol Transl Sci (ACS Pharmacology & Translational Science)
[2019, 2(6):485-490]

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Tumor-associated macrophages (TAMs) depend on Shp2 for their anti-tumor roles in colorectal cancer.

Saisai Wang, Yuanyuan Yao, Huixia Li, Gang Zheng, Sen Lu, Wenbin Chen,

Tumor associated macrophages (TAMs) in tumor microenvironment can interact with tumor cells and are related to tumor progression. However, the mechanisms that drive the anti-tumor functions of TAMs are not fully understood. The Src homology 2 domain-containing tyrosine phosphatase 2 (Shp2) has been reported to have tumor-suppressing roles in colorectal ... Read more >>

Am J Cancer Res (American journal of cancer research)
[2019, 9(9):1957-1969]

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Acute gouty arthritis following percutaneous cryoablation of renal cell carcinoma.

Ahmed-Zayn Mohamed, William J Wallach, Sen Lu, Bruce Zwiebel, Glenn Hoots,

We report a case of acute gouty monoarthritis of the left ankle in a 58-year-old female with chronic renal insufficiency after cryoablation of a 3.8 cm left renal cell carcinoma. The patient's symptoms resolved after intravenous Solumedrol and did not recur at her 1-month follow-up visit. To the best of ... Read more >>

Radiol Case Rep (Radiology case reports)
[2019, 14(11):1432-1437]

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Detection of pulmonary oedema by electrical impedance tomography: validation of previously proposed approaches in a clinical setting.

Zhanqi Zhao, Hongli He, Jingying Luo, Andy Adler, Xiaoqin Zhang, Rongan Liu, Yunping Lan, Sen Lu, Xiaoxiu Luo, Yu Lei, Inez Frerichs, Xiaobo Huang, Knut Möller,

OBJECTIVE:The aim of the present study was to evaluate two previously proposed approaches based on electrical impedance tomography (EIT) to assess pulmonary oedema at the bedside. APPROACH:Fourteen patients with acute respiratory distress syndrome were included and examined prospectively. Patients were rotated laterally along their longitudinal axis from supine to 45-degree ... Read more >>

Physiol Meas (Physiological measurement)
[2019, 40(5):054008]

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Osteopontin expression is associated with progression and adverse prognosis in patients with resectable gastrointestinal stromal tumor.

Jinhai Wang, Xiaobin Cheng, Sen Lu, Weina Fan,

OBJECTIVES:Osteopontin (OPN) is reported to be particularly associated with the progression of several human malignancies. This study was designed to examine the clinicopathologic significance of OPN in gastrointestinal stromal tumor (GISTs). METHODS:The level of OPN expression in a large cohort of resectable GISTs was evaluated with immunohistochemistry. Its correlation with ... Read more >>

Int J Clin Exp Pathol (International journal of clinical and experimental pathology)
[2019, 12(4):1385-1390]

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Effect of arterial curvature on hemodynamics and mass transport.

Sen Lu, Sen Lu, Shusheng Zhang,

BACKGROUND:Atherosclerotic lesions develop preferentially at certain sites in the human arterial system, such as the inner wall of curved segments and the outer wall of bifurcations. Local wall shear stress (WSS) and concentration of low density lipoprotein (LDL) have been identified as two important factors contributing to these lesions. OBJECTIVE:To ... Read more >>

Biorheology (Biorheology)
[2019, 56(4):253-263]

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miR-214 Down-Regulation Promoted Hypoxia/Reoxygenation-Induced Hepatocyte Apoptosis Through TRAF1/ASK1/JNK Pathway.

Xinli Huang, Yun Gao, Jianjie Qin, Sen Lu,

OBJECTIVE:This study investigated the role of miR-214 in the hepatocyte apoptosis induced by hypoxia/reoxygenation (H/R) injury. MATERIALS AND METHODS:In vivo hepatic ischemia/reperfusion (HIR) injury, mice model and in vitro HR model were established. miR-214, TRAF1, ASK1, and JNK expression levels were detected by qRT-PCR and western blot. The apoptosis of ... Read more >>

Dig. Dis. Sci. (Digestive diseases and sciences)
[2019, 64(5):1217-1225]

Cited: 1 time

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Determination of soil ground heat flux through heat pulse and plate methods: Effects of subsurface latent heat on surface energy balance closure

Sen Lu, Hesong Wang, Ping Meng, Jinsong Zhang, Xiao Zhang,

The soil heat flux plate method is popularly applied in surface energy balance studies. Previous studies have shown that impervious plate blocks the flow of water and vapor within soil. Soil heat flux is generally commonly measured below surface, and its exact constitution is required in calculating surface energy balance. ... Read more >>

(Agricultural and forest meteorology.)
[2018, 260-:176-182]

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Noninvasive prenatal detection of fetal trisomy and single gene disease by shotgun sequencing of placenta originated exosome DNA: a proof-of-concept validation

Weiting Zhang, Sen Lu, Jia Zhao, Dandan Pu, Haiping Zhang, Lin Yang, Peng Zeng, Fengxia Su, Zhichao Chen, Mei Guo, Ying Gu, Yanmei Luo, Huamei Hu, Yanping Lu, Hongyun Zhang, Fang Chen, Ya Gao,

Background During human pregnancy, Placental trophectoderm cells can release exosomes into maternal circulation. Trophoblast cells also give rise to cell-free DNA (cfDNA) and has been used for noninvasive prenatal screening for chromosomal aneuploidy. We intended to prove the existence of exosomal DNA (exoDNA) in the exosomes of maternal blood and ... Read more >>

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Cardamonin reduces chemotherapy resistance of colon cancer cells via the TSP50/NF-κB pathway in vitro.

Sen Lu, Caizhao Lin, Xiaobin Cheng, Hanju Hua, Tao Xiang, Yu Huang, Xi Huang,

It has previously been reported that cardamonin is able to regulate glycometabolism and vasodilation whilst also exhibiting anti-inflammatory and antitumor properties. The antitumor effect of cardamonin is multifaceted, and so it is necessary to investigate the antitumor mechanisms of cardamonin at the molecular level. Cardamonin alters chemotherapy-resistant colon cancer cell ... Read more >>

Oncol Lett (Oncology letters)
[2018, 15(6):9641-9646]

Cited: 4 times

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Heterogeneous activation of peroxymonosulfate by LaCo1-xCuxO3 perovskites for degradation of organic pollutants.

Sen Lu, Guanlong Wang, Shuo Chen, Hongtao Yu, Fei Ye, Xie Quan,

Recently cobalt-based heterogeneous catalysts have been widely investigated for peroxymonosulfate (PMS) activation in sulfate radical-based advanced oxidation processes. However, the improvement of the catalytic performance for PMS activation remains to be a challenge. As the limiting step, the rapid transformation of CoII/CoIII redox pairs is crucial for PMS activation. Perovskites ... Read more >>

J. Hazard. Mater. (Journal of hazardous materials)
[2018, 353:401-409]

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The Circular RNA Profiles of Colorectal Tumor Metastatic Cells.

Weiqin Jiang, Xingchen Zhang, Qinjie Chu, Sen Lu, Linfu Zhou, Xingang Lu, Chen Liu, Lingfeng Mao, Chuyu Ye, Michael P Timko, Longjiang Fan, Haixing Ju,

Circular RNAs (circRNAs) have been reported that can be used as biomarkers for colorectal cancers (CRC) and other types of tumors. However, a limited number of studies have been performed investigating the potential role of circRNAs in tumor metastasis. Here, we examined the circRNAs in two CRC cell lines (a ... Read more >>

Front Genet (Frontiers in genetics)
[2018, 9:34]

Cited: 9 times

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[Sap flux density in response to rainfall pulses for Pinus tabuliformis and Hippophae rhamnoides from mixed plantation in hilly Loess Plateau].

Sen Bao Lu, Yun Ming Chen, Ya Kun Tang, Xu Wu, Jie Wen,

Thermal dissipation probe (TDP) was used to continuously measure the sap flux density (Fd) of Pinus tabuliformis and Hippophae rhamnoides individuals in hilly Loess Plateau, from June to October 2015, and the environmental factors, i.e., photosynthetic active radiation (PAR), water vapor pressure deficit (VPD), and soil water content (SWC), were ... Read more >>

Ying Yong Sheng Tai Xue Bao (Ying yong sheng tai xue bao = The journal of applied ecology)
[2017, 28(11):3469-3478]

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lncRNA MIAT promotes proliferation and invasion of HCC cells via sponging miR-214.

Xinli Huang, Yun Gao, Jianjie Qin, Sen Lu,

The aberrant expression of long noncoding RNAs (lncRNAs) has been involved in various human tumors including hepatocellular carcinoma (HCC). Our study aimed to investigate the potential molecular mechanism of lncRNA myocardial infarction-associated transcript (MIAT) in HCC. The expression of MIAT and micro-RNA (miR)-214 in HCC tissues and cells was examined ... Read more >>

Am. J. Physiol. Gastrointest. Liver Physiol. (American journal of physiology. Gastrointestinal and liver physiology)
[2018, 314(5):G559-G565]

Cited: 6 times

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3D printing hydrogel with graphene oxide is functional in cartilage protection by influencing the signal pathway of Rank/Rankl/OPG.

Zhong Cheng, Bolaky Landish, Zhang Chi, Cui Nannan, Du Jingyu, Lu Sen, Lin Xiangjin,

3Dprinting is defined as the use of printing technology to deposit living cells, and biomaterials on a given /a substrate. Graphene oxide nanoparticles (GO-np) have been used as a delivery vehicle for small molecule drugs in order to investigate the state of GO-np within 3D tissue constructs in terms of ... Read more >>

Mater Sci Eng C Mater Biol Appl (Materials science & engineering. C, Materials for biological applications)
[2018, 82:244-252]

Cited: 5 times

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The mechanism of long non-coding RNA MEG3 for hepatic ischemia-reperfusion: Mediated by miR-34a/Nrf2 signaling pathway.

Xinli Huang, Yun Gao, Jianjie Qin, Sen Lu,

To investigate the function of MEG3 in hepatic ischemia-reperfusion (HIR) progress, involving its association with the level of miR-34a during hypoxia-induced hypoxia re-oxygenation (H/R) in vitro. HIR mice model in vivo was established. MEG3, miR-34a expression, along with Nrf2 mRNA and protein level were detected in tissues and cells. Serum ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2018, 119(1):1163-1172]

Cited: 7 times

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β‑thalassemia caused by compound heterozygous mutations and cured by bone marrow transplantation: A case report.

Liusong Wu, Zhiyu Peng, Sen Lu, Mei Tan, Ying Rong, Runmei Tian, Yuhang Yang, Yan Chen, Jindong Chen,

In the present study, a rare familial case of severe thalassemia with compound spontaneous mutations is reported. A 2.5‑year‑old boy, who suffered from severe anemia with yellowish skin, enlarged liver and spleen, was provided with a blood transfusion every 20 days to maintain hemoglobin levels between 90 and 100 g/l. Sanger sequencing ... Read more >>

Mol Med Rep (Molecular Medicine Reports)
[2017, 16(5):6552-6557]

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A Meta-analysis comparing the effect of anatomical resection vs. non-anatomical resection on the long-term outcomes for patients undergoing hepatic resection for hepatocellular carcinoma.

Xinli Huang, Sen Lu,

This study aimed to compare the outcomes of patients undergoing anatomical resection (AR) versus non-anatomical resection (NAR) for hepatocellular carcinoma (HCC) from the published comparative studies within the literatures.A meta-analysis of studies published from 2001 to 2010 were conducted using RevMan 5.0. Measured outcomes were morbidity, mortality, recurrence and 5 ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2017, 19(10):843-849]

Cited: 4 times

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Next-generation sequencing improves thalassemia carrier screening among premarital adults in a high prevalence population: the Dai nationality, China.

Jing He, Wenhui Song, Jinlong Yang, Sen Lu, Yuan Yuan, Junfu Guo, Jie Zhang, Kai Ye, Fan Yang, Fangfang Long, Zhiyu Peng, Haijing Yu, Le Cheng, Baosheng Zhu,

Thalassemia is one of the most common monogenic diseases in southwestern China, especially among the Dai ethnic group. Here, we explore the feasibility of a next-generation sequencing (NGS) screening method specifically for the Dai people.Blood samples were obtained from Dai people for premarital screening. Double-blind, parallel hemoglobinopathy screening was conducted ... Read more >>

Genet. Med. (Genetics in medicine : official journal of the American College of Medical Genetics)
[2017, 19(9):1022-1031]

Cited: 10 times

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