Full Text Journal Articles by
Author Semi Harrabi

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[Is proton radiotherapy superior to photon radiotherapy in terms of intellectual outcome?]

Semi B Harrabi,

Strahlenther Onkol (Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al])
[2020, 196(12):1135-1138]

Cited: 0 times

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The SIOP-Renal Tumour Study Group consensus statement on flank target volume delineation for highly conformal radiotherapy.

Geert O Janssens, Patrick Melchior, Joeri Mul, Daniel Saunders, Stephanie Bolle, Alison L Cameron, Line Claude, Kristin Gurtner, Kees P van de Ven, Martine van Grotel, Semi Harrabi, Yasmin Lassen-Ramshad, Naomi Lavan, Henriette Magelssen, Xavier Muracciole, Tom Boterberg, Henry Mandeville, Jan Godzinski, Norbert Graf, Marry M van den Heuvel-Eibrink, Christian Rübe,

For decades, radiotherapy with two opposing photon beams has been the standard technique used to cover the flank target volume in paediatric patients with renal tumours. Nowadays, many institutes are implementing advanced radiotherapy techniques that spare healthy tissue. To decrease the radiotherapy dose to healthy structures while preserving oncological efficacy, ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):846-852]

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Acute toxicity of normofractionated intensity modulated radiotherapy with simultaneous integrated boost compared to three-dimensional conformal radiotherapy with sequential boost in the adjuvant treatment of breast cancer.

David Krug, Christine Köder, Matthias F Häfner, Nathalie Arians, Semi B Harrabi, Stefan A Koerber, Tobias Forster, Ingmar Schlampp, Christof Sohn, Joerg Heil, Holger Hof, Juliane Hörner-Rieber, Jürgen Debus,

BACKGROUND:Intensity-modulated radiotherapy (IMRT) improves dose homogeneity and late toxicity compared to simple tangential techniques in adjuvant whole-breast radiotherapy for patients with breast cancer. Simultaneous-integrated boost (SIB) radiotherapy shortens the overall treatment time and improves dose homogeneity. However, prospective randomized trials regarding IMRT with SIB for adjuvant radiotherapy in breast cancer ... Read more >>

Radiat Oncol (Radiation oncology (London, England))
[2020, 15(1):235]

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Carbon ion reirradiation compared to intensity-modulated re-radiotherapy for recurrent head and neck cancer (CARE): a randomized controlled trial

Thomas Held, Kristin Lang, Sebastian Regnery, Katharina Weusthof, Adriane Hommertgen, Cornelia Jäkel, Eric Tonndorf-Martini, Johannes Krisam, Peter Plinkert, Karim Zaoui, Christian Freudlsperger, Julius Moratin, Jürgen Krauss, Semi Harrabi, Klaus Herfarth, Jürgen Debus, Sebastian Adeberg,

Abstract Background: Intensity-modulated re-radiotherapy (reIMRT) has been established as a standard local treatment option in patients with non-resectable, recurrent head and neck cancer (rHNC). However, the clinical outcome is unfavorable and severe toxicities (≥grade III) occurred in 30–40% of patients. The primary aim of the current trial is to investigate ... Read more >>

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Assessment of RBE-Weighted Dose Models for Carbon Ion Therapy Toward Modernization of Clinical Practice at HIT: In Vitro, in Vivo, and in Patients.

Stewart Mein, Carmen Klein, Benedikt Kopp, Giuseppe Magro, Semi Harrabi, Christian P Karger, Thomas Haberer, Jürgen Debus, Amir Abdollahi, Ivana Dokic, Andrea Mairani,

PURPOSE:Present-day treatment planning in carbon ion therapy is conducted with assumptions for a limited number of tissue types and models for effective dose. Here, we comprehensively assess relative biological effectiveness (RBE) in carbon ion therapy and associated models toward the modernization of current clinical practice in effective dose calculation. METHODS:Using ... Read more >>

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2020, 108(3):779-791]

Cited: 1 time

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Late Contrast Enhancing Brain Lesions in Proton-Treated Patients With Low-Grade Glioma: Clinical Evidence for Increased Periventricular Sensitivity and Variable RBE.

Emanuel Bahn, Julia Bauer, Semi Harrabi, Klaus Herfarth, Jürgen Debus, Markus Alber,

PURPOSE:Late radiation-induced contrast-enhancing brain lesions (CEBLs) on magnetic resonance imaging (MRI) after proton therapy of brain tumors have been observed to occur frequently in regions of high linear energy transfer (LET) and in proximity to the ventricular system. We analyzed 110 patients with low-grade glioma treated with proton therapy to ... Read more >>

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2020, 107(3):571-578]

Cited: 0 times

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Dose-Limiting Organs at Risk in Carbon Ion Re-Irradiation of Head and Neck Malignancies: An Individual Risk-Benefit Tradeoff.

Thomas Held, Semi B Harrabi, Kristin Lang, Sati Akbaba, Paul Windisch, Denise Bernhardt, Stefan Rieken, Klaus Herfarth, Jürgen Debus, Sebastian Adeberg,

Background: Carbon ion re-irradiation (CIR) was evaluated to investigate treatment planning and the consequences of individual risk-benefit evaluations concerning dose-limiting organs at risk (OAR). Methods: A total of 115 consecutive patients with recurrent head and neck cancer (HNC) were analyzed after initial radiotherapy and CIR at the same anatomical site. ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(12):]

Cited: 1 time

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Malignant pleural mesothelioma - Pleural cavity irradiation after decortication with helical tomotherapy.

Semi B Harrabi, Stefan A Koerber, Sebastian Adeberg, Sonja Katayama, Klaus Herfarth, Juergen Debus, Florian Sterzing,

BACKGROUND:Malignant pleural mesothelioma (MPM) is a rare and aggressive disease that poses a treatment challenge in spite of recent technical developments. The aim of this retrospective analysis is to assess the feasibility of administering intensity-modulated radiotherapy (IMRT) to the pleural cavity using helical tomotherapy in patients who had undergone pleurectomy/decortication ... Read more >>

Rep Pract Oncol Radiother (Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology)
[2017, 22(5):402-407]

Cited: 2 times

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Radiotherapy plus concomitant temozolomide in primary gliosarcoma.

Sebastian Adeberg, Denise Bernhardt, Semi Ben Harrabi, Christian Diehl, Christian Koelsche, Stefan Rieken, Andreas Unterberg, Andreas von Deimling, Juergen Debus,

Clinical guidelines for gliosarcoma (GSM) are poorly defined and GSM patients are usually treated in accordance with existing guidelines for glioblastoma (GBM), with maximal surgical resection followed by chemoradiation with temozolomide (TMZ). However, it is not clear yet if GSM patients profit from TMZ therapy and if O6-methylguanine-DNA-methyltransferase (MGMT) promoter ... Read more >>

J Neurooncol (Journal of neuro-oncology)
[2016, 128(2):341-348]

Cited: 9 times

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Do Increased Doses to Stem-Cell Niches during Radiation Therapy Improve Glioblastoma Survival?

Sebastian Adeberg, Semi Ben Harrabi, Nina Bougatf, Denise Bernhardt, Angela Mohr, Juliane Rieber, Christian Koelsche, Stefan Rieken, Juergen Debus,

Background and Purpose. The reasons for the inevitable glioblastoma recurrence are yet understood. However, recent data suggest that tumor cancer stem cells (CSCs) in the stem-cell niches, with self-renewing capacities, might be responsible for tumor initiation, propagation, and recurrence. We aimed to analyze the effect of higher radiation doses to ... Read more >>

Stem Cells Int (Stem cells international)
[2016, 2016:8793462]

Cited: 4 times

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Impact of delays in initiating postoperative chemoradiation while determining the MGMT promoter-methylation statuses of patients with primary glioblastoma.

Sebastian Adeberg, Tilman Bostel, Semi Harrabi, Denise Bernhardt, Thomas Welzel, Wolfgang Wick, Juergen Debus, Stephanie E Combs,

The benefits of new innovations in glioblastoma therapies should not be curtailed as a result of delays in commencement of radiation therapy, caused by clinical circumstances as well as diagnostic procedures. This study evaluates whether delays in chemo-radiotherapy after surgery, while determining O6-methylguanine-DNA-methyltransferase (MGMT) promoter status, affect the survival rates ... Read more >>

BMC Cancer (BMC cancer)
[2015, 15:558]

Cited: 10 times

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Glioblastoma recurrence patterns after radiation therapy with regard to the subventricular zone.

Sebastian Adeberg, Laila König, Tilman Bostel, Semi Harrabi, Thomas Welzel, Jürgen Debus, Stephanie E Combs,

We evaluated the influence of tumor location and tumor spread in primary glioblastoma (GBM), with respect to the subventricular zone (SVZ), on recurrence behavior, progression-free survival (PFS), and overall survival (OS).607 patients (376 male and 231 female) with a median age of 61.3 years (range, 3.0-87.9 years) and primary GBM ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2014, 90(4):886-893]

Cited: 39 times

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