Full Text Journal Articles by
Author Sebastian Schellong

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Quality of life in patients with pulmonary embolism treated with edoxaban versus warfarin.

Roisin Bavalia, Ingrid M Bistervels, Wim G Boersma, Isabelle Quere, Dominique Brisot, Nicolas Falvo, Dominique Stephan, Francis Couturaud, Sebastian Schellong, Jan Beyer-Westendorf, Karine Montaclair, Waleed Ghanima, Marije Ten Wolde, Michiel Coppens, Emile Ferrari, Olivier Sanchez, Patrick Carroll, Pierre-Marie Roy, Susan R Kahn, Karina Meijer, Simone Birocchi, Michael J Kovacs, Amanda Hugman, Hugo Ten Cate, Hilde Wik, Gilles Pernod, Marie-Antoinette Sevestre-Pietri, Michael A Grosso, Minggao Shi, Yong Lin, Barbara A Hutten, Peter Verhamme, Saskia Middeldorp, ,

<h4>Background</h4>Long-term sequelae of acute pulmonary embolism (PE) include decreased quality of life (QoL). Evidence suggests that adequacy of initial anticoagulant treatment in the acute phase of venous thrombosis has a key impact on late postthrombotic complications. We hypothesize that patients with acute PE treated with edoxaban for acute PE experience ... Read more >>

Res Pract Thromb Haemost (Research and practice in thrombosis and haemostasis)
[2021, 5(5):e12566]

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Pharmacokinetics of direct oral anticoagulants in emergency situations - Results of the prospective observational RADOA-registry.

Edelgard Lindhoff-Last, Ingvild Birschmann, Joachim Kuhn, Simone Lindau, Stavros Konstantinides, Oliver Grottke, Ulrike Nowak-Göttl, Jessica Lucks, Barbara Zydek, Christian von Heymann, Ariane Sümnig, Jan Beyer-Westendorf, Sebastian Schellong, Patrick Meybohm, Andreas Greinacher, Eva Herrmann,

Background Direct oral anticoagulants (DOAC) are increasingly used worldwide. Little is known so far about their pharmacokinetics in emergency situations. Methods A prospective, observational registry was performed to determine the clinical course in consecutive patients with major bleeding or urgent surgery treated with DOACs. In back-up blood samples from routine ... Read more >>

Thromb Haemost (Thrombosis and haemostasis)
[2021, :]

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[COVID-19: Learning from experience].

Bernd Salzberger, Sebastian Schellong,

Internist (Berl) (Der Internist)
[2021, 62(7):695-696]

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The influence of anemia on clinical outcomes in venous thromboembolism: Results from GARFIELD-VTE.

Shinya Goto, Alexander G G Turpie, Alfredo E Farjat, Jeffrey I Weitz, Sylvia Haas, Walter Ageno, Samuel Z Goldhaber, Pantep Angchaisuksiri, Gloria Kayani, Peter MacCallum, Sebastian Schellong, Henri Bounameaux, Lorenzo G Mantovani, Paolo Prandoni, Ajay K Kakkar, ,

<h4>Introduction</h4>Clinical characteristics and outcomes of venous thromboembolism (VTE) patients with concomitant anemia are unclear. This study compares baseline characteristics, treatment patterns, and 24-month outcomes in patients with and without anemia within GARFIELD-VTE.<h4>Materials and methods</h4>GARFIELD-VTE (ClinicalTrials.gov: NCT02155491) is a global, prospective, non-interventional registry of real-world treatment practices. Of the 10,679 patients ... Read more >>

Thromb Res (Thrombosis research)
[2021, 203:155-162]

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Profile of Patients with Isolated Distal Deep Vein Thrombosis versus Proximal Deep Vein Thrombosis or Pulmonary Embolism: RE-COVERY DVT/PE Study.

Sebastian Schellong, Walter Ageno, Ivan B Casella, Kok Han Chee, Sam Schulman, Daniel E Singer, Marc Desch, Wenbo Tang, Isabelle Voccia, Kristina Zint, Samuel Z Goldhaber,

Isolated distal deep vein thrombosis (IDDVT) is presumed to be more benign than proximal DVT (PDVT) or pulmonary embolism (PE), suggesting a need for different management approaches. This subgroup analysis of the RE-COVERY DVT/PE global, observational study investigated patient characteristics, hospitalization details, and anticoagulant therapy in patients with IDDVT in ... Read more >>

Semin Thromb Hemost (Seminars in thrombosis and hemostasis)
[2021, :]

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Profile of patients diagnosed with acute venous thromboembolism in routine practice according to age and renal function: RE-COVERY DVT/PE study.

Walter Ageno, Ivan B Casella, Kok Han Chee, Sebastian Schellong, Sam Schulman, Daniel E Singer, Marc Desch, Wenbo Tang, Isabelle Voccia, Kristina Zint, Samuel Z Goldhaber,

In randomized clinical trials (RCTs) of nonvitamin K antagonist oral anticoagulants (NOACs) for acute venous thromboembolism (VTE), ~ 12-13% of patients were elderly and ~ 26% had mild-to-moderate renal impairment. Observational studies are not restricted by the selection and treatment criteria of RCTs. In this ancillary analysis of the RE-COVERY DVT/PE global observational study, ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2021, 51(3):561-570]

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Provoked versus unprovoked venous thromboembolism: Findings from GARFIELD-VTE.

Walter Ageno, Alfredo Farjat, Sylvia Haas, Jeffrey I Weitz, Samuel Z Goldhaber, Alexander G G Turpie, Shinya Goto, Pantep Angchaisuksiri, Joern Dalsgaard Nielsen, Gloria Kayani, Sebastian Schellong, Henri Bounameaux, Lorenzo G Mantovani, Paolo Prandoni, Ajay K Kakkar,

<h4>Introduction</h4>Venous thromboembolism (VTE) has a long-term risk of recurrence, dependent on the presence or absence of provoking risk factors at the time of the event.<h4>Objective</h4>To compare clinical characteristics, anticoagulant patterns, and 12-month outcomes in patients with transient provoking factors, active cancer, and unprovoked VTE.<h4>Methods</h4>The Global Anticoagulant Registry in the FIELD ... Read more >>

Res Pract Thromb Haemost (Research and practice in thrombosis and haemostasis)
[2021, 5(2):326-341]

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Survival and quality of life after early discharge in low-risk pulmonary embolism.

Stefano Barco, Irene Schmidtmann, Walter Ageno, Toni Anušić, Rupert M Bauersachs, Cecilia Becattini, Enrico Bernardi, Jan Beyer-Westendorf, Luca Bonacchini, Johannes Brachmann, Michael Christ, Michael Czihal, Daniel Duerschmied, Klaus Empen, Christine Espinola-Klein, Joachim H Ficker, Cândida Fonseca, Sabine Genth-Zotz, David Jiménez, Veli-Pekka Harjola, Matthias Held, Lorenzo Iogna Prat, Tobias J Lange, Mareike Lankeit, Athanasios Manolis, Andreas Meyer, Thomas Münzel, Pirjo Mustonen, Ursula Rauch-Kroehnert, Pedro Ruiz-Artacho, Sebastian Schellong, Martin Schwaiblmair, Raoul Stahrenberg, Luca Valerio, Peter E Westerweel, Philipp S Wild, Stavros V Konstantinides, , ,

<h4>Introduction</h4>Early discharge of patients with acute low-risk pulmonary embolism requires validation by prospective trials with clinical and quality-of-life outcomes.<h4>Methods</h4>The multinational Home Treatment of Patients with Low-Risk Pulmonary Embolism with the Oral Factor Xa Inhibitor Rivaroxaban (HoT-PE) single-arm management trial investigated early discharge followed by ambulatory treatment with rivaroxaban. The study ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, 57(2):]

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Incidence and severity of postthrombotic syndrome after iliofemoral thrombosis - results of the Iliaca-PTS - Registry.

Jamil Nawasrah, Barbara Zydek, Jessica Lucks, Johannes Renczes, Barbara Haberichter, Ümniye Balaban, Sebastian Schellong, Edelgard Lindhoff-Last,

<i>Background:</i> Deep venous thrombosis (DVT) and in particular, iliofemoral thrombosis (IFT) can lead to recurrent thrombosis and postthrombotic syndrome (PTS). Data on the prevalence, predictors and outcome of IFT are scarce. <i>Patients and methods:</i> We retrospectively searched our database of outpatients who had presented with DVT and IFT including the ... Read more >>

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2021, 50(1):30-37]

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Pregnancy-Associated Venous Thromboembolism: Insights from GARFIELD-VTE.

Carlos Jerjes-Sánchez, David Rodriguez, Alfredo E Farjat, Gloria Kayani, Peter MacCallum, Renato D Lopes, Alexander G G Turpie, Jeffrey I Weitz, Sylvia Haas, Walter Ageno, Shinya Goto, Samuel Z Goldhaber, Pantep Angchaisuksiri, Joern Dalsgaard Nielsen, Sebastian Schellong, Henri Bounameaux, Lorenzo G Mantovani, Paolo Prandoni, Ajay K Kakkar, ,

<b>Introduction</b>  The risk of venous thromboembolism (VTE) increases during pregnancy and the puerperium such that VTE is a leading cause of maternal mortality. <b>Methods</b>  We describe the clinical characteristics, diagnostic strategies, treatment patterns, and outcomes of women with pregnancy-associated VTE (PA-VTE) enrolled in the Global Anticoagulant Registry in the FIELD ... Read more >>

TH Open (TH open : companion journal to thrombosis and haemostasis)
[2021, 5(1):e24-e34]

Cited: 2 times

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Comparative clinical prognosis of massive and non-massive pulmonary embolism: A registry-based cohort study.

Marc Blondon, David Jimenez, Helia Robert-Ebadi, Jorge Del Toro, Luciano Lopez-Jimenez, Conxita Falga, Andris Skride, Llorenç Font, Fernando Javier Vazquez, Henri Bounameaux, Manuel Monreal, ,

<h4>Aims</h4>Little is known about the prognosis of patients with massive pulmonary embolism (PE) and its risk of recurrent venous thromboembolism (VTE) compared with non-massive PE, which may inform clinical decisions. Our aim was to compare the risk of recurrent VTE, bleeding, and mortality after massive and non-massive PE during anticoagulation ... Read more >>

J Thromb Haemost (Journal of thrombosis and haemostasis : JTH)
[2021, 19(2):408-416]

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Prognostic Impact of Obstructive Sleep Apnea in Patients Presenting with Acute Symptomatic Pulmonary Embolism.

Raphael Le Mao, David Jiménez, Behnood Bikdeli, Mateo Porres-Aguilar, Alberto García-Ortega, Vladimir Rosa, Sebastian Schellong, Lucia Mazzolai, Francisco Rivera-Civico, Manuel Monreal, ,

<h4>Background</h4> In patients with pulmonary embolism (PE), there is a lack of comprehensive data on the prevalence and prognostic significance of pre-existing obstructive sleep apnea (OSA).<h4>Methods</h4> In this study of patients with PE from the Registro Informatizado de la Enfermedad TromboEmbólica (RIETE) registry, we assessed the prevalence of OSA, and the association ... Read more >>

Thromb Haemost (Thrombosis and haemostasis)
[2021, 121(6):808-815]

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Association between reperfusion therapy and outcomes in patients with acute pulmonary embolism and right heart thrombi.

Behnood Bikdeli, David Jiménez, Alfonso Muriel, Deisy Barrios, Aitor Ballaz, Peter Verhamme, Manuel Monreal, , ,

Eur Respir J (The European respiratory journal)
[2020, 56(5):]

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Timing and characteristics of venous thromboembolism after noncancer surgery.

Manuela Expósito-Ruiz, Juan Ignacio Arcelus, Joseph A Caprini, Cristina López-Espada, Alessandra Bura-Riviere, Cristina Amado, Mónica Loring, Daniela Mastroiacovo, Manuel Monreal, ,

<h4>Background</h4>Venous thromboembolism (VTE) is a major cause of morbidity and mortality postoperatively. The use of pharmacologic prophylaxis is effective in reducing the incidence of VTE. However, the prophylaxis is often discontinued at hospital discharge, especially for those with benign disease. The implications of this practice are not known. We assessed ... Read more >>

J Vasc Surg Venous Lymphat Disord (Journal of vascular surgery. Venous and lymphatic disorders)
[2021, 9(4):859-867.e2]

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Assessment of Outcomes Among Patients With Venous Thromboembolism With and Without Chronic Kidney Disease.

Shinya Goto, Sylvia Haas, Walter Ageno, Samuel Z Goldhaber, Alexander G G Turpie, Jeffrey I Weitz, Pantep Angchaisuksiri, Joern Dalsgaard Nielsen, Gloria Kayani, Alfredo Farjat, Sebastian Schellong, Henri Bounameaux, Lorenzo G Mantovani, Paolo Prandoni, Ajay K Kakkar, ,

<h4>Importance</h4>Patients with venous thromboembolism (VTE) and concomitant chronic kidney disease (CKD) have been reported to have a higher risk of thrombosis and major bleeding complications compared with patients without concomitant CKD. The use of anticoagulation therapy is challenging, as many anticoagulant medications are excreted by the kidney. Large-scale data are ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(10):e2022886]

Cited: 1 time

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Predicting the risk for major bleeding in elderly patients with venous thromboembolism using the Charlson index. Findings from the RIETE.

Covadonga Gómez-Cuervo, Agustina Rivas, Adriana Visonà, Nuria Ruiz-Giménez, Ángeles Blanco-Molina, Inmaculada Cañas, José Portillo, Patricia López-Miguel, Katia Flores, Manuel Monreal, ,

Old patients receiving anticoagulant therapy for venous thromboembolism (VTE) are at an increased risk for bleeding. We used data from the RIETE registry to assess the prognostic ability of the Comorbidity Charlson Index (CCI) to predict the risk for major bleeding in patients aged > 75 years receiving anticoagulation for VTE beyond the ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2021, 51(4):1017-1025]

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[Bridging the sector boundary].

Sebastian Schellong, Ivo G Grebe,

Internist (Berl) (Der Internist)
[2020, 61(9):893-894]

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["The show must go on …"].

Sebastian M Schellong,

Dtsch Med Wochenschr (Deutsche medizinische Wochenschrift (1946))
[2020, 145(16):1107]

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Cancer associated thrombosis in everyday practice: perspectives from GARFIELD-VTE.

Jeffrey I Weitz, Sylvia Haas, Walter Ageno, Samuel Z Goldhaber, Alexander G G Turpie, Shinya Goto, Pantep Angchaisuksiri, Jørn Dalsgaard Nielsen, Gloria Kayani, Alfredo E Farjat, Sebastian Schellong, Henri Bounameaux, Lorenzo G Mantovani, Paolo Prandoni, Ajay K Kakkar, ,

Venous thromboembolism (VTE) is common in cancer patients and is an important cause of morbidity and mortality. The Global Anticoagulant Registry in the FIELD (GARFIELD)-VTE (ClinicalTrials.gov: NCT02155491) is a prospective, observational study of 10,684 patients with objectively diagnosed VTE from 415 sites in 28 countries. We compared baseline characteristics, VTE ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2020, 50(2):267-277]

Cited: 1 time

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Clinical Characteristics and Outcomes of Women Presenting with Venous Thromboembolism during Pregnancy and Postpartum Period: Findings from the RIETE Registry.

Islam Y Elgendy, Annemarie Fogerty, Ángeles Blanco-Molina, Vladimir Rosa, Sebastian Schellong, Andris Skride, José Portillo, Patricia Lopez-Miguel, Manuel Monreal, Ido Weinberg,

Although venous thromboembolism (VTE) is a leading cause of maternal mortality, there is a paucity of real-world clinical data on clinical presentation and management of VTE during pregnancy and postpartum period. Using data from the international RIETE (Registro Informatizado Enfermedad Trombo Embólica) registry, pregnant and postpartum women with VTE were ... Read more >>

Thromb Haemost (Thrombosis and haemostasis)
[2020, 120(10):1454-1462]

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Demographic and procedural characteristics in the RECording COurses of vasculaR Diseases (RECCORD) registry - the first 1000 patients.

Nasser Malyar, Jürgen Stausberg, Ralf Langhoff, Federico Tatò, Christoph Kalka, Wulf D Ito, Jens Böhme, Jawed Arjumand, Jens Stegemann, Holger Lawall, Sebastian Schellong, Michael Lichtenberg, Ulrich Hoffmann,

<i>Background:</i> The RECcording COurses of vasculaR Diseases (RECCORD) registry established by the German Society of Angiology - Society for Vascular Medicine aimed to address the lack in contemporary real-world data regarding current practice of medical and interventional care in vascular patients. We herein report the demographic and procedural characteristics of ... Read more >>

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2020, 49(5):382-388]

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COMPARE: prospective, randomized, non-inferiority trial of high- vs. low-dose paclitaxel drug-coated balloons for femoropopliteal interventions.

Sabine Steiner, Andrej Schmidt, Thomas Zeller, Gunnar Tepe, Marcus Thieme, Lars Maiwald, Henrik Schröder, Wulf Euringer, Matthias Ulrich, Klaus Brechtel, Steffen Brucks, Erwin Blessing, Johannes Schuster, Ralf Langhoff, Sebastian Schellong, Norbert Weiss, Dierk Scheinert,

<h4>Aims</h4>Drug-coated balloons (DCBs) for femoropopliteal interventions have not been tested against each other. We aimed to directly compare efficacy and safety of a high-dose (In.Pact™) vs. low-dose (Ranger™) DCB with nominal paclitaxel densities of 3.5 vs. 2.0 μg/mm2.<h4>Methods and results</h4>Within a prospective, multicentre, non-inferiority, clinical trial 414 patients with symptomatic femoropopliteal ... Read more >>

Eur Heart J (European heart journal)
[2020, 41(27):2541-2552]

Cited: 1 time

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Venous thromboembolism in patients with COVID-19 (SARS-CoV-2 infection) - a position paper of the German Society of Angiology (DGA).

Birgit Linnemann, Rupert Bauersachs, Mathias Grebe, Robert Klamroth, Oliver Müller, Sebastian Schellong, Michael Lichtenberg,

As observed in other infections with a systemic inflammatory response, severe COVID-19 is associated with hypercoagulability and a prothrombotic state. Currently, there is growing evidence that pulmonary embolism and thrombosis contribute to adverse outcomes and increased mortality in critically ill patients with COVID-19. The optimal thromboprophylactic regimen for patients with ... Read more >>

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2020, 49(4):259-263]

Cited: 3 times

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Severe Hemorrhage Associated With Oral Anticoagulants.

Edelgard Lindhoff-Last, Eva Herrmann, Simone Lindau, Stavros Konstantinides, Oliver Grottke, Ulrike Nowak-Goettl, Jessica Lucks, Barbara Zydek, Christian von Heymann, Ingvild Birschmann, Ariane Sümnig, Jan Beyer-Westendorf, Sebastian Schellong, Patrick Meybohm, Andreas Greinacher,

<h4>Background</h4>Few data have been published to date on outcomes after the common clinical experience of severe hemorrhage in orally anticoagulated patients.<h4>Methods</h4>A prospective, multicenter observational study was carried out to investigate outcomes and management in a series of consecutive patients who sustained a severe hemorrhage under treatment with vitamin K antagonists ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2020, 117(18):312-319]

Cited: 5 times

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Comparative effectiveness of oral anticoagulants in venous thromboembolism: GARFIELD-VTE.

Henri Bounameaux, Sylvia Haas, Alfredo E Farjat, Walter Ageno, Jeffrey I Weitz, Samuel Z Goldhaber, Alexander G G Turpie, Shinya Goto, Pantep Angchaisuksiri, Joern Dalsgaard Nielsen, Gloria Kayani, Sebastian Schellong, Lorenzo G Mantovani, Paolo Prandoni, Ajay K Kakkar,

<h4>Introduction</h4>Randomized controlled trials have shown that direct oral anticoagulants (DOACs) are a safe and effective alternative to vitamin K antagonists (VKAs) for the treatment of venous thromboembolism (VTE). However, there are limited post-marketing data describing the effectiveness and safety of the DOACs in the community setting. We aimed to compare ... Read more >>

Thromb Res (Thrombosis research)
[2020, 191:103-112]

Cited: 2 times

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