Full Text Journal Articles by
Author Sebastian Lange

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Morphology Matters: A Critical Reappraisal of the Clinical Relevance of Morphologic Criteria From the 2019 WHO Classification in a Large Colorectal Cancer Cohort Comprising 1004 Cases.

Moritz Jesinghaus, Maxime Schmitt, Corinna Lang, Marianne Reiser, Alexander Scheiter, Björn Konukiewitz, Katja Steiger, Miguel Silva, Markus Tschurtschenthaler, Sebastian Lange, Sebastian Foersch, Karl F Becker, Dieter Saur, Helmut Friess, Kathrin Halfter, Jutta Engel, Melanie Boxberg, Nicole Pfarr, Dirk Wilhelm, Wilko Weichert,

The 2019 World Health Organization (WHO) classification of colorectal carcinoma (CRC) profoundly reclassified CRC subtypes and introduces tumor budding as a second major grading criterion, while condensing conventional grade into a 2-tiered system. So far it remains largely unexplored how these parameters interact with each other and whether they truly ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2021, 45(7):969-978]

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PALLD mutation in a European family conveys a stromal predisposition for familial pancreatic cancer.

Lucia Liotta, Sebastian Lange, H Carlo Maurer, Kenneth P Olive, Rickmer Braren, Nicole Pfarr, Sebastian Burger, Alexander Muckenhuber, Moritz Jesinghaus, Katja Steiger, Wilko Weichert, Helmut Friess, Roland Schmid, Hana Algül, Philipp J Jost, Juliane Ramser, Christine Fischer, Anne S Quante, Maximilian Reichert, Michael Quante,

BACKGROUNDPancreatic cancer is one of the deadliest cancers, with low long-term survival rates. Despite recent advances in treatment, it is important to identify and screen high-risk individuals for cancer prevention. Familial pancreatic cancer (FPC) accounts for 4%-10% of pancreatic cancers. Several germline mutations are related to an increased risk and ... Read more >>

JCI Insight (JCI insight)
[2021, 6(8):]

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Spatial and temporal plasticity of neoantigen-specific T-cell responses bases on characteristics associated to antigen and TCR

Eva Bräunlein, Gaia Lupoli, Esam Abualrous, Niklas de Andrade Krätzig, Dario Gosmann, Franziska Füchsl, Lukas Wietbrock, Sebastian Lange, Thomas Engleitner, Huan Lan, Stefan Audehm, Manuel Effenberger, Melanie Boxberg, Katja Steiger, Yinshui Chang, Kai Yu, Cigdem Atay, Florian Bassermann, Wilko Weichert, Dirk Busch, Roland Rad, Christian Freund, Iris Antes, Angela Krackhardt,

Neoantigens derived from somatic mutations have been demonstrated to correlate with therapeutic responses mediated by treatment with immune checkpoint inhibitors. Neoantigens are therefore highly attractive targets for the development of personalized medicine approaches although their quality and associated immune responses is not yet well understood. In a case study of ... Read more >>

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Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer.

Johann Gout, Lukas Perkhofer, Mareen Morawe, Frank Arnold, Michaela Ihle, Stephanie Biber, Sebastian Lange, Elodie Roger, Johann M Kraus, Katja Stifter, Stephan A Hahn, Andrea Zamperone, Thomas Engleitner, Martin Müller, Karolin Walter, Eva Rodriguez-Aznar, Bruno Sainz, Patrick C Hermann, Elisabeth Hessmann, Sebastian Müller, Ninel Azoitei, André Lechel, Stefan Liebau, Martin Wagner, Diane M Simeone, Hans A Kestler, Thomas Seufferlein, Lisa Wiesmüller, Roland Rad, Pierre-Olivier Frappart, Alexander Kleger,

<h4>Objective</h4><i>ATM serine/threonine kinase</i> (ATM) is the most frequently mutated DNA damage response gene, involved in homologous recombination (HR), in pancreatic ductal adenocarcinoma (PDAC).<h4>Design</h4>Combinational synergy screening was performed to endeavour a genotype-tailored targeted therapy.<h4>Results</h4>Synergy was found on inhibition of PARP, ATR and DNA-PKcs (PAD) leading to synthetic lethality in ATM-deficient murine ... Read more >>

Gut (Gut)
[2021, 70(4):743-760]

Cited: 3 times

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MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically.

Enkhtsetseg Munkhbaatar, Michelle Dietzen, Deepti Agrawal, Martina Anton, Moritz Jesinghaus, Melanie Boxberg, Nicole Pfarr, Pidassa Bidola, Sebastian Uhrig, Ulrike Höckendorf, Anna-Lena Meinhardt, Adam Wahida, Irina Heid, Rickmer Braren, Ritu Mishra, Arne Warth, Thomas Muley, Patrina S P Poh, Xin Wang, Stefan Fröhling, Katja Steiger, Julia Slotta-Huspenina, Martijn van Griensven, Franz Pfeiffer, Sebastian Lange, Roland Rad, Magda Spella, Georgios T Stathopoulos, Jürgen Ruland, Florian Bassermann, Wilko Weichert, Andreas Strasser, Caterina Branca, Mathias Heikenwalder, Charles Swanton, Nicholas McGranahan, Philipp J Jost,

Evasion of programmed cell death represents a critical form of oncogene addiction in cancer cells. Understanding the molecular mechanisms underpinning cancer cell survival despite the oncogenic stress could provide a molecular basis for potential therapeutic interventions. Here we explore the role of pro-survival genes in cancer cell integrity during clonal ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):4527]

Cited: 2 times

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Linkage of genetic drivers and strain-specific germline variants confound mouse cancer genome analyses.

Sebastian Mueller, Sebastian Lange, Katharina A N Collins, Stefan Krebs, Helmut Blum, Günter Schneider, Lena Rad, Dieter Saur, Roland Rad,

Nat Commun (Nature communications)
[2020, 11(1):4474]

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Implementing cell-free DNA of pancreatic cancer patient-derived organoids for personalized oncology.

Zahra Dantes, Hsi-Yu Yen, Nicole Pfarr, Christof Winter, Katja Steiger, Alexander Muckenhuber, Alexander Hennig, Sebastian Lange, Thomas Engleitner, Rupert Öllinger, Roman Maresch, Felix Orben, Irina Heid, Georgios Kaissis, Kuangyu Shi, Geoffrey Topping, Fabian Stögbauer, Matthias Wirth, Katja Peschke, Aristeidis Papargyriou, Massoud Rezaee-Oghazi, Karin Feldmann, Arlett Pg Schäfer, Raphela Ranjan, Clara Lubeseder-Martellato, Daniel E Stange, Thilo Welsch, Marc Martignoni, Güralp O Ceyhan, Helmut Friess, Alexander Herner, Lucia Liotta, Matthias Treiber, Guido von Figura, Mohamed Abdelhafez, Peter Klare, Christoph Schlag, Hana Algül, Jens Siveke, Rickmer Braren, Gregor Weirich, Wilko Weichert, Dieter Saur, Roland Rad, Roland M Schmid, Günter Schneider, Maximilian Reichert,

One of the major challenges in using pancreatic cancer patient-derived organoids (PDOs) in precision oncology is the time from biopsy to functional characterization. This is particularly true for endoscopic ultrasound-guided fine-needle aspiration biopsies, typically resulting in specimens with limited tumor cell yield. Here, we tested conditioned media of individual PDOs ... Read more >>

JCI Insight (JCI insight)
[2020, 5(15):]

Cited: 3 times

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Respect - A multicenter retrospective study on preoperative chemotherapy in locally advanced and borderline resectable pancreatic cancer.

Maximilian Weniger, John Moir, Marko Damm, Laura Maggino, Maximilian Kordes, Jonas Rosendahl, Güralp O Ceyhan, Stephan Schorn, ,

<h4>Background</h4>Neoadjuvant chemotherapy has become a powerful tool to convert borderline resectable (BRPC) and locally advanced pancreatic cancers (LAPC) into a resectable scenario. However, data analyzing the optimal type of therapy are scarce. In the present multicenter retrospective study, we evaluated the influence of FOLFIRINOX (FFX) and gemcitabine (GEM)-based neoadjuvant therapy ... Read more >>

Pancreatology (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.])
[2020, 20(6):1131-1138]

Cited: 1 time

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Notch Signaling Mediates Differentiation in Barrett's Esophagus and Promotes Progression to Adenocarcinoma.

Bettina Kunze, Frederik Wein, Hsin-Yu Fang, Akanksha Anand, Theresa Baumeister, Julia Strangmann, Sophie Gerland, Jonas Ingermann, Natasha Stephens Münch, Maria Wiethaler, Vincenz Sahm, Ana Hidalgo-Sastre, Sebastian Lange, Charles J Lightdale, Aqiba Bokhari, Gary W Falk, Richard A Friedman, Gregory G Ginsberg, Prasad G Iyer, Zhezhen Jin, Hiroshi Nakagawa, Carrie J Shawber, TheAnh Nguyen, William J Raab, Piero Dalerba, Anil K Rustgi, Antonia R Sepulveda, Kenneth K Wang, Roland M Schmid, Timothy C Wang, Julian A Abrams, Michael Quante,

<h4>Background & aims</h4>Studies are needed to determine the mechanism by which Barrett's esophagus (BE) progresses to esophageal adenocarcinoma (EAC). Notch signaling maintains stem cells in the gastrointestinal tract and is dysregulated during carcinogenesis. We explored the relationship between Notch signaling and goblet cell maturation, a feature of BE, during EAC ... Read more >>

Gastroenterology (Gastroenterology)
[2020, 159(2):575-590]

Cited: 4 times

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Analysis pipelines for cancer genome sequencing in mice.

Sebastian Lange, Thomas Engleitner, Sebastian Mueller, Roman Maresch, Maximilian Zwiebel, Laura González-Silva, Günter Schneider, Ruby Banerjee, Fengtang Yang, George S Vassiliou, Mathias J Friedrich, Dieter Saur, Ignacio Varela, Roland Rad,

Mouse models of human cancer have transformed our ability to link genetics, molecular mechanisms and phenotypes. Both reverse and forward genetics in mice are currently gaining momentum through advances in next-generation sequencing (NGS). Methodologies to analyze sequencing data were, however, developed for humans and hence do not account for species-specific ... Read more >>

Nat Protoc (Nature protocols)
[2020, 15(2):266-315]

Cited: 3 times

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Post-neoadjuvant cellular dissociation grading based on tumour budding and cell nest size is associated with therapy response and survival in oesophageal squamous cell carcinoma.

Moritz Jesinghaus, Melanie Boxberg, Dirk Wilhelm, Stefan Münch, Hendrik Dapper, Michael Quante, Christoph Schlag, Sebastian Lange, Jan Budczies, Björn Konukiewitz, Martin Mollenhauer, Anna Melissa Schlitter, Karl Friedrich Becker, Marcus Feith, Helmut Friess, Katja Steiger, Stephanie E Combs, Wilko Weichert,

<h4>Background</h4>Cellular Dissociation Grade (CDG) composed of tumour budding and cell nest size has been shown to independently predict prognosis in pre-therapeutic biopsies and primary resections of oesophageal squamous cell carcinoma (ESCC). Here, we aimed to evaluate the prognostic impact of CDG in ESCC after neoadjuvant therapy.<h4>Methods</h4>We evaluated cell nest size ... Read more >>

Br J Cancer (British journal of cancer)
[2019, 121(12):1050-1057]

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BarrettNET-a prospective registry for risk estimation of patients with Barrett's esophagus to progress to adenocarcinoma.

Maria Wiethaler, Julia Slotta-Huspenina, Anna Brandtner, Julia Horstmann, Frederik Wein, Theresa Baumeister, Nikole Radani, Sophie Gerland, Akanksha Anand, Sebastian Lange, Melissa Schmidt, Klaus-Peter Janssen, Anja Conrad, Widya Johannes, Konstantin Strauch, Anne S Quante, Birgit Linkohr, Klaus A Kuhn, Rainer Blaser, Andreas Lehmann, Florian Kohlmayer, Wilko Weichert, Roland M Schmid, Karl-Friedrich Becker, Michael Quante,

Risk stratification in patients with Barrett's esophagus (BE) to prevent the development of esophageal adenocarcinoma (EAC) is an unsolved task. The incidence of EAC and BE is increasing and patients are still at unknown risk. BarrettNET is an ongoing multicenter prospective cohort study initiated to identify and validate molecular and ... Read more >>

Dis Esophagus (Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus)
[2019, 32(8):]

Cited: 0 times

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The neuropeptide receptor subunit RAMP1 constrains the innate immune response during acute pancreatitis in mice.

Leonie S Jochheim, Georgios Odysseos, Ana Hidalgo-Sastre, Suyang Zhong, Lina M Staufer, Markus Kroiss, Derya Kabacaoglu, Sebastian Lange, Thomas Engleitner, Daniel Hartmann, Norbert Hüser, Katja Steiger, Roland M Schmid, Bernhard Holzmann, Guido von Figura,

OBJECTIVES:The importance of the Calcitonin-gene-related-peptide-pathway (CGRP) as neuronal modulator of innate immune responses in mice has been previously demonstrated. The CGRP-receptor is composed of two subunits: the receptor-activity-modifying-protein-1 (RAMP1) and the calcitonin-receptor-like-receptor (CLR). CGRP can influence immune cells and their capacity of producing inflammatory cytokines. Using a RAMP1 knockout-mouse (RAMP1-/-) ... Read more >>

Pancreatology (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.])
[2019, 19(4):541-547]

Cited: 1 time

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Biodiversity of biological soil crusts from the Polar Regions revealed by metabarcoding.

Martin Rippin, Sebastian Lange, Nicole Sausen, Burkhard Becker,

Biological soil crusts (BSCs) are amalgamations of autotrophic, heterotrophic and saprotrophic organisms. In the Polar Regions, these unique communities occupy essential ecological functions such as primary production, nitrogen fixation and ecosystem engineering. Here, we present the first molecular survey of BSCs from the Arctic and Antarctica focused on both eukaryotes ... Read more >>

FEMS Microbiol Ecol (FEMS microbiology ecology)
[2018, 94(4):]

Cited: 5 times

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Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes.

Sebastian Mueller, Thomas Engleitner, Roman Maresch, Magdalena Zukowska, Sebastian Lange, Thorsten Kaltenbacher, Björn Konukiewitz, Rupert Öllinger, Maximilian Zwiebel, Alex Strong, Hsi-Yu Yen, Ruby Banerjee, Sandra Louzada, Beiyuan Fu, Barbara Seidler, Juliana Götzfried, Kathleen Schuck, Zonera Hassan, Andreas Arbeiter, Nina Schönhuber, Sabine Klein, Christian Veltkamp, Mathias Friedrich, Lena Rad, Maxim Barenboim, Christoph Ziegenhain, Julia Hess, Oliver M Dovey, Stefan Eser, Swati Parekh, Fernando Constantino-Casas, Jorge de la Rosa, Marta I Sierra, Mario Fraga, Julia Mayerle, Günter Klöppel, Juan Cadiñanos, Pentao Liu, George Vassiliou, Wilko Weichert, Katja Steiger, Wolfgang Enard, Roland M Schmid, Fengtang Yang, Kristian Unger, Günter Schneider, Ignacio Varela, Allan Bradley, Dieter Saur, Roland Rad,

The poor correlation of mutational landscapes with phenotypes limits our understanding of the pathogenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC). Here we show that oncogenic dosage-variation has a critical role in PDAC biology and phenotypic diversification. We find an increase in gene dosage of mutant KRAS in human PDAC ... Read more >>

Nature (Nature)
[2018, 554(7690):62-68]

Cited: 84 times

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siRNA-coupled nanoparticles for improved therapeutic targeting of pancreatic cancer.

Sebastian Lange, Dieter Saur, Roland Rad,

Gut (Gut)
[2016, 65(11):1780-1781]

Cited: 1 time

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CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice.

Julia Weber, Rupert Öllinger, Mathias Friedrich, Ursula Ehmer, Maxim Barenboim, Katja Steiger, Irina Heid, Sebastian Mueller, Roman Maresch, Thomas Engleitner, Nina Gross, Ulf Geumann, Beiyuan Fu, Angela Segler, Detian Yuan, Sebastian Lange, Alexander Strong, Jorge de la Rosa, Irene Esposito, Pentao Liu, Juan Cadiñanos, George S Vassiliou, Roland M Schmid, Günter Schneider, Kristian Unger, Fengtang Yang, Rickmer Braren, Mathias Heikenwälder, Ignacio Varela, Dieter Saur, Allan Bradley, Roland Rad,

Here, we show CRISPR/Cas9-based targeted somatic multiplex-mutagenesis and its application for high-throughput analysis of gene function in mice. Using hepatic single guide RNA (sgRNA) delivery, we targeted large gene sets to induce hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). We observed Darwinian selection of target genes, which suppress tumorigenesis in ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2015, 112(45):13982-13987]

Cited: 69 times

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Inter-individual and intra-individual variability of the N2 component: on reliability and signal-to-noise ratio.

Anja Leue, Christoph Klein, Sebastian Lange, André Beauducel,

The nogo N2 component, an anterior negative peak supposed to be generated in the anterior cingulate cortex, has been used as an indicator of conflict monitoring and response conflict in basic and clinical research. Here, we investigate the reliability and the signal-to-noise ratio (SNR) of inter-individual differences of the N2 ... Read more >>

Brain Cogn (Brain and cognition)
[2013, 83(1):61-71]

Cited: 10 times

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A novel armed oncolytic measles vaccine virus for the treatment of cholangiocarcinoma.

Sebastian Lange, Johanna Lampe, Sascha Bossow, Martina Zimmermann, Wolfgang Neubert, Michael Bitzer, Ulrich M Lauer,

Cholangiocarcinoma (CC) is curable only in early stages by complete surgical resection. Thus, in advanced disease stages in which a complete removal of the tumor mass is no longer possible and palliative chemotherapy achieves only modest success, therapeutics employing new methods of action are desperately needed. Oncolytic viruses employed in ... Read more >>

Hum Gene Ther (Human gene therapy)
[2013, 24(5):554-564]

Cited: 21 times

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"Have You Ever Seen This Face?" - Individual Differences and Event-Related Potentials during Deception.

Anja Leue, Sebastian Lange, André Beauducel,

Deception studies emphasize on the importance of event-related potentials (ERP) for a reliable differentiation of the underlying neuro-cognitive processes. The stimulus-locked parietal P3 amplitude has been shown to reflect stimulus salience but also attentional control available for stimulus processing. Known stimuli requiring truthful responses (targets) and known stimuli requiring deceptive ... Read more >>

Front Psychol (Frontiers in psychology)
[2012, 3:570]

Cited: 7 times

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Modulation of the conflict monitoring intensity: the role of aversive reinforcement, cognitive demand, and trait-BIS.

Anja Leue, Sebastian Lange, André Beauducel,

According to Botvinick's (2007) integrative account, conflict monitoring is aversive because individuals anticipate cognitive demand, whereas the revised reinforcement sensitivity theory (rRST) predicts that conflict processing is aversive because individuals anticipate aversive reinforcement of erroneous responses. Because these accounts give different reasons for the aversive aspects of conflict, we manipulated ... Read more >>

Cogn Affect Behav Neurosci (Cognitive, affective & behavioral neuroscience)
[2012, 12(2):287-307]

Cited: 9 times

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Behavioral approach and reward processing: results on feedback-related negativity and P3 component.

Sebastian Lange, Anja Leue, André Beauducel,

This study examined the FRN, the P3, and individual differences in trait-BAS and trait-BIS in the context of reward expectation mismatch. A more negative FRN was predicted for higher vs. lower trait-BAS individuals and for higher vs. lower trait-BIS individuals. In the extinction-learning task, participants (N=102) chose between two response ... Read more >>

Biol Psychol (Biological psychology)
[2012, 89(2):416-425]

Cited: 31 times

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Reliability generalization: an examination of the Positive Affect and Negative Affect Schedule.

Anja Leue, Sebastian Lange,

The assessment of positive affect (PA) and negative affect (NA) by means of the Positive Affect and Negative Affect Schedule has received a remarkable popularity in the social sciences. Using a meta-analytic tool-namely, reliability generalization (RG)-population reliability scores of both scales have been investigated on the basis of a random ... Read more >>

Assessment (Assessment)
[2011, 18(4):487-501]

Cited: 8 times

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Improved reproducibility in preparing precision-cut liver tissue slices.

Martina Zimmermann, Johanna Lampe, Sebastian Lange, Irina Smirnow, Alfred Königsrainer, Claus Hann-von-Weyhern, Falko Fend, Michael Gregor, Michael Bitzer, Ulrich M Lauer,

Precision-cut liver tissue slices (PCLS) have been used for decades to study pharmacological metabolism as well as toxicology and efficacy of novel substances on primary material under standardized conditions. Slicing of primary liver tissue has been done using different slicing machines. Since there has been great variability in the results, ... Read more >>

Cytotechnology (Cytotechnology)
[2009, 61(3):145-152]

Cited: 16 times

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Measuring biomolecular binding events with a compact disc player device.

Sebastian A Lange, Günter Roth, Silke Wittemann, Thilo Lacoste, Andreas Vetter, Jürgen Grässle, Susanne Kopta, Matthias Kolleck, Beate Breitinger, Manfred Wick, J K Heinrich Hörber, Stefan Dübel, André Bernard,

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2005, 45(2):270-273]

Cited: 17 times

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