Full Text Journal Articles by
Author Sebastian Foersch

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Morphology Matters: A Critical Reappraisal of the Clinical Relevance of Morphologic Criteria From the 2019 WHO Classification in a Large Colorectal Cancer Cohort Comprising 1004 Cases.

Moritz Jesinghaus, Maxime Schmitt, Corinna Lang, Marianne Reiser, Alexander Scheiter, Björn Konukiewitz, Katja Steiger, Miguel Silva, Markus Tschurtschenthaler, Sebastian Lange, Sebastian Foersch, Karl F Becker, Dieter Saur, Helmut Friess, Kathrin Halfter, Jutta Engel, Melanie Boxberg, Nicole Pfarr, Dirk Wilhelm, Wilko Weichert,

The 2019 World Health Organization (WHO) classification of colorectal carcinoma (CRC) profoundly reclassified CRC subtypes and introduces tumor budding as a second major grading criterion, while condensing conventional grade into a 2-tiered system. So far it remains largely unexplored how these parameters interact with each other and whether they truly ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2021, 45(7):969-978]

Cited: 0 times

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Chronic intestinal inflammation drives colorectal tumor formation triggered by dietary heme iron in vivo.

Nina Seiwert, Janine Adam, Pablo Steinberg, Stefan Wirtz, Tanja Schwerdtle, Petra Adams-Quack, Nadine Hövelmeyer, Bernd Kaina, Sebastian Foersch, Jörg Fahrer,

The consumption of red meat is associated with an increased risk for colorectal cancer (CRC). Multiple lines of evidence suggest that heme iron as abundant constituent of red meat is responsible for its carcinogenic potential. However, the underlying mechanisms are not fully understood and particularly the role of intestinal inflammation ... Read more >>

Arch Toxicol (Archives of toxicology)
[2021, :]

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Growth Factor Receptor Expression in Oropharyngeal Squamous Cell Cancer: Her1-4 and c-Met in Conjunction with the Clinical Features and Human Papillomavirus (p16) Status.

Eric Deuss, Dorothee Gößwein, Désirée Gül, Stefanie Zimmer, Sebastian Foersch, Claudia S Eger, Ivonne Limburg, Roland H Stauber, Julian Künzel,

This study aimed to assess the distribution of growth factor receptors in oropharyngeal squamous cell cancer (OPSCC) and evaluate their role in the context of human papillomavirus (HPV) status, prognosis and potential relevance for targeted therapy. The protein expression of human epidermal growth factor receptor (Her)1-4 and c-Met were retrospectively ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(11):]

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Tumor Lipids of Pediatric Papillary Renal Cell Carcinoma Stimulate Unconventional T Cells.

Nadine Lehmann, Claudia Paret, Khalifa El Malki, Alexandra Russo, Marie Astrid Neu, Arthur Wingerter, Larissa Seidmann, Sebastian Foersch, Nicole Ziegler, Lea Roth, Nora Backes, Roger Sandhoff, Joerg Faber,

Papillary renal cell carcinoma (PRCC) is a rare entity in children with no established therapy protocols for advanced diseases. Immunotherapy is emerging as an important therapeutic tool for childhood cancer. Tumor cells can be recognized and killed by conventional and unconventional T cells. Unconventional T cells are able to recognize ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:1819]

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Deep Learning Predicts Molecular Subtype of Muscle-invasive Bladder Cancer from Conventional Histopathological Slides.

Ann-Christin Woerl, Markus Eckstein, Josephine Geiger, Daniel C Wagner, Tamas Daher, Philipp Stenzel, Aurélie Fernandez, Arndt Hartmann, Michael Wand, Wilfried Roth, Sebastian Foersch,

<h4>Background</h4>Muscle-invasive bladder cancer (MIBC) is the second most common genitourinary malignancy, and is associated with high morbidity and mortality. Recently, molecular subtypes of MIBC have been identified, which have important clinical implications.<h4>Objective</h4>In the current study, we tried to predict the molecular subtype of MIBC samples from conventional histomorphology alone using ... Read more >>

Eur Urol (European urology)
[2020, 78(2):256-264]

Cited: 4 times

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Prognostic and Predictive Value of Tumor-infiltrating Leukocytes and of Immune Checkpoint Molecules PD1 and PDL1 in Clear Cell Renal Cell Carcinoma.

Philipp J Stenzel, Mario Schindeldecker, Katrin E Tagscherer, Sebastian Foersch, Esther Herpel, Markus Hohenfellner, Gencay Hatiboglu, Juergen Alt, Christian Thomas, Axel Haferkamp, Wilfried Roth, Stephan Macher-Goeppinger,

INTRODUCTION:Immune checkpoint inhibitors (ICI) have been approved for patients with clear cell renal cell carcinoma (ccRCC), but not all patients benefit from ICI. One reason is the tumor microenvironment (TME) that has substantial influence on patient's prognosis and therapy response. Thus, we comprehensively analyzed the TME of ccRCC regarding prognostic ... Read more >>

Transl Oncol (Translational oncology)
[2020, 13(2):336-345]

Cited: 11 times

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High Accumulation of Metformin in Colonic Tissue of Subjects With Diabetes or the Metabolic Syndrome.

Laura Paleari, Jürgen Burhenne, Johanna Weiss, Sebastian Foersch, Wilfried Roth, Andrea Parodi, Michael Gnant, Thomas Bachleitner-Hofmann, Dominique Scherer, Cornelia M Ulrich, Borut Stabuc, Matteo Puntoni, Gianni Coccia, Marilena Petrera, Walter-Emil Haefeli, Andrea DeCensi,

Gastroenterology (Gastroenterology)
[2018, 154(5):1543-1545]

Cited: 10 times

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Relationship between EGFR expression and subcellular localization with cancer development and clinical outcome.

Ge Yan, Mohamed E M Saeed, Sebastian Foersch, Jose Schneider, Wilfried Roth, Thomas Efferth,

Epidermal growth factor receptor (EGFR) as a prevalent oncogene regulates proliferation, apoptosis and differentiation and thereby contributes to carcinogenesis. Even though, the documentation on its clinical relevance is surprisingly heterogeneous in the scientific literature. Here, we systematically investigated the correlation of mRNA to survival time and pathological parameters by analyzing ... Read more >>

Oncotarget (Oncotarget)
[2019, 10(20):1918-1931]

Cited: 0 times

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PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression.

Bastian Dörsam, Nina Seiwert, Sebastian Foersch, Svenja Stroh, Georg Nagel, Diana Begaliew, Erika Diehl, Alexander Kraus, Maureen McKeague, Vera Minneker, Vassilis Roukos, Sonja Reißig, Ari Waisman, Markus Moehler, Anna Stier, Aswin Mangerich, Françoise Dantzer, Bernd Kaina, Jörg Fahrer,

Colorectal cancer (CRC) is one of the most common tumor entities, which is causally linked to DNA repair defects and inflammatory bowel disease (IBD). Here, we studied the role of the DNA repair protein poly(ADP-ribose) polymerase-1 (PARP-1) in CRC. Tissue microarray analysis revealed PARP-1 overexpression in human CRC, correlating with ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2018, 115(17):E4061-E4070]

Cited: 20 times

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Appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid are genetically distinct from primary colorectal-type adenocarcinoma of the appendix.

Moritz Jesinghaus, Björn Konukiewitz, Sebastian Foersch, Albrecht Stenzinger, Katja Steiger, Alexander Muckenhuber, Claudia Groß, Martin Mollenhauer, Wilfried Roth, Sönke Detlefsen, Wilko Weichert, Günter Klöppel, Nicole Pfarr, Anna Melissa Schlitter,

The appendix gives rise to goblet cell carcinoids, which represent special carcinomas with distinct biological and histological features. Their genetic background and molecular relationship to colorectal adenocarcinoma is largely unknown. We therefore performed a next-generation sequencing analysis of 25 appendiceal carcinomas including 11 goblet cell carcinoids, 7 adenocarcinomas ex-goblet cell ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2018, 31(5):829-839]

Cited: 7 times

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Prognostic relevance of androgen receptor expression in renal cell carcinomas.

Sebastian Foersch, Mario Schindeldecker, Martina Keith, Katrin E Tagscherer, Aurélie Fernandez, Philipp J Stenzel, Sascha Pahernik, Markus Hohenfellner, Peter Schirmacher, Wilfried Roth, Stephan Macher-Goeppinger,

Despite rapid discoveries in molecular biology of renal cell carcinoma (RCC) and advances in systemic targeted therapies, development of new diagnostic and therapeutic strategies is urgently needed. The androgen receptor (AR) has been shown to hold prognostic and predicitve value in several malignancies. Here, we studied a possible association between ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(45):78545-78555]

Cited: 4 times

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Programming of Intestinal Epithelial Differentiation by IL-33 Derived from Pericryptal Fibroblasts in Response to Systemic Infection.

Mousumi Mahapatro, Sebastian Foersch, Manuela Hefele, Gui-Wei He, Elisa Giner-Ventura, Tamar Mchedlidze, Markus Kindermann, Stefania Vetrano, Silvio Danese, Claudia Günther, Markus F Neurath, Stefan Wirtz, Christoph Becker,

The intestinal epithelium constitutes an efficient barrier against the microbial flora. Here, we demonstrate an unexpected function of IL-33 as a regulator of epithelial barrier functions. Mice lacking IL-33 showed decreased Paneth cell numbers and lethal systemic infection in response to Salmonella typhimurium. IL-33 was produced upon microbial challenge by a distinct population ... Read more >>

Cell Rep (Cell reports)
[2016, 15(8):1743-1756]

Cited: 46 times

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Interferon Gamma Counteracts the Angiogenic Switch and Induces Vascular Permeability in Dextran Sulfate Sodium Colitis in Mice.

Lisa Haep, Nathalie Britzen-Laurent, Thomas G Weber, Elisabeth Naschberger, Alexander Schaefer, Elisabeth Kremmer, Sebastian Foersch, Michael Vieth, Werner Scheuer, Stefan Wirtz, Maximilian Waldner, Michael Stürzl,

<h4>Background</h4>Interferon (IFN)-γ is a central pathogenesis factor in inflammatory bowel disease (IBD) with pleiotropic effects on many different cell types. However, as yet, the immune modulatory functions of IFN-γ in IBD have been predominantly investigated. Based on previous studies showing that IFN-γ acts antiangiogenic in colorectal carcinoma, we investigated the ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2015, 21(10):2360-2371]

Cited: 13 times

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VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice With Colitis.

Sebastian Foersch, Tobias Sperka, Christina Lindner, Astrid Taut, Karl L Rudolph, Georg Breier, Frank Boxberger, Tilman T Rau, Arndt Hartmann, Michael Stürzl, Nadine Wittkopf, Lisa Haep, Stefan Wirtz, Markus F Neurath, Maximilian J Waldner,

<h4>Background & aims</h4>Senescence prevents cellular transformation. We investigated whether vascular endothelial growth factor (VEGF) signaling via its receptor, VEGFR2, regulates senescence and proliferation of tumor cells in mice with colitis-associated cancer (CAC).<h4>Methods</h4>CAC was induced in VEGFR2(ΔIEC) mice, which do not express VEGFR2 in the intestinal epithelium, and VEGFR2(fl/fl) mice (controls) ... Read more >>

Gastroenterology (Gastroenterology)
[2015, 149(1):177-189.e10]

Cited: 16 times

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Colitis-associated neoplasia: molecular basis and clinical translation.

Sebastian Foersch, Markus F Neurath,

Crohn's disease and ulcerative colitis are both associated with an increased risk of inflammation-associated colorectal carcinoma. Colitis-associated cancer (CAC) is one of the most important causes for morbidity and mortality in patients with inflammatory bowel diseases (IBD). Colitis-associated neoplasia distinctly differs from sporadic colorectal cancer in its biology and the ... Read more >>

Cell Mol Life Sci (Cellular and molecular life sciences : CMLS)
[2014, 71(18):3523-3535]

Cited: 21 times

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Innate and adaptive immunity in inflammatory bowel diseases.

Sebastian Foersch, Maximilian J Waldner, Markus F Neurath,

While barrier function and the effects of the intestinal microbiome have only recently moved into the focus of inflammatory bowel disease research, the role of the innate and the adaptive immune system in these gastrointestinal disorders has extensively been studied. Although still not completely understood, the increasing knowledge about the ... Read more >>

Dig Dis (Digestive diseases (Basel, Switzerland))
[2013, 31(3-4):317-320]

Cited: 7 times

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Label-free imaging of inflammatory bowel disease using multiphoton microscopy.

Sebastian Schürmann, Sebastian Foersch, Raja Atreya, Helmut Neumann, Oliver Friedrich, Markus F Neurath, Maximilian J Waldner,

Gastroenterology (Gastroenterology)
[2013, 145(3):514-516]

Cited: 13 times

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Endomicroscopic Imaging of COX-2 Activity in Murine Sporadic and Colitis-Associated Colorectal Cancer.

Sebastian Foersch, Clemens Neufert, Markus F Neurath, Maximilian J Waldner,

Although several studies propose a chemopreventive effect of aspirin for colorectal cancer (CRC) development, the general use of aspirin cannot be recommended due to its adverse side effects. As the protective effect of aspirin has been associated with an increased expression of COX-2, molecular imaging of COX-2, for instance, during ... Read more >>

Diagn Ther Endosc (Diagnostic and therapeutic endoscopy)
[2013, 2013:250641]

Cited: 3 times

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Interleukin-6--a key regulator of colorectal cancer development.

Maximilian J Waldner, Sebastian Foersch, Markus F Neurath,

Growing evidence proposes an important role for pro-inflammatory cytokines during tumor development. Several experimental and clinical studies have linked the pleiotropic cytokine interleukin-6 (IL-6) to the pathogenesis of sporadic and inflammation-associated colorectal cancer (CRC). Increased IL-6 expression has been related to advanced stage of disease and decreased survival in CRC ... Read more >>

Int J Biol Sci (International journal of biological sciences)
[2012, 8(9):1248-1253]

Cited: 147 times

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Colitis and colorectal cancer.

Sebastian Foersch, Maximilian J Waldner, Markus F Neurath,

Inflammatory bowel diseases (IBD) are accompanied by an increased risk of developing colitis-associated carcinoma (CAC). These tumors are one of the most important causes of morbidity and mortality in patients with IBD and distinctly differ from sporadic colorectal cancer in their biology and underlying mechanisms. First, this review discusses risk ... Read more >>

Dig Dis (Digestive diseases (Basel, Switzerland))
[2012, 30(5):469-476]

Cited: 16 times

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Confocal laser endomicroscopy for diagnosis and histomorphologic imaging of brain tumors in vivo.

Sebastian Foersch, Axel Heimann, Ali Ayyad, Gilles A Spoden, Luise Florin, Konstantin Mpoukouvalas, Ralf Kiesslich, Oliver Kempski, Martin Goetz, Patra Charalampaki,

Early detection and evaluation of brain tumors during surgery is crucial for accurate resection. Currently cryosections during surgery are regularly performed. Confocal laser endomicroscopy (CLE) is a novel technique permitting in vivo histologic imaging with miniaturized endoscopic probes at excellent resolution. Aim of the current study was to evaluate CLE ... Read more >>

PLoS One (PloS one)
[2012, 7(7):e41760]

Cited: 37 times

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Molecular imaging of VEGF in gastrointestinal cancer in vivo using confocal laser endomicroscopy.

Sebastian Foersch, Ralf Kiesslich, Maximillian J Waldner, Peter Delaney, Peter R Galle, Markus F Neurath, Martin Goetz,

<h4>Background</h4>Vascular endothelial growth factor (VEGF) is a therapeutic target in gastrointestinal cancer (GiC). However, its in vivo visualisation could not be achieved to date with endoscopic techniques. Confocal laser endomicroscopy (CLE) is a novel imaging technique for gastrointestinal endoscopy providing in vivo microscopy at subcellular resolution. The aim of the ... Read more >>

Gut (Gut)
[2010, 59(8):1046-1055]

Cited: 65 times

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In vivo molecular imaging of colorectal cancer with confocal endomicroscopy by targeting epidermal growth factor receptor.

Martin Goetz, Alex Ziebart, Sebastian Foersch, Michael Vieth, Maximilian J Waldner, Peter Delaney, Peter R Galle, Markus F Neurath, Ralf Kiesslich,

<h4>Background & aims</h4>Epidermal growth factor receptor (EGFR) is a therapeutic target for colorectal cancer (CRC). However, technical challenges have limited in vivo imaging of EGFR in CRCs. Confocal laser endomicroscopy (CLE) enables accurate microscopic visualization of CRC in patients during endoscopy. We evaluated the ability to use CLE in vivo ... Read more >>

Gastroenterology (Gastroenterology)
[2010, 138(2):435-446]

Cited: 125 times

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