Full Text Journal Articles by
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A replication-competent late liver stage-attenuated human malaria parasite.

Debashree Goswami, William Betz, Navin K Locham, Chaitra Parthiban, Carolyn Brager, Carola Schäfer, Nelly Camargo, Thao Nguyen, Spencer Y Kennedy, Sean C Murphy, Ashley M Vaughan, Stefan Hi Kappe,

Whole sporozoite vaccines engender sterilizing immunity against malaria in animal models and importantly, in humans. Gene editing allows for the removal of specific parasite genes, enabling generation of genetically attenuated parasite (GAP) strains for vaccination. Using rodent malaria parasites, we have previously shown that late liver stage-arresting replication-competent (LARC) GAPs ... Read more >>

JCI Insight (JCI insight)
[2020, :]

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Daratumumab, Lenalidomide, Bortezomib, & Dexamethasone for Transplant-eligible Newly Diagnosed Multiple Myeloma: GRIFFIN.

Peter M Voorhees, Jonathan L Kaufman, Jacob Peter Laubach, Douglas Weston Sborov, Brandi Reeves, Cesar Rodriguez, Ajai Chari, Rebecca Silbermann, Luciano J Costa, Larry D Anderson, Nitya Nathwani, Nina Shah, Yvonne Adeduni Efebera, Sarah A Holstein, Caitlin Costello, Andrzej Jakubowiak, Tanya Wildes, Robert Z Orlowski, Kenneth H Shain, Andrew J Cowan, Sean P Murphy, Yana Lutska, Huiling Pei, Jon Ukropec, Jessica Vermeulen, Carla de Boer, Daniela Hoehn, Thomas Lin, Paul G Richardson,

Lenalidomide, bortezomib, and dexamethasone (RVd) followed by autologous stem cell transplantation (ASCT) is standard frontline therapy for transplant-eligible patients with newly diagnosed multiple myeloma (NDMM). This study evaluated addition of daratumumab (D) to RVd in ASCT-eligible NDMM patients. Patients (N=207) were randomized 1:1 to receive RVd ±D induction (4 cycles), ... Read more >>

Blood (Blood)
[2020, :]

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Anti-inflammatory therapy for preventing stroke and other vascular events after ischaemic stroke or transient ischaemic attack.

Sarah Coveney, John J McCabe, Sean Murphy, Martin O'Donnell, Peter J Kelly,

BACKGROUND:An increasing body of evidence suggests that inflammation plays a key role in stroke, in particular stroke of atherosclerotic origin. Anti-inflammatory medications are a widely heterogeneous group of drugs that are used to suppress the innate inflammatory pathway and thus prevent persistent or recurrent inflammation. Anti-inflammatory agents have the potential ... Read more >>

Cochrane Database Syst Rev (The Cochrane Database of Systematic Reviews)
[2020, 5:CD012825]

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Ethics of controlled human infection to address COVID-19.

Seema K Shah, Franklin G Miller, Thomas C Darton, Devan Duenas, Claudia Emerson, Holly Fernandez Lynch, Euzebiusz Jamrozik, Nancy S Jecker, Dorcas Kamuya, Melissa Kapulu, Jonathan Kimmelman, Douglas MacKay, Matthew J Memoli, Sean C Murphy, Ricardo Palacios, Thomas L Richie, Meta Roestenberg, Abha Saxena, Katherine Saylor, Michael J Selgelid, Vina Vaswani, Annette Rid,

Science (Science (New York, N.Y.))
[2020, 368(6493):832-834]

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Home-Time After Discharge Among Patients With Type 2 Myocardial Infarction.

Cian P McCarthy, Sean Murphy, Saad Rehman, Maeve Jones-O'Connor, David S Olshan, Joshua A Cohen, Jinghan Cui, Avinainder Singh, Muthiah Vaduganathan, James L Januzzi, Jason H Wasfy,

Background Home-time, defined as the time spent alive outside of a healthcare institution, has emerged as a patient-centered health outcome. The discharge locations and distribution of home-time after a type 2 myocardial infarction are unknown. Methods and Results Patients with a type 2 myocardial infarction between October 2017 and May ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(10):e015978]

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Corrigendum to The Cost of Inflammatory Bowel Disease: An Initiative From the Crohn's & Colitis Foundation.

K T Park, Orna G Ehrlich, John I Allen, Perry Meadows, Eva M Szigethy, Kim Henrichsen, Sandra C Kim, Rachel C Lawton, Sean M Murphy, Miguel Regueiro, David T Rubin, Nicole M Engel-Nitz, Caren A Heller,

Inflamm. Bowel Dis. (Inflammatory bowel diseases)
[2020, :]

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Neuroticism may not reflect emotional variability.

Elise K Kalokerinos, Sean C Murphy, Peter Koval, Natasha H Bailen, Geert Crombez, Tom Hollenstein, John Gleeson, Renee J Thompson, Dimitri M L Van Ryckeghem, Peter Kuppens, Brock Bastian,

Neuroticism is one of the major traits describing human personality, and a predictor of mental and physical disorders with profound public health significance. Individual differences in emotional variability are thought to reflect the core of neuroticism. However, the empirical relation between emotional variability and neuroticism may be partially the result ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(17):9270-9276]

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Medication treatment for opioid use disorder in expectant mothers (MOMs): Design considerations for a pragmatic randomized trial comparing extended-release and daily buprenorphine formulations.

Theresa Winhusen, Michelle Lofwall, Hendrée E Jones, Christine Wilder, Robert Lindblad, Davida M Schiff, Scott Wexelblatt, Stephanie Merhar, Sean M Murphy, Shelly F Greenfield, Mishka Terplan, Elisha M Wachman, Frankie Kropp, Jeff Theobald, Mitra Lewis, Abigail G Matthews, Connie Guille, Michael Silverstein, Carmen Rosa,

Opioid use disorder (OUD) in pregnant women has increased significantly in recent years. Maintaining these women on sublingual (SL) buprenorphine (BUP) is an evidence-based practice but BUP-SL is associated with several disadvantages that an extended-release (XR) BUP formulation could eliminate. The National Drug Abuse Treatment Clinical Trials Network (CTN) is ... Read more >>

Contemp Clin Trials (Contemporary clinical trials)
[2020, 93:106014]

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Vancomycin improves Plasmodium yoelii malaria parasite in vitro liver stage cultures by controlling Elizabethkingia anophelis, a bacterium in the microbiome of lab-reared Anopheles mosquitoes.

Melanie J Shears, Sean C Murphy,

Studies of Plasmodium sporozoites and liver stages require dissection of Anopheles mosquitoes to obtain sporozoites for experiments. Sporozoites from the rodent parasite P. yoelii are routinely used to infect hepatocytes for liver stage culture, but sometimes these cultures become contaminated. Using standard microbiological techniques, a single colony type of Gram-negative ... Read more >>

Mol. Biochem. Parasitol. (Molecular and biochemical parasitology)
[2020, 237:111279]

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Health and economic outcomes of treatment with extended-release naltrexone among pre-release prisoners with opioid use disorder (HOPPER): protocol for an evaluation of two randomized effectiveness trials.

Sean M Murphy, Philip J Jeng, Sabrina A Poole, Ali Jalali, Frank J Vocci, Michael S Gordon, George E Woody, Daniel Polsky,

BACKGROUND:Persons with an opioid use disorder (OUD) who were incarcerated face many challenges to remaining abstinent; concomitantly, opioid-overdose is the leading cause of death among this population, with the initial weeks following release proving especially fatal. Extended-release naltrexone (XR-NTX) is the most widely-accepted, evidence-based OUD pharmacotherapy in criminal justice settings, ... Read more >>

Addict Sci Clin Pract (Addiction science & clinical practice)
[2020, 15(1):15]

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Early repatriation post-thrombectomy: a model of care which maximises the capacity of a stroke network to treat patients with large vessel ischaemic stroke.

Emma Griffin, Sean Murphy, Mark Sheehan, Sarah Power, Paul Brennan, Alan O'Hare, Seamus Looby, Sebastian McWilliams, Barry Moynihan, David Williams, Karl Boyle, Damien O'Neill, Ronan Collins, Eamon Dolan, Tim Cassidy, Joe Harbison, Margaret O'Connor, Jack Alderson, John Thornton,

BACKGROUND AND PURPOSE:Healthcare systems are challenged to provide access to thrombectomy in acute stroke patients. Either the "drip and ship" or "mothership" models result in increased numbers of patients in the endovascular stroke centre (ESC). We describe our approach for a "drip, ship, retrieve and leave" model repatriating patients immediately ... Read more >>

J Neurointerv Surg (Journal of neurointerventional surgery)
[2020, :]

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Sustained release of stromal cell-derived factor-1 alpha from silk fibroin microfiber promotes urethral reconstruction in rabbits.

Yang Liu, Li Huang, Wei Yuan, Dongliang Zhang, Yubo Gu, Jianwen Huang, Sean Murphy, Mohamed Ali, Yaopeng Zhang, Lujie Song,

We developed a stromal cell-derived factor-1 alpha (SDF-1α)-aligned silk fibroin (SF)/three-dimensional porous bladder acellular matrix graft (3D-BAMG) composite scaffold for long-section ventral urethral regeneration and repair in vivo. SDF-1α-aligned SF microfiber/3D-BAMG, aligned SF microfiber/3D-BAMG, and nonaligned SF microfiber/3D-BAMG scaffolds were prepared using electrostatic spinning and wet processing. Adipose-derived stem cell ... Read more >>

J Biomed Mater Res A (Journal of biomedical materials research. Part A)
[2020, :]

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WHO malaria nucleic acid amplification test external quality assessment scheme: results of distribution programmes one to three.

Jane A Cunningham, Rebecca M Thomson, Sean C Murphy, Maria de la Paz Ade, Xavier C Ding, Sandra Incardona, Eric Legrand, Naomi W Lucchi, Didier Menard, Samuel L Nsobya, Agatha C Saez, Peter L Chiodini, Jaya Shrivastava,

BACKGROUND:The World Health Organization (WHO) recommends parasite-based diagnosis of malaria. In recent years, there has been surge in the use of various kinds of nucleic-acid amplification based tests (NAATs) for detection and identification of Plasmodium spp. to support clinical care in high-resource settings and clinical and epidemiological research worldwide. However, ... Read more >>

Malar. J. (Malaria journal)
[2020, 19(1):129]

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Cardiovascular magnetic resonance in immune checkpoint inhibitor-associated myocarditis.

Lili Zhang, Magid Awadalla, Syed S Mahmood, Anju Nohria, Malek Z O Hassan, Franck Thuny, Daniel A Zlotoff, Sean P Murphy, James R Stone, Doll Lauren Alexandra Golden, Raza M Alvi, Adam Rokicki, Maeve Jones-O'Connor, Justine V Cohen, Lucie M Heinzerling, Connor Mulligan, Merna Armanious, Ana Barac, Brian J Forrestal, Ryan J Sullivan, Raymond Y Kwong, Eric H Yang, Rongras Damrongwatanasuk, Carol L Chen, Dipti Gupta, Michael C Kirchberger, Javid J Moslehi, Otavio R Coelho-Filho, Sarju Ganatra, Muhammad A Rizvi, Gagan Sahni, Carlo G Tocchetti, Valentina Mercurio, Michael Mahmoudi, Donald P Lawrence, Kerry L Reynolds, Jonathan W Weinsaft, A John Baksi, Stephane Ederhy, John D Groarke, Alexander R Lyon, Michael G Fradley, Paaladinesh Thavendiranathan, Tomas G Neilan,

AIMS:Myocarditis is a potentially fatal complication of immune checkpoint inhibitors (ICI). Sparse data exist on the use of cardiovascular magnetic resonance (CMR) in ICI-associated myocarditis. In this study, the CMR characteristics and the association between CMR features and cardiovascular events among patients with ICI-associated myocarditis are presented. METHODS AND RESULTS:From ... Read more >>

Eur. Heart J. (European heart journal)
[2020, 41(18):1733-1743]

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Slow release oral morphine versus methadone for opioid use disorder in the fentanyl era (pRESTO): Protocol for a non-inferiority randomized clinical trial.

M Eugenia Socias, Evan Wood, Huiru Dong, Rupinder Brar, Paxton Bach, Sean M Murphy, Nadia Fairbairn,

BACKGROUND:North America is facing an unprecedented public health crisis of opioid-related morbidity and mortality, increasingly as a result of the introduction of illicitly manufactured fentanyl into the street drug market. Although the treatment of opioid use disorder (OUD) is a key element in the response to the opioid overdose epidemic, ... Read more >>

Contemp Clin Trials (Contemporary clinical trials)
[2020, 91:105993]

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Single pedicle advancement flap for treatment of feline stenotic nares: technique and results in five cases.

Chanel N Berns, Chad W Schmiedt, Vanna M Dickerson, Sean M Murphy,

OBJECTIVES:Brachycephalic obstructive airway syndrome (BOAS) is a common cause of upper airway obstruction in dogs, but is appreciated less commonly in cats. Of the components of BOAS, stenotic nares appear to play a major role in cats. However, the axial deviation of the alar wing, a common cause of nasal ... Read more >>

J. Feline Med. Surg. (Journal of feline medicine and surgery)
[2020, :1098612X20910539]

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Metabolic and evolutionary responses of Clostridium thermocellum to genetic interventions aimed at improving ethanol production.

Evert K Holwerda, Daniel G Olson, Natalie M Ruppertsberger, David M Stevenson, Sean J L Murphy, Marybeth I Maloney, Anthony A Lanahan, Daniel Amador-Noguez, Lee R Lynd,

Background:Engineering efforts targeted at increasing ethanol by modifying the central fermentative metabolism of Clostridium thermocellum have been variably successful. Here, we aim to understand this variation by a multifaceted approach including genomic and transcriptomic analysis combined with chemostat cultivation and high solids cellulose fermentation. Three strain lineages comprising 16 strains ... Read more >>

Biotechnol Biofuels (Biotechnology for Biofuels)
[2020, 13:40]

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Paraburkholderia madseniana sp. nov., a phenolic acid-degrading bacterium isolated from acidic forest soil.

Roland C Wilhelm, Sean J L Murphy, Nicole M Feriancek, David C Karasz, Christopher M DeRito, Jeffrey D Newman, Daniel H Buckley,

RP11T was isolated from forest soil following enrichment with 4-hydroxybenzoic acid. Cells of RP11T are aerobic, non-sporulating, exhibit swimming motility, and are rods (0.8 µm by 1.4 µm) that often occur as diplobacillus or in short chains (3-4 cells). Optimal growth on minimal media containing 4-hydroxybenzoic acid (µ=0.216 hr-1) occurred at 30 °C, pH 6.5 ... Read more >>

Int. J. Syst. Evol. Microbiol. (International journal of systematic and evolutionary microbiology)
[2020, 70(3):2137-2146]

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Cost-effectiveness of Hepatitis C Virus Treatment Models for People Who Inject Drugs in Opioid Agonist Treatment Programs.

Sarah Gutkind, Bruce R Schackman, Jake R Morgan, Jared A Leff, Linda Agyemang, Sean M Murphy, Matthew J Akiyama, Brianna L Norton, Alain H Litwin, Benjamin P Linas,

BACKGROUND:Many people who inject drugs in the United States have chronic hepatitis C virus (HCV). On-site treatment in opiate agonist treatment (OAT) programs addresses HCV treatment barriers, but few evidence-based models exist. METHODS:We evaluated the cost-effectiveness of HCV treatment models for OAT patients using data from a randomized trial conducted ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 70(7):1397-1405]

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Drug compound screening in single and integrated multi-organoid body-on-a-chip systems.

Aleksander Skardal, Julio Aleman, Steven Forsythe, Shiny Rajan, Sean Murphy, Mahesh Devarasetty, Nima Pourhabibi Zarandi, Goodwell Nzou, Robert Wicks, Hooman Sadri-Ardekani, Colin Bishop, Shay Soker, Adam Hall, Thomas Shupe, Anthony Atala,

Current practices in drug development have led to therapeutic compounds being approved for widespread use in humans, only to be later withdrawn due to unanticipated toxicity. These occurrences are largely the result of erroneous data generated by in vivo and in vitro preclinical models that do not accurately recapitulate human ... Read more >>

Biofabrication (Biofabrication)
[2020, 12(2):025017]

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Economic evaluation in the National Drug Abuse Treatment Clinical Trials Network: Past, present, and future.

Ali Jalali, Danielle A Ryan, Kathryn E McCollister, Lisa A Marsch, Bruce R Schackman, Sean M Murphy,

Economic evaluations provide evidence that informs stakeholders on how to efficiently allocate real and financial healthcare resources. The purpose of this study was to review and discuss the integration of economic evaluations into the National Drug Abuse Treatment Clinical Trials Network (CTN) since its inception, as well as expectations for ... Read more >>

J Subst Abuse Treat (Journal of substance abuse treatment)
[2020, 112S:18-27]

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Inflammation in Heart Failure: JACC State-of-the-Art Review.

Sean P Murphy, Rahul Kakkar, Cian P McCarthy, James L Januzzi,

It has long been observed that heart failure (HF) is associated with measures of systemic inflammation. In recent years, there have been significant advancements in our understanding of how inflammation contributes to the pathogenesis and progression of HF. However, although numerous studies have validated the association between measures of inflammation ... Read more >>

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2020, 75(11):1324-1340]

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Growth Rate of Plasmodium falciparum: Analysis of Parasite Growth Data From Malaria Volunteer Infection Studies.

Leesa F Wockner, Isabell Hoffmann, Lachlan Webb, Benjamin Mordmüller, Sean C Murphy, James G Kublin, Peter O'Rourke, James S McCarthy, Louise Marquart,

BACKGROUND:Growth rate of malaria parasites in the blood of infected subjects is an important measure of efficacy of drugs and vaccines. METHODS:We used log-linear and sine-wave models to estimate the parasite growth rate of the 3D7 strain of Plasmodium falciparum using data from 177 subjects from 14 induced blood stage ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2020, 221(6):963-972]

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The Modern Physical Exam - A Transatlantic Perspective from the Resident Level.

Alan P Jacobsen, Yii Chun Khiew, Sean P Murphy, Conor M Lane, Brian T Garibaldi,

Issue: The physical examination has been in decline for many years and poorer skills contribute to medical errors and adverse events. Diagnostic error is also increasing with the complexity of medicine. Comparing the physical examination in Ireland and the United States with a focus on education, assessment, culture, and health ... Read more >>

Teach Learn Med (Teaching and learning in medicine)
[2020, :1-7]

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Mental Health Costs of Inflammatory Bowel Diseases.

Eva Szigethy, Sean M Murphy, Orna G Ehrlich, Nicole M Engel-Nitz, Caren A Heller, Kim Henrichsen, Rachel Lawton, Perry Meadows, John I Allen,

BACKGROUND:Mental health diagnoses (MHDs) were identified as significant drivers of inflammatory bowel disease (IBD)-related costs in an analysis titled "Cost of Care Initiative" supported by the Crohn's & Colitis Foundation. In this subanalysis, we sought to characterize and compare IBD patients with and without MHDs based on insurance claims data ... Read more >>

Inflamm. Bowel Dis. (Inflammatory bowel diseases)
[2020, :]

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