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FIGO staging for carcinoma of the vulva: 2021 revision.

Alexander B Olawaiye, Joseph Cotler, Mauricio A Cuello, Neerja Bhatla, Aikou Okamoto, Sarikapan Wilailak, Chittaranjan N Purandare, Gerhard Lindeque, Jonathan S Berek, Sean Kehoe,

To revise the FIGO staging for carcinoma of the vulva using a new approach that involves analyses of prospectively collected data. The FIGO Committee for Gynecologic Oncology reviewed the recent literature to gain an insight into the impact of the 2009 vulvar cancer staging revision. The Committee resolved to revise ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):43-47]

Cited: 0 times

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Aberrant activation of the Hedgehog signalling pathway in squamous cell carcinoma of the vulva as a potential target for cancer therapy.

Jason K W Yap, Khalil Uddin, Rachel Pounds, Danielle O'Neill, Sean Kehoe, Raji Ganesan, Christopher W Dawson,

In a previous study, we showed that the Hedgehog (Hh) signalling pathway is aberrantly activated in vulval squamous cell carcinoma (VSCC). In this study, we further validated our findings on a prospective cohort of primary VSCC cases, where immunohistochemical staining confirmed that key Hh pathway components were overexpressed in VSCC ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):17665]

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Neoadjuvant chemotherapy before surgery versus surgery followed by chemotherapy for initial treatment in advanced ovarian epithelial cancer.

Sarah L Coleridge, Andrew Bryant, Sean Kehoe, Jo Morrison,

<h4>Background</h4>Epithelial ovarian cancer presents at an advanced stage in the majority of women. These women require a combination of surgery and chemotherapy for optimal treatment. Conventional treatment has been to perform surgery first and then give chemotherapy. However, there may be advantages to using chemotherapy before surgery.<h4>Objectives</h4>To assess whether there ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2021, 7:CD005343]

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Computational modeling of ovarian cancer dynamics suggests optimal strategies for therapy and screening.

Shengqing Gu, Stephanie Lheureux, Azin Sayad, Paulina Cybulska, Liat Hogen, Iryna Vyarvelska, Dongsheng Tu, Wendy R Parulekar, Matthew Nankivell, Sean Kehoe, Dennis S Chi, Douglas A Levine, Marcus Q Bernardini, Barry Rosen, Amit Oza, Myles Brown, Benjamin G Neel,

High-grade serous tubo-ovarian carcinoma (HGSC) is a major cause of cancer-related death. Treatment is not uniform, with some patients undergoing primary debulking surgery followed by chemotherapy (PDS) and others being treated directly with chemotherapy and only having surgery after three to four cycles (NACT). Which strategy is optimal remains controversial. ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(25):]

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Population-based cancer staging for oesophageal, gastric, and pancreatic cancer 2012-2014: International Cancer Benchmarking Partnership SurvMark-2.

Citadel J Cabasag, Melina Arnold, Marion Piñeros, Eileen Morgan, James Brierley, Jim Hofferkamp, Sean Kehoe, John Butler, Oliver Bucher, Freddie Bray, Isabelle Soerjomataram, D Maxwell Parkin,

Cancer stage at diagnosis is important information for management and treatment of individual patients as well as in epidemiological studies to evaluate effectiveness of health care system in managing cancer patients. Population-based studies to examine international disparities on cancer survival by stage, however, has been challenging due to the lack ... Read more >>

Int J Cancer (International journal of cancer)
[2021, 149(6):1239-1246]

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Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer.

Sarah L Coleridge, Andrew Bryant, Sean Kehoe, Jo Morrison,

<h4>Background</h4>Epithelial ovarian cancer presents at an advanced stage in the majority of women. These women require surgery and chemotherapy for optimal treatment. Conventional treatment has been to perform surgery first and then give chemotherapy. However, there may be advantages to using chemotherapy before surgery.<h4>Objectives</h4>To assess whether there is an advantage ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2021, 2:CD005343]

Cited: 2 times

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The evolving role of one-step nucleic acid amplification (OSNA) for the intra-operative detection of lymph node metastases: A diagnostic accuracy meta-analysis.

Anastasios Tranoulis, Dimitra Georgiou, Jason Yap, Stephen Attard-Montalto, Jeremy Twigg, Ahmed Elattar, Kavita Singh, Janos Balega, Sean Kehoe,

<h4>Background</h4>One Step Nucleic Acid Amplification (OSNA) assay has recently emerged as a rapid molecular diagnostic tool for the detection of lymph node (LN) metastases. It is a molecular technique that analyses the entire LN tissue using a reverse-transcriptase loop-mediated isothermal amplification reaction to detect tumour specific cytoceratin 19 mRNA.<h4>Aim</h4>To ascertain ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2021, 47(6):1233-1243]

Cited: 1 time

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Maintaining surgical care delivery during the COVID-19 pandemic: A comparative cohort study at a tertiary gynecological cancer centre.

Elaine Leung, Zahra Pervaiz, Jack Lowe-Zinola, Sian Cree, Audrey Kwong, Natalie Marriott, Florence Cole, Uchechukwu Arum, Barbara Szopinski, Ahmed Elattar, Sudha Sundar, Sean Kehoe, Kavita Singh, Janos Balega, Jason Yap,

<h4>Background</h4>Surgery is the cornerstone of gynecological cancer management, but inpatient treatment may expose both patients and healthcare staff to COVID-19 infections. Plans to mitigate the impact of the COVID-19 pandemic have been implemented widely, but few studies have evaluated the effectiveness of these plans in maintaining safe surgical care delivery.<h4>Aim</h4>To ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, 160(3):649-654]

Cited: 2 times

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Serum Albumin as a Predictor of Survival after Interval Debulking Surgery for Advanced Ovarian Cancer (AOC): A Retrospective Study.

Dairui Dai, Janos Balega, Sudha Sundar, Sean Kehoe, Ahmed Elattar, Andrew Phillips, Kavita Singh,

<h4>Objective</h4>To investigate the impact of serum albumin (at diagnosis and pre-operatively) on survival in patients undergoing cytoreductive surgery for advanced ovarian cancer(AOC) and whether improvement in albumin achieved following neoadjuvant chemotherapy (NACT) affects overall survival (OS).<h4>Methods</h4>Outcomes of 441 patients who underwent cytoreduction for AOC were reviewed. Albumin was recorded at ... Read more >>

J Invest Surg (Journal of investigative surgery : the official journal of the Academy of Surgical Research)
[2020, :1-6]

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FIGO staging in ovarian carcinoma and histological subtypes.

Sean Kehoe,

J Gynecol Oncol (Journal of gynecologic oncology)
[2020, 31(4):e70]

Cited: 3 times

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Prolonged interruption of chemotherapy in patients undergoing delayed debulking surgery for advanced high grade serous ovarian cancer is associated with a worse prognosis.

Gemma Searle, Rachel Pounds, Andrew Phillips, Sean Kehoe, Janos Balega, Kavita Singh, Jason Yap,

<h4>Introduction</h4>The current standard of care for advanced high grade serous ovarian cancer (HGSC) comprises a combination of debulking surgery and platinum-based chemotherapy given in the neoadjuvant or adjuvant setting. In the neoadjuvant setting, patients usually undergo 3 cycles of chemotherapy followed by interval cytoreductive surgery (ICS), then 3 further cycles of ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 158(1):54-58]

Cited: 2 times

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FIGO stage IIB cervical cancer prognostication in low-resource settings.

Sean Kehoe, Neerja Bhatla, ,

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2020, 149(2):254]

Cited: 0 times

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Does sites of recurrence impact survival in secondary cytoreduction surgery for recurrent epithelial ovarian cancer?

Satyam Kumar, Ananth Srinivasan, Andrew Phillips, R Madhupriya, Jennifer Pascoe, James Nevin, Ahmed Elattar, Janos Balega, Carole Cummins, Sudha Sundar, Sean T Kehoe, Kavita Singh,

Outcomes of secondary cytoreduction surgery (SCS) were evaluated for morbidity, progression free survival (PFS) and overall survival (OS) and factors influencing results were explored. Retrospective analysis of all cases of SCS for epithelial ovarian cancer (EOC) was performed from October 2010 to December 2017. 62 patients were prospectively identified as ... Read more >>

J Obstet Gynaecol (Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology)
[2020, 40(6):849-855]

Cited: 1 time

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The role of preoperative computerized tomography (CT) scan of the pelvis and groin in the management of clinically early staged vulva squamous cell carcinoma.

Rachel Pounds, Danielle O'Neill, Kamana Subba, Akanksha Garg, Miski Scerif, Elizabeth Leong, James Nevin, Sean Kehoe, Jason Yap,

INTRODUCTION:Vulvar squamous cell carcinoma (VSCC) commonly metastasises through groin lymphatics. However, the use of pre-operative imaging in detecting inguinal nodal metastasis before staging surgery or to triage patients for sentinel node biopsy remains unclear. Here, we investigated if pre-operative CT scan, the imaging choice in our cancer centre, influences the ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 157(2):444-449]

Cited: 0 times

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Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer.

Sarah L Coleridge, Andrew Bryant, Thomas J Lyons, Richard J Goodall, Sean Kehoe, Jo Morrison,

<h4>Background</h4>Epithelial ovarian cancer presents at an advanced stage in the majority of women. These women require surgery and chemotherapy for optimal treatment. Conventional treatment has been to perform surgery first and then give chemotherapy. However, there may be advantages to using chemotherapy before surgery.<h4>Objectives</h4>To assess whether there is an advantage ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2019, 2019(10):]

Cited: 9 times

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Computational Modeling of Ovarian Cancer Reveals Optimal Strategies for Therapy and Screening

Shengqing Gu, Stephanie Lheureux, Azin Sayad, Paulina Cybulska, Liat Ben-David Hogen, Iryna Vyarvelska, Dongsheng Tu, Wendy Parulekar, Matthew Nankivell, Sean Kehoe, Dennis Chi, Douglas Levine, Marcus Bernardini, Barry Rosen, Amit Oza, Benjamin Neel,

High-grade serous tubo-ovarian carcinoma (HGSC) is a major cause of cancer-related death. Whether treatment order—primary debulking surgery followed by adjuvant chemotherapy (PDS) or neo-adjuvant chemotherapy with interval surgery (NACT)—affects outcome is controversial. We developed a mathematical framework that holds for hierarchical or stochastic models of tumor initiation and reproduces HGSC ... Read more >>

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Socioeconomic differences impact overall survival in advanced ovarian cancer (AOC) prior to achievement of standard therapy.

Andrew Phillips, Sean Kehoe, Kavita Singh, Ahmed Elattar, James Nevin, Janos Balega, Rachel Pounds, Ahmed Elmodir, Jennifer Pascoe, Indrajit Fernando, Sudha Sundar,

<h4>Purpose</h4>Survival difference between socioeconomic groups with ovarian cancer has persisted in the United Kingdom despite efforts to reduce disparities in care. Our aim was to delineate critical episodes in the patient journey, where deprivation has most impact on survival.<h4>Methods</h4>A retrospective review of 834 patients with advanced ovarian cancer (AOC) between ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2019, 300(5):1261-1270]

Cited: 1 time

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Quality of life outcomes following surgery for advanced ovarian cancer: a systematic review and meta-analysis.

Satyam Kumar, Joanna Long, Sean Kehoe, Sudha Sundar, Carole Cummins,

BACKGROUND:Quality of life after ovarian cancer treatment is an important goal for patients. Complex debulking surgeries and platinum based chemotherapy are often required but quality of life after surgery is rarely reported. OBJECTIVES:To describe quality of life outcomes after surgery for advanced ovarian cancer in a systematic review and meta-analysis. ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2019, 29(8):1285-1291]

Cited: 4 times

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An international, phase III randomized trial in patients with mucinous epithelial ovarian cancer (mEOC/GOG 0241) with long-term follow-up: and experience of conducting a clinical trial in a rare gynecological tumor.

Martin Gore, Allan Hackshaw, William E Brady, Richard T Penson, Richard Zaino, W Glenn McCluggage, Raji Ganesan, Nafisa Wilkinson, Timothy Perren, Ana Montes, Jeffrey Summers, Rosemary Lord, Graham Dark, Gordon Rustin, Melanie Mackean, Nicholas Reed, Sean Kehoe, Michael Frumovitz, Helen Christensen, Amanda Feeney, Jonathan Ledermann, David M Gershenson,

<h4>Objectives</h4>We evaluated four different treatment regimens for advanced-stage mucinous epithelial ovarian cancer.<h4>Methods</h4>We conducted a multicenter randomized factorial trial (UK and US). Patients were diagnosed with primary mEOC: FIGO stage II-IV or recurrence after stage I disease. Treatment arms were paclitaxel-carboplatin, oxaliplatin-capecitabine, paclitaxel-carboplatin-bevacizumab, or oxaliplatin-capecitabine-bevacizumab. Chemotherapy was given 3-weekly for 6 cycles, ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 153(3):541-548]

Cited: 15 times

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Revised FIGO staging for carcinoma of the cervix uteri.

Neerja Bhatla, Jonathan S Berek, Mauricio Cuello Fredes, Lynette A Denny, Seija Grenman, Kanishka Karunaratne, Sean T Kehoe, Ikuo Konishi, Alexander B Olawaiye, Jaime Prat, Rengaswamy Sankaranarayanan, James Brierley, David Mutch, Denis Querleu, David Cibula, Michael Quinn, Hennie Botha, Lax Sigurd, Laurel Rice, Hee-Sug Ryu, Hextan Ngan, Johanna Mäenpää, Andri Andrijono, Gatot Purwoto, Amita Maheshwari, Uttam D Bafna, Marie Plante, Jayashree Natarajan,

<h4>Objective</h4>To revise FIGO staging of carcinoma of the cervix uteri, allowing incorporation of imaging and/or pathological findings, and clinical assessment of tumor size and disease extent.<h4>Methods</h4>Review of literature and consensus view of the FIGO Gynecologic Oncology Committee and related societies and organizations.<h4>Results</h4>In stage I, revision of the definition of microinvasion ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2019, 145(1):129-135]

Cited: 88 times

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Neoadjuvant chemotherapy versus debulking surgery in advanced tubo-ovarian cancers: pooled analysis of individual patient data from the EORTC 55971 and CHORUS trials.

Ignace Vergote, Corneel Coens, Matthew Nankivell, Gunnar B Kristensen, Mahesh K B Parmar, Tom Ehlen, Gordon C Jayson, Nick Johnson, Ann Marie Swart, René Verheijen, W Glenn McCluggage, Tim Perren, Pierluigi Benedetti Panici, Gemma Kenter, Antonio Casado, Cesar Mendiola, Gavin Stuart, Nick S Reed, Sean Kehoe, , ,

<h4>Background</h4>Individual patient data from two randomised trials comparing neoadjuvant chemotherapy with upfront debulking surgery in advanced tubo-ovarian cancer were analysed to examine long-term outcomes for patients and to identify any preferable therapeutic approaches for subgroup populations.<h4>Methods</h4>We did a per-protocol pooled analysis of individual patient data from the European Organisation for ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2018, 19(12):1680-1687]

Cited: 31 times

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Under expression of the Sonic Hedgehog receptor, Patched1 (PTCH1), is associated with an increased risk of local recurrence in squamous cell carcinoma of the vulva arising on a background of Lichen Sclerosus.

Jason Yap, Richard Fox, Natalie Narsia, Sonia Pinheiro-Maia, Rachel Pounds, Ciaran Woodman, David Luesley, Raji Ganesan, Sean Kehoe, Christopher Dawson,

<h4>Objective</h4>Dysregulation of the Hedgehog (Hh) pathway has been described in a variety of cancers, including cervical cancer, a disease which shares a common aetiology with vulval squamous cell carcinoma (VSCC). Here, we investigate a large number of primary VSCC cases for evidence of Hedgehog pathway activation and examine the implications ... Read more >>

PLoS One (PloS one)
[2018, 13(10):e0206553]

Cited: 2 times

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Cancer of the ovary, fallopian tube, and peritoneum.

Jonathan S Berek, Sean T Kehoe, Lalit Kumar, Michael Friedlander,

The Gynecologic Oncology Committee of FIGO in 2014 revised the staging of ovarian cancer, incorporating ovarian, fallopian tube, and peritoneal cancer into the same system. Most of these malignancies are high-grade serous carcinomas (HGSC). Stage IC is now divided into three categories: IC1 (surgical spill); IC2 (capsule ruptured before surgery or ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2018, 143 Suppl 2:59-78]

Cited: 32 times

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The Impact of Saphenous Vein Sparing During Inguinal Lymphadenectomy on Postoperative Morbidity in Women With Vulval Cancer: An Updated Per-Groin Meta-analysis of Short-term Outcomes.

Anastasios Tranoulis, Alexandros Laios, George Theophilou, Konstantinos Bramis, Sean Kehoe,

<h4>Objective</h4>Inguinofemoral lymphadenectomy (IFL) is included in the standard surgical management of early-stage vulval cancer (VC) but is often accompanied by surgical complications. Efforts have been made to limit the postoperative morbidity by adopting more conservative IFL techniques without compromising the surgical outcomes. Saphenous vein (SV) preservation during IFL for VC ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2018, 28(6):1232-1238]

Cited: 0 times

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Diaphragm disease in advanced ovarian cancer: Predictability of pre-operative imaging and safety of surgical intervention.

Rachel Pounds, Andrew Phillips, Sean Kehoe, James Nevin, Sudha Sundar, Ahmed Elattar, Hong Giap Teo, Kavita Singh, Janos Balega,

OBJECTIVES:To establish the positive predictive values of pre-operative identification with CT imaging of metastatic diaphragm disease in surgically managed cases of advanced ovarian cancer (AOC). Additionally, we have assessed the post-operative morbidity and survival following diaphragmatic surgical intervention in a large regional cancer centre in the United Kingdom. STUDY DESIGN:A ... Read more >>

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2018, 226:47-53]

Cited: 2 times

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