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An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement

Guilian Tian, May Hui, Desiree Macchia, Pieter Derdeyn, Alexandra Rogers, Elizabeth Hubbard, Chengfeng Liu, Katrina Bartas, Sean Carroll, Kevin Beier,

<h4>ABSTRACT</h4> While midbrain dopamine (DA) neuronal circuits are central to motivated behaviors, much remains unknown about our knowledge of how these circuits are modified over time by experience to facilitate selective aspects of experience-dependent plasticity. Most studies of the DA system in drug addiction focus on the role of the ... Read more >>

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Ratings of perceived exertion at the ventilatory anaerobic threshold in people with coronary heart disease: A CARE CR study.

Simon Nichols, Buket Engin, Sean Carroll, John Buckley, Lee Ingle,

<h4>Background</h4>Exercise prescription guidelines for individuals undergoing cardiovascular rehabilitation (CR) are often based on heart rate training zones and rating of perceived exertion (RPE). United Kingdom guidelines indicate that patients should exercise at an intensity of RPE 11 to 14.<h4>Objectives</h4>We aimed to determine the accuracy of this approach by comparing this ... Read more >>

Ann Phys Rehabil Med (Annals of physical and rehabilitation medicine)
[2021, 64(6):101462]

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Deep learning-based segmentation of high-resolution computed tomography image data outperforms commonly used automatic bone segmentation methods

Daniella Patton, Emilie Henning, Rob Goulet, Sean Carroll, Erin M.R. Bigelow, Benjamin Provencher, Nicolas Piché, Mike Marsh, Karl Jepsen, Todd Bredbenner,

Segmenting bone from background is required to quantify bone architecture in computed tomography (CT) image data. A deep learning approach using convolutional neural networks (CNN) is a promising alternative method for automatic segmentation. The study objectives were to evaluate the performance of CNNs in automatic segmentation of human vertebral body ... Read more >>

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Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers.

Alistair James Marsden, David R J Riley, Stefan Birkett, Quentin Rodriguez-Barucg, Barbara-Ann Guinn, Sean Carroll, Lee Ingle, Thozhukat Sathyapalan, Pedro Beltran-Alvarez,

Cardiovascular disease is the major cause of death worldwide. Extensive cardiovascular biomarkers are available using blood tests but very few, if any, investigations have described non-invasive tests for cardiovascular biomarkers based on readily available hair samples. Here we show, first, that human hair proteins are post-translationally modified by arginine methylation ... Read more >>

Amino Acids (Amino acids)
[2021, :]

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FTO gene polymorphism and longitudinal changes in nutritional/obesity status in children and adolescents: Schoolchildren's health cohort study.

Éboni Marília Reuter, Cézane Priscila Reuter, João Francisco de Castro Silveira, Sean Carroll, James Philip Hobkirk, Pâmela Ferreira Todendi, Andréia Rosane de Moura Valim, Elza Daniel de Mello,

The fat mass and obesity-associated gene (FTO) has been extensively reported in the literature related to nutritional status, but there has been limited description of the genetic contribution to obesity risk during childhood and adolescence, especially in Latin Americans. This study aims to associate the rs9939609 polymorphism, of the FTO ... Read more >>

Eur J Pediatr (European journal of pediatrics)
[2021, 180(11):3325-3333]

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Considering the Feasibility, Tolerability, and Safety of High-Intensity Interval Training as a Novel Treatment for Patients With Intermittent Claudication.

Sean Pymer, Saïd Ibeggazene, Joanne Palmer, George E Smith, Amy E Harwood, Sean Carroll, Lee Ingle, Ian C Chetter,

<h4>Purpose</h4>This study assessed the feasibility, tolerability, safety, and potential efficacy of a novel, 6-wk, high-intensity interval training (HIIT) program for patients with intermittent claudication (IC).<h4>Methods</h4>Patients referred to a usual-care supervised exercise program were invited to undertake a HIIT program. All recruited patients performed a baseline cardiopulmonary exercise test (CPX) to ... Read more >>

J Cardiopulm Rehabil Prev (Journal of cardiopulmonary rehabilitation and prevention)
[2021, 41(3):188-193]

Cited: 1 time

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Outcomes following coronary artery bypass surgery in diabetic treatment sub-groups. A propensity matched analysis of >7000 patients over 18 years.

Yama Haqzad, James Hobkirk, Priyadharshanan Ariyaratnam, Mubarak Chaudhry, Sean Carroll, Mahmoud Loubani,

<h4>Background</h4>European System for Cardiac Operative Risk Evaluation II incorporates insulin-controlled diabetes whilst omitting tablet-controlled diabetes. Differences in adverse clinical outcomes following coronary artery bypass graft between these groups are poorly established. Therefore, a propensity matched comparison of short and longer term mortality and morbidity in insulin-controlled diabetes, tablet-controlled diabetes and ... Read more >>

Asian Cardiovasc Thorac Ann (Asian cardiovascular & thoracic annals)
[2021, :218492321999551]

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Is a verification phase useful for confirming maximal oxygen uptake in apparently healthy adults? A systematic review and meta-analysis.

Victor A B Costa, Adrian W Midgley, Sean Carroll, Todd A Astorino, Tainah de Paula, Paulo Farinatti, Felipe A Cunha,

<h4>Background</h4>The 'verification phase' has emerged as a supplementary procedure to traditional maximal oxygen uptake (VO2max) criteria to confirm that the highest possible VO2 has been attained during a cardiopulmonary exercise test (CPET).<h4>Objective</h4>To compare the highest VO2 responses observed in different verification phase procedures with their preceding CPET for confirmation that ... Read more >>

PLoS One (PloS one)
[2021, 16(2):e0247057]

Cited: 3 times

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The effects of exercise to promote quality of life in individuals with traumatic brain injuries: a systematic review.

Grace C O'Carroll, Stephanie L King, Sean Carroll, John L Perry, Natalie Vanicek,

<h4>Objective</h4>To systematically review the effects of exercise interventions that may enhance quality of life (QOL) in individuals with traumatic brain injury (TBI).<h4>Methods</h4>A systematic search was conducted using five databases up to April 2018. Studies were included if QOL was quantified following an exercise programme for people with a TBI. Methodological ... Read more >>

Brain Inj (Brain injury)
[2020, 34(13-14):1701-1713]

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Powdered activated carbon (PAC) amendment enhances naphthalene biodegradation under strictly sulfate-reducing conditions.

Giovanna Pagnozzi, Sean Carroll, Danny D Reible, Kayleigh Millerick,

Capping represents an efficient and well-established practice to contain polycyclic aromatic hydrocarbons (PAHs) in sediments, reduce mobility, and minimize risks. Exposure to PAHs can encourage biodegradation, which can improve the performance of capping. This study investigates biodegradation of naphthalene (a model PAH) in highly reducing, sediment-like environments with amendment of ... Read more >>

Environ Pollut (Environmental pollution (Barking, Essex : 1987))
[2021, 268(Pt A):115641]

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High INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): protocol for a multicentre, proof-of-concept, prospective interventional study.

Sean Pymer, Amy Harwood, Said Ibeggazene, Gordon McGregor, Chao Huang, Maureen Twiddy, Adam R Nicholls, Lee Ingle, Sean Carroll, Judith Long, Marjorie Rooms, I C Chetter, ,

<h4>Introduction</h4>The first-line recommended treatment for patients with intermittent claudication (IC) is a supervised exercise programme (SEP), which includes a minimum of 2-hours of exercise per week over a 12-week period. However, provision, uptake and adherence rates for these SEP programmes are poor, with time constraints cited as a common participant ... Read more >>

BMJ Open (BMJ open)
[2020, 10(7):e038825]

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Safety, Tolerability, and Physiological Effects of AXA1665, a Novel Composition of Amino Acids, in Subjects With Child-Pugh A and B Cirrhosis.

Manu V Chakravarthy, Joel Neutel, Scharmen Confer, Peng Zhao, Noriaki Tatsuta, Sam Rebello, William C Comb, Michael Hamill, Tony Tramontin, Sean Carroll, Raffi Afeyan, Arun J Sanyal,

<h4>Introduction</h4>AXA1665 is a novel investigational amino acid (AA) composition specifically designed to impact AA imbalance, ammoniagenesis, and dysregulated anabolic activity associated with cirrhosis.<h4>Methods</h4>This 2-part study examined AXA1665 effects on safety, tolerability, and hepatic/muscle physiology in subjects with Child-Pugh A and B cirrhosis. Part 1 established plasma ammonia and AA concentration ... Read more >>

Clin Transl Gastroenterol (Clinical and translational gastroenterology)
[2020, 11(8):e00222]

Cited: 3 times

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Characterising the application of the "progressive overload" principle of exercise training within cardiac rehabilitation: A United Kingdom-based community programme.

Alaa Khushhal, Simon Nichols, Sean Carroll, Grant Abt, Lee Ingle,

BACKGROUND:Recent concerns have cast doubt over the effectiveness of cardiac rehabilitation [CR] programmes for improving cardiorespiratory fitness [CRF] in patients with a history of cardiac disease in the United Kingdom [UK]. We aimed to characterise the weekly progression of exercise training dose over an 8-week Phase III CR programme as ... Read more >>

PLoS One (PloS one)
[2020, 15(8):e0237197]

Cited: 1 time

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The origin and diversification of a novel protein family in venomous snakes.

Matt W Giorgianni, Noah L Dowell, Sam Griffin, Victoria A Kassner, Jane E Selegue, Sean B Carroll,

The genetic origins of novelty are a central interest of evolutionary biology. Most new proteins evolve from preexisting proteins but the evolutionary path from ancestral gene to novel protein is challenging to trace, and therefore the requirements for and order of coding sequence changes, expression changes, or gene duplication are ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(20):10911-10920]

Cited: 15 times

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A prospective observational cohort study considering the feasibility and tolerability of high intensity interval training as a novel treatment therapy for patients with intermittent claudication

Sean Pymer, Said Ibeggazene, Joanne Palmer, George Smith, Amy Harwood, Sean Carroll, Lee Ingle, Ian Chetter,

<h4>Background</h4> Uptake and completion rates for supervised exercise programmes (SEP) for patients with intermittent claudication (IC) are low. Current exercise prescription is a one size fits all approach , based on claudication pain thresholds, potentially limiting individual benefits. High-intensity interval training (HIIT) has the potential to overcome these barriers as ... Read more >>

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Objective Quantification of Opioid Usage After Thyroid Surgery.

Andrew Agnew, Sean Carroll, Rick Fornelli, Stephen Schell, Kirk Steehler,

<b>Introduction</b>  It is well established that America is in the midst of an opioid crisis with 46 people dying every day from overdoses involving prescription opioids. In the last 2 years, multiple articles have been published indicating that the amount of opioid pain medication needed after discharge from thyroid and ... Read more >>

Int Arch Otorhinolaryngol (International archives of otorhinolaryngology)
[2020, 24(4):e482-e486]

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Levels of Evidence in Plastic and Reconstructive Surgery Research: Have We Improved Over the Past 10 Years?

Conor M Sugrue, Cormac W Joyce, Sean M Carroll,

Levels of evidence (LOE) aid in the critical appraisal of evidence by ranking studies based on limitation of its design. Analyzing LOE provides insight into application of evidence-based medicine. The aim of this study is to determine if the quality of evidence in plastic surgery research has improved over the ... Read more >>

Plast Reconstr Surg Glob Open (Plastic and reconstructive surgery. Global open)
[2019, 7(9):e2408]

Cited: 4 times

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Core stability and low-back pain: a causal fallacy.

Nathan Augeard, Sean Paul Carroll,

J Exerc Rehabil (Journal of exercise rehabilitation)
[2019, 15(3):493-495]

Cited: 2 times

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Cardiorespiratory fitness as a predictor of short-term and lifetime estimated cardiovascular disease risk.

Michelle G Swainson, Lee Ingle, Sean Carroll,

Development of cardiovascular disease (CVD) remains a public health concern for young to middle-aged adults, now exacerbated by the increasing prevalence of obesity and sedentary lifestyles. Cardiorespiratory fitness (CRF) improves the reclassification of short-term (10-year) CVD risk, but has not been uniformly defined across studies. This study evaluated cross-sectional differences ... Read more >>

Scand J Med Sci Sports (Scandinavian journal of medicine & science in sports)
[2019, 29(9):1402-1413]

Cited: 1 time

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Identifying Priorities for Physiotherapy Research in the UK: the James Lind Alliance Physiotherapy Priority Setting Partnership.

Gabrielle Rankin, Rachael Summers, Katherine Cowan, Karen Barker, Kate Button, Sean Paul Carroll, Billy Fashanu, Fidelma Moran, Brenda O'Neill, Ruth Ten Hove, Jackie Waterfield, Sarah Westwater-Wood, Ian Wellwood, ,

<h4>Objectives</h4>To identify unanswered questions for physiotherapy research and help set and prioritise the top 10 generic research priorities for the UK physiotherapy profession; updating previous clinical condition- specific priorities to include patient and carer perspectives, and reflect changes in physiotherapy practice, service provision and new technologies.<h4>Design</h4>The James Lind Alliance (JLA) ... Read more >>

Physiotherapy (Physiotherapy)
[2020, 107:161-168]

Cited: 1 time

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The Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polycystic Ovary Syndrome.

Thozhukat Sathyapalan, James P Hobkirk, Zeeshan Javed, Sean Carroll, Anne-Marie Coady, Philip Pemberton, Alexander Smith, Katherine Cianflone, Stephen L Atkin,

<b>Background:</b> Atorvastatin has been shown to improve cardiovascular risk (CVR) indices in women with polycystic ovary syndrome (PCOS). Low-grade chronic inflammation of adipose tissue may link PCOS and adverse CVR. In pro-inflammatory states such as PCOS, spontaneous activation of the alternative pathway of complement results in increased generation of acylation ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2019, 10:394]

Cited: 5 times

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Influence of appendicular skeletal muscle mass on resting metabolic equivalents in patients with cardiovascular disease: Implications for exercise training and prescription.

Simon Nichols, Alasdair O'Doherty, Sean Carroll, Lee Ingle,

Eur J Prev Cardiol (European journal of preventive cardiology)
[2020, 27(9):1001-1003]

Cited: 0 times

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Insufficient exercise intensity for clinical benefit? Monitoring and quantification of a community-based Phase III cardiac rehabilitation programme: A United Kingdom perspective.

Alaa Khushhal, Simon Nichols, Sean Carroll, Grant Abt, Lee Ingle,

<h4>Background</h4>In recent years, criticism of the percentage range approach for individualised exercise prescription has intensified and we were concerned that sub-optimal exercise dose (especially intensity) may be in part responsible for the variability in the effectiveness of cardiac rehabilitation (CR) programmes in the United Kingdom (UK). The aim was to ... Read more >>

PLoS One (PloS one)
[2019, 14(6):e0217654]

Cited: 3 times

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Birth-and-Death Evolution of the Fatty Acyl-CoA Reductase (FAR) Gene Family and Diversification of Cuticular Hydrocarbon Synthesis in Drosophila.

Cédric Finet, Kailey Slavik, Jian Pu, Sean B Carroll, Henry Chung,

The birth-and-death evolutionary model proposes that some members of a multigene family are phylogenetically stable and persist as a single copy over time, whereas other members are phylogenetically unstable and undergo frequent duplication and loss. Functional studies suggest that stable genes are likely to encode essential functions, whereas rapidly evolving ... Read more >>

Genome Biol Evol (Genome biology and evolution)
[2019, 11(6):1541-1551]

Cited: 8 times

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A major role for noncoding regulatory mutations in the evolution of enzyme activity.

David W Loehlin, Jesse R Ames, Kathy Vaccaro, Sean B Carroll,

The quantitative evolution of protein activity is a common phenomenon, yet we know little about any general mechanistic tendencies that underlie it. For example, an increase (or decrease) in enzyme activity may evolve from changes in protein sequence that alter specific activity, or from changes in gene expression that alter ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2019, 116(25):12383-12389]

Cited: 7 times

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