Full Text Journal Articles by
Author Se Min Kim

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Beyond Bone Biology: Lessons from Team Science.

Mone Zaidi, Daria Lizneva, Sakshi Gera, Charit Taneja, Funda Korkmaz, Anisa Gumerova, Kseniia Ievleva, Naseer Ahmad, Vitaly Ryu, Li Sun, Se-Min Kim, Maria I New, Shozeb Haider, Jameel Iqbal, Clifford Rosen, Tony Yuen,

Today, research in biomedicine often requires the knowledge and technologies in diverse fields. Therefore, there is an increasing need for collaborative team science that crosses traditional disciplines. Here, we discuss our own lessons from both interdisciplinary and transdisciplinary teams, which ultimately ushered us to expand our research realm beyond bone ... Read more >>

J. Orthop. Res. (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2020, :]

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Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass.

Se-Min Kim, Charit Taneja, Helena Perez-Pena, Vitaly Ryu, Anisa Gumerova, Wenliang Li, Naseer Ahmad, Ling-Ling Zhu, Peng Liu, Mehr Mathew, Funda Korkmaz, Sakshi Gera, Damini Sant, Elina Hadelia, Kseniia Ievleva, Tan-Chun Kuo, Hirotaka Miyashita, Li Liu, Irina Tourkova, Sarah Stanley, Daria Lizneva, Jameel Iqbal, Li Sun, Ronald Tamler, Harry C Blair, Maria I New, Shozeb Haider, Tony Yuen, Mone Zaidi,

We report that two widely-used drugs for erectile dysfunction, tadalafil and vardenafil, trigger bone gain in mice through a combination of anabolic and antiresorptive actions on the skeleton. Both drugs were found to enhance osteoblastic bone formation in vivo using a unique gene footprint and to inhibit osteoclast formation. The ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(25):14386-14394]

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Bone modifying agents for bone loss in patients with aromatase inhibitor as adjuvant treatment for breast cancer; insights from a network meta-analysis.

Hirotaka Miyashita, Sera Satoi, Toshiki Kuno, Christina Cruz, Stephen Malamud, Se-Min Kim,

PURPOSE:The data of head-to-head comparisons of the anti-fracture efficacy of bone modifying agents (BMAs) in patients with hormone receptor-positive breast cancer receiving aromatase inhibitor (AI) are not available. Therefore, we conducted a network meta-analysis to compare the efficacy of different BMAs in patients with breast cancer receiving adjuvant AI. METHODS:We ... Read more >>

Breast Cancer Res. Treat. (Breast cancer research and treatment)
[2020, 181(2):279-289]

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CUSHING DISEASE MASQUERADING AS GLAUCOMA.

Yumiko Tsushima, Lubna Bashir Munshi, Charit Taneja, Se-Min Kim,

Objective:Glaucoma is a well-recognized side effect of corticosteroids. However, steroid-induced glaucoma typically refers to that caused by exogenous corticosteroid administration. Glaucoma secondary to endogenous overproduction of corticosteroids has only been reported in a few case reports. We aim to bring attention to glaucoma as a rare but important manifestation of ... Read more >>

AACE Clin Case Rep (AACE clinical case reports)
[2019, 5(5):e290-e293]

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Oxytocin regulates body composition.

Li Sun, Daria Lizneva, Yaoting Ji, Graziana Colaianni, Elina Hadelia, Anisa Gumerova, Kseniia Ievleva, Tan-Chun Kuo, Funda Korkmaz, Vitaly Ryu, Alina Rahimova, Sakshi Gera, Charit Taneja, Ayesha Khan, Naseer Ahmad, Roberto Tamma, Zhuan Bian, Alberta Zallone, Se-Min Kim, Maria I New, Jameel Iqbal, Tony Yuen, Mone Zaidi,

The primitive neurohypophyseal nonapeptide oxytocin (OXT) has established functions in parturition, lactation, appetite, and social behavior. We have shown that OXT has direct actions on the mammalian skeleton, stimulating bone formation by osteoblasts and modulating the genesis and function of bone-resorbing osteoclasts. We deleted OXT receptors (OXTRs) selectively in osteoblasts ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2019, :]

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FSH-metabolic circuitry and menopause.

Charit Taneja, Sakshi Gera, Se-Min Kim, Jameel Iqbal, Tony Yuen, Mone Zaidi,

FSH has a primary function in procreation, wherein it induces estrogen production in females and regulates spermatogenesis in males. However, in line with our discoveries over the past decade of non-unitary functions of pituitary hormones, we and others have described hitherto uncharacterized functions of FSH. Through high-affinity receptors, some of ... Read more >>

J. Mol. Endocrinol. (Journal of molecular endocrinology)
[2019, 63(3):R73-R80]

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FSH Beyond Fertility.

Daria Lizneva, Alina Rahimova, Se-Min Kim, Ihor Atabiekov, Seher Javaid, Bateel Alamoush, Charit Taneja, Ayesha Khan, Li Sun, Ricardo Azziz, Tony Yuen, Mone Zaidi,

The traditional view of follicle-stimulating hormone (FSH) as a reproductive hormone is changing. It has been shown that FSH receptors (FSHRs) are expressed in various extra-gonadal tissues and mediate the biological effects of FSH at those sites. Molecular, animal, epidemiologic, and clinical data suggest that elevated serum FSH may play ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2019, 10:136]

Cited: 3 times

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FSIP1 regulates autophagy in breast cancer.

Caigang Liu, Lisha Sun, Jie Yang, Tong Liu, Yongliang Yang, Se-Min Kim, Xunyan Ou, Yining Wang, Li Sun, Mone Zaidi, Maria I New, Tony Yuen, Qiyong Guo,

Fibrous sheath interacting protein 1 (FSIP1) is a cancer antigen expressed in the majority of breast cancer tissues and is associated with poor prognosis. However, the role of FSIP1 in the progression and drug sensitivity of triple-negative breast cancer (TNBC) has not been explored. Here, we show that FSIP1 deficiency ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2018, 115(51):13075-13080]

Cited: 0 times

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Anti-inflammatory and Osteogenic Effects of Calcium Silicate-based Root Canal Sealers.

Bin-Na Lee, Ji-Uk Hong, Se-Min Kim, Ji-Hyun Jang, Hoon-Sang Chang, Yun-Chan Hwang, In-Nam Hwang, Won-Mann Oh,

INTRODUCTION:An ideal root canal sealer creates a bacteria-resistant seal and exhibits antimicrobial activity, biocompatibility, and osteoconductivity. The aim of this study was to assess the effects of 3 root canal sealers on cell viability, inflammatory response, and osteogenic potential in MC3T3-E1 cells. METHODS:AH Plus (Dentsply Caulk, Milford, DE), MTA Fillapex ... Read more >>

J Endod (Journal of endodontics)
[2019, 45(1):73-78]

Cited: 3 times

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FSH, Bone Mass, Body Fat, and Biological Aging.

Mone Zaidi, Daria Lizneva, Se-Min Kim, Li Sun, Jameel Iqbal, Maria I New, Clifford J Rosen, Tony Yuen,

The Study of Women's Health Across the Nation has taught us that impending ovarian failure during late perimenopause is associated with a sharp rise in serum FSH, which coincides with the most rapid rate of bone loss and the onset of visceral adiposity. At this time in a woman's life, ... Read more >>

Endocrinology (Endocrinology)
[2018, 159(10):3503-3514]

Cited: 4 times

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Emerging concepts in the epidemiology, pathophysiology, and clinical care of osteoporosis across the menopausal transition.

Daria Lizneva, Tony Yuen, Li Sun, Se-Min Kim, Ihor Atabiekov, Lubna Bashir Munshi, Sol Epstein, Maria New, Mone Zaidi,

Bone loss in women accelerates during perimenopause, and continues into old age. To-date, there has been little progress made in stratifying for fracture risk in premenopausal and early postmenopausal women. Epidemiologic data suggests that changes in serum FSH could predict decrements in bone mass during peri- and postmenopause. In bone, ... Read more >>

Matrix Biol. (Matrix biology : journal of the International Society for Matrix Biology)
[2018, 71-72:70-81]

Cited: 1 time

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Opening windows for bone remodeling through a SLIT.

Jameel Iqbal, Tony Yuen, Se-Min Kim, Mone Zaidi,

Bone formation and resorption are tightly coupled, and dysfunction of either process leads to bone diseases, such as osteoporosis. Bone-forming agents have been explored clinically to increase bone density; however, long-term efficacy of these strategies is limited due to the accompanying increase in resorption in response to increased bone formation. ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2018, 128(4):1255-1257]

Cited: 1 time

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THYMIC CARCINOID WITH ADRENOCORTICOTROPIC HORMONE-PRODUCING ECTOPIC CUSHING SYNDROME AND EMPTY SELLA.

Artak Labadzhyan, Se-Min Kim, Jane Rhyu, Takako Araki, Ali Mahtabifard, Shlomo Melmed,

Objective:Ectopic Cushing's syndrome secondary to thymic carcinoid is a rare disorder that may be difficult to diagnose and manage. Methods:We describe a case of severe Cushing's syndrome secondary to a large adrenocorticotropic hormone (ACTH) producing thymic carcinoid in a patient with history of primary hyperaldosteronism. Results:A 43-year-old female with a ... Read more >>

AACE Clin Case Rep (AACE clinical case reports)
[2018, 4(5):e375-e378]

Cited: 0 times

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Association between site-specific bone mineral density and glucose homeostasis and anthropometric traits in healthy men and women.

Se-Min Kim, Jinrui Cui, Jane Rhyu, Xiuqing Guo, Yii-Der I Chen, Willa A Hsueh, Jerome I Rotter, Mark O Goodarzi,

OBJECTIVE:Patients with type 2 diabetes mellitus have an increased risk of fracture despite normal or increased bone mineral density (BMD). Studies on the relationship of glucose homeostasis with BMD phenotypes have been inconclusive because distinguishing the roles of insulin resistance and hyperglycaemia in bone remodelling is challenging. In this study, ... Read more >>

Clin. Endocrinol. (Oxf) (Clinical endocrinology)
[2018, 88(6):848-855]

Cited: 1 time

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Clinical, genetic, and structural basis of apparent mineralocorticoid excess due to 11β-hydroxysteroid dehydrogenase type 2 deficiency.

Mabel Yau, Shozeb Haider, Ahmed Khattab, Chen Ling, Mehr Mathew, Samir Zaidi, Madison Bloch, Monica Patel, Sinead Ewert, Wafa Abdullah, Aysenur Toygar, Vitalii Mudryi, Maryam Al Badi, Mouch Alzubdi, Robert C Wilson, Hanan Said Al Azkawi, Hatice Nur Ozdemir, Wahid Abu-Amer, Jozef Hertecant, Maryam Razzaghy-Azar, John W Funder, Aisha Al Senani, Li Sun, Se-Min Kim, Tony Yuen, Mone Zaidi, Maria I New,

Mutations in 11β-hydroxysteroid dehydrogenase type 2 gene (HSD11B2) cause an extraordinarily rare autosomal recessive disorder, apparent mineralocorticoid excess (AME). AME is a form of low renin hypertension that is potentially fatal if untreated. Mutations in the HSD11B2 gene result either in severe AME or a milder phenotype (type 2 AME). ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2017, 114(52):E11248-E11256]

Cited: 5 times

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Odontogenic Potential of Parathyroid Hormone-related Protein (107-111) Alone or in Combination with Mineral Trioxide Aggregate in Human Dental Pulp Cells.

Jeong-Won Han, Bin-Na Lee, Se-Min Kim, Jeong-Tae Koh, Kyung-San Min, Yun-Chan Hwang,

INTRODUCTION:Parathyroid hormone-related protein plays an important role in bone remodeling. Its N-terminal domain parathyroid hormone-related protein (107-111) is called osteostatin (OST). OST has demonstrated osteogenic potential when combined with biomaterials such as hydroxyapatite or bioceramics. However, the odontogenic potential of OST has not yet been reported. Therefore, the aim of ... Read more >>

J Endod (Journal of endodontics)
[2017, 43(12):2054-2060]

Cited: 0 times

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The effect of chlormadinone acetate on odontogenic differentiation of human dental pulp cells: in vitro study.

Se-Min Kim, Bin-Na Lee, Jeong-Tae Koh, Hoon-Sang Chang, In-Nam Hwang, Won-Mann Oh, Kyung-San Min, Yun-Chan Hwang,

Chlormadinone acetate (CMA) is a derivative of progesterone and is used as an oral contraceptive. The aim of this study was to investigate the effects of CMA on odontogenic differentiation and mineralization of human dental pulp cells (hDPCs) and related signaling pathways.Cell viability was determined by the water-soluble tetrazolium (WST)-1 ... Read more >>

BMC Oral Health (BMC oral health)
[2017, 17(1):89]

Cited: 0 times

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Questioning the association between bisphosphonates and atypical femoral fractures.

Michael Pazianas, Se-min Kim, Tony Yuen, Li Sun, Sol Epstein, Mone Zaidi,

Bisphosphonates are the first-line treatment for osteoporosis. Structurally, they are stable analogues of pyrophosphate and therefore exhibit a high affinity for bone mineral. They reduce bone loss by attenuating the ability of the osteoclast to resorb bone, decreasing activation frequency, and the rate of remodeling. Large prospective randomized placebo-control trials ... Read more >>

Ann. N. Y. Acad. Sci. (Annals of the New York Academy of Sciences)
[2015, 1335:1-9]

Cited: 5 times

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First record of Cosmocephalus obvelatus (Acuariidae) in common gulls (Larus canus) from Gangneung, Korea.

Se-Min Kim, Bae-Keun Park, Bae Dong Jung, Hyeon-Cheol Kim,

A nematode species belonging to the genus Cosmocephalus was collected from the stomach of 2 common gulls, Larus canus. The common gulls were found dead on the seaside of Gangneung City, the Republic of Korea. The worms were identified and classified by light (LM) and scanning electron microscopy (SEM) on ... Read more >>

Korean J. Parasitol. (The Korean journal of parasitology)
[2015, 53(1):101-104]

Cited: 0 times

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Bisphosphonates inactivate human EGFRs to exert antitumor actions.

Tony Yuen, Agnes Stachnik, Jameel Iqbal, Miriam Sgobba, Yogesh Gupta, Ping Lu, Graziana Colaianni, Yaoting Ji, Ling-Ling Zhu, Se-Min Kim, Jianhua Li, Peng Liu, Sudeh Izadmehr, Jaya Sangodkar, Jack Bailey, Yathin Latif, Shiraz Mujtaba, Solomon Epstein, Terry F Davies, Zhuan Bian, Alberta Zallone, Aneel K Aggarwal, Shozeb Haider, Maria I New, Li Sun, Goutham Narla, Mone Zaidi,

Bisphosphonates are the most commonly prescribed medicines for osteoporosis and skeletal metastases. The drugs have also been shown to reduce cancer progression, but only in certain patient subgroups, suggesting that there is a molecular entity that mediates bisphosphonate action on tumor cells. Using connectivity mapping, we identified human epidermal growth ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2014, 111(50):17989-17994]

Cited: 23 times

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Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer.

Agnes Stachnik, Tony Yuen, Jameel Iqbal, Miriam Sgobba, Yogesh Gupta, Ping Lu, Graziana Colaianni, Yaoting Ji, Ling-Ling Zhu, Se-Min Kim, Jianhua Li, Peng Liu, Sudeh Izadmehr, Jaya Sangodkar, Thomas Scherer, Shiraz Mujtaba, Matthew Galsky, Jorge Gomez, Solomon Epstein, Christoph Buettner, Zhuan Bian, Alberta Zallone, Aneel K Aggarwal, Shozeb Haider, Maria I New, Li Sun, Goutham Narla, Mone Zaidi,

A variety of human cancers, including nonsmall cell lung (NSCLC), breast, and colon cancers, are driven by the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases. Having shown that bisphosphonates, a class of drugs used widely for the therapy of osteoporosis and metastatic bone disease, reduce cancer ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2014, 111(50):17995-18000]

Cited: 25 times

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Noninvasive prenatal diagnosis of congenital adrenal hyperplasia using cell-free fetal DNA in maternal plasma.

Maria I New, Yu K Tong, Tony Yuen, Peiyong Jiang, Christian Pina, K C Allen Chan, Ahmed Khattab, Gary J W Liao, Mabel Yau, Se-Min Kim, Rossa W K Chiu, Li Sun, Mone Zaidi, Y M Dennis Lo,

Congenital adrenal hyperplasia (CAH) is an autosomal recessive condition that arises from mutations in CYP21A2 gene, which encodes for the steroidogenic enzyme 21-hydroxylase. To prevent genital ambiguity in affected female fetuses, prenatal treatment with dexamethasone must begin on or before gestational week 9. Currently used chorionic villus sampling and amniocentesis ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2014, 99(6):E1022-30]

Cited: 68 times

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Therapeutics in pediatric diabetes: insulin and non-insulin approaches. Part of a series on Pediatric Pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo Molteni.

Jongoh Kim, Se Min Kim, Ha Cam Thuy Nguyen, Maria Jose Redondo,

Treatment of pediatric diabetes can be challenging. Strict glucose control can be accompanied by hypoglycemia and weight gain. Recently, there have been many developments in insulin preparations and delivery methods which make insulin levels more close to a physiologic pattern. Newly developed rapid/long acting analogues and delivery devices such as ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2012, 65(1):1-4]

Cited: 1 time

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Energy intake and snack choice by the meal patterns of employed people.

Seok-Young Kim, Se Min Kim,

The aim of this study was to provide descriptive information on meal and snack patterns and to investigate snacks in relation to energy intake and food choice according to the meal patterns of employed people in Korea. 683 employed people (292 males, 391 females) were interviewed to collect one day ... Read more >>

Nutr Res Pract (Nutrition research and practice)
[2010, 4(1):43-50]

Cited: 9 times

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Viability of preserved Cryptosporidium baileyi oocysts.

Chan-Gu Surl, Se-Min Kim, Hyeon-Cheol Kim,

The present study was undertaken to determine the viability and infectivity of oocysts of Cryptosporidium baileyi that had been stored from 1 to 40 months at 4 degrees C preserved in 2.5% potassium dichromate solution. Oocysts of C. baileyi were purified from the feces of experimentally infected chickens using discontinuous ... Read more >>

Korean J. Parasitol. (The Korean journal of parasitology)
[2003, 41(4):197-201]

Cited: 7 times

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