Full Text Journal Articles by
Author Scott M Sutherland

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Cumulative Application of Creatinine and Urine Output Staging Optimizes the Kidney Disease: Improving Global Outcomes Definition and Identifies Increased Mortality Risk in Hospitalized Patients With Acute Kidney Injury.

Scott M Sutherland, Ahmad Kaddourah, Scott E Gillespie, Danielle E Soranno, Robert P Woroniecki, Rajit K Basu, Michael Zappitelli, ,

<h4>Objectives</h4>Acute kidney injury is diagnosed according to creatinine and urine output criteria. Traditionally, both are applied, and a severity stage (1-3) is conferred based upon the more severe of the two; information from the other criteria is discarded. Physiologically, however, rising creatinine and oliguria represent two distinct types of renal ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):1912-1922]

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Association of Plasma Uremic Solute Levels with Residual Kidney Function in Children on Peritoneal Dialysis.

Lakshmi L Ganesan, Frank J O'Brien, Tammy L Sirich, Natalie S Plummer, Rita Sheth, Cecile Fajardo, Paul Brakeman, Scott M Sutherland, Timothy W Meyer,

<h4>Background and objectives</h4>Residual native kidney function confers health benefits in patients on dialysis. It can facilitate control of extracellular volume and inorganic ion concentrations. Residual kidney function can also limit the accumulation of uremic solutes. This study assessed whether lower plasma concentrations of uremic solutes were associated with residual kidney ... Read more >>

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2021, 16(10):1531-1538]

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Using kinetic eGFR to identify acute kidney injury risk in children undergoing cardiac transplantation.

Minnie N Dasgupta, Maria E Montez-Rath, Seth A Hollander, Scott M Sutherland,

<h4>Background</h4>Acute kidney injury (AKI) is common following pediatric cardiac transplantation. Since no treatments exist, strategies focus on early identification and prevention. Kinetic glomerular filtration rate (kGFR) was developed to assess renal function in the non-steady state. Although used to predict AKI in adults, kGFR has not been explored in children. ... Read more >>

Pediatr Res (Pediatric research)
[2021, 90(3):632-636]

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Quality improvement goals for pediatric acute kidney injury: pediatric applications of the 22nd Acute Disease Quality Initiative (ADQI) conference.

David T Selewski, David J Askenazi, Kianoush Kashani, Rajit K Basu, Katja M Gist, Matthew W Harer, Jennifer G Jetton, Scott M Sutherland, Michael Zappitelli, Claudio Ronco, Stuart L Goldstein, Theresa Ann Mottes,

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2021, 36(4):733-746]

Cited: 2 times

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Baseline creatinine determination method impacts association between acute kidney injury and clinical outcomes.

W Alton Russell, David Scheinker, Scott M Sutherland,

<h4>Background</h4>Current consensus definition for acute kidney injury (AKI) does not specify how baseline serum creatinine should be determined. We assessed how baseline determination impacted AKI incidence and association between AKI and clinical outcomes.<h4>Methods</h4>We retrospectively applied empirical (measured serum creatinine) and imputed (age/height) baseline estimation methods to pediatric patients discharged between ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2021, 36(5):1289-1297]

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Acute kidney injury and chronic kidney disease after combined heart-liver transplant in patients with congenital heart disease: A retrospective case series.

Angela Lee, Waldo Concepcion, Selena Gonzales, Scott M Sutherland, Seth A Hollander,

Although it is known that children undergoing heart transplantation are at increased risk for both AKI and CKD, renal function following CHLT remains understudied. All pediatric CHLT patients from 2006 to 2019 were included. The prevalence of AKI in the first 7 post-operative days, renal recovery at 30 post-operative days, ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, 24(7):e13833]

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Policy in pediatric nephrology: successes, failures, and the impact on disparities.

Jill R Krissberg, Scott M Sutherland, Lisa J Chamberlain, Paul H Wise,

Pediatric nephrology has a history rooted in pediatric advocacy and has made numerous contributions to child health policy affecting pediatric kidney diseases. Despite this progress, profound social disparities remain for marginalized and socially vulnerable children with kidney disease. Different risk factors, such as genetic predisposition, environmental factors, social risk factors, ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2021, 36(8):2177-2188]

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Improving the quality of neonatal acute kidney injury care: neonatal-specific response to the 22nd Acute Disease Quality Initiative (ADQI) conference.

Matthew W Harer, David T Selewski, Kianoush Kashani, Rajit K Basu, Katja M Gist, Jennifer G Jetton, Scott M Sutherland, Michael Zappitelli, Stuart L Goldstein, Theresa Ann Mottes, David J Askenazi,

With the adoption of standardized neonatal acute kidney injury (AKI) definitions over the past decade and the concomitant surge in research studies, the epidemiology of and risk factors for neonatal AKI have become much better understood. Thus, there is now a need to focus on strategies designed to improve AKI ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2021, 41(2):185-195]

Cited: 2 times

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Clinical evaluation of the Prismaflex™ HF 20 set and Prismaflex™ system 7.10 for acute continuous kidney replacement therapy (CKRT) in children.

Raj Munshi, Kathy Lee-Son, Richard M Hackbarth, Raymond Quigley, Scott M Sutherland, Jorge Echeverri, Stuart L Goldstein,

<h4>Background</h4>Continuous kidney replacement therapy (CKRT) is a common modality for treatment of severe acute kidney injury (AKI) in children. Adult technologies routinely utilized to provide this therapy have a large extracorporeal volume. The Prismaflex™ HF20 filter set has a relatively low extracorporeal blood volume of 60 mL, which provides technological benefit ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, 35(12):2345-2352]

Cited: 3 times

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Acute Kidney Injury in Children Hospitalized With Diarrheal Illness in the United States.

Christina Bradshaw, Jialin Han, Glenn M Chertow, Jin Long, Scott M Sutherland, Shuchi Anand,

OBJECTIVES:To determine the incidence, correlates, and consequences of acute kidney injury (AKI) among children hospitalized with diarrheal illness in the United States. METHODS:Using data from Kids' Inpatient Database in 2009 and 2012, we studied children hospitalized with a primary diagnosis of diarrheal illness (weighted <i>N</i> = 113 195). We used the ... Read more >>

Hosp Pediatr (Hospital pediatrics)
[2019, 9(12):933-941]

Cited: 2 times

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Plasma pseudouridine levels reflect body size in children on hemodialysis.

Frank J O'Brien, Tammy L Sirich, Abigail Taussig, Enrica Fung, Lakshmi L Ganesan, Natalie S Plummer, Paul Brakeman, Scott M Sutherland, Timothy W Meyer,

<h4>Background</h4>Dialysis in children as well as adults is prescribed to achieve a target spKt/V<sub>urea</sub>, where V<sub>urea</sub> is the volume of distribution of urea. Waste solute production may however be more closely correlated with body surface area (BSA) than V<sub>urea</sub> which rises in proportion with body weight. Plasma levels of waste ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, 35(2):305-312]

Cited: 0 times

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Nephrotoxins and nephrotoxic acute kidney injury.

Amanda M Uber, Scott M Sutherland,

Although the concept of nephrotoxicity has been recognized for more than 80 years, interest in nephrotoxins has intensified dramatically over the past two decades. Much of this attention has rightfully been focused on pharmaceutical agents and iatrogenic harm; however, it is important for providers to recognize that nephrotoxins can be ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, 35(10):1825-1833]

Cited: 3 times

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Antimicrobial Disposition During Pediatric Continuous Renal Replacement Therapy Using an Ex Vivo Model.

Prashant J Purohit, Mohammed H Elkomy, Adam Frymoyer, Scott M Sutherland, David R Drover, Gregory B Hammer, Felice Su,

<h4>Objectives</h4>Little is known on the impact of continuous renal replacement therapy on antimicrobial dose requirements in children. In this study, we evaluated the pharmacokinetics of commonly administered antimicrobials in an ex vivo continuous renal replacement therapy model.<h4>Design</h4>An ex vivo continuous renal replacement therapy circuit was used to evaluate drug-circuit interactions ... Read more >>

Crit Care Med (Critical care medicine)
[2019, 47(9):e767-e773]

Cited: 2 times

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Oliguria and Acute Kidney Injury in Critically Ill Children: Implications for Diagnosis and Outcomes.

Ahmad Kaddourah, Rajit K Basu, Stuart L Goldstein, Scott M Sutherland, ,

<h4>Objectives</h4>Consensus definitions for acute kidney injury are based on changes in serum creatinine and urine output. Although the creatinine criteria have been widely applied, the contribution of the urine output criteria remains poorly understood. We evaluated these criteria individually and collectively to determine their impact on the diagnosis and outcome ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2019, 20(4):332-339]

Cited: 13 times

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Renal injury and recovery in pediatric patients after ventricular assist device implantation and cardiac transplant.

Seth A Hollander, Ryan S Cantor, Scott M Sutherland, Devin A Koehl, Elizabeth Pruitt, Nancy McDonald, James K Kirklin, William J Ravekes, Rebecca Ameduri, Maryanne Chrisant, Timothy M Hoffman, Irene D Lytrivi, Jennifer Conway,

<h4>Background</h4>The use of ventricular assist devices (VADs) in children with heart failure may be of particular benefit to those with accompanying renal failure, as improved renal function is seen in some, but not all recipients. We hypothesized that persistent renal dysfunction at 7 days and/or 1 month after VAD implantation would predict ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2019, 23(5):e13477]

Cited: 1 time

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Acute kidney injury in hospitalized children: consequences and outcomes.

Amanda M Uber, Scott M Sutherland,

Over the past decade, the nephrology and critical care communities have adopted a consensus approach to diagnosing acute kidney injury (AKI) and, as a result, we have seen transformative changes in our understanding of pediatric AKI epidemiology. The data regarding outcomes among neonates and children who develop AKI have become ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, 35(2):213-220]

Cited: 4 times

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Big Data and Pediatric Acute Kidney Injury: The Promise of Electronic Health Record Systems.

Scott M Sutherland,

Over the last decade, our understanding of acute kidney injury (AKI) has evolved considerably. The development of a consensus definition standardized the approach to identifying and investigating AKI in children. As a result, pediatric AKI epidemiology has been refined and the consequences of renal injury are better established. Similarly, "big ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:536]

Cited: 1 time

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Evaluation and management of elevated blood pressures in hospitalized children.

Abanti Chaudhuri, Scott M Sutherland,

Elevated blood pressures (BP) are common among hospitalized children and, if not recognized and treated promptly, can lead to potentially significant consequences. Even though we have normative BP data and well-developed guidelines for the diagnosis and management of hypertension (HTN) in the ambulatory setting, our understanding of elevated BPs and ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2019, 34(10):1671-1681]

Cited: 0 times

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Nephrotoxin exposure and acute kidney injury in critically ill children undergoing congenital cardiac surgery.

Amanda M Uber, Maria E Montez-Rath, David M Kwiatkowski, Catherine D Krawczeski, Scott M Sutherland,

<h4>Background</h4>Though acute kidney injury (AKI) is often multifactorial, investigators are now emphasizing the specific contribution of nephrotoxins. This study examines the epidemiology of nephrotoxin exposure and nephrotoxin-associated AKI among children undergoing congenital heart surgery (CHS).<h4>Methods</h4>This is a retrospective cohort study of children admitted following CHS between June 1, 2014, and ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2018, 33(11):2193-2199]

Cited: 2 times

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Electronic Health Record-Enabled Big-Data Approaches to Nephrotoxin-Associated Acute Kidney Injury Risk Prediction.

Scott M Sutherland,

Nephrotoxin-associated acute kidney injury (NTx-AKI) has become one of the most common causes of AKI among hospitalized adults and children; across acute and intensive care populations, exposure to nephrotoxins accounts for 15-25% of AKI cases. Although some interventions have shown promise in observational studies, no treatments currently exist for NTx-AKI ... Read more >>

Pharmacotherapy (Pharmacotherapy)
[2018, 38(8):804-812]

Cited: 3 times

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Long-Term Consequences of Acute Kidney Injury in Children.

Scott M Sutherland,

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2018, 13(5):677-678]

Cited: 2 times

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Acute Kidney Injury and Big Data.

Scott M Sutherland, Stuart L Goldstein, Sean M Bagshaw,

The recognition of a standardized, consensus definition for acute kidney injury (AKI) has been an important milestone in critical care nephrology, which has facilitated innovation in prevention, quality of care, and outcomes research among the growing population of hospitalized patients susceptible to AKI. Concomitantly, there have been substantial advances in ... Read more >>

Contrib Nephrol (Contributions to nephrology)
[2018, 193:55-67]

Cited: 10 times

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Pediatric acute kidney injury and the subsequent risk for chronic kidney disease: is there cause for alarm?

Vaka K Sigurjonsdottir, Swasti Chaturvedi, Cherry Mammen, Scott M Sutherland,

Acute kidney injury (AKI) is characterized clinically as an abrupt decline in renal function marked by reduced excretion of waste products, disordered electrolytes, and disrupted fluid homeostasis. The recent development of a standardized AKI definition has transformed our understanding of AKI epidemiology and outcomes. We now know that in the ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2018, 33(11):2047-2055]

Cited: 12 times

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Children tolerate intradialytic oral nutrition.

Andrew M South, Bonnie Fainman, Scott M Sutherland, Cynthia J Wong,

<h4>Background</h4>People undergoing haemodialysis (HD) often have poor nutrition, which in turn can contribute to worse outcomes. Inadequate nutrition has a particularly deleterious effect on growth and neurocognitive development, as well as mortality, in children and adolescents. Nutritional supplementation can improve outcomes but can be difficult to administer.<h4>Objective</h4>Determine the tolerability of ... Read more >>

J Ren Care (Journal of renal care)
[2018, 44(1):38-43]

Cited: 0 times

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Acute kidney injury in pediatric patients.

David M Kwiatkowski, Scott M Sutherland,

Acute kidney injury (AKI) is highly prevalent among hospitalized children, especially those who are critically ill. The incorporation of pediatric elements into consensus definitions has led to a greater understanding of pediatric AKI epidemiology, risk factors, and outcomes. The best available data suggest that AKI occurs in 5% and 27% ... Read more >>

Best Pract Res Clin Anaesthesiol (Best practice & research. Clinical anaesthesiology)
[2017, 31(3):427-439]

Cited: 2 times

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