Full Text Journal Articles by
Author Scott L Weiss

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A Stitch in Time: Optimizing Antibiotic Use From the Start.

Kathleen Chiotos, Scott L Weiss, Jeffrey S Gerber,

Crit Care Med (Critical care medicine)
[2021, 49(11):1993-1996]

Cited: 0 times

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Implementation of a Follow-Up System for Pediatric Sepsis Survivors in a Large Academic Pediatric Intensive Care Unit.

Julie C Fitzgerald, Nancy-Ann Kelly, Christopher Hickey, Fran Balamuth, Nina H Thomas, Annique Hogan, Noelle J Stack, Tara Trimarchi, Scott L Weiss,

<b>Background:</b> Survivors of pediatric sepsis often develop new morbidities and deterioration in quality of life after sepsis, leading to a need for improved follow-up for children who survive sepsis. <b>Objective:</b> To implement a follow-up system for pediatric sepsis survivors in a pediatric health system. <b>Methods:</b> We performed a retrospective case ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:691692]

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Incorporating Real-time Influenza Detection Into the Test-negative Design for Estimating Influenza Vaccine Effectiveness: The Real-time Test-negative Design (rtTND).

Leora R Feldstein, Wesley H Self, Jill M Ferdinands, Adrienne G Randolph, Michael Aboodi, Adrienne H Baughman, Samuel M Brown, Matthew C Exline, D Clark Files, Kevin Gibbs, Adit A Ginde, Michelle N Gong, Carlos G Grijalva, Natasha Halasa, Akram Khan, Christopher J Lindsell, Margaret Newhams, Ithan D Peltan, Matthew E Prekker, Todd W Rice, Nathan I Shapiro, Jay Steingrub, H Keipp Talbot, M Elizabeth Halloran, Manish Patel, ,

With rapid and accurate molecular influenza testing now widely available in clinical settings, influenza vaccine effectiveness (VE) studies can prospectively select participants for enrollment based on real-time results rather than enrolling all eligible patients regardless of influenza status, as in the traditional test-negative design (TND). Thus, we explore advantages and ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, 72(9):1669-1675]

Cited: 1 time

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Let Us Not Forget Early Mortality in Pediatric Sepsis.

Scott L Weiss, Julie C Fitzgerald, Fran Balamuth,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(4):434-436]

Cited: 0 times

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Recalibration of the Renal Angina Index for Pediatric Septic Shock.

Natalja L Stanski, Hector R Wong, Rajit K Basu, Natalie Z Cvijanovich, Julie C Fitzgerald, Scott L Weiss, Michael T Bigham, Parag N Jain, Adam Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L Allen, Neal J Thomas, Jocelyn R Grunwell, Michael Quasney, Bereketeab Haileselassie, Lakhmir S Chawla, Stuart L Goldstein,

<h4>Introduction</h4>Sepsis-associated acute kidney injury (AKI) is a common diagnosis in children that is associated with poor outcomes. The lack of therapeutic options once present makes early identification of at-risk patients essential. The renal angina index (RAI) has been previously validated to predict severe AKI in heterogeneous populations of critically ill ... Read more >>

Kidney Int Rep (Kidney international reports)
[2021, 6(7):1858-1867]

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Integrating Focused Cardiac Ultrasound Into Pediatric Septic Shock Assessment.

Sara Arnoldi, Christie L Glau, Sarah B Walker, Adam S Himebauch, Darshana S Parikh, Simone C Udeh, Scott L Weiss, Julie C Fitzgerald, Akira Nishisaki, Thomas W Conlon,

<h4>Objectives</h4>To assess focused cardiac ultrasound impact on clinician hemodynamic characterization of patients with suspected septic shock as well as expert-generated focused cardiac ultrasound algorithm performance.<h4>Design</h4>Retrospective, observational study.<h4>Setting</h4>Single-center, noncardiac PICU.<h4>Patients</h4>Less than 18 years old receiving focused cardiac ultrasound study within 72 hours of sepsis pathway initiation from January 2014 to December ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(3):262-274]

Cited: 1 time

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Decreased Intestinal Microbiome Diversity in Pediatric Sepsis: A Conceptual Framework for Intestinal Dysbiosis to Influence Immunometabolic Function.

Scott L Weiss, Kyle Bittinger, Jung-Jin Lee, Elliot S Friedman, Lisa M Mattei, Kathryn Graham, Donglan Zhang, Jeny Bush, Fran Balamuth, Francis X McGowan, Frederic D Bushman, Robert N Baldassano, Gary D Wu, Douglas C Wallace, Ronald G Collman,

<h4>Objectives</h4>The intestinal microbiome can modulate immune function through production of microbial-derived short-chain fatty acids. We explored whether intestinal dysbiosis in children with sepsis leads to changes in microbial-derived short-chain fatty acids in plasma and stool that are associated with immunometabolic dysfunction in peripheral blood mononuclear cells.<h4>Design</h4>Prospective observational pilot study.<h4>Setting</h4>Single academic ... Read more >>

Crit Care Explor (Critical care explorations)
[2021, 3(3):e0360]

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A Wrinkle in Time to Antibiotics in Sepsis: When Should ONE Hour Be the Goal?

Kathleen Chiotos, Scott L Weiss,

J Pediatr (The Journal of pediatrics)
[2021, 233:13-15]

Cited: 0 times

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Endothelial Biomarkers Are Associated With Indirect Lung Injury in Sepsis-Associated Pediatric Acute Respiratory Distress Syndrome.

Jane E Whitney, Rui Feng, Natalka Koterba, Fang Chen, Jenny Bush, Kathryn Graham, Simon F Lacey, Jan Joseph Melenhorst, Samir M Parikh, Scott L Weiss, Nadir Yehya,

<h4>Objectives</h4>Acute respiratory distress syndrome occurring in the setting of direct versus indirect lung injury may reflect different pathobiologies amenable to different treatment strategies. We sought to test whether a panel of plasma biomarkers differed between children with sepsis-associated direct versus indirect acute respiratory distress syndrome. We hypothesized that a biomarker ... Read more >>

Crit Care Explor (Critical care explorations)
[2020, 2(12):e0295]

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The authors reply.

Heidi R Flori, Robert C Tasker, Pierre Tissieres, Niranjan Kissoon, Mark J Peters, Scott L Weiss,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(11):1029]

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Perspective of the Surviving Sepsis Campaign on the Management of Pediatric Sepsis in the Era of Coronavirus Disease 2019.

Scott L Weiss, Mark J Peters, Michael S D Agus, Waleed Alhazzani, Karen Choong, Heidi R Flori, David P Inwald, Simon Nadel, Mark E Nunnally, Luregn J Schlapbach, Robert C Tasker, Pierre Tissieres, Niranjan Kissoon, ,

Severe acute respiratory syndrome coronavirus 2 is a novel cause of organ dysfunction in children, presenting as either coronavirus disease 2019 with sepsis and/or respiratory failure or a hyperinflammatory shock syndrome. Clinicians must now consider these diagnoses when evaluating children for septic shock and sepsis-associated organ dysfunction. The Surviving Sepsis ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(11):e1031-e1037]

Cited: 7 times

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Publisher Correction: Exuberant fibroblast activity compromises lung function via ADAMTS4.

David F Boyd, E Kaitlynn Allen, Adrienne G Randolph, Xi-Zhi J Guo, Yunceng Weng, Catherine J Sanders, Resha Bajracharya, Natalie K Lee, Clifford S Guy, Peter Vogel, Wenda Guan, Yimin Li, Xiaoqing Liu, Tanya Novak, Margaret M Newhams, Thomas P Fabrizio, Nicholas Wohlgemuth, Peter M Mourani, , Thomas N Wight, Stacey Schultz-Cherry, Stephania A Cormier, Kathryn Shaw-Saliba, Andrew Pekosz, Richard E Rothman, Kuan-Fu Chen, Zifeng Yang, Richard J Webby, Nanshan Zhong, Jeremy Chase Crawford, Paul G Thomas,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nature (Nature)
[2020, 588(7836):E5]

Cited: 1 time

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Clinical Signs to Categorize Shock and Target Vasoactive Medications in Warm Versus Cold Pediatric Septic Shock.

Sarah B Walker, Thomas W Conlon, Bingqing Zhang, Janell L Mensinger, Julie C Fitzgerald, Adam S Himebauch, Christie Glau, Akira Nishisaki, Suchitra Ranjit, Vinay Nadkarni, Scott L Weiss,

<h4>Objectives</h4>Determine level of agreement among clinical signs of shock type, identify which signs clinicians prioritize to determine shock type and select vasoactive medications, and test the association of shock type-vasoactive mismatch with prolonged organ dysfunction or death (complicated course).<h4>Design</h4>Retrospective observational study.<h4>Setting</h4>Single large academic PICU.<h4>Patients</h4>Patients less than 18 years treated on ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(12):1051-1058]

Cited: 1 time

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The authors reply.

Robert C Tasker, Niranjan Kissoon, Pierre Tissieres, Scott L Weiss, Mark J Peters,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(10):925-926]

Cited: 0 times

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The authors reply.

Niranjan Kissoon, Pierre Tissieres, Scott L Weiss, Mark J Peters, David P Inwald,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(9):857]

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Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children.

Caroline Diorio, Pamela A Shaw, Edward Pequignot, Alena Orlenko, Fang Chen, Richard Aplenc, David M Barrett, Hamid Bassiri, Edward Behrens, Amanda M DiNofia, Vanessa Gonzalez, Natalka Koterba, Bruce L Levine, Shannon L Maude, Nuala J Meyer, Jason H Moore, Michele Paessler, David L Porter, Jenny L Bush, Don L Siegel, Megan M Davis, Donglan Zhang, Carl H June, Stephan A Grupp, J Joseph Melenhorst, Simon F Lacey, Scott L Weiss, David T Teachey,

Chimeric antigen receptor (CAR) T-cells directed against CD19 have drastically altered outcomes for children with relapsed and refractory acute lymphoblastic leukemia (r/r ALL). Pediatric patients with r/r ALL treated with CAR-T are at increased risk of both cytokine release syndrome (CRS) and sepsis. We sought to investigate the biologic differences ... Read more >>

Blood Adv (Blood advances)
[2020, 4(20):5174-5183]

Cited: 4 times

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Exuberant fibroblast activity compromises lung function via ADAMTS4.

David F Boyd, E Kaitlynn Allen, Adrienne G Randolph, Xi-Zhi J Guo, Yunceng Weng, Catherine J Sanders, Resha Bajracharya, Natalie K Lee, Clifford S Guy, Peter Vogel, Wenda Guan, Yimin Li, Xiaoqing Liu, Tanya Novak, Margaret M Newhams, Thomas P Fabrizio, Nicholas Wohlgemuth, Peter M Mourani, , Thomas N Wight, Stacey Schultz-Cherry, Stephania A Cormier, Kathryn Shaw-Saliba, Andrew Pekosz, Richard E Rothman, Kuan-Fu Chen, Zifeng Yang, Richard J Webby, Nanshan Zhong, Jeremy Chase Crawford, Paul G Thomas,

Severe respiratory infections can result in acute respiratory distress syndrome (ARDS)<sup>1</sup>. There are no effective pharmacological therapies that have been shown to improve outcomes for patients with ARDS. Although the host inflammatory response limits spread of and eventually clears the pathogen, immunopathology is a major contributor to tissue damage and ... Read more >>

Nature (Nature)
[2020, 587(7834):466-471]

Cited: 17 times

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Diaphragm Atrophy During Pediatric Acute Respiratory Failure Is Associated With Prolonged Noninvasive Ventilation Requirement Following Extubation.

Christie L Glau, Thomas W Conlon, Adam S Himebauch, Nadir Yehya, Scott L Weiss, Robert A Berg, Akira Nishisaki,

<h4>Objectives</h4>Diaphragm atrophy is evident during invasive ventilation for pediatric acute respiratory failure, but with unknown significance. We hypothesized that diaphragm atrophy in pediatric acute respiratory failure is associated with prolonged noninvasive positive pressure ventilation following extubation.<h4>Design</h4>Prospective observational study.<h4>Setting</h4>Single-center academic PICU.<h4>Patients</h4>Invasively ventilated children with acute respiratory failure.<h4>Interventions</h4>Diaphragm ultrasound was performed within ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(9):e672-e678]

Cited: 1 time

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Mitochondrial Dysfunction is Associated With an Immune Paralysis Phenotype in Pediatric Sepsis.

Scott L Weiss, Donglan Zhang, Jenny Bush, Kathryn Graham, Jonathan Starr, Jennifer Murray, Florin Tuluc, Sarah Henrickson, Clifford S Deutschman, Lance Becker, Francis X McGowan, Douglas C Wallace,

<h4>Objective</h4>Immune dysregulation is a defining feature of sepsis, but the role for mitochondria in the development of immunoparalysis in pediatric sepsis is not known. We sought to determine if mitochondrial dysfunction measured in peripheral blood mononuclear cells (PBMCs) is associated with immunoparalysis and systemic inflammation in children with sepsis.<h4>Design</h4>Prospective observational ... Read more >>

Shock (Shock (Augusta, Ga.))
[2020, 54(3):285-293]

Cited: 5 times

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Utility of Procalcitonin as a Biomarker for Sepsis in Children.

Kevin J Downes, Julie C Fitzgerald, Scott L Weiss,

Sepsis is a complex process defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. It is associated with significant morbidity and mortality rates in both adults and children, and emphasis has been placed on its early recognition and prompt provision of antimicrobials. Owing to limitations of ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2020, 58(7):]

Cited: 1 time

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The authors reply.

Niranjan Kissoon, Pierre Tissieres, Scott L Weiss, Mark J Peters, David P Inwald,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(9):853-854]

Cited: 0 times

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Association of early hypotension in pediatric sepsis with development of new or persistent acute kidney injury.

Julie C Fitzgerald, Michelle E Ross, Neal J Thomas, Scott L Weiss, Fran Balamuth, Marianne Chilutti, Robert W Grundmeier, Amanda Hyre Anderson,

<h4>Objective</h4>To determine how hypotension in the first 48 h of sepsis management impacts acute kidney injury (AKI) development and persistence.<h4>Study design</h4>Retrospective study of patients > 1 month to < 20 years old with sepsis in a pediatric ICU between November 2012 and January 2015 (n = 217). All systolic blood ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2021, 36(2):451-461]

Cited: 0 times

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Risk of Mortality in Immunocompromised Children With Severe Sepsis and Septic Shock.

Robert B Lindell, Akira Nishisaki, Scott L Weiss, Danielle M Traynor, Julie C Fitzgerald,

<h4>Objectives</h4>To assess the prevalence of immunocompromised diagnoses among children with severe sepsis and septic shock, and to determine the association between immunocompromised diagnoses and clinical outcomes after adjustment for demographics and illness severity.<h4>Design</h4>Retrospective multicenter cohort study.<h4>Setting</h4>Eighty-three centers in the Virtual Pediatric Systems database.<h4>Patients</h4>Children with severe sepsis or septic shock admitted ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(7):1026-1033]

Cited: 1 time

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Might the surviving sepsis campaign international guidelines be less confusing? Authors' reply.

Pierre Tissieres, Mark J Peters, Niranjan Kissoon, Scott L Weiss,

Intensive Care Med (Intensive care medicine)
[2020, 46(8):1658-1659]

Cited: 0 times

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Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated With a Lower Occurrence of Adverse Hemodynamic Events.

J Arden Conway, Priyanka Kharayat, Ronald C Sanders, Sholeen Nett, Scott L Weiss, Lauren R Edwards, Ryan Breuer, Aileen Kirby, Conrad Krawiec, Christopher Page-Goertz, Lee Polikoff, David A Turner, Justine Shults, John S Giuliano, Alberto Orioles, Sylvain Balkandier, Guillaume Emeriaud, Kyle J Rehder, Joel Lim Kian Boon, Asha Shenoi, Paula Vanderford, Gabrielle Nuthall, Anthony Lee, Jonida Zeqo, Simon J Parsons, Jamie Furlong-Dillard, Keith Meyer, Ilana Harwayne-Gidansky, Philipp Jung, Michelle Adu-Darko, G Kris Bysani, Melissa A McCarthy, Mark Shlomovich, Iris Toedt-Pingel, Aline Branca, Maria Christina Esperanza, Awni M Al-Subu, Matthew Pinto, Sarah Tallent, Rakshay Shetty, Sujatha Thyagarajan, Takanari Ikeyama, Keiko M Tarquinio, Peter Skippen, Mioko Kasagi, Joy D Howell, Vinay M Nadkarni, Akira Nishisaki, ,

<h4>Objectives</h4>Tracheal intubation in critically ill children with shock poses a risk of hemodynamic compromise. Ketamine has been considered the drug of choice for induction in these patients, but limited data exist. We investigated whether the administration of ketamine for tracheal intubation in critically ill children with or without shock was ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(6):e489-e497]

Cited: 2 times

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