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Author Scott Holmes

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A lateralized model of the pain-depression dyad.

Anne Margarette S Maallo, Eric A Moulton, Christine B Sieberg, Donald B Giddon, David Borsook, Scott A Holmes,

Chronic pain and depression are two frequently co-occurring and debilitating conditions. Even though the former is treated as a physical affliction, and the latter as a mental illness, both disorders closely share neural substrates. Here, we review the association of pain with depression, especially when symptoms are lateralized on either ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2021, 127:876-883]

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Left to themselves: Time to target chronic pain in childhood rare diseases.

Christine B Sieberg, Alyssa Lebel, Erin Silliman, Scott Holmes, David Borsook, Igor Elman,

<h4>Background</h4>Chronic pain is prevalent among patients with rare diseases (RDs). However, little is understood about how biopsychosocial mechanisms may be integrated in the unique set of clinical features and therapeutic challenges inherent in their pain conditions.<h4>Methods</h4>This review presents examples of major categories of RDs with particular pain conditions. In addition, ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2021, 126:276-288]

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Vascularized Bone Grafts for Spinal Fusion-Part 4: The Scapula.

Edward M Reece, Matthew J Davis, Amjed Abu-Ghname, Edward Chamata, Scott Holmes, Sebastian Winocour, Scott L Hansen, David S Xu, Michael A Bohl, Alexander E Ropper,

<h4>Background</h4>Solid arthrodesis is the long-term goal of most spinal reconstruction surgeries. A multitube of biologics as well as autograft is commonly used to augment the bony fusion. Medial scapular vascularized bone grafts (S-VBGs) are a novel approach to supplement cervicothoracic arthrodesis in patients at high risk for failed fusion.<h4>Objective</h4>To discuss ... Read more >>

Oper Neurosurg (Hagerstown) (Operative neurosurgery (Hagerstown, Md.))
[2021, 20(5):508-512]

Cited: 1 time

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The Historical Role of the Plastic Surgeon in Spine Reconstruction.

Annie Do, Matthew J Davis, Amjed Abu-Ghname, Sebastian J Winocour, Edward M Reece, Scott Holmes, David S Xu, Alexander E Ropper, Scott L Hansen,

Wound complications occur in up to 19% of patients undergoing complex spine surgery. The role of the plastic surgeon in complex and redo spine surgery is important and evolving. Classically, plastic surgeons have been involved in the management of patients who develop wound complications following surgery. This involves reconstruction of ... Read more >>

Semin Plast Surg (Seminars in plastic surgery)
[2021, 35(1):3-9]

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Altered Brain Network Connectivity Underlies Persistent Post-Traumatic Headache following Mild Traumatic Brain Injury in Youth.

Jordan Lemme, Scott Holmes, Diana Sibai, Joud Mari, Laura E Simons, Rami Burstein, David Zurakowski, Alyssa Lebel, Michael O'Brien, Jaymin Upadhyay, David Borsook,

Post-traumatic headaches (PTHs) are associated with mild traumatic brain injuries (mTBI) and may predict the persistence of concussion symptoms. Altered brain networks implicated in brain injury and the affective components of headache-related pain may underlie the resolution of PTH. This is a hypothesis-generating investigation to evaluate the extent to which ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, 38(12):1632-1641]

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Commentary: Novel Use of Offset Analgesia to Assess Adolescents and Adults with Treatment Resistant Endometriosis-Associated Pain.

Claire E Lunde, Edina Szabo, Scott A Holmes, David Borsook, Christine B Sieberg,

<h4>Background and objective</h4>Endometriosis, affecting approximately 176 million adults and adolescents worldwide, is a debilitating condition in which uterine tissue grows outside the uterus. The condition costs the US economy approximately $78 billion annually in pain-related disability. By understanding the neural underpinnings of endometriosis-associated pain (EAP) and risk factors for chronification, ... Read more >>

J Pain Res (Journal of pain research)
[2020, 13:2775-2782]

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Safety Unseen: Leveraging Design to Improve Inpatient Mental Health-Care Practices.

Scott Holmes, Melanie Baumhover, James Lockwood,

When a patient attacks a nurse, there is more than physical trauma that occurs. The consequences of the violence can manifest in anger, fear, anxiety, shame, blame, and post-traumatic stress disorder symptoms that can have negative effects on patient care and job satisfaction. In the past, design strategies in inpatient ... Read more >>

Creat Nurs (Creative nursing)
[2020, 26(3):e48-e55]

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Clinical features and sex differences in pediatric post-traumatic headache: A retrospective chart review at a Boston area concussion clinic.

Haley McEvoy, David Borsook, Scott A Holmes,

<h4>Background</h4>Often concussion/mTBI triggers a chronic headache syndrome called persistent post-traumatic headache (P-PTH) that can last from months to years post-injury, and produce significant disruption of childhood education, social interaction and development. Although prevalent and highly disabling, P-PTH is underrepresented in headache and pain research and lacks clear definition and pathophysiology. ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2020, 40(7):701-711]

Cited: 1 time

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Delineating conditions and subtypes in chronic pain using neuroimaging.

Scott A Holmes, Jaymin Upadhyay, David Borsook,

Differentiating subtypes of chronic pain still remains a challenge-both from a subjective and objective point of view. Personalized medicine is the current goal of modern medical care and is limited by the subjective nature of patient self-reporting of symptoms and behavioral evaluation. Physiology-focused techniques such as genome and epigenetic analyses ... Read more >>

Pain Rep (Pain reports)
[2019, 4(4):e768]

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Evaluating task-based brain network activity in pediatric subjects with an mTBI: mechanisms of functional compensation are symptom-level dependent.

Scott A Holmes, Rajeet Singh-Saluja, Jen-Kai Chen, Isabelle Gagnon, Alain Ptito,

The diagnosis of a mild traumatic brain injury (mTBI) places large emphasis on patient-reported symptoms which has restricted our ability to evaluate patients. Task-based functional magnetic resonance imaging has the potential to act as an objective measurement of abnormal brain activity and inform clinical decision-making; however, there is little research ... Read more >>

Brain Inj (Brain injury)
[2019, 33(3):383-393]

Cited: 1 time

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Bridge-bonded methylthiolate on Au(111) observed with the scanning tunneling microscope.

Scott Holmes, Jianzhi Gao, Lin Tang, Fangsen Li, Richard E Palmer, Quanmin Guo,

We report the discovery of bridge-bonded methylthiolate, SCH3, along the step edges of the Au(111) surface. Real-space imaging with a scanning tunnelling microscope reveals the presence of bridge-bonded SCH3 along both the [11[combining macron]0] and the [112[combining macron]] oriented step edges. The nearest neighbour distances of SCH3 along these steps ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2018, 20(29):19486-19491]

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Nucleolar structure: Yeast rDNA feels the heat.

Scott G Holmes,

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2017, 16(16):1485-1486]

Cited: 0 times

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Combined structural and functional patterns discriminating upper limb motor disability in multiple sclerosis using multivariate approaches.

Jidan Zhong, David Qixiang Chen, Julia C Nantes, Scott A Holmes, Mojgan Hodaie, Lisa Koski,

A structural or functional pattern of neuroplasticity that could systematically discriminate between people with impaired and preserved motor performance could help us to understand the brain networks contributing to preservation or compensation of behavior in multiple sclerosis (MS). This study aimed to (1) investigate whether a machine learning-based technique could ... Read more >>

Brain Imaging Behav (Brain imaging and behavior)
[2017, 11(3):754-768]

Cited: 6 times

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Corrigendum to "Intracortical inhibition abnormality during the remission phase of multiple sclerosis is related to upper limb dexterity and lesions" [Clin. Neurophysiol. 127 (2016) 1503-1511].

Julia C Nantes, Jidan Zhong, Scott A Holmes, Benjamin Whatley, Sridar Narayanan, Yves Lapierre, Douglas L Arnold, Lisa Koski,

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2017, 128(2):393]

Cited: 0 times

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GABA and glutamate levels correlate with MTR and clinical disability: Insights from multiple sclerosis.

Julia C Nantes, S├ębastien Proulx, Jidan Zhong, Scott A Holmes, Sridar Narayanan, Robert A Brown, Richard D Hoge, Lisa Koski,

Converging areas of research have implicated glutamate and ╬│-aminobutyric acid (GABA) as key players in neuronal signalling and other central functions. Further research is needed, however, to identify microstructural and behavioral links to regional variability in levels of these neurometabolites, particularly in the presence of demyelinating disease. Thus, we sought ... Read more >>

Neuroimage (NeuroImage)
[2017, 157:705-715]

Cited: 11 times

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Neer Award 2017: A rapid method for detecting Propionibacterium acnes in surgical biopsy specimens from the shoulder.

Scott Holmes, Ana M Pena Diaz, George S Athwal, Kenneth J Faber, David B O'Gorman,

<h4>Background</h4>Propionibacterium (P) acnes infection of the shoulder after arthroplasty is a common and serious complication. Current detection methods for P acnes involve anaerobic cultures that require prolonged incubation periods (typically 7-14 days). We have developed a polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) approach that sensitively and specifically identifies ... Read more >>

J Shoulder Elbow Surg (Journal of shoulder and elbow surgery)
[2017, 26(2):179-185]

Cited: 11 times

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Surface-induced symmetry reduction in molecular switching: asymmetric cis-trans switching of CH3S-Au-SCH3 on Au(111).

Jianzhi Gao, Lin Tang, Scott Holmes, Fangsen Li, Richard E Palmer, Quanmin Guo,

The cis-trans isomerization of CH<sub>3</sub>S-Au-SCH<sub>3</sub> driven by the tip of the scanning tunneling microscope is investigated at 77 K. CH<sub>3</sub>S-Au-SCH<sub>3</sub> anchored on the Au(111) surface with the S-Au-S axis parallel to the substrate functions as a molecular switch due to the flipping of the CH<sub>3</sub> groups. The bonding between CH<sub>3</sub>S-Au-SCH<sub>3</sub> ... Read more >>

Nanoscale (Nanoscale)
[2016, 8(47):19787-19793]

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Abnormal functional connectivity and cortical integrity influence dominant hand motor disability in multiple sclerosis: a multimodal analysis.

Jidan Zhong, Julia C Nantes, Scott A Holmes, Serge Gallant, Sridar Narayanan, Lisa Koski,

Functional reorganization and structural damage occur in the brains of people with multiple sclerosis (MS) throughout the disease course. However, the relationship between resting-state functional connectivity (FC) reorganization in the sensorimotor network and motor disability in MS is not well understood. This study used resting-state fMRI, T1-weighted and T2-weighted, and ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2016, 37(12):4262-4275]

Cited: 4 times

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Cortical Damage and Disability in Multiple Sclerosis: Relation to Intracortical Inhibition and Facilitation.

Julia C Nantes, Jidan Zhong, Scott A Holmes, Sridar Narayanan, Yves Lapierre, Lisa Koski,

<h4>Background</h4>Multimodal research combining biomarkers of intracortical activity and cortical damage could shed light on pathophysiological and adaptive neural processes related to the clinical severity of neurological conditions such as multiple sclerosis (MS).<h4>Objective</h4>Among people with relapsing-remitting and progressive forms of MS, we assessed the extent to which transcranial magnetic stimulation (TMS)-based ... Read more >>

Brain Stimul (Brain stimulation)
[2016, 9(4):566-573]

Cited: 9 times

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Intracortical inhibition abnormality during the remission phase of multiple sclerosis is related to upper limb dexterity and lesions.

Julia C Nantes, Jidan Zhong, Scott A Holmes, Benjamin Whatley, Sridar Narayanan, Yves Lapierre, Douglas L Arnold, Lisa Koski,

<h4>Objective</h4>The impact of inhibitory cortical activity on motor impairment of people with relapsing-remitting multiple sclerosis (RRMS) has not been fully elucidated despite its relevance to neurorehabilitation. The present study assessed the extent to which transcranial magnetic stimulation (TMS)-based metrics of intracortical inhibition are related to motor disability and brain damage.<h4>Methods</h4>Participants ... Read more >>

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2016, 127(2):1503-1511]

Cited: 6 times

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An Inverse Grip Starting Posture Gives Rise to Time-Dependent Adherence to Weber's Law: A Reply to Ganel et al. (2014).

Matthew Heath, Shirin Davarpanah Jazi, Scott A Holmes,

J Vis (Journal of vision)
[2015, 15(6):1]

Cited: 10 times

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Making BAC transgene constructs with lambda-red recombineering system for transgenic animals or cell lines.

Scott Holmes, Suzanne Lyman, Jen-Kang Hsu, JrGang Cheng,

The genomic DNA libraries based on Bacteria Artificial Chromosomes (BAC) are the foundation of whole genomic mapping, sequencing, and annotation for many species like mice and humans. With their large insert size, BACs harbor the gene-of-interest and nearby transcriptional regulatory elements necessary to direct the expression of the gene-of-interest in ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2015, 1227:71-98]

Cited: 3 times

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Assessing aggression following traumatic brain injury: a systematic review of validated aggression scales.

Michael D Cusimano, Scott A Holmes, Carolyn Sawicki, Jane Topolovec-Vranic,

<h4>Background</h4>Every year, millions of people worldwide suffer traumatic brain injuries (TBIs). Aggressive behavior, a known psychological symptom following TBI, has been regarded as an obstacle toward rehabilitation. Having measures that accurately assess aggression during rehabilitation is critical toward proper evaluation.<h4>Objective</h4>To undertake a systematic review of the validated scales used to ... Read more >>

J Head Trauma Rehabil (The Journal of head trauma rehabilitation)
[2014, 29(2):172-184]

Cited: 3 times

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Yeast Tdh3 (glyceraldehyde 3-phosphate dehydrogenase) is a Sir2-interacting factor that regulates transcriptional silencing and rDNA recombination.

Alison E Ringel, Rebecca Ryznar, Hannah Picariello, Kuan-lin Huang, Asmitha G Lazarus, Scott G Holmes,

Sir2 is an NAD(+)-dependent histone deacetylase required to mediate transcriptional silencing and suppress rDNA recombination in budding yeast. We previously identified Tdh3, a glyceraldehyde 3-phosphate dehydrogenase (GAPDH), as a high expression suppressor of the lethality caused by Sir2 overexpression in yeast cells. Here we show that Tdh3 interacts with Sir2, ... Read more >>

PLoS Genet (PLoS genetics)
[2013, 9(10):e1003871]

Cited: 26 times

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Histone variant H2A.Z functions in sister chromatid cohesion in Saccharomyces cerevisiae.

Upasna Sharma, Dessislava Stefanova, Scott G Holmes,

H2A.Z is a highly conserved variant of histone H2A with well-characterized roles in transcriptional regulation. We previously reported that H2A.Z and Mcd1, a subunit of the cohesin complex, regulate the establishment of transcriptional silencing at telomeres in Saccharomyces cerevisiae and that H2A.Z broadly dissociated from chromatin during the anaphase-to-telophase transition, ... Read more >>

Mol Cell Biol (Molecular and cellular biology)
[2013, 33(17):3473-3481]

Cited: 17 times

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